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Coexpression cluster:C2938: Difference between revisions

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{{Coexpression_clusters
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|full_id=C2938_CD4_Peripheral_CD8_Natural_acute_chronic_Renal
|id=C2938
}}

Latest revision as of 12:16, 17 September 2013


Full id: C2938_CD4_Peripheral_CD8_Natural_acute_chronic_Renal



Phase1 CAGE Peaks

Hg19::chr9:134152345..134152369,-p1@FAM78A
Hg19::chr9:134152371..134152402,-p2@FAM78A
Hg19::chr9:134152417..134152430,-p6@FAM78A
Hg19::chr9:134152434..134152466,-p@chr9:134152434..134152466
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen
hematopoietic stem cell3.23e-65168
angioblastic mesenchymal cell3.23e-65168
hematopoietic cell3.13e-64177
hematopoietic oligopotent progenitor cell1.13e-61161
hematopoietic multipotent progenitor cell1.13e-61161
nongranular leukocyte3.86e-50115
leukocyte3.33e-45136
hematopoietic lineage restricted progenitor cell3.98e-43120
myeloid cell1.61e-36108
common myeloid progenitor1.61e-36108
monopoietic cell1.48e-2459
monocyte1.48e-2459
monoblast1.48e-2459
promonocyte1.48e-2459
myeloid leukocyte5.05e-2372
macrophage dendritic cell progenitor5.41e-2361
nucleate cell1.69e-2255
myeloid lineage restricted progenitor cell4.00e-2266
lymphocyte7.10e-2253
common lymphoid progenitor7.10e-2253
lymphoid lineage restricted progenitor cell1.45e-2152
granulocyte monocyte progenitor cell1.16e-2067
defensive cell1.21e-1848
phagocyte1.21e-1848
classical monocyte3.73e-1642
CD14-positive, CD16-negative classical monocyte3.73e-1642
T cell3.78e-1625
pro-T cell3.78e-1625
mature alpha-beta T cell2.36e-1418
alpha-beta T cell2.36e-1418
immature T cell2.36e-1418
mature T cell2.36e-1418
immature alpha-beta T cell2.36e-1418
CD8-positive, alpha-beta T cell1.83e-0911
mesenchymal cell4.15e-08354
connective tissue cell1.14e-07361
Uber Anatomy
Ontology termp-valuen
hematopoietic system7.82e-2798
blood island7.82e-2798
hemolymphoid system5.23e-24108
bone marrow1.89e-1676
immune system2.43e-1693
adult organism1.37e-15114
bone element3.26e-1482
skeletal element3.76e-1190
lateral plate mesoderm2.69e-10203
blood3.09e-1015
haemolymphatic fluid3.09e-1015
organism substance3.09e-1015
skeletal system3.34e-08100
connective tissue9.65e-07371
Disease
Ontology termp-valuen
leukemia4.42e-2039
myeloid leukemia9.05e-1931
hematologic cancer9.57e-1851
immune system cancer9.57e-1851


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.8989
MA0004.10.71247
MA0006.11.31813
MA0007.10.6918
MA0009.11.20602
MA0014.11.86845
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.709734
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.125954
MA0056.10
MA0057.10.248209
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.12.31526
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.16.9203
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.536981
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.10.656404
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.13.8752
MA0113.10.886811
MA0114.11.13665
MA0115.11.45393
MA0116.10.457606
MA0117.12.78257
MA0119.11.43218
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.11.63368
MA0140.10.779643
MA0141.11.46638
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.10.569905
MA0146.10.221129
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.24.29465
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.551048
MA0065.21.7213
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.11.88496
MA0155.10.533581
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.14.24646
MA0163.13.14178
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.211.9208
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
EGR1#195844.988179094810140.001615011500076050.0101688181139714



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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