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{{Coexpression_clusters
{{Coexpression_clusters|coexpression_dpi_cluster_scores_median=0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.144064671875115,0.0492874841524395,0.165674064961392,0,0,0,0,0,0,0.191449731291012,0.162163447814838,0.187155693785898,0.746361818582331,0.666622190676029,0.686960842452741,0.355763814461113,0.460804619998697,0.319753060141984,0.456279817913854,0.544155047247858,0.559811137464283,0.38711598527456,0.461406446552545,0.338936571693931,0.424646258890656,0.467823209448954,0.371855321441455,0.346662406209483,0.502870638667975,0.4483183513051,0.452783301463467,0.603364114545418,0.411384612917741,0.248480624778254,0.360659139847428,0.267746377672919,0.377599530524293,0.431710365575549,0.457649819641544,0.495973723666937,0.489386306020099,0.501317905101422,0.344549260502074,0.453530569481038,0.39116394186345,0.213189816297791,0.219922211025325,0.152079493649239,0.126126825037818,0.161526918504429,0.100206359929544,0.127503246075011,0.0787890013723437,0.104049264131897,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.101044953091069,0,0,1.16040270121791,1.0843279532564,1.09025063774202,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.941910911931328,1.31007728868327,1.14623510903713,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1.00653393187322,0.845663051646968,1.07744794603,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0837604101916885,0.0848314897427103,0.0452746336782597,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0813768443325499,0,0,0,0,0,0,0,0,0,0,0,0.0355204411879812,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.11721277736131,0,0,0,0,0,0,0,0,0,0,0,0,0.0390744040629657,0,0,0,0,0,0,0,0.0179867494991323,0.0180194588287629,0,0.166684825355637,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.353544150137305,0,0,0,0,0,0,0,0,0,0,0,0.0789089986057754,0,0,0,0,0,0,0,0,0.0408567533019575,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0321956448428329,0,0,0,0,0,0.0730563942977996,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0368115019473605,0,0,0,0,0.0174269743267879,0,0,0,0,0,0,0,0,0.0516822929650548,0,0,0,0,0,0,0,0,0,0,0,0.0349684140344003,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0881268324752877,0,0,0,0.0329432353726146,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0593938447453515,0,0,0,0,0,0.154469515426605,0,0.344173325095624,0.157476452571649,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0261639379934246,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0865518120240767,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0270351810347199,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.031493427513643,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0369091684033041,0,0,0,0,0,0,0.0386878702943,0,0,0,0,0,0.0299826682885844,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0264666388845284,0,0,0,0,0,0,0,0,0.123234905507807,0.0552972523246157,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.027905690705129,0,0,0,0,0,0.0271819376754428,0.0508240440617333,0,0.0133987920685569,0,0,0,0.0415951580869847,0.084635829807314,0,0,0,0,0,0,0,0,0,0.0796420028184954,0|full_id=C314_Macrophage_Dendritic_Monocytederived_CD14_Esophageal_Mast_Keratinocyte|gostat_on_coexpression_clusters=GO:0005764!lysosome!4.52582062239315e-06!4074;2760;1522;54;2799$GO:0000323!lytic vacuole!4.52582062239315e-06!4074;2760;1522;54;2799$GO:0005773!vacuole!6.15010206948201e-06!4074;2760;1522;54;2799$GO:0030290!sphingolipid activator protein activity!0.012127634522548!2760$GO:0032428!beta-N-acetylgalactosaminidase activity!0.012127634522548!2760$GO:0047939!L-glucuronate reductase activity!0.012127634522548!10327$GO:0046185!aldehyde catabolic process!0.012127634522548!10327$GO:0042839!D-glucuronate metabolic process!0.012127634522548!10327$GO:0042840!D-glucuronate catabolic process!0.012127634522548!10327$GO:0008449!N-acetylglucosamine-6-sulfatase activity!0.012127634522548!2799$GO:0019853!L-ascorbic acid biosynthetic process!0.012127634522548!10327$GO:0006064!glucuronate catabolic process!0.012127634522548!10327$GO:0007243!protein kinase cascade!0.0132272258457848!5603;10783;79092$GO:0045177!apical part of cell!0.0132272258457848!10327;2760$GO:0009056!catabolic process!0.0132272258457848!10327;2760;2799;7941$GO:0005889!hydrogen:potassium-exchanging ATPase complex!0.0132272258457848!2760$GO:0015761!mannose transport!0.0132272258457848!4074$GO:0008106!alcohol dehydrogenase (NADP+) activity!0.0132272258457848!10327$GO:0015578!mannose transmembrane transporter activity!0.0132272258457848!4074$GO:0016004!phospholipase activator activity!0.0132272258457848!2760$GO:0045179!apical cortex!0.0132272258457848!2760$GO:0009313!oligosaccharide catabolic process!0.0132272258457848!2760$GO:0008339!MP kinase activity!0.0161630403516077!5603$GO:0004032!aldehyde reductase activity!0.0161630403516077!10327$GO:0006063!uronic acid metabolic process!0.0161630403516077!10327$GO:0019852!L-ascorbic acid metabolic process!0.0161630403516077!10327$GO:0019585!glucuronate metabolic process!0.0161630403516077!10327$GO:0004563!beta-N-acetylhexosaminidase activity!0.0191472672715482!2760$GO:0008247!2-acetyl-1-alkylglycerophosphocholine esterase complex!0.0191472672715482!7941$GO:0006689!ganglioside catabolic process!0.0191472672715482!2760$GO:0007249!I-kappaB kinase/NF-kappaB cascade!0.0191472672715482!10783;79092$GO:0016042!lipid catabolic process!0.0204320329707988!2760;7941$GO:0046479!glycosphingolipid catabolic process!0.021805657903249!2760$GO:0008333!endosome to lysosome transport!0.021805657903249!4074$GO:0006026!aminoglycan catabolic process!0.021805657903249!2799$GO:0016909!SAP kinase activity!0.021805657903249!5603$GO:0050700!CARD domain binding!0.021805657903249!79092$GO:0003847!1-alkyl-2-acetylglycerophosphocholine esterase activity!0.021805657903249!7941$GO:0006027!glycosaminoglycan catabolic process!0.021805657903249!2799$GO:0009898!internal side of plasma membrane!0.021805657903249!2760$GO:0005737!cytoplasm!0.0226485989309556!4074;2760;54;10783;23150;2799;79092;10327;1522$GO:0019377!glycolipid catabolic process!0.0242231611391587!2760$GO:0019915!sequestering of lipid!0.0260623078098239!2760$GO:0001573!ganglioside metabolic process!0.0260623078098239!2760$GO:0044425!membrane part!0.0260623078098239!284129;4074;2760;56833;54;23150;140885;145389;10327$GO:0016054!organic acid catabolic process!0.0309027153522172!10327$GO:0046395!carboxylic acid catabolic process!0.0309027153522172!10327$GO:0016020!membrane!0.0322521867971921!284129;4074;2760;56833;54;23150;140885;79092;145389;10327$GO:0030071!regulation of mitotic metaphase/anaphase transition!0.0325983230004245!10783$GO:0004033!aldo-keto reductase activity!0.0328706422062493!10327$GO:0005537!mannose binding!0.0328706422062493!4074$GO:0007091!mitotic metaphase/anaphase transition!0.0328706422062493!10783$GO:0007250!activation of NF-kappaB-inducing kinase!0.0328706422062493!79092$GO:0005975!carbohydrate metabolic process!0.0331554372984391!10327;2760;2799$GO:0044248!cellular catabolic process!0.033577971469853!10327;2760;2799$GO:0043085!positive regulation of catalytic activity!0.0349332211990327!2760;79092$GO:0007041!lysosomal transport!0.0356421855368791!4074$GO:0030149!sphingolipid catabolic process!0.0375213613292531!2760$GO:0048029!monosaccharide binding!0.0410886012693866!4074$GO:0015929!hexosaminidase activity!0.0410886012693866!2760$GO:0050885!neuromuscular process controlling balance!0.0427829322362058!2760$GO:0006687!glycosphingolipid metabolic process!0.0444215781542066!2760|id=C314|kegg_enrichment=hsa04142;Lysosome;1.88E-09|ontology_enrichment_celltype=CL:0002194!1.61e-98!59;CL:0000576!1.61e-98!59;CL:0000040!1.61e-98!59;CL:0000559!1.61e-98!59;CL:0002009!1.89e-98!61;CL:0000473!2.82e-97!48;CL:0000234!2.82e-97!48;CL:0000557!2.94e-88!67;CL:0000766!2.01e-87!72;CL:0000839!1.82e-86!66;CL:0000860!2.55e-83!42;CL:0002057!2.55e-83!42;CL:0000763!4.42e-57!108;CL:0000049!4.42e-57!108;CL:0002087!1.74e-48!115;CL:0000738!6.10e-47!136;CL:0000325!6.85e-47!87;CL:0002031!3.02e-42!120;CL:0000037!1.15e-34!168;CL:0000566!1.15e-34!168;CL:0002032!9.89e-33!161;CL:0000837!9.89e-33!161;CL:0000988!5.09e-32!177;CL:0002393!2.68e-17!9;CL:0002397!2.68e-17!9;CL:0000235!8.99e-15!6;CL:0000134!2.15e-08!354;CL:0002619!4.56e-08!3;CL:0002320!6.08e-08!361|ontology_enrichment_disease=|ontology_enrichment_uberon=UBERON:0002390!4.16e-79!98;UBERON:0003061!4.16e-79!98;UBERON:0002371!5.90e-76!76;UBERON:0002193!5.38e-75!108;UBERON:0002405!7.86e-74!93;UBERON:0001474!3.06e-69!82;UBERON:0004765!1.14e-61!90;UBERON:0001434!6.65e-54!100;UBERON:0003081!5.88e-35!203;UBERON:0002204!1.76e-29!167;UBERON:0000926!3.08e-22!315;UBERON:0004120!3.08e-22!315;UBERON:0006603!3.08e-22!315;UBERON:0000923!7.00e-09!560;UBERON:0010316!7.00e-09!560;UBERON:0005291!7.00e-09!560;UBERON:0006598!7.00e-09!560;UBERON:0010317!7.00e-09!560;UBERON:0002532!7.00e-09!560;UBERON:0002050!1.14e-08!564;UBERON:0000062!1.91e-08!503;UBERON:0005423!2.70e-08!581;UBERON:0002384!7.63e-08!371;UBERON:0000922!9.50e-08!592;UBERON:0000467!2.98e-07!624;UBERON:0000480!3.31e-07!625;UBERON:0007023!6.95e-07!114|pathway_enrichment=5.2977040485515e-09;3.3534466627331e-06;5;121;Lysosome (KEGG):04142!4.72529853545926e-05;0.00997037990981903;3;128;Osteoclast differentiation (KEGG):04380!2.61528773412653e-05;0.00827738567851046;3;105;Membrane Trafficking (Reactome):REACT_11123!0.000300489277244246;0.047552428123902;2;46;Interactions of the immunoglobulin superfamily (IgSF) member proteins 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260032,1.11687,1.18005,0.514278,0.0771797,0.768712,0.246171,0.118188,0.0144227,0.509774,0.172166,0.362655,0.0742005,0.664296,0.566868,0.338986,0.44158,0.937213,0.641418,0.145574,0.109634,0.580933,0.316185,0.437184,0.326573,0.398925,1.00586,0.454267,0.284555,0.289532,0.697144,0.431946,0.617591,0.113929,0.193524,0.511615,0.84452,0.252724,0.694297,0.159463,0.283097,0.0064758,0.435532,0.156593,0.554573,0.325609,0.591305,0.250452,0.139243,0.523431,0.21514,0.11375,0.148102,0.393629,0.0745262,0.029565,0.0425068,0.16062,0.938457,0.593054,0.3721,0.748112,0.0978526,0.6328,0.235083,0.321341,0.303144,0.490968,0.707013,0.119692,0.267958,0.299005,0.236974,0.186264,0.454019,0.642031,0.0961651,0.335877,0.0660161,0.277186,0.804892,0.250193,0.22161,0.550855,0.292074,0.176165,0.734841,0.19204,0.215337,0.428712,0.480692,0.241713,1.81687,0.649027,1.11907,0.32941,0.275599,0.464097,0.236949,0.973695,0.425728,0.47619,0.375782,0.604481,1.5757,0.0484641,0.23427,0.566997,1.37965,0.988471,0.534449,0.331626,0.812959,0.187364,0.275579,0.177026,1.22368,0.383037,0.364365,0.348888,0.023163,0.372949,1.13782,0.341425,0.722291,0.151194,0.875067,0.144827,0.119806,1.32053,0.358374,0.697233,0.5384,1.08881,0.113349,0.527815,0.102654,0.159165|tfbs_overrepresentation_jaspar=MA0003.1;0.35984,MA0004.1;1.73666,MA0006.1;0.0748843,MA0007.1;0.762606,MA0009.1;0.340234,MA0014.1;0.814487,MA0017.1;1.52767,MA0019.1;0.800905,MA0024.1;0.261871,MA0025.1;0.448136,MA0027.1;1.8578,MA0028.1;0.0858631,MA0029.1;0.275814,MA0030.1;0.267514,MA0031.1;0.222414,MA0038.1;0.341188,MA0040.1;0.280083,MA0041.1;0.0671563,MA0042.1;0.202534,MA0043.1;0.902517,MA0046.1;0.331797,MA0048.1;0.436461,MA0050.1;0.448287,MA0051.1;0.10258,MA0052.1;0.282917,MA0055.1;0.609737,MA0056.1;0,MA0057.1;0.171126,MA0058.1;2.71276,MA0059.1;1.23663,MA0060.1;0.0191619,MA0061.1;0.735081,MA0063.1;0,MA0066.1;0.104867,MA0067.1;0.607707,MA0068.1;0.519997,MA0069.1;0.328825,MA0070.1;0.320241,MA0071.1;0.0863631,MA0072.1;0.31681,MA0073.1;0.0894974,MA0074.1;0.684284,MA0076.1;0.13753,MA0077.1;0.310955,MA0078.1;0.921365,MA0081.1;0.856296,MA0083.1;0.346089,MA0084.1;0.778769,MA0087.1;0.314949,MA0088.1;0.646938,MA0089.1;0,MA0090.1;0.0383435,MA0091.1;0.478767,MA0092.1;0.1799,MA0093.1;2.18474,MA0095.1;0,MA0098.1;0,MA0100.1;0.359565,MA0101.1;0.079118,MA0103.1;0.180166,MA0105.1;0.223736,MA0106.1;0.125937,MA0107.1;0.108386,MA0108.2;0.220346,MA0109.1;0,MA0111.1;0.665563,MA0113.1;0.419724,MA0114.1;0.609295,MA0115.1;0.540206,MA0116.1;2.48859,MA0117.1;0.369828,MA0119.1;0.495524,MA0122.1;0.390603,MA0124.1;0.504249,MA0125.1;0.433225,MA0130.1;0,MA0131.1;0.500131,MA0132.1;0,MA0133.1;0,MA0135.1;0.364077,MA0136.1;1.17291,MA0139.1;0.0343753,MA0140.1;0.288493,MA0141.1;0.849021,MA0142.1;0.201309,MA0143.1;0.134991,MA0144.1;0.0296118,MA0145.1;0.581966,MA0146.1;0.335436,MA0147.1;0.243119,MA0148.1;0.0697009,MA0149.1;0.276655,MA0062.2;0.185973,MA0035.2;0.0848533,MA0039.2;0.196139,MA0138.2;0.924385,MA0002.2;0.233979,MA0137.2;0.0205235,MA0104.2;0.428693,MA0047.2;0.119486,MA0112.2;1.09571,MA0065.2;0.320244,MA0150.1;0.1453,MA0151.1;0,MA0152.1;0.617339,MA0153.1;0.419293,MA0154.1;0.3257,MA0155.1;0.159223,MA0156.1;0.712454,MA0157.1;0.183768,MA0158.1;0,MA0159.1;1.66071,MA0160.1;0.55715,MA0161.1;0,MA0162.1;0.222108,MA0163.1;0.379462,MA0164.1;0.141853,MA0080.2;1.72508,MA0018.2;0.126682,MA0099.2;1.03556,MA0079.2;0.0911683,MA0102.2;0.813509,MA0258.1;0.753327,MA0259.1;0.125674,MA0442.1;0}}
|full_id=C314_Macrophage_Dendritic_Monocytederived_CD14_Esophageal_Mast_Keratinocyte
|gostat_on_coexpression_clusters=GO:0005764!lysosome!4.52582062239315e-06!4074;2760;1522;54;2799$GO:0000323!lytic vacuole!4.52582062239315e-06!4074;2760;1522;54;2799$GO:0005773!vacuole!6.15010206948201e-06!4074;2760;1522;54;2799$GO:0030290!sphingolipid activator protein activity!0.012127634522548!2760$GO:0032428!beta-N-acetylgalactosaminidase activity!0.012127634522548!2760$GO:0047939!L-glucuronate reductase activity!0.012127634522548!10327$GO:0046185!aldehyde catabolic process!0.012127634522548!10327$GO:0042839!D-glucuronate metabolic process!0.012127634522548!10327$GO:0042840!D-glucuronate catabolic process!0.012127634522548!10327$GO:0008449!N-acetylglucosamine-6-sulfatase activity!0.012127634522548!2799$GO:0019853!L-ascorbic acid biosynthetic process!0.012127634522548!10327$GO:0006064!glucuronate catabolic process!0.012127634522548!10327$GO:0007243!protein kinase cascade!0.0132272258457848!5603;10783;79092$GO:0045177!apical part of cell!0.0132272258457848!10327;2760$GO:0009056!catabolic process!0.0132272258457848!10327;2760;2799;7941$GO:0005889!hydrogen:potassium-exchanging ATPase complex!0.0132272258457848!2760$GO:0015761!mannose transport!0.0132272258457848!4074$GO:0008106!alcohol dehydrogenase (NADP+) activity!0.0132272258457848!10327$GO:0015578!mannose transmembrane transporter activity!0.0132272258457848!4074$GO:0016004!phospholipase activator activity!0.0132272258457848!2760$GO:0045179!apical cortex!0.0132272258457848!2760$GO:0009313!oligosaccharide catabolic process!0.0132272258457848!2760$GO:0008339!MP kinase activity!0.0161630403516077!5603$GO:0004032!aldehyde reductase activity!0.0161630403516077!10327$GO:0006063!uronic acid metabolic process!0.0161630403516077!10327$GO:0019852!L-ascorbic acid metabolic process!0.0161630403516077!10327$GO:0019585!glucuronate metabolic process!0.0161630403516077!10327$GO:0004563!beta-N-acetylhexosaminidase activity!0.0191472672715482!2760$GO:0008247!2-acetyl-1-alkylglycerophosphocholine esterase complex!0.0191472672715482!7941$GO:0006689!ganglioside catabolic process!0.0191472672715482!2760$GO:0007249!I-kappaB kinase/NF-kappaB cascade!0.0191472672715482!10783;79092$GO:0016042!lipid catabolic process!0.0204320329707988!2760;7941$GO:0046479!glycosphingolipid catabolic process!0.021805657903249!2760$GO:0008333!endosome to lysosome transport!0.021805657903249!4074$GO:0006026!aminoglycan catabolic process!0.021805657903249!2799$GO:0016909!SAP kinase activity!0.021805657903249!5603$GO:0050700!CARD domain binding!0.021805657903249!79092$GO:0003847!1-alkyl-2-acetylglycerophosphocholine esterase activity!0.021805657903249!7941$GO:0006027!glycosaminoglycan catabolic process!0.021805657903249!2799$GO:0009898!internal side of plasma membrane!0.021805657903249!2760$GO:0005737!cytoplasm!0.0226485989309556!4074;2760;54;10783;23150;2799;79092;10327;1522$GO:0019377!glycolipid catabolic process!0.0242231611391587!2760$GO:0019915!sequestering of lipid!0.0260623078098239!2760$GO:0001573!ganglioside metabolic process!0.0260623078098239!2760$GO:0044425!membrane part!0.0260623078098239!284129;4074;2760;56833;54;23150;140885;145389;10327$GO:0016054!organic acid catabolic process!0.0309027153522172!10327$GO:0046395!carboxylic acid catabolic process!0.0309027153522172!10327$GO:0016020!membrane!0.0322521867971921!284129;4074;2760;56833;54;23150;140885;79092;145389;10327$GO:0030071!regulation of mitotic metaphase/anaphase transition!0.0325983230004245!10783$GO:0004033!aldo-keto reductase activity!0.0328706422062493!10327$GO:0005537!mannose binding!0.0328706422062493!4074$GO:0007091!mitotic metaphase/anaphase transition!0.0328706422062493!10783$GO:0007250!activation of NF-kappaB-inducing kinase!0.0328706422062493!79092$GO:0005975!carbohydrate metabolic process!0.0331554372984391!10327;2760;2799$GO:0044248!cellular catabolic process!0.033577971469853!10327;2760;2799$GO:0043085!positive regulation of catalytic activity!0.0349332211990327!2760;79092$GO:0007041!lysosomal transport!0.0356421855368791!4074$GO:0030149!sphingolipid catabolic process!0.0375213613292531!2760$GO:0048029!monosaccharide binding!0.0410886012693866!4074$GO:0015929!hexosaminidase activity!0.0410886012693866!2760$GO:0050885!neuromuscular process controlling balance!0.0427829322362058!2760$GO:0006687!glycosphingolipid metabolic process!0.0444215781542066!2760
|id=C314
|kegg_enrichment=hsa04142;Lysosome;1.88E-09
|ontology_enrichment_celltype=CL:0000766!4.89e-35!76;CL:0000557!1.13e-32!71;CL:0002009!1.85e-30!65;CL:0000839!6.45e-30!70;CL:0002194!2.31e-29!63;CL:0000576!2.31e-29!63;CL:0000040!2.31e-29!63;CL:0000559!2.31e-29!63;CL:0002057!1.44e-26!42;CL:0000860!1.57e-22!45;CL:0000763!1.49e-19!112;CL:0000049!1.49e-19!112;CL:0000738!1.39e-18!140;CL:0002031!3.64e-13!124;CL:0002087!2.20e-12!119;CL:0000988!2.13e-10!182;CL:0000037!2.20e-10!172;CL:0000566!2.20e-10!172;CL:0002032!1.37e-09!165;CL:0000837!1.37e-09!165;CL:0000451!9.57e-07!10
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0002193!1.01e-35!112;UBERON:0002390!6.45e-34!102;UBERON:0003061!6.45e-34!102;UBERON:0002371!7.00e-30!80;UBERON:0003081!1.39e-27!216;UBERON:0002405!5.13e-27!115;UBERON:0001474!6.24e-24!86;UBERON:0004765!1.09e-20!101;UBERON:0001434!1.09e-20!101;UBERON:0000926!8.14e-12!448;UBERON:0004120!8.14e-12!448;UBERON:0006603!8.14e-12!448;UBERON:0002204!1.27e-11!167;UBERON:0000480!3.32e-10!626;UBERON:0000467!4.48e-10!625;UBERON:0002050!1.34e-07!605;UBERON:0005423!1.34e-07!605;UBERON:0000062!1.43e-07!511;UBERON:0000923!1.67e-07!604;UBERON:0005291!1.67e-07!604;UBERON:0006598!1.67e-07!604;UBERON:0002532!1.67e-07!604;UBERON:0000468!2.15e-07!659;UBERON:0000922!4.64e-07!612
}}

Latest revision as of 11:20, 17 September 2013


Full id: C314_Macrophage_Dendritic_Monocytederived_CD14_Esophageal_Mast_Keratinocyte



Phase1 CAGE Peaks

Hg19::chr10:49893321..49893329,+p8@WDFY4
Hg19::chr11:72431299..72431322,-p@chr11:72431299..72431322
-
Hg19::chr12:65153154..65153171,-p2@GNS
Hg19::chr12:9102224..9102270,-p1@M6PR
Hg19::chr14:61449197..61449207,+p15@SLC38A6
Hg19::chr15:78351618..78351622,-p@chr15:78351618..78351622
-
Hg19::chr17:46022728..46022773,+p@chr17:46022728..46022773
+
Hg19::chr17:7483714..7483726,+p@chr17:7483714..7483726
+
Hg19::chr17:7483994..7484032,+p@chr17:7483994..7484032
+
Hg19::chr17:7484124..7484142,+p@chr17:7484124..7484142
+
Hg19::chr17:78180739..78180750,+p2@AK095416
Hg19::chr17:78180789..78180807,+p1@AK095416
Hg19::chr17:78193607..78193642,+p@chr17:78193607..78193642
+
Hg19::chr17:78194046..78194081,+p2@SLC26A11
Hg19::chr18:9772139..9772150,+p@chr18:9772139..9772150
+
Hg19::chr19:11689752..11689799,-p2@ACP5
Hg19::chr19:11689803..11689815,-p5@ACP5
Hg19::chr1:159796480..159796494,+p5@SLAMF8
Hg19::chr1:46016762..46016777,+p3@AKR1A1
Hg19::chr20:1875058..1875060,+p21@SIRPA
Hg19::chr20:39518079..39518082,-p@chr20:39518079..39518082
-
Hg19::chr20:57582296..57582325,-p1@CTSZ
Hg19::chr3:69591495..69591521,-p7@FRMD4B
Hg19::chr5:131280548..131280574,-p1@ENST00000425320
Hg19::chr5:131280595..131280605,-p2@ENST00000425320
Hg19::chr5:150632732..150632758,+p1@GM2A
Hg19::chr6:134758827..134758863,+p1@LOC154092
Hg19::chr6:160406578..160406590,+p@chr6:160406578..160406590
+
Hg19::chr6:36097945..36097981,+p3@MAPK13
Hg19::chr6:36097992..36098038,+p4@MAPK13
Hg19::chr6:46703069..46703081,-p2@PLA2G7
Hg19::chr6:46703092..46703156,-p1@PLA2G7
Hg19::chr6:46703447..46703465,-p3@PLA2G7
Hg19::chr6:6799417..6799457,-p@chr6:6799417..6799457
-
Hg19::chr6:6801396..6801410,-p@chr6:6801396..6801410
-
Hg19::chr8:132916703..132916721,+p@chr8:132916703..132916721
+
Hg19::chr8:66891425..66891440,+p@chr8:66891425..66891440
+
Hg19::chr9:127023704..127023756,+p3@NEK6


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

p.valueFDRnGenesnPathwayName
5.2977040485515e-093.3534466627331e-065121Lysosome (KEGG):04142
4.72529853545926e-050.009970379909819033128Osteoclast differentiation (KEGG):04380
2.61528773412653e-050.008277385678510463105Membrane Trafficking (Reactome):REACT_11123
0.0003004892772442460.047552428123902246Interactions of the immunoglobulin superfamily (IgSF) member proteins (Reactome):REACT_23853



Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0005764lysosome4.52582062239315e-06
GO:0000323lytic vacuole4.52582062239315e-06
GO:0005773vacuole6.15010206948201e-06
GO:0030290sphingolipid activator protein activity0.012127634522548
GO:0032428beta-N-acetylgalactosaminidase activity0.012127634522548
GO:0047939L-glucuronate reductase activity0.012127634522548
GO:0046185aldehyde catabolic process0.012127634522548
GO:0042839D-glucuronate metabolic process0.012127634522548
GO:0042840D-glucuronate catabolic process0.012127634522548
GO:0008449N-acetylglucosamine-6-sulfatase activity0.012127634522548
GO:0019853L-ascorbic acid biosynthetic process0.012127634522548
GO:0006064glucuronate catabolic process0.012127634522548
GO:0007243protein kinase cascade0.0132272258457848
GO:0045177apical part of cell0.0132272258457848
GO:0009056catabolic process0.0132272258457848
GO:0005889hydrogen:potassium-exchanging ATPase complex0.0132272258457848
GO:0015761mannose transport0.0132272258457848
GO:0008106alcohol dehydrogenase (NADP+) activity0.0132272258457848
GO:0015578mannose transmembrane transporter activity0.0132272258457848
GO:0016004phospholipase activator activity0.0132272258457848
GO:0045179apical cortex0.0132272258457848
GO:0009313oligosaccharide catabolic process0.0132272258457848
GO:0008339MP kinase activity0.0161630403516077
GO:0004032aldehyde reductase activity0.0161630403516077
GO:0006063uronic acid metabolic process0.0161630403516077
GO:0019852L-ascorbic acid metabolic process0.0161630403516077
GO:0019585glucuronate metabolic process0.0161630403516077
GO:0004563beta-N-acetylhexosaminidase activity0.0191472672715482
GO:00082472-acetyl-1-alkylglycerophosphocholine esterase complex0.0191472672715482
GO:0006689ganglioside catabolic process0.0191472672715482
GO:0007249I-kappaB kinase/NF-kappaB cascade0.0191472672715482
GO:0016042lipid catabolic process0.0204320329707988
GO:0046479glycosphingolipid catabolic process0.021805657903249
GO:0008333endosome to lysosome transport0.021805657903249
GO:0006026aminoglycan catabolic process0.021805657903249
GO:0016909SAP kinase activity0.021805657903249
GO:0050700CARD domain binding0.021805657903249
GO:00038471-alkyl-2-acetylglycerophosphocholine esterase activity0.021805657903249
GO:0006027glycosaminoglycan catabolic process0.021805657903249
GO:0009898internal side of plasma membrane0.021805657903249
GO:0005737cytoplasm0.0226485989309556
GO:0019377glycolipid catabolic process0.0242231611391587
GO:0019915sequestering of lipid0.0260623078098239
GO:0001573ganglioside metabolic process0.0260623078098239
GO:0044425membrane part0.0260623078098239
GO:0016054organic acid catabolic process0.0309027153522172
GO:0046395carboxylic acid catabolic process0.0309027153522172
GO:0016020membrane0.0322521867971921
GO:0030071regulation of mitotic metaphase/anaphase transition0.0325983230004245
GO:0004033aldo-keto reductase activity0.0328706422062493
GO:0005537mannose binding0.0328706422062493
GO:0007091mitotic metaphase/anaphase transition0.0328706422062493
GO:0007250activation of NF-kappaB-inducing kinase0.0328706422062493
GO:0005975carbohydrate metabolic process0.0331554372984391
GO:0044248cellular catabolic process0.033577971469853
GO:0043085positive regulation of catalytic activity0.0349332211990327
GO:0007041lysosomal transport0.0356421855368791
GO:0030149sphingolipid catabolic process0.0375213613292531
GO:0048029monosaccharide binding0.0410886012693866
GO:0015929hexosaminidase activity0.0410886012693866
GO:0050885neuromuscular process controlling balance0.0427829322362058
GO:0006687glycosphingolipid metabolic process0.0444215781542066



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
monopoietic cell1.61e-9859
monocyte1.61e-9859
monoblast1.61e-9859
promonocyte1.61e-9859
macrophage dendritic cell progenitor1.89e-9861
defensive cell2.82e-9748
phagocyte2.82e-9748
granulocyte monocyte progenitor cell2.94e-8867
myeloid leukocyte2.01e-8772
myeloid lineage restricted progenitor cell1.82e-8666
classical monocyte2.55e-8342
CD14-positive, CD16-negative classical monocyte2.55e-8342
myeloid cell4.42e-57108
common myeloid progenitor4.42e-57108
nongranular leukocyte1.74e-48115
leukocyte6.10e-47136
stuff accumulating cell6.85e-4787
hematopoietic lineage restricted progenitor cell3.02e-42120
hematopoietic stem cell1.15e-34168
angioblastic mesenchymal cell1.15e-34168
hematopoietic oligopotent progenitor cell9.89e-33161
hematopoietic multipotent progenitor cell9.89e-33161
hematopoietic cell5.09e-32177
intermediate monocyte2.68e-179
CD14-positive, CD16-positive monocyte2.68e-179
macrophage8.99e-156
mesenchymal cell2.15e-08354
adult endothelial progenitor cell4.56e-083
connective tissue cell6.08e-08361
Uber Anatomy
Ontology termp-valuen
hematopoietic system4.16e-7998
blood island4.16e-7998
bone marrow5.90e-7676
hemolymphoid system5.38e-75108
immune system7.86e-7493
bone element3.06e-6982
skeletal element1.14e-6190
skeletal system6.65e-54100
lateral plate mesoderm5.88e-35203
musculoskeletal system1.76e-29167
mesoderm3.08e-22315
mesoderm-derived structure3.08e-22315
presumptive mesoderm3.08e-22315
germ layer7.00e-09560
germ layer / neural crest7.00e-09560
embryonic tissue7.00e-09560
presumptive structure7.00e-09560
germ layer / neural crest derived structure7.00e-09560
epiblast (generic)7.00e-09560
embryonic structure1.14e-08564
organ1.91e-08503
developing anatomical structure2.70e-08581
connective tissue7.63e-08371
embryo9.50e-08592
anatomical system2.98e-07624
anatomical group3.31e-07625
adult organism6.95e-07114


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.35984
MA0004.11.73666
MA0006.10.0748843
MA0007.10.762606
MA0009.10.340234
MA0014.10.814487
MA0017.11.52767
MA0019.10.800905
MA0024.10.261871
MA0025.10.448136
MA0027.11.8578
MA0028.10.0858631
MA0029.10.275814
MA0030.10.267514
MA0031.10.222414
MA0038.10.341188
MA0040.10.280083
MA0041.10.0671563
MA0042.10.202534
MA0043.10.902517
MA0046.10.331797
MA0048.10.436461
MA0050.10.448287
MA0051.10.10258
MA0052.10.282917
MA0055.10.609737
MA0056.10
MA0057.10.171126
MA0058.12.71276
MA0059.11.23663
MA0060.10.0191619
MA0061.10.735081
MA0063.10
MA0066.10.104867
MA0067.10.607707
MA0068.10.519997
MA0069.10.328825
MA0070.10.320241
MA0071.10.0863631
MA0072.10.31681
MA0073.10.0894974
MA0074.10.684284
MA0076.10.13753
MA0077.10.310955
MA0078.10.921365
MA0081.10.856296
MA0083.10.346089
MA0084.10.778769
MA0087.10.314949
MA0088.10.646938
MA0089.10
MA0090.10.0383435
MA0091.10.478767
MA0092.10.1799
MA0093.12.18474
MA0095.10
MA0098.10
MA0100.10.359565
MA0101.10.079118
MA0103.10.180166
MA0105.10.223736
MA0106.10.125937
MA0107.10.108386
MA0108.20.220346
MA0109.10
MA0111.10.665563
MA0113.10.419724
MA0114.10.609295
MA0115.10.540206
MA0116.12.48859
MA0117.10.369828
MA0119.10.495524
MA0122.10.390603
MA0124.10.504249
MA0125.10.433225
MA0130.10
MA0131.10.500131
MA0132.10
MA0133.10
MA0135.10.364077
MA0136.11.17291
MA0139.10.0343753
MA0140.10.288493
MA0141.10.849021
MA0142.10.201309
MA0143.10.134991
MA0144.10.0296118
MA0145.10.581966
MA0146.10.335436
MA0147.10.243119
MA0148.10.0697009
MA0149.10.276655
MA0062.20.185973
MA0035.20.0848533
MA0039.20.196139
MA0138.20.924385
MA0002.20.233979
MA0137.20.0205235
MA0104.20.428693
MA0047.20.119486
MA0112.21.09571
MA0065.20.320244
MA0150.10.1453
MA0151.10
MA0152.10.617339
MA0153.10.419293
MA0154.10.3257
MA0155.10.159223
MA0156.10.712454
MA0157.10.183768
MA0158.10
MA0159.11.66071
MA0160.10.55715
MA0161.10
MA0162.10.222108
MA0163.10.379462
MA0164.10.141853
MA0080.21.72508
MA0018.20.126682
MA0099.21.03556
MA0079.20.0911683
MA0102.20.813509
MA0258.10.753327
MA0259.10.125674
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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