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{{Coexpression_clusters
{
|full_id=C3631_signet_liver_Hepatocyte_lung_gastrointestinal_duodenum_gall
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Latest revision as of 12:30, 17 September 2013


Full id: C3631_signet_liver_Hepatocyte_lung_gastrointestinal_duodenum_gall



Phase1 CAGE Peaks

Hg19::chr17:39928985..39929000,-p16@JUP
Hg19::chr3:149193560..149193572,+p3@TM4SF4
Hg19::chr3:149193636..149193643,+p10@TM4SF4


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0005916fascia adherens0.00800506168636512
GO:0009898internal side of plasma membrane0.00800506168636512
GO:0005624membrane fraction0.00800506168636512
GO:0030057desmosome0.00800506168636512
GO:0000267cell fraction0.00800506168636512
GO:0005913cell-cell adherens junction0.00800506168636512
GO:0030018Z disc0.00800506168636512
GO:0031674I band0.00850500241229507
GO:0014704intercalated disc0.0166161071869071
GO:0030017sarcomere0.0166161071869071
GO:0030016myofibril0.0166161071869071
GO:0006487protein amino acid N-linked glycosylation0.0166161071869071
GO:0005912adherens junction0.0166161071869071
GO:0044449contractile fiber part0.0170648948467576
GO:0043292contractile fiber0.0170648948467576
GO:0044459plasma membrane part0.0192194868159395
GO:0043296apical junction complex0.0233168186805186
GO:0016327apicolateral plasma membrane0.0233168186805186
GO:0005911intercellular junction0.0330299548248979
GO:0006486protein amino acid glycosylation0.0330299548248979
GO:0043413biopolymer glycosylation0.0330299548248979
GO:0009101glycoprotein biosynthetic process0.0330299548248979
GO:0009100glycoprotein metabolic process0.0357413648296294
GO:0005886plasma membrane0.0357413648296294
GO:0008285negative regulation of cell proliferation0.0359061114950822
GO:0005625soluble fraction0.0359061114950822
GO:0015629actin cytoskeleton0.0436974359223854
GO:0016337cell-cell adhesion0.0493596312651508



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen
metabolising cell8.00e-0812
endopolyploid cell8.00e-0812
parenchymal cell8.00e-0812
polyploid cell8.00e-0812
hepatocyte8.00e-0812
Uber Anatomy
Ontology termp-valuen
epithelium of foregut-midgut junction3.32e-1825
anatomical boundary3.32e-1825
hepatobiliary system3.32e-1825
foregut-midgut junction3.32e-1825
septum transversum3.32e-1825
hepatic diverticulum2.17e-1522
liver primordium2.17e-1522
digestive tract diverticulum1.06e-1423
epithelial sac1.71e-1325
gut epithelium3.83e-1354
sac5.85e-1326
liver1.04e-1219
digestive gland1.04e-1219
liver bud1.04e-1219
endo-epithelium3.18e-1082
endocrine system8.30e-1045
endocrine gland1.65e-0935
exocrine gland9.94e-0831
exocrine system9.94e-0831
digestive system1.65e-07145
digestive tract1.65e-07145
primitive gut1.65e-07145
Disease
Ontology termp-valuen
clear cell adenocarcinoma1.41e-192
papillary adenocarcinoma1.33e-101


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0471418
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.377374
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.886807
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0185922
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.11.31954
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.12.29531
MA0144.10.531867
MA0145.10.273764
MA0146.10.348055
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.20.195278
MA0138.21.04628
MA0002.21.20011
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.838867
MA0155.10.256269
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.149099
MA0163.10.387745
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.20.0107199
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
ESRRA#21011161.2801047120420.006187620080219560.0273489717532714



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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