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{{Coexpression_clusters
{
|full_id=C2904_Mesenchymal_adenocarcinoma_Cardiac_small_sacrococcigeal_Preadipocyte_Smooth
 

Latest revision as of 12:15, 17 September 2013


Full id: C2904_Mesenchymal_adenocarcinoma_Cardiac_small_sacrococcigeal_Preadipocyte_Smooth



Phase1 CAGE Peaks

Hg19::chr7:81399311..81399323,-p6@HGF
Hg19::chr7:81399376..81399392,-p5@HGF
Hg19::chr7:81399411..81399432,-p4@HGF
Hg19::chr7:81399438..81399454,-p2@HGF


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
muscle tissue7.58e-2064
musculature7.58e-2064
musculature of body7.58e-2064
dense mesenchyme tissue9.94e-2073
skeletal muscle tissue2.12e-1962
striated muscle tissue2.12e-1962
myotome2.12e-1962
paraxial mesoderm3.30e-1972
presumptive paraxial mesoderm3.30e-1972
somite4.87e-1971
presomitic mesoderm4.87e-1971
presumptive segmental plate4.87e-1971
dermomyotome4.87e-1971
trunk paraxial mesoderm4.87e-1971
musculoskeletal system1.88e-18167
mesoderm3.80e-16315
mesoderm-derived structure3.80e-16315
presumptive mesoderm3.80e-16315
epithelial vesicle1.81e-1578
germ layer2.71e-14560
germ layer / neural crest2.71e-14560
embryonic tissue2.71e-14560
presumptive structure2.71e-14560
germ layer / neural crest derived structure2.71e-14560
epiblast (generic)2.71e-14560
tissue4.47e-14773
embryonic structure4.89e-14564
multilaminar epithelium9.17e-1483
trunk mesenchyme2.22e-13122
developing anatomical structure5.00e-12581
multi-cellular organism9.48e-12656
multi-tissue structure1.50e-11342
embryo1.80e-11592
mesenchyme2.07e-11160
entire embryonic mesenchyme2.07e-11160
anatomical system3.89e-11624
anatomical group5.80e-11625
adult organism9.62e-11114
heart9.87e-1024
primitive heart tube9.87e-1024
primary heart field9.87e-1024
anterior lateral plate mesoderm9.87e-1024
heart tube9.87e-1024
heart primordium9.87e-1024
cardiac mesoderm9.87e-1024
cardiogenic plate9.87e-1024
heart rudiment9.87e-1024
primary circulatory organ1.71e-0927
splanchnic layer of lateral plate mesoderm8.69e-0983
unilaminar epithelium4.30e-08148
circulatory system5.83e-08112
lateral plate mesoderm7.72e-08203
cardiovascular system8.31e-08109
structure with developmental contribution from neural crest9.42e-08132
epithelium2.09e-07306
cell layer2.66e-07309
anatomical cluster2.93e-07373


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0938548
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.14.37547
MA0014.10.0695829
MA0017.10.577281
MA0019.12.02743
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.396851
MA0056.10
MA0057.11.28333
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.841508
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.110.5183
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.13.89719
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.10.232357
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.11.57689
MA0113.12.05499
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.13.57466
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.912459
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.10.195821
MA0146.10.061409
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.20.0247757
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.187982
MA0065.20.199162
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.229241
MA0155.10.180766
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.11.78721
MA0161.10
MA0162.10.0928415
MA0163.10.918944
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.21.6798
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTCF#1066445.360256373075030.001211145381643620.00819984522970818
RAD21#5885410.35503389545638.6948481184721e-050.00130004472819629



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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