Coexpression cluster:C2955

Full id: C2955_Adipocyte_Endothelial_Osteoblast_neuroectodermal_salivary_Smooth_Fibroblast

Phase1 CAGE Peaks

Hg19::chrX:1508197..1508219,-	p@chrX:1508197..1508219 -
Hg19::chrX:1508481..1508521,-	p2@SLC25A6
Hg19::chrX:1510994..1511012,-	p1@SLC25A6
Hg19::chrX:1571759..1571808,-	p1@ASMTL

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005471	ATP:ADP antiporter activity	0.00244315254826876
GO:0017096	acetylserotonin O-methyltransferase activity	0.00244315254826876
GO:0030186	melatonin metabolic process	0.00244315254826876
GO:0030187	melatonin biosynthetic process	0.00244315254826876
GO:0042435	indole derivative biosynthetic process	0.00488601741722185
GO:0046219	indolalkylamine biosynthetic process	0.00488601741722185
GO:0042430	indole and derivative metabolic process	0.00597135955542775
GO:0006586	indolalkylamine metabolic process	0.00597135955542775
GO:0042434	indole derivative metabolic process	0.00597135955542775
GO:0008171	O-methyltransferase activity	0.0066618683710385
GO:0005744	mitochondrial inner membrane presequence translocase complex	0.0066618683710385
GO:0042401	biogenic amine biosynthetic process	0.013838010375701
GO:0042398	amino acid derivative biosynthetic process	0.0149988803209093
GO:0042446	hormone biosynthetic process	0.0149988803209093
GO:0006839	mitochondrial transport	0.0155638645169341
GO:0015300	solute:solute antiporter activity	0.0155638645169341
GO:0006576	biogenic amine metabolic process	0.0201850584132047
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	0.0201850584132047
GO:0042445	hormone metabolic process	0.0201850584132047
GO:0007005	mitochondrion organization and biogenesis	0.0201850584132047
GO:0006575	amino acid derivative metabolic process	0.0201850584132047
GO:0015297	antiporter activity	0.0201850584132047
GO:0009309	amine biosynthetic process	0.0245919726276852
GO:0044455	mitochondrial membrane part	0.0245919726276852
GO:0046483	heterocycle metabolic process	0.025360916663867
GO:0044271	nitrogen compound biosynthetic process	0.0275674568476008
GO:0006725	aromatic compound metabolic process	0.0330300604508557
GO:0008168	methyltransferase activity	0.0466508466277305
GO:0016741	transferase activity, transferring one-carbon groups	0.0466508466277305

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.