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|gostat_on_coexpression_clusters=GO:0019987!negative regulation of anti-apoptosis!0.0024726245143059!25816$GO:0043027!caspase inhibitor activity!0.0024726245143059!25816$GO:0045767!regulation of anti-apoptosis!0.0032968326857412!25816$GO:0043028!caspase regulator activity!0.00432709290003532!25816$GO:0006916!anti-apoptosis!0.0270811256328741!25816$GO:0043066!negative regulation of apoptosis!0.0270811256328741!25816$GO:0043069!negative regulation of programmed cell death!0.0270811256328741!25816$GO:0004857!enzyme inhibitor activity!0.0413134345931944!25816$GO:0042981!regulation of apoptosis!0.0474743906746733!25816$GO:0043067!regulation of programmed cell death!0.0474743906746733!25816
|gostat_on_coexpression_clusters=GO:0019987!negative regulation of anti-apoptosis!0.0024726245143059!25816$GO:0043027!caspase inhibitor activity!0.0024726245143059!25816$GO:0045767!regulation of anti-apoptosis!0.0032968326857412!25816$GO:0043028!caspase regulator activity!0.00432709290003532!25816$GO:0006916!anti-apoptosis!0.0270811256328741!25816$GO:0043066!negative regulation of apoptosis!0.0270811256328741!25816$GO:0043069!negative regulation of programmed cell death!0.0270811256328741!25816$GO:0004857!enzyme inhibitor activity!0.0413134345931944!25816$GO:0042981!regulation of apoptosis!0.0474743906746733!25816$GO:0043067!regulation of programmed cell death!0.0474743906746733!25816
|id=C3020
|id=C3020
|ontology_enrichment_celltype=CL:0000037!1.35e-39!172;CL:0000566!1.35e-39!172;CL:0000988!3.60e-36!182;CL:0002032!4.26e-36!165;CL:0000837!4.26e-36!165;CL:0000738!4.78e-36!140;CL:0002087!1.71e-34!119;CL:0002031!5.17e-32!124;CL:0000542!1.69e-26!53;CL:0000051!1.69e-26!53;CL:0000838!5.27e-26!52;CL:0000084!2.99e-14!25;CL:0000827!2.99e-14!25;CL:0000763!6.96e-13!112;CL:0000049!6.96e-13!112;CL:0000791!8.83e-12!18;CL:0000789!8.83e-12!18;CL:0002420!8.83e-12!18;CL:0002419!8.83e-12!18;CL:0000790!8.83e-12!18;CL:0000945!1.88e-11!24;CL:0000826!1.88e-11!24;CL:0000839!2.10e-09!70;CL:0002194!2.61e-09!63;CL:0000576!2.61e-09!63;CL:0000040!2.61e-09!63;CL:0000559!2.61e-09!63;CL:0002009!2.67e-09!65;CL:0000557!4.65e-09!71;CL:0000766!5.63e-09!76;CL:0000236!6.25e-09!14;CL:0002320!1.50e-08!365;CL:0000134!2.26e-08!358;CL:0000625!4.63e-08!11;CL:0002057!1.00e-07!42;CL:0000860!2.05e-07!45
|ontology_enrichment_disease=DOID:2531!2.47e-09!51;DOID:0060083!2.47e-09!51
|ontology_enrichment_uberon=UBERON:0002390!3.55e-15!102;UBERON:0003061!3.55e-15!102;UBERON:0002193!1.18e-13!112;UBERON:0002384!2.06e-08!375;UBERON:0002371!7.60e-08!80;UBERON:0000178!6.22e-07!15;UBERON:0000179!6.22e-07!15;UBERON:0000463!6.22e-07!15
}}
}}

Revision as of 14:31, 21 May 2012


Full id: C3020_thymus_CD19_CD8_CD4_lymph_blood_vein



Phase1 CAGE Peaks

Hg19::chr10:47640768..47640792,-p1@ENST00000454837
Hg19::chr1:160616854..160616893,+p@chr1:160616854..160616893
+
Hg19::chr5:118604403..118604434,+p4@TNFAIP8


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0019987negative regulation of anti-apoptosis0.0024726245143059
GO:0043027caspase inhibitor activity0.0024726245143059
GO:0045767regulation of anti-apoptosis0.0032968326857412
GO:0043028caspase regulator activity0.00432709290003532
GO:0006916anti-apoptosis0.0270811256328741
GO:0043066negative regulation of apoptosis0.0270811256328741
GO:0043069negative regulation of programmed cell death0.0270811256328741
GO:0004857enzyme inhibitor activity0.0413134345931944
GO:0042981regulation of apoptosis0.0474743906746733
GO:0043067regulation of programmed cell death0.0474743906746733



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
hematopoietic stem cell1.35e-39172
angioblastic mesenchymal cell1.35e-39172
hematopoietic cell3.60e-36182
hematopoietic oligopotent progenitor cell4.26e-36165
hematopoietic multipotent progenitor cell4.26e-36165
leukocyte4.78e-36140
nongranular leukocyte1.71e-34119
hematopoietic lineage restricted progenitor cell5.17e-32124
lymphocyte1.69e-2653
common lymphoid progenitor1.69e-2653
lymphoid lineage restricted progenitor cell5.27e-2652
T cell2.99e-1425
pro-T cell2.99e-1425
myeloid cell6.96e-13112
common myeloid progenitor6.96e-13112
mature alpha-beta T cell8.83e-1218
alpha-beta T cell8.83e-1218
immature T cell8.83e-1218
mature T cell8.83e-1218
immature alpha-beta T cell8.83e-1218
lymphocyte of B lineage1.88e-1124
pro-B cell1.88e-1124
myeloid lineage restricted progenitor cell2.10e-0970
monopoietic cell2.61e-0963
monocyte2.61e-0963
monoblast2.61e-0963
promonocyte2.61e-0963
macrophage dendritic cell progenitor2.67e-0965
granulocyte monocyte progenitor cell4.65e-0971
myeloid leukocyte5.63e-0976
B cell6.25e-0914
connective tissue cell1.50e-08365
mesenchymal cell2.26e-08358
CD8-positive, alpha-beta T cell4.63e-0811
CD14-positive, CD16-negative classical monocyte1.00e-0742
classical monocyte2.05e-0745
Uber Anatomy
Ontology termp-valuen
hematopoietic system3.55e-15102
blood island3.55e-15102
hemolymphoid system1.18e-13112
connective tissue2.06e-08375
bone marrow7.60e-0880
blood6.22e-0715
haemolymphatic fluid6.22e-0715
organism substance6.22e-0715
Disease
Ontology termp-valuen
hematologic cancer2.47e-0951
immune system cancer2.47e-0951


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.