Coexpression cluster:C985

Full id: C985_smooth_aorta_bladder_Mast_umbilical_heart_vagina

Phase1 CAGE Peaks

Hg19::chr10:97168311..97168312,-	p@chr10:97168311..97168312 -
Hg19::chr10:97173718..97173724,-	p7@SORBS1
Hg19::chr10:97192249..97192269,-	p@chr10:97192249..97192269 -
Hg19::chr10:97321120..97321163,-	p1@SORBS1
Hg19::chr10:97321165..97321176,-	p4@SORBS1
Hg19::chr3:184870541..184870568,-	p3@C3orf70
Hg19::chr3:184870642..184870706,-	p2@C3orf70
Hg19::chr3:184870751..184870872,-	p1@C3orf70

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005915	zonula adherens	0.0038266807959496
GO:0043149	stress fiber formation	0.00414557086227874
GO:0001725	stress fiber	0.00414557086227874
GO:0032432	actin filament bundle	0.00414557086227874
GO:0048041	focal adhesion formation	0.00414557086227874
GO:0005913	cell-cell adherens junction	0.00414557086227874
GO:0051017	actin filament bundle formation	0.00510224106126614
GO:0005158	insulin receptor binding	0.00510224106126614
GO:0015758	glucose transport	0.00510224106126614
GO:0008645	hexose transport	0.00510224106126614
GO:0008286	insulin receptor signaling pathway	0.00510224106126614
GO:0015749	monosaccharide transport	0.00510224106126614
GO:0005924	cell-substrate adherens junction	0.00522979708779779
GO:0030055	cell-matrix junction	0.00522979708779779
GO:0007015	actin filament organization	0.00522979708779779
GO:0045121	lipid raft	0.00550085364417756
GO:0005912	adherens junction	0.00607766949944937
GO:0016323	basolateral plasma membrane	0.00873481486031975
GO:0007160	cell-matrix adhesion	0.00873481486031975
GO:0032403	protein complex binding	0.00873481486031975
GO:0031589	cell-substrate adhesion	0.00873481486031975
GO:0043296	apical junction complex	0.00873481486031975
GO:0016327	apicolateral plasma membrane	0.00873481486031975
GO:0008643	carbohydrate transport	0.00884919934063346
GO:0005911	intercellular junction	0.0132403155539856
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	0.0154539032144119
GO:0030036	actin cytoskeleton organization and biogenesis	0.0175035214185102
GO:0030029	actin filament-based process	0.0177667322669089
GO:0015629	actin cytoskeleton	0.019133403979748
GO:0007167	enzyme linked receptor protein signaling pathway	0.019133403979748
GO:0030054	cell junction	0.0261888466972801
GO:0003779	actin binding	0.0261888466972801
GO:0008092	cytoskeletal protein binding	0.034961947272085
GO:0007010	cytoskeleton organization and biogenesis	0.038604456265021
GO:0044430	cytoskeletal part	0.0496434265420489
GO:0022610	biological adhesion	0.0496434265420489
GO:0007155	cell adhesion	0.0496434265420489

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
adult organism	1.31e-48	115
central nervous system	1.59e-34	82
neural tube	3.79e-31	57
neural rod	3.79e-31	57
future spinal cord	3.79e-31	57
neural keel	3.79e-31	57
regional part of nervous system	8.41e-31	94
nervous system	8.41e-31	94
regional part of brain	1.54e-28	59
brain	2.93e-28	69
future brain	2.93e-28	69
anterior neural tube	7.32e-24	42
regional part of forebrain	1.71e-23	41
forebrain	1.71e-23	41
future forebrain	1.71e-23	41
neural plate	4.67e-23	86
presumptive neural plate	4.67e-23	86
telencephalon	1.45e-20	34
gray matter	1.54e-20	34
brain grey matter	1.54e-20	34
neurectoderm	2.49e-20	90
regional part of telencephalon	5.52e-20	33
cerebral hemisphere	2.20e-19	32
ectoderm-derived structure	7.15e-18	169
anterior region of body	1.27e-16	129
craniocervical region	1.27e-16	129
head	2.51e-16	123
ectoderm	2.56e-16	173
presumptive ectoderm	2.56e-16	173
cerebral cortex	2.21e-15	25
pallium	2.21e-15	25
pre-chordal neural plate	2.82e-15	61
regional part of cerebral cortex	2.37e-14	22
neocortex	3.97e-13	20
organ	5.91e-10	511
tube	6.65e-09	194
posterior neural tube	2.17e-08	15
chordal neural plate	2.17e-08	15
anatomical conduit	6.08e-08	241
multi-cellular organism	8.08e-08	659
organism subdivision	1.23e-07	365
anatomical system	3.96e-07	625
segmental subdivision of nervous system	4.05e-07	13
anatomical group	5.77e-07	626

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.