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{{Coexpression_clusters
{
|full_id=C1874_left_Hepatocyte_liver_heart_Adipocyte_mature_small
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Latest revision as of 11:54, 17 September 2013


Full id: C1874_left_Hepatocyte_liver_heart_Adipocyte_mature_small



Phase1 CAGE Peaks

Hg19::chr20:7238917..7238933,-p1@ENST00000428954
Hg19::chr3:48936246..48936268,-p2@SLC25A20
Hg19::chr3:48936272..48936353,-p1@SLC25A20
Hg19::chr4:159593418..159593517,+p1@ETFDH
Hg19::chr5:41213584..41213598,-p2@C6


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0009054electron acceptor activity0.00558580461822105
GO:0005743mitochondrial inner membrane0.00558580461822105
GO:0004174electron-transferring-flavoprotein dehydrogenase activity0.00558580461822105
GO:0016649oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor0.00558580461822105
GO:0019866organelle inner membrane0.00558580461822105
GO:0031966mitochondrial membrane0.00678749457995214
GO:0005740mitochondrial envelope0.00678749457995214
GO:0005579membrane attack complex0.00764833106111847
GO:0044429mitochondrial part0.00898406663165033
GO:0031967organelle envelope0.00898406663165033
GO:0031975envelope0.00898406663165033
GO:0019835cytolysis0.011651512098125
GO:0006958complement activation, classical pathway0.017470065340674
GO:0005739mitochondrion0.017470065340674
GO:0002455humoral immune response mediated by circulating immunoglobulin0.017470065340674
GO:0006956complement activation0.0194054685455721
GO:0002541activation of plasma proteins during acute inflammatory response0.0194054685455721
GO:00515394 iron, 4 sulfur cluster binding0.0194054685455721
GO:0016064immunoglobulin mediated immune response0.0216155960363867
GO:0019724B cell mediated immunity0.0216155960363867
GO:0016645oxidoreductase activity, acting on the CH-NH group of donors0.0216155960363867
GO:0031090organelle membrane0.0223513859044162
GO:0002253activation of immune response0.0223513859044162
GO:0002449lymphocyte mediated immunity0.0223513859044162
GO:0006959humoral immune response0.0223513859044162
GO:0002460adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains0.0223513859044162
GO:0002250adaptive immune response0.0223513859044162
GO:0002443leukocyte mediated immunity0.0223513859044162
GO:0002526acute inflammatory response0.0223513859044162
GO:0050778positive regulation of immune response0.0223513859044162
GO:0002684positive regulation of immune system process0.0223513859044162
GO:0016021integral to membrane0.0223513859044162
GO:0031224intrinsic to membrane0.0223513859044162
GO:0051536iron-sulfur cluster binding0.0223513859044162
GO:0051540metal cluster binding0.0223513859044162
GO:0005319lipid transporter activity0.0223513859044162
GO:0046930pore complex0.0223513859044162
GO:0050776regulation of immune response0.0223513859044162
GO:0002682regulation of immune system process0.0223513859044162
GO:0051240positive regulation of multicellular organismal process0.0228788602740446
GO:0002252immune effector process0.0233802913039492
GO:0045087innate immune response0.0236507793913901
GO:0044425membrane part0.0270730510644044
GO:0009055electron carrier activity0.0498973553192995



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
fat cell1.58e-0815
Uber Anatomy
Ontology termp-valuen
adult organism6.61e-22114
primary circulatory organ2.00e-0727


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.40197
MA0004.10.626788
MA0006.10.452993
MA0007.10.606704
MA0009.11.11255
MA0014.10.369468
MA0017.11.24112
MA0019.10.784036
MA0024.11.00439
MA0025.11.24931
MA0027.12.73598
MA0028.12.0635
MA0029.11.02437
MA0030.11.01252
MA0031.10.945567
MA0038.10.736268
MA0040.11.03042
MA0041.10.64667
MA0042.10.612397
MA0043.11.11288
MA0046.11.10134
MA0048.10.569896
MA0050.10.613347
MA0051.10.731787
MA0052.11.03442
MA0055.10.288856
MA0056.10
MA0057.10.189508
MA0058.10.523638
MA0059.10.522232
MA0060.10.321781
MA0061.10.291022
MA0063.10
MA0066.10.736721
MA0067.11.43651
MA0068.10.247962
MA0069.11.09737
MA0070.11.08584
MA0071.10.695094
MA0072.11.0812
MA0073.10.0140295
MA0074.10.730989
MA0076.12.29573
MA0077.11.07324
MA0078.10.836493
MA0081.10.522409
MA0083.11.12028
MA0084.11.62584
MA0087.11.07867
MA0088.11.92154
MA0089.10
MA0090.10.556637
MA0091.10.629594
MA0092.10.588959
MA0093.10.456342
MA0095.10
MA0098.10
MA0100.10.750974
MA0101.10.459973
MA0103.10.442769
MA0105.10.175503
MA0106.10.779931
MA0107.10.378225
MA0108.20.94238
MA0109.10
MA0111.10.5713
MA0113.10.797251
MA0114.10.973423
MA0115.11.35895
MA0116.10.382106
MA0117.11.1512
MA0119.11.25946
MA0122.11.17777
MA0124.11.31673
MA0125.11.23103
MA0130.10
MA0131.10.855546
MA0132.10
MA0133.10
MA0135.11.14377
MA0136.10.743749
MA0139.10.277033
MA0140.10.692258
MA0141.10.520334
MA0142.10.912455
MA0143.10.797437
MA0144.11.67417
MA0145.10.143698
MA0146.10.333008
MA0147.10.386018
MA0148.10.653474
MA0149.10.681935
MA0062.22.17426
MA0035.20.691506
MA0039.21.12758
MA0138.20.837782
MA0002.20.83106
MA0137.20.47779
MA0104.20.320919
MA0047.20.767096
MA0112.20.136971
MA0065.21.41695
MA0150.10.550239
MA0151.10
MA0152.10.69926
MA0153.11.21379
MA0154.10.172764
MA0155.10.130813
MA0156.10.480289
MA0157.10.883854
MA0158.10
MA0159.10.386729
MA0160.10.669748
MA0161.10
MA0162.10.81299
MA0163.10.0439995
MA0164.10.810347
MA0080.20.456437
MA0018.20.781393
MA0099.20.699641
MA0079.20.0442129
MA0102.21.66336
MA0258.10.345771
MA0259.10.395396
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTBP2#1488225.08680013573130.002461438599678380.013850764327145
GTF2B#2959212.77753197372970.00919936089559720.0347904132595334
THAP1#55145212.54765784114050.009528434667386530.0358906548933235
ZNF143#770238.100525931336740.003624870512090980.0183348436367818



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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