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{{Coexpression_clusters
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|full_id=C2442_Adipocyte_Cardiac_Mesenchymal_heart_mature_Hair_Smooth
|id=C2442
|ontology_enrichment_celltype=CL:0000055!2.79e-18!180;CL:0000680!1.53e-15!57;CL:0000056!1.53e-15!57;CL:0000355!1.53e-15!57;CL:0000187!5.52e-15!54;CL:0000183!8.92e-15!59;CL:0000192!9.47e-15!42;CL:0000514!9.47e-15!42;CL:0000359!1.32e-13!32;CL:0000393!3.28e-12!60;CL:0000211!3.28e-12!60;CL:0002494!1.41e-09!16;CL:0000057!6.99e-09!75;CL:0000136!7.22e-09!15;CL:0000222!1.13e-07!119
|ontology_enrichment_disease=DOID:2394!5.50e-07!14
|ontology_enrichment_uberon=UBERON:0000481!1.95e-23!347;UBERON:0000475!7.19e-22!365;UBERON:0000468!5.56e-20!659;UBERON:0000914!7.06e-20!83;UBERON:0002329!7.06e-20!83;UBERON:0003077!7.06e-20!83;UBERON:0003059!7.06e-20!83;UBERON:0007282!7.06e-20!83;UBERON:0009618!7.06e-20!83;UBERON:0007285!7.06e-20!83;UBERON:0000477!1.04e-19!286;UBERON:0000486!1.63e-19!82;UBERON:0000119!4.53e-19!312;UBERON:0000483!5.54e-19!309;UBERON:0005256!6.99e-18!143;UBERON:0004290!7.33e-18!70;UBERON:0004872!2.01e-17!84;UBERON:0004111!4.01e-17!241;UBERON:0002385!4.67e-17!63;UBERON:0001015!4.67e-17!63;UBERON:0000383!4.67e-17!63;UBERON:0001134!1.13e-16!61;UBERON:0002036!1.13e-16!61;UBERON:0003082!1.13e-16!61;UBERON:0000467!3.03e-16!625;UBERON:0002100!4.50e-16!216;UBERON:0000480!6.25e-16!626;UBERON:0007100!1.59e-15!27;UBERON:0002050!5.31e-15!605;UBERON:0005423!5.31e-15!605;UBERON:0000923!8.52e-15!604;UBERON:0005291!8.52e-15!604;UBERON:0006598!8.52e-15!604;UBERON:0002532!8.52e-15!604;UBERON:0003104!8.69e-15!238;UBERON:0009142!8.69e-15!238;UBERON:0000922!1.04e-14!612;UBERON:0000948!1.19e-13!24;UBERON:0005498!1.19e-13!24;UBERON:0004140!1.19e-13!24;UBERON:0009881!1.19e-13!24;UBERON:0004141!1.19e-13!24;UBERON:0003084!1.19e-13!24;UBERON:0007005!1.19e-13!24;UBERON:0004139!1.19e-13!24;UBERON:0004291!1.19e-13!24;UBERON:0003914!2.70e-13!118;UBERON:0007023!1.42e-12!115;UBERON:0001009!4.69e-12!113;UBERON:0000025!1.63e-11!194;UBERON:0004573!2.29e-11!33;UBERON:0004571!2.29e-11!33;UBERON:0002049!2.66e-11!79;UBERON:0007798!2.66e-11!79;UBERON:0001637!2.74e-11!42;UBERON:0003509!2.74e-11!42;UBERON:0004572!2.74e-11!42;UBERON:0004535!8.20e-11!110;UBERON:0001981!1.17e-10!60;UBERON:0007500!1.17e-10!60;UBERON:0004537!1.17e-10!60;UBERON:0006965!1.17e-10!60;UBERON:0000490!1.71e-10!138;UBERON:0000055!2.32e-10!69;UBERON:0003103!3.51e-10!69;UBERON:0000062!3.03e-08!511;UBERON:0001048!3.58e-08!168;UBERON:0003102!4.68e-08!95;UBERON:0000926!2.37e-07!448;UBERON:0004120!2.37e-07!448;UBERON:0006603!2.37e-07!448;UBERON:0001135!7.42e-07!15
}}

Latest revision as of 12:05, 17 September 2013


Full id: C2442_Adipocyte_Cardiac_Mesenchymal_heart_mature_Hair_Smooth



Phase1 CAGE Peaks

Hg19::chr17:77020224..77020262,+p1@C1QTNF1
Hg19::chr17:77020273..77020288,+p4@C1QTNF1
Hg19::chr17:77020303..77020314,+p5@C1QTNF1
Hg19::chr17:77020325..77020348,+p2@C1QTNF1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Uber Anatomy
Ontology termp-valuen
multi-tissue structure1.34e-23342
multi-cellular organism1.21e-20656
anatomical cluster1.41e-20373
multilaminar epithelium7.37e-2083
cell layer2.72e-19309
epithelium3.34e-19306
dense mesenchyme tissue4.27e-1873
paraxial mesoderm4.87e-1872
presumptive paraxial mesoderm4.87e-1872
somite4.95e-1871
presomitic mesoderm4.95e-1871
presumptive segmental plate4.95e-1871
dermomyotome4.95e-1871
trunk paraxial mesoderm4.95e-1871
splanchnic layer of lateral plate mesoderm8.90e-1883
mesenchyme1.59e-17160
entire embryonic mesenchyme1.59e-17160
anatomical system1.92e-17624
anatomical group3.94e-17625
muscle tissue4.01e-1764
musculature4.01e-1764
musculature of body4.01e-1764
anatomical conduit9.72e-17240
skeletal muscle tissue1.05e-1662
striated muscle tissue1.05e-1662
myotome1.05e-1662
trunk mesenchyme1.24e-16122
organism subdivision1.57e-16264
epithelial vesicle4.77e-1678
primary circulatory organ1.84e-1527
embryonic structure3.43e-14564
embryo9.16e-14592
developing anatomical structure1.17e-13581
heart1.31e-1324
primitive heart tube1.31e-1324
primary heart field1.31e-1324
anterior lateral plate mesoderm1.31e-1324
heart tube1.31e-1324
heart primordium1.31e-1324
cardiac mesoderm1.31e-1324
cardiogenic plate1.31e-1324
heart rudiment1.31e-1324
germ layer2.25e-13560
germ layer / neural crest2.25e-13560
embryonic tissue2.25e-13560
presumptive structure2.25e-13560
germ layer / neural crest derived structure2.25e-13560
epiblast (generic)2.25e-13560
epithelial tube3.48e-13117
adult organism4.58e-13114
trunk6.32e-13199
circulatory system4.74e-12112
artery9.97e-1242
arterial blood vessel9.97e-1242
arterial system9.97e-1242
unilaminar epithelium1.04e-11148
vasculature1.42e-1178
vascular system1.42e-1178
structure with developmental contribution from neural crest2.31e-11132
systemic artery2.44e-1133
systemic arterial system2.44e-1133
tube2.66e-11192
epithelial tube open at both ends7.73e-1159
blood vessel7.73e-1159
blood vasculature7.73e-1159
vascular cord7.73e-1159
cardiovascular system8.18e-11109
vessel1.22e-1068
compound organ5.75e-1068
surface structure4.19e-0899
organ4.24e-08503
primordium4.79e-08160
smooth muscle tissue7.96e-0715
tissue8.69e-07773
Disease
Ontology termp-valuen
ovarian cancer3.99e-0714


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.12.39007
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.244769
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.11.35734
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.11.30988
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.11.28887
MA0056.10
MA0057.10.248209
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.11.52107
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.11.93422
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.11.4709
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.536981
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.11.6149
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.12.66951
MA0106.10.869173
MA0107.11.1497
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.16.43968
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.13.39971
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.10.195821
MA0146.10.061409
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.22.51225
MA0035.20.778873
MA0039.21.5472
MA0138.20.928035
MA0002.20.98779
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.24.85059
MA0065.20.199162
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.15.34766
MA0155.10.180766
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.309472
MA0163.10.539587
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.22.35343
MA0102.21.75932
MA0258.11.88931
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
ZNF263#1012748.221841637010680.0002187871180958320.00248747091517642



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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