Coexpression cluster:C234: Difference between revisions
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{{Coexpression_clusters | {{Coexpression_clusters|coexpression_dpi_cluster_scores_median=0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.815822729604275,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0|full_id=C234_oral_epidermoid_malignant_cervical_ductal_lung_keratoacanthoma|gostat_on_coexpression_clusters=GO:0043687!post-translational protein modification!0.00082997889119931!1056;84231;11078;79589;56924;1956$GO:0006464!protein modification process!0.00107200405349154!1056;84231;11078;79589;56924;1956$GO:0043412!biopolymer modification!0.00107200405349154!1056;84231;11078;79589;56924;1956$GO:0017048!Rho GTPase binding!0.00247625807933599!23191;11078$GO:0051015!actin filament binding!0.00295708866151386!23191;1956$GO:0032501!multicellular organismal process!0.00318135985201998!23191;1056;84231;11078;79589;1956$GO:0051246!regulation of protein metabolic process!0.00586455504111573!11078;79589;1956$GO:0003779!actin binding!0.00586455504111573!23191;11078;1956$GO:0017016!Ras GTPase binding!0.00607853526433533!23191;11078$GO:0031267!small GTPase binding!0.00607853526433533!23191;11078$GO:0051020!GTPase binding!0.00607853526433533!23191;11078$GO:0030047!actin modification!0.00607853526433533!11078$GO:0044258!intestinal lipid catabolic process!0.00607853526433533!1056$GO:0045159!myosin II binding!0.00607853526433533!11078$GO:0044240!multicellular organismal lipid catabolic process!0.00607853526433533!1056$GO:0004710!MAP/ERK kinase kinase activity!0.00607853526433533!1956$GO:0051248!negative regulation of protein metabolic process!0.00623852478682341!11078;79589$GO:0008092!cytoskeletal protein binding!0.00668992561804517!23191;11078;1956$GO:0044267!cellular protein metabolic process!0.00845473637666067!1056;84231;11078;79589;56924;1956$GO:0044260!cellular macromolecule metabolic process!0.00845473637666067!1056;84231;11078;79589;56924;1956$GO:0018350!protein amino acid esterification!0.00845473637666067!1056$GO:0043006!calcium-dependent phospholipase A2 activation!0.00845473637666067!1956$GO:0045860!positive regulation of protein kinase activity!0.00845473637666067!84231;1956$GO:0033674!positive regulation of kinase activity!0.00845473637666067!84231;1956$GO:0051347!positive regulation of transferase activity!0.00845647520355778!84231;1956$GO:0019538!protein metabolic process!0.00848128371102795!1056;84231;11078;79589;56924;1956$GO:0005515!protein binding!0.00857969337402409!23191;84231;11078;79589;56924;123355;1956$GO:0004842!ubiquitin-protein ligase activity!0.00857969337402409!84231;79589$GO:0008639!small protein conjugating enzyme activity!0.00857969337402409!84231;79589$GO:0032429!regulation of phospholipase A2 activity!0.00857969337402409!1956$GO:0032431!activation of phospholipase A2!0.00857969337402409!1956$GO:0032430!positive regulation of phospholipase A2 activity!0.00857969337402409!1956$GO:0005006!epidermal growth factor receptor activity!0.00857969337402409!1956$GO:0004771!sterol esterase activity!0.00857969337402409!1056$GO:0005768!endosome!0.0103727594682946!79589;1956$GO:0030235!nitric-oxide synthase regulator activity!0.0105670098153156!1956$GO:0009889!regulation of biosynthetic process!0.0105670098153156!79589;1956$GO:0065007!biological regulation!0.0105670098153156!23191;1056;84231;11078;79589;1956$GO:0017049!GTP-Rho binding!0.0105670098153156!11078$GO:0031529!ruffle organization and biogenesis!0.0105670098153156!23191$GO:0030669!clathrin-coated endocytic vesicle membrane!0.0105670098153156!1956$GO:0030128!clathrin coat of endocytic vesicle!0.0105670098153156!1956$GO:0009062!fatty acid catabolic process!0.0105670098153156!1056$GO:0030122!AP-2 adaptor complex!0.0105670098153156!1956$GO:0000185!activation of MAPKKK activity!0.0105670098153156!84231$GO:0030157!pancreatic juice secretion!0.0105670098153156!1056$GO:0045859!regulation of protein kinase activity!0.01159391976791!84231;1956$GO:0019787!small conjugating protein ligase activity!0.01159391976791!84231;79589$GO:0043549!regulation of kinase activity!0.01159391976791!84231;1956$GO:0030666!endocytic vesicle membrane!0.0115984429230449!1956$GO:0051338!regulation of transferase activity!0.0115984429230449!84231;1956$GO:0043085!positive regulation of catalytic activity!0.0122082524778653!84231;1956$GO:0050999!regulation of nitric-oxide synthase activity!0.0123411361574347!1956$GO:0048365!Rac GTPase binding!0.0123411361574347!23191$GO:0045334!clathrin-coated endocytic vesicle!0.0123411361574347!1956$GO:0048523!negative regulation of cellular process!0.0123411361574347!11078;79589;1956$GO:0030299!cholesterol absorption!0.0123411361574347!1056$GO:0035272!exocrine system development!0.0123411361574347!84231$GO:0030032!lamellipodium biogenesis!0.0123411361574347!23191$GO:0043410!positive regulation of MAPKKK cascade!0.0123411361574347!84231$GO:0045429!positive regulation of nitric oxide biosynthetic process!0.0123411361574347!1956$GO:0044241!lipid digestion!0.0123411361574347!1056$GO:0017022!myosin binding!0.0123411361574347!11078$GO:0048519!negative regulation of biological process!0.012675187205804!11078;79589;1956$GO:0016881!acid-amino acid ligase activity!0.012675187205804!84231;79589$GO:0005737!cytoplasm!0.012675187205804!23191;1056;84231;11078;79589;1956$GO:0051205!protein insertion into membrane!0.012675187205804!1956$GO:0006707!cholesterol catabolic process!0.012675187205804!1056$GO:0016127!sterol catabolic process!0.012675187205804!1056$GO:0019899!enzyme binding!0.0128068140604994!23191;11078$GO:0050892!intestinal absorption!0.0131305978956997!1056$GO:0016054!organic acid catabolic process!0.0131305978956997!1056$GO:0045428!regulation of nitric oxide biosynthetic process!0.0131305978956997!1956$GO:0046395!carboxylic acid catabolic process!0.0131305978956997!1056$GO:0051341!regulation of oxidoreductase activity!0.0155434250131146!1956$GO:0043283!biopolymer metabolic process!0.0158624483417039!1056;84231;11078;79589;56924;1956$GO:0030132!clathrin coat of coated pit!0.0160591317186777!1956$GO:0051668!localization within membrane!0.0160591317186777!1956$GO:0042802!identical protein binding!0.0160591317186777!84231;1956$GO:0016879!ligase activity, forming carbon-nitrogen bonds!0.0164614413104735!84231;79589$GO:0046903!secretion!0.0173924417206685!1056;84231$GO:0043408!regulation of MAPKKK cascade!0.017551154462669!84231$GO:0017157!regulation of exocytosis!0.017551154462669!84231$GO:0007202!phospholipase C activation!0.0182788488059503!1956$GO:0042036!negative regulation of cytokine biosynthetic process!0.0182788488059503!79589$GO:0006706!steroid catabolic process!0.0185464998780557!1056$GO:0004806!triacylglycerol lipase activity!0.0185464998780557!1056$GO:0030335!positive regulation of cell migration!0.0185464998780557!1956$GO:0048675!axon extension!0.0185464998780557!23191$GO:0031410!cytoplasmic vesicle!0.0185910089984781!84231;1956$GO:0050679!positive regulation of epithelial cell proliferation!0.0185910089984781!1956$GO:0006641!triacylglycerol metabolic process!0.0185910089984781!1056$GO:0004709!MAP kinase kinase kinase activity!0.0185910089984781!1956$GO:0007589!fluid secretion!0.0185910089984781!1056$GO:0031982!vesicle!0.0186677100515402!84231;1956$GO:0009892!negative regulation of metabolic process!0.0187235319239128!11078;79589$GO:0016043!cellular component organization and biogenesis!0.0187235319239128!23191;84231;11078;1956$GO:0022600!digestive system process!0.0188209308384392!1056$GO:0048731!system development!0.019239974086359!23191;84231;1956$GO:0051272!positive regulation of cell motility!0.019239974086359!1956$GO:0044243!multicellular organismal catabolic process!0.019239974086359!1056$GO:0040017!positive regulation of locomotion!0.019239974086359!1956$GO:0051693!actin filament capping!0.019239974086359!11078$GO:0051016!barbed-end actin filament capping!0.019239974086359!11078$GO:0030835!negative regulation of actin filament depolymerization!0.019239974086359!11078$GO:0030125!clathrin vesicle coat!0.019239974086359!1956$GO:0030139!endocytic vesicle!0.019239974086359!1956$GO:0006809!nitric oxide biosynthetic process!0.019239974086359!1956$GO:0046209!nitric oxide metabolic process!0.019239974086359!1956$GO:0030834!regulation of actin filament depolymerization!0.019239974086359!11078$GO:0030042!actin filament depolymerization!0.019239974086359!11078$GO:0044236!multicellular organismal metabolic process!0.019239974086359!1056$GO:0030665!clathrin coated vesicle membrane!0.019239974086359!1956$GO:0042327!positive regulation of phosphorylation!0.019239974086359!1956$GO:0006638!neutral lipid metabolic process!0.019239974086359!1056$GO:0006639!acylglycerol metabolic process!0.019239974086359!1056$GO:0046486!glycerolipid metabolic process!0.0199028506092353!1056$GO:0045937!positive regulation of phosphate metabolic process!0.0203815973892503!1956$GO:0006662!glycerol ether metabolic process!0.0203815973892503!1056$GO:0050730!regulation of peptidyl-tyrosine phosphorylation!0.0226283921998209!1956$GO:0050789!regulation of biological process!0.0226283921998209!23191;84231;11078;79589;1956$GO:0006512!ubiquitin cycle!0.0231655327028394!84231;79589$GO:0050678!regulation of epithelial cell proliferation!0.0236503549970233!1956$GO:0007173!epidermal growth factor receptor signaling pathway!0.0255912361987488!1956$GO:0050673!epithelial cell proliferation!0.0255912361987488!1956$GO:0050790!regulation of catalytic activity!0.0270642111962022!84231;1956$GO:0019717!synaptosome!0.0274695750993926!23191$GO:0019722!calcium-mediated signaling!0.0280091669531585!1956$GO:0030027!lamellipodium!0.0291752041501888!23191$GO:0048856!anatomical structure development!0.0291752041501888!23191;84231;1956$GO:0016874!ligase activity!0.029626590944466!84231;79589$GO:0017148!negative regulation of translation!0.0299085397152955!79589$GO:0022603!regulation of anatomical structure morphogenesis!0.0299085397152955!23191$GO:0022604!regulation of cell morphogenesis!0.0299085397152955!23191$GO:0008360!regulation of cell shape!0.0299085397152955!23191$GO:0018108!peptidyl-tyrosine phosphorylation!0.0299085397152955!1956$GO:0065009!regulation of a molecular function!0.0299566856550253!84231;1956$GO:0005905!coated pit!0.0299566856550253!1956$GO:0001726!ruffle!0.0299566856550253!23191$GO:0018212!peptidyl-tyrosine modification!0.0300886059507785!1956$GO:0008064!regulation of actin polymerization and/or depolymerization!0.0300886059507785!11078$GO:0019222!regulation of metabolic process!0.0300886059507785!84231;11078;79589;1956$GO:0031327!negative regulation of cellular biosynthetic process!0.0300886059507785!79589$GO:0001932!regulation of protein amino acid phosphorylation!0.0300886059507785!1956$GO:0033238!regulation of amine metabolic process!0.0300886059507785!1956$GO:0051261!protein depolymerization!0.0300886059507785!11078$GO:0030832!regulation of actin filament length!0.0300886059507785!11078$GO:0006521!regulation of amino acid metabolic process!0.0300886059507785!1956$GO:0004674!protein serine/threonine kinase activity!0.0301288214400606!56924;1956$GO:0032535!regulation of cellular component size!0.0301288214400606!11078$GO:0032956!regulation of actin cytoskeleton organization and biogenesis!0.0301288214400606!11078$GO:0044242!cellular lipid catabolic process!0.0305642797103058!1056$GO:0030031!cell projection biogenesis!0.0314178431974939!23191$GO:0030120!vesicle coat!0.0314178431974939!1956$GO:0030662!coated vesicle membrane!0.0314306160342309!1956$GO:0009890!negative regulation of biosynthetic process!0.0314306160342309!79589$GO:0005770!late endosome!0.0314306160342309!79589$GO:0051129!negative regulation of cellular component organization and biogenesis!0.0318407956846703!11078$GO:0030131!clathrin adaptor complex!0.0322456909329477!1956$GO:0030119!AP-type membrane coat adaptor complex!0.0326454008835614!1956$GO:0051493!regulation of cytoskeleton organization and biogenesis!0.033363553798076!11078$GO:0033043!regulation of organelle organization and biogenesis!0.033363553798076!11078$GO:0044459!plasma membrane part!0.033363553798076!23191;84231;1956$GO:0007275!multicellular organismal development!0.0337195370824305!23191;84231;1956$GO:0019752!carboxylic acid metabolic process!0.0345307987301992!1056;1956$GO:0042035!regulation of cytokine biosynthetic process!0.0345307987301992!79589$GO:0030334!regulation of cell migration!0.0345307987301992!1956$GO:0006082!organic acid metabolic process!0.0345307987301992!1056;1956$GO:0008154!actin polymerization and/or depolymerization!0.034888185905067!11078$GO:0044444!cytoplasmic part!0.0359544511748904!23191;84231;79589;1956$GO:0042325!regulation of phosphorylation!0.0359544511748904!1956$GO:0048471!perinuclear region of cytoplasm!0.0359544511748904!23191$GO:0043406!positive regulation of MAP kinase activity!0.0366442986191015!1956$GO:0030118!clathrin coat!0.0366442986191015!1956$GO:0042089!cytokine biosynthetic process!0.0369831395401929!79589$GO:0042107!cytokine metabolic process!0.0372283403277171!79589$GO:0051174!regulation of phosphorus metabolic process!0.0372283403277171!1956$GO:0019220!regulation of phosphate metabolic process!0.0372283403277171!1956$GO:0051270!regulation of cell motility!0.0372283403277171!1956$GO:0009891!positive regulation of biosynthetic process!0.0373467125137524!1956$GO:0032147!activation of protein kinase activity!0.0373467125137524!84231$GO:0040012!regulation of locomotion!0.0379861184081674!1956$GO:0031252!leading edge!0.0379861184081674!23191$GO:0016567!protein ubiquitination!0.0380934180166467!84231$GO:0040011!locomotion!0.0380934180166467!1956$GO:0008201!heparin binding!0.0392226289753796!1056$GO:0051345!positive regulation of hydrolase activity!0.0392226289753796!1956$GO:0004702!receptor signaling protein serine/threonine kinase activity!0.0392853115748897!1956$GO:0032446!protein modification by small protein conjugation!0.0392853115748897!84231$GO:0043170!macromolecule metabolic process!0.0392853115748897!1056;84231;11078;79589;56924;1956$GO:0008203!cholesterol metabolic process!0.0394036592692397!1056$GO:0000151!ubiquitin ligase complex!0.0416896941200092!84231$GO:0065008!regulation of biological quality!0.0419631073177305!1056;11078$GO:0048522!positive regulation of cellular process!0.0419631073177305!84231;1956$GO:0001503!ossification!0.0430571056967989!1956$GO:0007200!G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)!0.0430571056967989!1956$GO:0031214!biomineral formation!0.0430571056967989!1956$GO:0043405!regulation of MAP kinase activity!0.0452504293491098!1956$GO:0016125!sterol metabolic process!0.0455024768032393!1056$GO:0007586!digestion!0.0457519052151574!1056$GO:0046849!bone remodeling!0.0459987536924159!1956$GO:0051128!regulation of cellular component organization and biogenesis!0.0476585458323638!11078$GO:0048518!positive regulation of biological process!0.0490445590213351!84231;1956$GO:0048771!tissue remodeling!0.0490445590213351!1956$GO:0046982!protein heterodimerization activity!0.0490445590213351!1956$GO:0030659!cytoplasmic vesicle membrane!0.0490445590213351!1956$GO:0044433!cytoplasmic vesicle part!0.0497270655458818!1956$GO:0003690!double-stranded DNA binding!0.0499453594652825!1956|id=C234|ontology_enrichment_celltype=CL:0002251!2.29e-11!20|ontology_enrichment_disease=DOID:1749!1.43e-15!14|ontology_enrichment_uberon=UBERON:0003343!3.10e-50!4;UBERON:0004785!3.10e-50!4;UBERON:0000974!3.81e-21!10;UBERON:0003729!1.21e-16!13;UBERON:0000344!2.29e-11!20;UBERON:0000166!1.80e-10!22;UBERON:0000165!2.67e-08!29;UBERON:0000930!2.67e-08!29;UBERON:0000161!5.81e-07!36|pathway_enrichment=3.37554285299587e-05;0.0213671862594639;3;214;Regulation of actin cytoskeleton 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Latest revision as of 11:02, 17 September 2013
Full id: C234_oral_epidermoid_malignant_cervical_ductal_lung_keratoacanthoma
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
p.value | FDR | nGenes | nPathway | Name |
---|---|---|---|---|
3.37554285299587e-05 | 0.0213671862594639 | 3 | 214 | Regulation of actin cytoskeleton (KEGG):04810 |
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0043687 | post-translational protein modification | 0.00082997889119931 |
GO:0006464 | protein modification process | 0.00107200405349154 |
GO:0043412 | biopolymer modification | 0.00107200405349154 |
GO:0017048 | Rho GTPase binding | 0.00247625807933599 |
GO:0051015 | actin filament binding | 0.00295708866151386 |
GO:0032501 | multicellular organismal process | 0.00318135985201998 |
GO:0051246 | regulation of protein metabolic process | 0.00586455504111573 |
GO:0003779 | actin binding | 0.00586455504111573 |
GO:0017016 | Ras GTPase binding | 0.00607853526433533 |
GO:0031267 | small GTPase binding | 0.00607853526433533 |
GO:0051020 | GTPase binding | 0.00607853526433533 |
GO:0030047 | actin modification | 0.00607853526433533 |
GO:0044258 | intestinal lipid catabolic process | 0.00607853526433533 |
GO:0045159 | myosin II binding | 0.00607853526433533 |
GO:0044240 | multicellular organismal lipid catabolic process | 0.00607853526433533 |
GO:0004710 | MAP/ERK kinase kinase activity | 0.00607853526433533 |
GO:0051248 | negative regulation of protein metabolic process | 0.00623852478682341 |
GO:0008092 | cytoskeletal protein binding | 0.00668992561804517 |
GO:0044267 | cellular protein metabolic process | 0.00845473637666067 |
GO:0044260 | cellular macromolecule metabolic process | 0.00845473637666067 |
GO:0018350 | protein amino acid esterification | 0.00845473637666067 |
GO:0043006 | calcium-dependent phospholipase A2 activation | 0.00845473637666067 |
GO:0045860 | positive regulation of protein kinase activity | 0.00845473637666067 |
GO:0033674 | positive regulation of kinase activity | 0.00845473637666067 |
GO:0051347 | positive regulation of transferase activity | 0.00845647520355778 |
GO:0019538 | protein metabolic process | 0.00848128371102795 |
GO:0005515 | protein binding | 0.00857969337402409 |
GO:0004842 | ubiquitin-protein ligase activity | 0.00857969337402409 |
GO:0008639 | small protein conjugating enzyme activity | 0.00857969337402409 |
GO:0032429 | regulation of phospholipase A2 activity | 0.00857969337402409 |
GO:0032431 | activation of phospholipase A2 | 0.00857969337402409 |
GO:0032430 | positive regulation of phospholipase A2 activity | 0.00857969337402409 |
GO:0005006 | epidermal growth factor receptor activity | 0.00857969337402409 |
GO:0004771 | sterol esterase activity | 0.00857969337402409 |
GO:0005768 | endosome | 0.0103727594682946 |
GO:0030235 | nitric-oxide synthase regulator activity | 0.0105670098153156 |
GO:0009889 | regulation of biosynthetic process | 0.0105670098153156 |
GO:0065007 | biological regulation | 0.0105670098153156 |
GO:0017049 | GTP-Rho binding | 0.0105670098153156 |
GO:0031529 | ruffle organization and biogenesis | 0.0105670098153156 |
GO:0030669 | clathrin-coated endocytic vesicle membrane | 0.0105670098153156 |
GO:0030128 | clathrin coat of endocytic vesicle | 0.0105670098153156 |
GO:0009062 | fatty acid catabolic process | 0.0105670098153156 |
GO:0030122 | AP-2 adaptor complex | 0.0105670098153156 |
GO:0000185 | activation of MAPKKK activity | 0.0105670098153156 |
GO:0030157 | pancreatic juice secretion | 0.0105670098153156 |
GO:0045859 | regulation of protein kinase activity | 0.01159391976791 |
GO:0019787 | small conjugating protein ligase activity | 0.01159391976791 |
GO:0043549 | regulation of kinase activity | 0.01159391976791 |
GO:0030666 | endocytic vesicle membrane | 0.0115984429230449 |
GO:0051338 | regulation of transferase activity | 0.0115984429230449 |
GO:0043085 | positive regulation of catalytic activity | 0.0122082524778653 |
GO:0050999 | regulation of nitric-oxide synthase activity | 0.0123411361574347 |
GO:0048365 | Rac GTPase binding | 0.0123411361574347 |
GO:0045334 | clathrin-coated endocytic vesicle | 0.0123411361574347 |
GO:0048523 | negative regulation of cellular process | 0.0123411361574347 |
GO:0030299 | cholesterol absorption | 0.0123411361574347 |
GO:0035272 | exocrine system development | 0.0123411361574347 |
GO:0030032 | lamellipodium biogenesis | 0.0123411361574347 |
GO:0043410 | positive regulation of MAPKKK cascade | 0.0123411361574347 |
GO:0045429 | positive regulation of nitric oxide biosynthetic process | 0.0123411361574347 |
GO:0044241 | lipid digestion | 0.0123411361574347 |
GO:0017022 | myosin binding | 0.0123411361574347 |
GO:0048519 | negative regulation of biological process | 0.012675187205804 |
GO:0016881 | acid-amino acid ligase activity | 0.012675187205804 |
GO:0005737 | cytoplasm | 0.012675187205804 |
GO:0051205 | protein insertion into membrane | 0.012675187205804 |
GO:0006707 | cholesterol catabolic process | 0.012675187205804 |
GO:0016127 | sterol catabolic process | 0.012675187205804 |
GO:0019899 | enzyme binding | 0.0128068140604994 |
GO:0050892 | intestinal absorption | 0.0131305978956997 |
GO:0016054 | organic acid catabolic process | 0.0131305978956997 |
GO:0045428 | regulation of nitric oxide biosynthetic process | 0.0131305978956997 |
GO:0046395 | carboxylic acid catabolic process | 0.0131305978956997 |
GO:0051341 | regulation of oxidoreductase activity | 0.0155434250131146 |
GO:0043283 | biopolymer metabolic process | 0.0158624483417039 |
GO:0030132 | clathrin coat of coated pit | 0.0160591317186777 |
GO:0051668 | localization within membrane | 0.0160591317186777 |
GO:0042802 | identical protein binding | 0.0160591317186777 |
GO:0016879 | ligase activity, forming carbon-nitrogen bonds | 0.0164614413104735 |
GO:0046903 | secretion | 0.0173924417206685 |
GO:0043408 | regulation of MAPKKK cascade | 0.017551154462669 |
GO:0017157 | regulation of exocytosis | 0.017551154462669 |
GO:0007202 | phospholipase C activation | 0.0182788488059503 |
GO:0042036 | negative regulation of cytokine biosynthetic process | 0.0182788488059503 |
GO:0006706 | steroid catabolic process | 0.0185464998780557 |
GO:0004806 | triacylglycerol lipase activity | 0.0185464998780557 |
GO:0030335 | positive regulation of cell migration | 0.0185464998780557 |
GO:0048675 | axon extension | 0.0185464998780557 |
GO:0031410 | cytoplasmic vesicle | 0.0185910089984781 |
GO:0050679 | positive regulation of epithelial cell proliferation | 0.0185910089984781 |
GO:0006641 | triacylglycerol metabolic process | 0.0185910089984781 |
GO:0004709 | MAP kinase kinase kinase activity | 0.0185910089984781 |
GO:0007589 | fluid secretion | 0.0185910089984781 |
GO:0031982 | vesicle | 0.0186677100515402 |
GO:0009892 | negative regulation of metabolic process | 0.0187235319239128 |
GO:0016043 | cellular component organization and biogenesis | 0.0187235319239128 |
GO:0022600 | digestive system process | 0.0188209308384392 |
GO:0048731 | system development | 0.019239974086359 |
GO:0051272 | positive regulation of cell motility | 0.019239974086359 |
GO:0044243 | multicellular organismal catabolic process | 0.019239974086359 |
GO:0040017 | positive regulation of locomotion | 0.019239974086359 |
GO:0051693 | actin filament capping | 0.019239974086359 |
GO:0051016 | barbed-end actin filament capping | 0.019239974086359 |
GO:0030835 | negative regulation of actin filament depolymerization | 0.019239974086359 |
GO:0030125 | clathrin vesicle coat | 0.019239974086359 |
GO:0030139 | endocytic vesicle | 0.019239974086359 |
GO:0006809 | nitric oxide biosynthetic process | 0.019239974086359 |
GO:0046209 | nitric oxide metabolic process | 0.019239974086359 |
GO:0030834 | regulation of actin filament depolymerization | 0.019239974086359 |
GO:0030042 | actin filament depolymerization | 0.019239974086359 |
GO:0044236 | multicellular organismal metabolic process | 0.019239974086359 |
GO:0030665 | clathrin coated vesicle membrane | 0.019239974086359 |
GO:0042327 | positive regulation of phosphorylation | 0.019239974086359 |
GO:0006638 | neutral lipid metabolic process | 0.019239974086359 |
GO:0006639 | acylglycerol metabolic process | 0.019239974086359 |
GO:0046486 | glycerolipid metabolic process | 0.0199028506092353 |
GO:0045937 | positive regulation of phosphate metabolic process | 0.0203815973892503 |
GO:0006662 | glycerol ether metabolic process | 0.0203815973892503 |
GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 0.0226283921998209 |
GO:0050789 | regulation of biological process | 0.0226283921998209 |
GO:0006512 | ubiquitin cycle | 0.0231655327028394 |
GO:0050678 | regulation of epithelial cell proliferation | 0.0236503549970233 |
GO:0007173 | epidermal growth factor receptor signaling pathway | 0.0255912361987488 |
GO:0050673 | epithelial cell proliferation | 0.0255912361987488 |
GO:0050790 | regulation of catalytic activity | 0.0270642111962022 |
GO:0019717 | synaptosome | 0.0274695750993926 |
GO:0019722 | calcium-mediated signaling | 0.0280091669531585 |
GO:0030027 | lamellipodium | 0.0291752041501888 |
GO:0048856 | anatomical structure development | 0.0291752041501888 |
GO:0016874 | ligase activity | 0.029626590944466 |
GO:0017148 | negative regulation of translation | 0.0299085397152955 |
GO:0022603 | regulation of anatomical structure morphogenesis | 0.0299085397152955 |
GO:0022604 | regulation of cell morphogenesis | 0.0299085397152955 |
GO:0008360 | regulation of cell shape | 0.0299085397152955 |
GO:0018108 | peptidyl-tyrosine phosphorylation | 0.0299085397152955 |
GO:0065009 | regulation of a molecular function | 0.0299566856550253 |
GO:0005905 | coated pit | 0.0299566856550253 |
GO:0001726 | ruffle | 0.0299566856550253 |
GO:0018212 | peptidyl-tyrosine modification | 0.0300886059507785 |
GO:0008064 | regulation of actin polymerization and/or depolymerization | 0.0300886059507785 |
GO:0019222 | regulation of metabolic process | 0.0300886059507785 |
GO:0031327 | negative regulation of cellular biosynthetic process | 0.0300886059507785 |
GO:0001932 | regulation of protein amino acid phosphorylation | 0.0300886059507785 |
GO:0033238 | regulation of amine metabolic process | 0.0300886059507785 |
GO:0051261 | protein depolymerization | 0.0300886059507785 |
GO:0030832 | regulation of actin filament length | 0.0300886059507785 |
GO:0006521 | regulation of amino acid metabolic process | 0.0300886059507785 |
GO:0004674 | protein serine/threonine kinase activity | 0.0301288214400606 |
GO:0032535 | regulation of cellular component size | 0.0301288214400606 |
GO:0032956 | regulation of actin cytoskeleton organization and biogenesis | 0.0301288214400606 |
GO:0044242 | cellular lipid catabolic process | 0.0305642797103058 |
GO:0030031 | cell projection biogenesis | 0.0314178431974939 |
GO:0030120 | vesicle coat | 0.0314178431974939 |
GO:0030662 | coated vesicle membrane | 0.0314306160342309 |
GO:0009890 | negative regulation of biosynthetic process | 0.0314306160342309 |
GO:0005770 | late endosome | 0.0314306160342309 |
GO:0051129 | negative regulation of cellular component organization and biogenesis | 0.0318407956846703 |
GO:0030131 | clathrin adaptor complex | 0.0322456909329477 |
GO:0030119 | AP-type membrane coat adaptor complex | 0.0326454008835614 |
GO:0051493 | regulation of cytoskeleton organization and biogenesis | 0.033363553798076 |
GO:0033043 | regulation of organelle organization and biogenesis | 0.033363553798076 |
GO:0044459 | plasma membrane part | 0.033363553798076 |
GO:0007275 | multicellular organismal development | 0.0337195370824305 |
GO:0019752 | carboxylic acid metabolic process | 0.0345307987301992 |
GO:0042035 | regulation of cytokine biosynthetic process | 0.0345307987301992 |
GO:0030334 | regulation of cell migration | 0.0345307987301992 |
GO:0006082 | organic acid metabolic process | 0.0345307987301992 |
GO:0008154 | actin polymerization and/or depolymerization | 0.034888185905067 |
GO:0044444 | cytoplasmic part | 0.0359544511748904 |
GO:0042325 | regulation of phosphorylation | 0.0359544511748904 |
GO:0048471 | perinuclear region of cytoplasm | 0.0359544511748904 |
GO:0043406 | positive regulation of MAP kinase activity | 0.0366442986191015 |
GO:0030118 | clathrin coat | 0.0366442986191015 |
GO:0042089 | cytokine biosynthetic process | 0.0369831395401929 |
GO:0042107 | cytokine metabolic process | 0.0372283403277171 |
GO:0051174 | regulation of phosphorus metabolic process | 0.0372283403277171 |
GO:0019220 | regulation of phosphate metabolic process | 0.0372283403277171 |
GO:0051270 | regulation of cell motility | 0.0372283403277171 |
GO:0009891 | positive regulation of biosynthetic process | 0.0373467125137524 |
GO:0032147 | activation of protein kinase activity | 0.0373467125137524 |
GO:0040012 | regulation of locomotion | 0.0379861184081674 |
GO:0031252 | leading edge | 0.0379861184081674 |
GO:0016567 | protein ubiquitination | 0.0380934180166467 |
GO:0040011 | locomotion | 0.0380934180166467 |
GO:0008201 | heparin binding | 0.0392226289753796 |
GO:0051345 | positive regulation of hydrolase activity | 0.0392226289753796 |
GO:0004702 | receptor signaling protein serine/threonine kinase activity | 0.0392853115748897 |
GO:0032446 | protein modification by small protein conjugation | 0.0392853115748897 |
GO:0043170 | macromolecule metabolic process | 0.0392853115748897 |
GO:0008203 | cholesterol metabolic process | 0.0394036592692397 |
GO:0000151 | ubiquitin ligase complex | 0.0416896941200092 |
GO:0065008 | regulation of biological quality | 0.0419631073177305 |
GO:0048522 | positive regulation of cellular process | 0.0419631073177305 |
GO:0001503 | ossification | 0.0430571056967989 |
GO:0007200 | G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) | 0.0430571056967989 |
GO:0031214 | biomineral formation | 0.0430571056967989 |
GO:0043405 | regulation of MAP kinase activity | 0.0452504293491098 |
GO:0016125 | sterol metabolic process | 0.0455024768032393 |
GO:0007586 | digestion | 0.0457519052151574 |
GO:0046849 | bone remodeling | 0.0459987536924159 |
GO:0051128 | regulation of cellular component organization and biogenesis | 0.0476585458323638 |
GO:0048518 | positive regulation of biological process | 0.0490445590213351 |
GO:0048771 | tissue remodeling | 0.0490445590213351 |
GO:0046982 | protein heterodimerization activity | 0.0490445590213351 |
GO:0030659 | cytoplasmic vesicle membrane | 0.0490445590213351 |
GO:0044433 | cytoplasmic vesicle part | 0.0497270655458818 |
GO:0003690 | double-stranded DNA binding | 0.0499453594652825 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>
Ontology term | p-value | n |
---|---|---|
epithelial cell of alimentary canal | 2.29e-11 | 20 |
Ontology term | p-value | n |
---|---|---|
mucosa of oral region | 3.10e-50 | 4 |
respiratory system mucosa | 3.10e-50 | 4 |
neck | 3.81e-21 | 10 |
mouth mucosa | 1.21e-16 | 13 |
mucosa | 2.29e-11 | 20 |
oral opening | 1.80e-10 | 22 |
mouth | 2.67e-08 | 29 |
stomodeum | 2.67e-08 | 29 |
orifice | 5.81e-07 | 36 |
Ontology term | p-value | n |
---|---|---|
squamous cell carcinoma | 1.43e-15 | 14 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
MA0003.1 | 0.000291637 |
MA0004.1 | 0.2028 |
MA0006.1 | 0.0495356 |
MA0007.1 | 0.0145963 |
MA0009.1 | 1.13224 |
MA0014.1 | 2.40648e-05 |
MA0017.1 | 0.310725 |
MA0019.1 | 0.437282 |
MA0024.1 | 0.146446 |
MA0025.1 | 0.299942 |
MA0027.1 | 1.66118 |
MA0028.1 | 0.00306998 |
MA0029.1 | 0.157192 |
MA0030.1 | 0.459763 |
MA0031.1 | 0.116937 |
MA0038.1 | 0.999586 |
MA0040.1 | 0.160513 |
MA0041.1 | 0.0206872 |
MA0042.1 | 0.0153775 |
MA0043.1 | 0.208842 |
MA0046.1 | 0.584097 |
MA0048.1 | 0.112662 |
MA0050.1 | 0.365844 |
MA0051.1 | 0.630425 |
MA0052.1 | 1.51341 |
MA0055.1 | 0.000586332 |
MA0056.1 | 0 |
MA0057.1 | 0.00068919 |
MA0058.1 | 0.587459 |
MA0059.1 | 0.207159 |
MA0060.1 | 1.01739 |
MA0061.1 | 0.202501 |
MA0063.1 | 0 |
MA0066.1 | 0.0400007 |
MA0067.1 | 0.442801 |
MA0068.1 | 0.0609137 |
MA0069.1 | 0.199334 |
MA0070.1 | 0.192383 |
MA0071.1 | 0.294552 |
MA0072.1 | 0.554995 |
MA0073.1 | 0.0930573 |
MA0074.1 | 0.0385277 |
MA0076.1 | 0.00746275 |
MA0077.1 | 0.543642 |
MA0078.1 | 0.532313 |
MA0081.1 | 0.369786 |
MA0083.1 | 0.213446 |
MA0084.1 | 0.602392 |
MA0087.1 | 0.188122 |
MA0088.1 | 1.03546 |
MA0089.1 | 0 |
MA0090.1 | 0.261968 |
MA0091.1 | 0.206239 |
MA0092.1 | 0.159356 |
MA0093.1 | 0.384399 |
MA0095.1 | 0 |
MA0098.1 | 0 |
MA0100.1 | 0.043811 |
MA0101.1 | 0.00263019 |
MA0103.1 | 1.32508 |
MA0105.1 | 0.17498 |
MA0106.1 | 3.35916 |
MA0107.1 | 0.0512679 |
MA0108.2 | 0.115431 |
MA0109.1 | 0 |
MA0111.1 | 0.491686 |
MA0113.1 | 0.210051 |
MA0114.1 | 0.461975 |
MA0115.1 | 0.993103 |
MA0116.1 | 0.207045 |
MA0117.1 | 0.658194 |
MA0119.1 | 0.771548 |
MA0122.1 | 0.6988 |
MA0124.1 | 0.349309 |
MA0125.1 | 0.287016 |
MA0130.1 | 0 |
MA0131.1 | 0.269326 |
MA0132.1 | 0 |
MA0133.1 | 0 |
MA0135.1 | 0.228328 |
MA0136.1 | 0.0418532 |
MA0139.1 | 0.168517 |
MA0140.1 | 0.121617 |
MA0141.1 | 0.0947759 |
MA0142.1 | 0.682233 |
MA0143.1 | 1.70351 |
MA0144.1 | 3.47125 |
MA0145.1 | 1.88765 |
MA0146.1 | 0.993466 |
MA0147.1 | 0.119405 |
MA0148.1 | 0.0953439 |
MA0149.1 | 0.0272934 |
MA0062.2 | 0.0282275 |
MA0035.2 | 0.849045 |
MA0039.2 | 0.0385291 |
MA0138.2 | 0.0716075 |
MA0002.2 | 0.00550067 |
MA0137.2 | 1.57004 |
MA0104.2 | 0.10293 |
MA0047.2 | 0.40823 |
MA0112.2 | 0.394353 |
MA0065.2 | 0.364372 |
MA0150.1 | 4.15102 |
MA0151.1 | 0 |
MA0152.1 | 0.551972 |
MA0153.1 | 0.275019 |
MA0154.1 | 0.165438 |
MA0155.1 | 1.01648 |
MA0156.1 | 0.277572 |
MA0157.1 | 0.300508 |
MA0158.1 | 0 |
MA0159.1 | 1.23399 |
MA0160.1 | 0.105936 |
MA0161.1 | 0 |
MA0162.1 | 1.47251e-07 |
MA0163.1 | 0.00053525 |
MA0164.1 | 1.7643 |
MA0080.2 | 0.581946 |
MA0018.2 | 0.432694 |
MA0099.2 | 3.95798 |
MA0079.2 | 7.60816e-10 |
MA0102.2 | 0.635361 |
MA0258.1 | 0.52733 |
MA0259.1 | 0.0243485 |
MA0442.1 | 0 |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)
TF | #promoters | Enrichment | p-value | q-value |
---|---|---|---|---|
POLR3A#11128 | 2 | 11.3044036697248 | 0.0137214101015376 | 0.0483191836804397 |
STAT3#6774 | 16 | 2.8051906659078 | 0.000111308593550471 | 0.00154628334687652 |
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data