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{{Coexpression_clusters
{
|full_id=C3380_Eosinophils_CD14_Mast_Neutrophils_CD19_CD14CD16_CD34
 

Latest revision as of 12:25, 17 September 2013


Full id: C3380_Eosinophils_CD14_Mast_Neutrophils_CD19_CD14CD16_CD34



Phase1 CAGE Peaks

Hg19::chr13:50698820..50698842,+p@chr13:50698820..50698842
+
Hg19::chr6:32163757..32163854,+p@chr6:32163757..32163854
+
Hg19::chr8:12613275..12613329,+p@chr8:12613275..12613329
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
leukocyte1.89e-41136
hematopoietic cell2.85e-36177
hematopoietic stem cell1.76e-35168
angioblastic mesenchymal cell1.76e-35168
hematopoietic lineage restricted progenitor cell3.13e-33120
nongranular leukocyte7.69e-33115
hematopoietic oligopotent progenitor cell3.11e-32161
hematopoietic multipotent progenitor cell3.11e-32161
myeloid leukocyte3.68e-2372
classical monocyte6.63e-2042
CD14-positive, CD16-negative classical monocyte6.63e-2042
granulocyte monocyte progenitor cell1.07e-1967
defensive cell6.16e-1848
phagocyte6.16e-1848
myeloid lineage restricted progenitor cell1.07e-1766
macrophage dendritic cell progenitor1.32e-1761
myeloid cell1.97e-17108
common myeloid progenitor1.97e-17108
monopoietic cell1.11e-1659
monocyte1.11e-1659
monoblast1.11e-1659
promonocyte1.11e-1659
lymphocyte2.80e-1453
common lymphoid progenitor2.80e-1453
lymphoid lineage restricted progenitor cell2.90e-1452
nucleate cell1.21e-1355
mature alpha-beta T cell3.19e-0918
alpha-beta T cell3.19e-0918
immature T cell3.19e-0918
mature T cell3.19e-0918
immature alpha-beta T cell3.19e-0918
stuff accumulating cell1.94e-0887
T cell3.58e-0825
pro-T cell3.58e-0825
B cell1.43e-0714
intermediate monocyte2.01e-079
CD14-positive, CD16-positive monocyte2.01e-079
Uber Anatomy
Ontology termp-valuen
hematopoietic system1.59e-2498
blood island1.59e-2498
hemolymphoid system6.13e-20108
bone marrow1.43e-1876
bone element3.98e-1782
immune system1.52e-1493
skeletal element1.84e-1490
lateral plate mesoderm1.26e-12203
skeletal system4.00e-11100
blood3.69e-0715
haemolymphatic fluid3.69e-0715
organism substance3.69e-0715


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.54338
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.11.24048
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.11.58389
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.557638
MA0056.10
MA0057.10.333427
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.12.01615
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.11.04561
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.211629
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.12.3269
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.11.3784
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.11.12079
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.12.11725
MA0146.11.16674
MA0147.11.38767
MA0148.10.854239
MA0149.10.884158
MA0062.21.141
MA0035.20.894194
MA0039.23.37171
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.22.13189
MA0047.20.973066
MA0112.21.34467
MA0065.22.13692
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.12.83144
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.12.05956
MA0163.10.387745
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.28.15771
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BRCA1#672213.45615376214920.007119807716084560.0296131261672702
E2F1#186934.907389214879320.008460985347239390.032421825304727
EBF1#187938.9064668465690.00141523283560980.0091333808390442
EGR1#195834.988179094810140.008056488137383440.0319648810766322
ELF1#199734.258097958807540.01295179875054610.0460860927978019
FOSL2#2355211.28680040304110.0100534586973120.0376617946443044
GABPB1#255337.067683836182170.002832212825417420.015380276376548
IRF1#365937.63716375356390.002244692747297240.0127784512065288
USF1#739136.361499277207960.00388404057290560.018981998754969



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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