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MCL coexpression mm9:1628: Difference between revisions

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{{MCL_coexpression_mm9
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protein binding;0.0240996832705677;55925!GO:0007340;acrosome reaction;0.0240996832705677;55925!GO:0017156;calcium ion-dependent exocytosis;0.0277047634426189;55925!GO:0004364;glutathione transferase activity;0.0277047634426189;14860!GO:0007338;single fertilization;0.0318944565643738;55925!GO:0009566;fertilization;0.0318944565643738;55925!GO:0016765;transferase activity, transferring alkyl or aryl (other than methyl) groups;0.0318944565643738;14860!GO:0008021;synaptic vesicle;0.0318944565643738;55925!GO:0030136;clathrin-coated vesicle;0.0380408858425117;55925!GO:0006887;exocytosis;0.0380408858425117;55925!GO:0030135;coated vesicle;0.0380408858425117;55925!|ontology_enrichment_celltype=CL:0000068!6.26e-08!3;CL:0002202!6.26e-08!3;CL:0000069!6.26e-08!3;CL:0002632!6.26e-08!3;CL:0002368!6.26e-08!3;CL:0000307!6.26e-08!3;CL:0000377!6.26e-08!3|ontology_enrichment_disease=|ontology_enrichment_uberon=UBERON:0000945!3.67e-09!16;UBERON:0010039!3.67e-09!16;UBERON:0003126!6.26e-08!3;UBERON:0001005!6.26e-08!3;UBERON:0007196!6.26e-08!3;UBERON:0001558!6.26e-08!3|tfbs_overrepresentation_for_novel_motifs=0.557864,1.02681,0.529553,0.603273,2.76252,0.618805,0.715644,0.812379,0.310789,0.115752,0.668936,0.702872,0.300533,0.728641,1.0876,0,0.930881,0.397593,0.283802,0.185796,0.489529,0.874994,0.727684,0.404661,0.537749,0.757752,0.754069,0.641282,0.456327,1.20535,0.626183,1.03545,0.395107,0.704734,1.08876,0.20704,0.384813,0.699032,0.360612,0.328675,0.401916,0.631725,1.34408,0.426986,0.0637209,0.591277,0.847828,0.658142,0.746467,0.459555,0.912738,0.786094,0.627649,1.18062,1.19842,0.73621,0.469329,0.689304,0.26467,0.734051,1.01481,0.796017,0.323911,0.901018,0.747985,0.943088,1.33705,1.68977,1.00999,1.54147,0.509047,0.30684,0.152094,1.23259,0.257421,0.245132,0.253065,0.835925,0.997094,0.494135,0.830212,0.948899,0.794502,0.293164,1.1148,0.0793594,1.53502,1.20595,0.852952,1.85284,1.40768,1.11989,1.04863,0.412897,0.356133,0.3366,0.806207,1.05152,0.848095,0.20438,0.384901,1.03517,1.16282,0.913356,0.91226,0.631253,0.97421,0.653843,1.24825,0.491483,0.550229,1.16464,1.23956,0.674448,1.41481,0.399936,0.0998646,0.607321,0.932233,0.380707,1.23809,0.879184,0.759676,0.834976,1.46955,1.00091,0.724289,1.04166,1.33551,0.416189,1.14546,0.595426,1.3055,0.750642,1.43666,0.143464,0.566955,0.633235,1.3869,2.2222,1.82084,1.34183,0.772375,1.04623,0.905521,0.632211,0.851091,2.18247,0.569503,0.408309,0.651755,0.133815,1.18223,0.343194,0.749664,1.26545,0.787153,0.438007,0.555203,0.566652,1.39653,1.11392,1.00137,0.547782,0.90208,0.741834,0.383572,0.701187,0.191104|tfbs_overrepresentation_jaspar=MA0003.1;0.0185483,MA0004.1;0.603793,MA0006.1;0.419915,MA0007.1;0.587678,MA0009.1;1.06266,MA0014.1;0.0502051,MA0017.1;0.449113,MA0019.1;0.874061,MA0024.1;1.01759,MA0025.1;1.30092,MA0027.1;2.72141,MA0028.1;0.43138,MA0029.1;0.995171,MA0030.1;1.00195,MA0031.1;0.965177,MA0038.1;0.757669,MA0040.1;1.07552,MA0041.1;0.522007,MA0042.1;0.507715,MA0043.1;1.1618,MA0046.1;1.09955,MA0048.1;0.205696,MA0050.1;0.645342,MA0051.1;0.767098,MA0052.1;1.08379,MA0055.1;0.602741,MA0056.1;0,MA0057.1;0.192781,MA0058.1;0.50032,MA0059.1;0.513699,MA0060.1;0.330907,MA0061.1;0.955135,MA0063.1;0,MA0066.1;1.76548,MA0067.1;1.41352,MA0068.1;0.197245,MA0069.1;1.08414,MA0070.1;1.07418,MA0071.1;0.644448,MA0072.1;1.06547,MA0073.1;0.000589538,MA0074.1;0.708108,MA0076.1;0.470037,MA0077.1;1.04318,MA0078.1;0.801834,MA0081.1;0.53877,MA0083.1;1.16099,MA0084.1;1.74401,MA0087.1;1.11687,MA0088.1;0.888325,MA0089.1;0,MA0090.1;0.566938,MA0091.1;0.617887,MA0092.1;0.567278,MA0093.1;0.440484,MA0095.1;0,MA0098.1;0,MA0100.1;0.695835,MA0101.1;0.523409,MA0103.1;0.460936,MA0105.1;0.693075,MA0106.1;0.809991,MA0107.1;0.454197,MA0108.2;0.897859,MA0109.1;0,MA0111.1;0.582193,MA0113.1;0.780358,MA0114.1;0.361633,MA0115.1;1.16466,MA0116.1;0.419688,MA0117.1;1.13165,MA0119.1;0.524046,MA0122.1;1.15196,MA0124.1;1.35963,MA0125.1;1.28445,MA0130.1;0,MA0131.1;0.869325,MA0132.1;0,MA0133.1;0,MA0135.1;1.19898,MA0136.1;0.729175,MA0139.1;0.295945,MA0140.1;0.695713,MA0141.1;0.482463,MA0142.1;0.950155,MA0143.1;0.797553,MA0144.1;0.365053,MA0145.1;0.157686,MA0146.1;0.475727,MA0147.1;0.378658,MA0148.1;0.621195,MA0149.1;0.529387,MA0062.2;0.254018,MA0035.2;0.700704,MA0039.2;0.140205,MA0138.2;0.861035,MA0002.2;0.809945,MA0137.2;0.479301,MA0104.2;0.315156,MA0047.2;0.75686,MA0112.2;0.47695,MA0065.2;0.477991,MA0150.1;0.587557,MA0151.1;0,MA0152.1;0.756973,MA0153.1;1.21594,MA0154.1;1.11105,MA0155.1;0.515751,MA0156.1;0.469089,MA0157.1;0.91689,MA0158.1;0,MA0159.1;0.389847,MA0160.1;1.51238,MA0161.1;0,MA0162.1;0.0699535,MA0163.1;0.0644585,MA0164.1;0.729558,MA0080.2;0.455167,MA0018.2;0.739807,MA0099.2;1.98867,MA0079.2;0.00167664,MA0102.2;1.79669,MA0258.1;0.91616,MA0259.1;0.366802,MA0442.1;0}}
|coexpression_dpi_cluster_scores_mean=0.0819783772482406,-0.132395584057612,-0.0279427808644058,0.0142245424053251,-0.00910364773117754,-0.046082903155191,0.0274341216965467,-0.260402443231702,-0.128286546798885,-0.212640021282012,-0.275113355922932,-0.288840901220666,-0.1871185436127,-0.252214138415358,-0.115830943895659,-0.0861566354493218,-0.0150497860626252,-0.230995084656396,-0.213849302998174,-0.235463887074394,0.09905897127382,-0.257971940842796,-0.25233517022578,0.281954329233712,0.210930422912042,-0.0619219567035752,-0.00347487334283421,0.0172279391765118,0.0219072356552916,-0.13632660632743,-0.0053662813835551,-0.246135720318128,-0.24720291151249,-0.288840901220666,-0.115527487888966,0.00967897084856348,-0.094484236349953,-0.258473096373518,-0.288840901220666,-0.252271055810676,-0.248658140815598,-0.288840901220666,-0.288840901220666,0.00272730620997418,0.0146872917150188,-0.158442171139598,-0.0577697283516888,-0.0306909431137456,0.0421039665323234,0.098017807035201,-0.00995865004653624,-0.0514764276413944,-0.263707881555558,-0.122302120377544,-0.244183901584556,-0.239159025158388,-0.159395588306985,-0.00326709618086066,-0.148245785216782,-0.15436707169517,-0.217725205809734,-0.0562457324272282,-0.057534572385333,-0.199415516922398,-0.288840901220666,-0.212043370187358,-0.097135740744103,0.00262560322705174,-0.102251409127317,-0.155440759432679,-0.1001219815468,-0.0357607688101882,-0.0410096859290868,-0.144196115319559,-0.155497480850138,-0.288840901220666,-0.142287623491067,-0.0416529775438248,-0.0353542456588232,-0.129311905599512,-0.112825621209419,-0.105100797116887,0.0129148432533675,-0.033051772651677,-0.0262439864699568,-0.104340291967792,-0.0373791116028636,-0.0815217435653388,0.0512068767684656,-0.0744286042279525,-0.13861847794126,0.171633225056675,0.0831032008682364,0.108573570674127,0.128792123507436,0.157200911659717,0.109503952431895,-0.0191651664929903,-0.0086984340672712,-0.00555570802754968,0.120442832586185,0.0385523858240664,0.0240277554118298,-0.288840901220666,0.352971496993202,0.373408300323799,0.387571703297442,0.179078325439301,-0.21669611863373,0.0335694327466518,-0.0321084871313424,-0.0318738951142972,-0.0363689004247062,-0.034777124225205,0,0.0129753472446152,-0.0858842382063768,0.0680313878589324,-0.176291194402791,-0.20369331865519,-0.117705754255825,-0.151961599567335,0.734319053831833,0.0220349160911494,0.0110393763292576,0.140839527947475,-0.235938448639262,-0.248022185274098,-0.2396189515627,0.0630489569609374,0.00739038361363726,-0.150885306481988,0.00148697247781144,-0.00230162216764858,0.0469579758784098,0.0398376599753684,0.0224985591824028,0.00700401216138239,0.168652460254757,0.261532213710332,0.0523935945137764,0.0351710456058384,0.0264904653538889,0.0510472577061898,0.0133561552419846,0.0187576922967762,0.0192486076398109,0.21957002628413,0.0771619409275054,0.0485841160841538,0.034333980955863,-0.00229740324162626,0.00951294275143902,-0.0978978727404558,-0.0834961609020086,0.0526008935184586,-0.242638111072632,-0.227367728318038,-0.222894061280778,0.0576767640910558,0.0591384009504622,0.033277751505678,0.0159968411597993,0.00861901883430404,0.03556206127528,0.038499150179193,0.0634676624414052,0.0679167472368982,0.038109596204583,0.0372416954619188,0.0521524330932194,0.0607520150631576,0.0811865260784284,0.112275420051544,0.027141028546551,-0.0512992819542254,0.364175066173324,-0.0307825929874916,0.04531394625834,0.020888633801487,0.0105104951589543,0.0150398451207143,-0.0107525430916647,-0.0293661225757642,0.110069146632923,-0.0102429814879312,-0.0906246529648278,0.046558660433412,-0.0402173116407075,0.0947573675646466,0.148066183405822,0.228671951163535,0.0843611697868294,0.0424332205704782,0.0628716410242602,0.147639988043526,0.145513057612894,0.152917775664354,0.131732376496963,0.246788602060011,0.245855885584049,0.252319377946573,0.214329291881576,-0.05353589823988,-0.0451959963220262,-0.0207037979215882,0.0171050561407148,0.036801053679239,0.0694348734783132,0.0280264697996434,-0.0294741513250936,0.0699551439440426,0.0532145196450566,0.0928671508924048,0.139125183854506,0.164298217161733,0.163093445092909,0.182096441167989,0.199697311376301,0.021174025546325,-0.00716674774641342,0.0159637961209295,0.0489796706242476,0.0630165138615928,0.0978761520469739,0.0586958101119582,0.0855117072033298,0.0678454047815588,0.0324038213683552,0.184481060057939,0.103433779501837,0.111357998530007,-0.288840901220666,-0.288840901220666,-0.115077517203622,-0.0556398432266894,0.0837363686332372,0.0748281177700182,0.0859054176107136,-0.0394276081506506,0.147420850591308,0.152777642071683,0.116675874707296,0.0870897700243216,0.0583932555905252,0.0606676336844434,0.0934516982954372,0.0847370672254032,0.0769018338702372,0.0247712390742586,0.157233829733083,0.0580756553805853,0.065307071424214,0.19787338286677,-0.0983336686672094,-0.00829214072670972,0.023312191773302,0.0662901865894822,0.0451559033031766,-0.000198139307279943,-0.040037901393883,-0.0485348059830532,-0.0562868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|coexpression_dpi_cluster_scores_median=0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0354470656487682,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0570741246689917,0,0,0,0,0,0,0,0.156240760022301,0.178032475525152,0.177687811491981,0.16338070954688,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.819000914748279,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.245060439302742,0,0,0,0,0,0,0,0.0184452443692147,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.123988367667141,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0788703512227347,0,0,0,0,0.0769870445726752,0.0570083229196787,0,0.0597943799295356,0.0633328814307688,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0635717028550276,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0576433181427177,0.0711694759496908,0,0.174615154231399,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0660055475634404,0,0,0,0,0,0,0,0,0,0,0,1.52451037407471,0,0.148182634048186,0.318074486211121,0.65844080484096,0.779765196044025,1.02979891652086,1.17277161256817,1.55720990591184,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1.59385669635898,0,0.39185444823096,0.316356610833226,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.107523539997041,0.0269518943326477,0.0242538736058389,0,0,0,0,0,0,0.0709519923534245,0.092873634605593,0.00348727840524377,0.0390607415003592,0,0,0,0,0,0,0,0,0,0.0511502257083116,0,0.0363981196925645,0,0,0,0
|gostat_on_MCL_coexpression=GO:0048306;calcium-dependent protein binding;0.0240996832705677;55925!GO:0007340;acrosome reaction;0.0240996832705677;55925!GO:0017156;calcium ion-dependent exocytosis;0.0277047634426189;55925!GO:0004364;glutathione transferase activity;0.0277047634426189;14860!GO:0007338;single fertilization;0.0318944565643738;55925!GO:0009566;fertilization;0.0318944565643738;55925!GO:0016765;transferase activity, transferring alkyl or aryl (other than methyl) groups;0.0318944565643738;14860!GO:0008021;synaptic vesicle;0.0318944565643738;55925!GO:0030136;clathrin-coated vesicle;0.0380408858425117;55925!GO:0006887;exocytosis;0.0380408858425117;55925!GO:0030135;coated vesicle;0.0380408858425117;55925!
|ontology_enrichment_celltype=CL:0000068!6.26e-08!3;CL:0002202!6.26e-08!3;CL:0000069!6.26e-08!3;CL:0002632!6.26e-08!3;CL:0002368!6.26e-08!3;CL:0000307!6.26e-08!3;CL:0000377!6.26e-08!3
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0000945!3.67e-09!16;UBERON:0010039!3.67e-09!16;UBERON:0003126!6.26e-08!3;UBERON:0001005!6.26e-08!3;UBERON:0007196!6.26e-08!3;UBERON:0001558!6.26e-08!3
}}

Latest revision as of 17:14, 17 September 2013


Phase1 CAGE Peaks

 Short description
Mm9::chr12:75194203..75194212,+p@chr12:75194203..75194212
+
Mm9::chr2:155878686..155878700,-p2@Fer1l4
Mm9::chr2:155878703..155878745,-p1@Fer1l4
Mm9::chr7:149620885..149620896,+p3@Syt8
Mm9::chr9:78039813..78039830,+p1@Gsta4


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0048306calcium-dependent protein binding0.0240996832705677
GO:0007340acrosome reaction0.0240996832705677
GO:0017156calcium ion-dependent exocytosis0.0277047634426189
GO:0004364glutathione transferase activity0.0277047634426189
GO:0007338single fertilization0.0318944565643738
GO:0009566fertilization0.0318944565643738
GO:0016765transferase activity, transferring alkyl or aryl (other than methyl) groups0.0318944565643738
GO:0008021synaptic vesicle0.0318944565643738
GO:0030136clathrin-coated vesicle0.0380408858425117
GO:0006887exocytosis0.0380408858425117
GO:0030135coated vesicle0.0380408858425117



Relative expression of the co-expression cluster over median <br>Analyst:




Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
stomach3.67e-0916
food storage organ3.67e-0916
trachea6.26e-083
respiratory airway6.26e-083
tracheobronchial tree6.26e-083
lower respiratory tract6.26e-083


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs




JASPAR motifs


Motifs-log10(p-value)
MA0003.10.0185483
MA0004.10.603793
MA0006.10.419915
MA0007.10.587678
MA0009.11.06266
MA0014.10.0502051
MA0017.10.449113
MA0019.10.874061
MA0024.11.01759
MA0025.11.30092
MA0027.12.72141
MA0028.10.43138
MA0029.10.995171
MA0030.11.00195
MA0031.10.965177
MA0038.10.757669
MA0040.11.07552
MA0041.10.522007
MA0042.10.507715
MA0043.11.1618
MA0046.11.09955
MA0048.10.205696
MA0050.10.645342
MA0051.10.767098
MA0052.11.08379
MA0055.10.602741
MA0056.10
MA0057.10.192781
MA0058.10.50032
MA0059.10.513699
MA0060.10.330907
MA0061.10.955135
MA0063.10
MA0066.11.76548
MA0067.11.41352
MA0068.10.197245
MA0069.11.08414
MA0070.11.07418
MA0071.10.644448
MA0072.11.06547
MA0073.10.000589538
MA0074.10.708108
MA0076.10.470037
MA0077.11.04318
MA0078.10.801834
MA0081.10.53877
MA0083.11.16099
MA0084.11.74401
MA0087.11.11687
MA0088.10.888325
MA0089.10
MA0090.10.566938
MA0091.10.617887
MA0092.10.567278
MA0093.10.440484
MA0095.10
MA0098.10
MA0100.10.695835
MA0101.10.523409
MA0103.10.460936
MA0105.10.693075
MA0106.10.809991
MA0107.10.454197
MA0108.20.897859
MA0109.10
MA0111.10.582193
MA0113.10.780358
MA0114.10.361633
MA0115.11.16466
MA0116.10.419688
MA0117.11.13165
MA0119.10.524046
MA0122.11.15196
MA0124.11.35963
MA0125.11.28445
MA0130.10
MA0131.10.869325
MA0132.10
MA0133.10
MA0135.11.19898
MA0136.10.729175
MA0139.10.295945
MA0140.10.695713
MA0141.10.482463
MA0142.10.950155
MA0143.10.797553
MA0144.10.365053
MA0145.10.157686
MA0146.10.475727
MA0147.10.378658
MA0148.10.621195
MA0149.10.529387
MA0062.20.254018
MA0035.20.700704
MA0039.20.140205
MA0138.20.861035
MA0002.20.809945
MA0137.20.479301
MA0104.20.315156
MA0047.20.75686
MA0112.20.47695
MA0065.20.477991
MA0150.10.587557
MA0151.10
MA0152.10.756973
MA0153.11.21594
MA0154.11.11105
MA0155.10.515751
MA0156.10.469089
MA0157.10.91689
MA0158.10
MA0159.10.389847
MA0160.11.51238
MA0161.10
MA0162.10.0699535
MA0163.10.0644585
MA0164.10.729558
MA0080.20.455167
MA0018.20.739807
MA0099.21.98867
MA0079.20.00167664
MA0102.21.79669
MA0258.10.91616
MA0259.10.366802
MA0442.10
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