Coexpression cluster:C2054: Difference between revisions
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|full_id=C2054_Eosinophils_Dendritic_Neutrophils_CD19_CD14_Basophils_CD34
|id=C2054
}}") |
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{{Coexpression_clusters | 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dendritic cell differentiation!0.0085925308502013!5971$GO:0001773!myeloid dendritic cell activation!0.0085925308502013!5971$GO:0045063!T-helper 1 cell differentiation!0.0085925308502013!5971$GO:0042994!cytoplasmic sequestering of transcription factor!0.0085925308502013!4794$GO:0002294!CD4-positive, alpha-beta T cell differentiation during immune response!0.0085925308502013!5971$GO:0002292!T cell differentiation during immune response!0.0085925308502013!5971$GO:0042093!T-helper cell differentiation!0.0085925308502013!5971$GO:0002366!leukocyte activation during immune response!0.0085925308502013!5971$GO:0002285!lymphocyte activation during immune response!0.0085925308502013!5971$GO:0051220!cytoplasmic sequestering of protein!0.0085925308502013!4794$GO:0002293!alpha-beta T cell differentiation during immune response!0.0085925308502013!5971$GO:0002286!T cell activation during immune response!0.0085925308502013!5971$GO:0002263!cell activation during immune response!0.0085925308502013!5971$GO:0042308!negative regulation of protein import into nucleus!0.0085925308502013!4794$GO:0042992!negative regulation of transcription factor import into nucleus!0.0085925308502013!4794$GO:0043367!CD4-positive, alpha beta T cell differentiation!0.0085925308502013!5971$GO:0042088!T-helper 1 type immune response!0.0085925308502013!5971$GO:0046823!negative regulation of nucleocytoplasmic transport!0.0085925308502013!4794$GO:0051224!negative regulation of protein transport!0.00881839046160363!4794$GO:0046632!alpha-beta T cell differentiation!0.0103098228262197!5971$GO:0004709!MAP kinase kinase kinase activity!0.0109026941205202!1326$GO:0046631!alpha-beta T cell activation!0.0109026941205202!5971$GO:0042990!regulation of transcription factor import into nucleus!0.0109026941205202!4794$GO:0042991!transcription factor import into nucleus!0.0109026941205202!4794$GO:0042306!regulation of protein import into nucleus!0.0109026941205202!4794$GO:0033157!regulation of intracellular protein transport!0.0109026941205202!4794$GO:0032507!maintenance of cellular protein localization!0.0111067793515641!4794$GO:0051651!maintenance of cellular localization!0.0111067793515641!4794$GO:0032386!regulation of intracellular transport!0.0111067793515641!4794$GO:0045185!maintenance of protein localization!0.0111656867381263!4794$GO:0002274!myeloid leukocyte activation!0.0112207691804314!5971$GO:0051223!regulation of protein transport!0.0112723852677017!4794$GO:0046822!regulation of nucleocytoplasmic transport!0.0113208501237992!4794$GO:0002573!myeloid leukocyte differentiation!0.0113664417991907!5971$GO:0051051!negative regulation of transport!0.0114094065671464!4794$GO:0030217!T cell differentiation!0.0142699894330178!5971$GO:0051235!maintenance of localization!0.0142699894330178!4794$GO:0030098!lymphocyte differentiation!0.0216742314407406!5971$GO:0002250!adaptive immune response!0.0235842708301034!5971$GO:0002460!adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains!0.0235842708301034!5971$GO:0030099!myeloid cell differentiation!0.0235842708301034!5971$GO:0004702!receptor signaling protein serine/threonine kinase activity!0.0235842708301034!1326$GO:0002521!leukocyte differentiation!0.0269146502620051!5971$GO:0006606!protein import into nucleus!0.0273892766352992!4794$GO:0051170!nuclear import!0.0273892766352992!4794$GO:0042110!T cell activation!0.0273892766352992!5971$GO:0003714!transcription corepressor activity!0.0292605890034004!5971$GO:0051049!regulation of transport!0.0294516884986195!4794$GO:0017038!protein import!0.0319866615733457!4794$GO:0006913!nucleocytoplasmic transport!0.0385026978699054!4794$GO:0046649!lymphocyte activation!0.0385026978699054!5971$GO:0051169!nuclear transport!0.0385026978699054!4794$GO:0030097!hemopoiesis!0.0389812617561175!5971$GO:0048534!hemopoietic or lymphoid organ development!0.0409480756328063!5971$GO:0005057!receptor signaling protein activity!0.0409480756328063!1326$GO:0045321!leukocyte activation!0.0409480756328063!5971$GO:0002520!immune system development!0.0409480756328063!5971$GO:0001775!cell activation!0.0461752674458715!5971$GO:0016564!transcription repressor activity!0.0464717294069291!5971$GO:0006605!protein targeting!0.0465458612671562!4794|id=C2054|ontology_enrichment_celltype=CL:0000738!3.58e-52!136;CL:0000988!2.36e-45!177;CL:0000037!8.71e-45!168;CL:0000566!8.71e-45!168;CL:0002087!1.39e-42!115;CL:0002032!2.79e-42!161;CL:0000837!2.79e-42!161;CL:0002031!3.72e-40!120;CL:0000766!1.34e-32!72;CL:0000557!3.44e-29!67;CL:0002009!2.19e-28!61;CL:0000473!2.30e-27!48;CL:0000234!2.30e-27!48;CL:0002194!4.37e-27!59;CL:0000576!4.37e-27!59;CL:0000040!4.37e-27!59;CL:0000559!4.37e-27!59;CL:0000763!9.49e-27!108;CL:0000049!9.49e-27!108;CL:0000839!3.83e-25!66;CL:0000860!5.13e-25!42;CL:0002057!5.13e-25!42;CL:0000542!7.28e-14!53;CL:0000051!7.28e-14!53;CL:0000838!1.99e-13!52;CL:0002242!2.67e-12!55;CL:0000325!7.30e-11!87;CL:0000134!8.90e-11!354;CL:0002320!1.62e-10!361;CL:0000945!3.14e-10!24;CL:0000826!3.14e-10!24;CL:0000451!2.18e-07!10;CL:0000034!4.91e-07!441|ontology_enrichment_disease=|ontology_enrichment_uberon=UBERON:0002193!1.13e-34!108;UBERON:0002390!1.16e-33!98;UBERON:0003061!1.16e-33!98;UBERON:0002405!2.55e-28!93;UBERON:0002371!2.58e-25!76;UBERON:0001474!1.12e-22!82;UBERON:0004765!3.53e-20!90;UBERON:0001434!2.78e-16!100;UBERON:0003081!1.31e-15!203;UBERON:0002384!9.21e-10!371;UBERON:0000178!4.04e-07!15;UBERON:0000179!4.04e-07!15;UBERON:0000463!4.04e-07!15|pathway_enrichment=0.000261809543829384;0.0331450882488;2;268;MAPK signaling pathway (KEGG):04010!4.24401547463794e-05;0.00895487265148605;2;108;T cell receptor signaling pathway (KEGG):04660!2.8113975272981e-07;0.00017796146347797;3;188;TNF-alpha/NF-kB Signaling Pathway (Wikipathways):WP231!6.25100917324437e-05;0.00989222201665921;2;131;IL-5 up reg. targets (Netpath):NetPath_17!3.88503833680646e-06;0.00122961463359924;2;33;{NFKB1,33} (Static 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| ||
|full_id=C2054_Eosinophils_Dendritic_Neutrophils_CD19_CD14_Basophils_CD34 | |||
|id=C2054 | |||
}} |
Latest revision as of 11:57, 17 September 2013
Full id: C2054_Eosinophils_Dendritic_Neutrophils_CD19_CD14_Basophils_CD34
Phase1 CAGE Peaks
Hg19::chr10:30723045..30723060,+ | p2@MAP3K8 |
Hg19::chr15:75495066..75495090,- | p@chr15:75495066..75495090 - |
Hg19::chr19:45504688..45504782,+ | p1@RELB |
Hg19::chr6:44233297..44233330,- | p2@NFKBIE |
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
p.value | FDR | nGenes | nPathway | Name |
---|---|---|---|---|
0.000261809543829384 | 0.0331450882488 | 2 | 268 | MAPK signaling pathway (KEGG):04010 |
4.24401547463794e-05 | 0.00895487265148605 | 2 | 108 | T cell receptor signaling pathway (KEGG):04660 |
2.8113975272981e-07 | 0.00017796146347797 | 3 | 188 | TNF-alpha/NF-kB Signaling Pathway (Wikipathways):WP231 |
6.25100917324437e-05 | 0.00989222201665921 | 2 | 131 | IL-5 up reg. targets (Netpath):NetPath_17 |
3.88503833680646e-06 | 0.00122961463359924 | 2 | 33 | {NFKB1,33} (Static Module):NA |
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0043011 | myeloid dendritic cell differentiation | 0.0085925308502013 |
GO:0001773 | myeloid dendritic cell activation | 0.0085925308502013 |
GO:0045063 | T-helper 1 cell differentiation | 0.0085925308502013 |
GO:0042994 | cytoplasmic sequestering of transcription factor | 0.0085925308502013 |
GO:0002294 | CD4-positive, alpha-beta T cell differentiation during immune response | 0.0085925308502013 |
GO:0002292 | T cell differentiation during immune response | 0.0085925308502013 |
GO:0042093 | T-helper cell differentiation | 0.0085925308502013 |
GO:0002366 | leukocyte activation during immune response | 0.0085925308502013 |
GO:0002285 | lymphocyte activation during immune response | 0.0085925308502013 |
GO:0051220 | cytoplasmic sequestering of protein | 0.0085925308502013 |
GO:0002293 | alpha-beta T cell differentiation during immune response | 0.0085925308502013 |
GO:0002286 | T cell activation during immune response | 0.0085925308502013 |
GO:0002263 | cell activation during immune response | 0.0085925308502013 |
GO:0042308 | negative regulation of protein import into nucleus | 0.0085925308502013 |
GO:0042992 | negative regulation of transcription factor import into nucleus | 0.0085925308502013 |
GO:0043367 | CD4-positive, alpha beta T cell differentiation | 0.0085925308502013 |
GO:0042088 | T-helper 1 type immune response | 0.0085925308502013 |
GO:0046823 | negative regulation of nucleocytoplasmic transport | 0.0085925308502013 |
GO:0051224 | negative regulation of protein transport | 0.00881839046160363 |
GO:0046632 | alpha-beta T cell differentiation | 0.0103098228262197 |
GO:0004709 | MAP kinase kinase kinase activity | 0.0109026941205202 |
GO:0046631 | alpha-beta T cell activation | 0.0109026941205202 |
GO:0042990 | regulation of transcription factor import into nucleus | 0.0109026941205202 |
GO:0042991 | transcription factor import into nucleus | 0.0109026941205202 |
GO:0042306 | regulation of protein import into nucleus | 0.0109026941205202 |
GO:0033157 | regulation of intracellular protein transport | 0.0109026941205202 |
GO:0032507 | maintenance of cellular protein localization | 0.0111067793515641 |
GO:0051651 | maintenance of cellular localization | 0.0111067793515641 |
GO:0032386 | regulation of intracellular transport | 0.0111067793515641 |
GO:0045185 | maintenance of protein localization | 0.0111656867381263 |
GO:0002274 | myeloid leukocyte activation | 0.0112207691804314 |
GO:0051223 | regulation of protein transport | 0.0112723852677017 |
GO:0046822 | regulation of nucleocytoplasmic transport | 0.0113208501237992 |
GO:0002573 | myeloid leukocyte differentiation | 0.0113664417991907 |
GO:0051051 | negative regulation of transport | 0.0114094065671464 |
GO:0030217 | T cell differentiation | 0.0142699894330178 |
GO:0051235 | maintenance of localization | 0.0142699894330178 |
GO:0030098 | lymphocyte differentiation | 0.0216742314407406 |
GO:0002250 | adaptive immune response | 0.0235842708301034 |
GO:0002460 | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | 0.0235842708301034 |
GO:0030099 | myeloid cell differentiation | 0.0235842708301034 |
GO:0004702 | receptor signaling protein serine/threonine kinase activity | 0.0235842708301034 |
GO:0002521 | leukocyte differentiation | 0.0269146502620051 |
GO:0006606 | protein import into nucleus | 0.0273892766352992 |
GO:0051170 | nuclear import | 0.0273892766352992 |
GO:0042110 | T cell activation | 0.0273892766352992 |
GO:0003714 | transcription corepressor activity | 0.0292605890034004 |
GO:0051049 | regulation of transport | 0.0294516884986195 |
GO:0017038 | protein import | 0.0319866615733457 |
GO:0006913 | nucleocytoplasmic transport | 0.0385026978699054 |
GO:0046649 | lymphocyte activation | 0.0385026978699054 |
GO:0051169 | nuclear transport | 0.0385026978699054 |
GO:0030097 | hemopoiesis | 0.0389812617561175 |
GO:0048534 | hemopoietic or lymphoid organ development | 0.0409480756328063 |
GO:0005057 | receptor signaling protein activity | 0.0409480756328063 |
GO:0045321 | leukocyte activation | 0.0409480756328063 |
GO:0002520 | immune system development | 0.0409480756328063 |
GO:0001775 | cell activation | 0.0461752674458715 |
GO:0016564 | transcription repressor activity | 0.0464717294069291 |
GO:0006605 | protein targeting | 0.0465458612671562 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
Ontology term | p-value | n |
---|---|---|
hemolymphoid system | 1.13e-34 | 108 |
hematopoietic system | 1.16e-33 | 98 |
blood island | 1.16e-33 | 98 |
immune system | 2.55e-28 | 93 |
bone marrow | 2.58e-25 | 76 |
bone element | 1.12e-22 | 82 |
skeletal element | 3.53e-20 | 90 |
skeletal system | 2.78e-16 | 100 |
lateral plate mesoderm | 1.31e-15 | 203 |
connective tissue | 9.21e-10 | 371 |
blood | 4.04e-07 | 15 |
haemolymphatic fluid | 4.04e-07 | 15 |
organism substance | 4.04e-07 | 15 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
MA0003.1 | 3.49532 |
MA0004.1 | 1.69588 |
MA0006.1 | 1.31813 |
MA0007.1 | 0.6918 |
MA0009.1 | 1.20602 |
MA0014.1 | 3.76953 |
MA0017.1 | 0.577281 |
MA0019.1 | 0.873355 |
MA0024.1 | 1.09684 |
MA0025.1 | 1.34373 |
MA0027.1 | 2.83281 |
MA0028.1 | 0.550763 |
MA0029.1 | 1.11704 |
MA0030.1 | 1.10506 |
MA0031.1 | 1.03735 |
MA0038.1 | 0.824639 |
MA0040.1 | 1.12314 |
MA0041.1 | 0.732902 |
MA0042.1 | 0.697662 |
MA0043.1 | 1.20635 |
MA0046.1 | 1.19471 |
MA0048.1 | 0.25531 |
MA0050.1 | 0.69864 |
MA0051.1 | 0.820063 |
MA0052.1 | 1.12718 |
MA0055.1 | 0.125954 |
MA0056.1 | 0 |
MA0057.1 | 1.28333 |
MA0058.1 | 1.47358 |
MA0059.1 | 0.604454 |
MA0060.1 | 0.393285 |
MA0061.1 | 3.49299 |
MA0063.1 | 0 |
MA0066.1 | 0.825101 |
MA0067.1 | 1.53181 |
MA0068.1 | 1.52107 |
MA0069.1 | 1.19071 |
MA0070.1 | 1.17908 |
MA0071.1 | 0.782546 |
MA0072.1 | 1.1744 |
MA0073.1 | 5.01475 |
MA0074.1 | 0.819248 |
MA0076.1 | 1.51122 |
MA0077.1 | 1.16637 |
MA0078.1 | 0.926725 |
MA0081.1 | 0.604638 |
MA0083.1 | 1.21381 |
MA0084.1 | 1.72172 |
MA0087.1 | 1.17185 |
MA0088.1 | 0.536981 |
MA0089.1 | 0 |
MA0090.1 | 0.640115 |
MA0091.1 | 0.715356 |
MA0092.1 | 0.673508 |
MA0093.1 | 1.32557 |
MA0095.1 | 0 |
MA0098.1 | 0 |
MA0100.1 | 0.83965 |
MA0101.1 | 4.54044 |
MA0103.1 | 0.521546 |
MA0105.1 | 2.66951 |
MA0106.1 | 0.869173 |
MA0107.1 | 4.0488 |
MA0108.2 | 1.03412 |
MA0109.1 | 0 |
MA0111.1 | 0.655276 |
MA0113.1 | 0.886811 |
MA0114.1 | 0.447443 |
MA0115.1 | 1.45393 |
MA0116.1 | 0.457606 |
MA0117.1 | 1.24497 |
MA0119.1 | 0.586221 |
MA0122.1 | 1.27173 |
MA0124.1 | 1.41151 |
MA0125.1 | 1.32534 |
MA0130.1 | 0 |
MA0131.1 | 0.94608 |
MA0132.1 | 0 |
MA0133.1 | 0 |
MA0135.1 | 1.23748 |
MA0136.1 | 0.832277 |
MA0139.1 | 0.344952 |
MA0140.1 | 0.779643 |
MA0141.1 | 0.602484 |
MA0142.1 | 1.00381 |
MA0143.1 | 0.887001 |
MA0144.1 | 0.430413 |
MA0145.1 | 0.569905 |
MA0146.1 | 1.75643 |
MA0147.1 | 1.16748 |
MA0148.1 | 0.739888 |
MA0149.1 | 0.769072 |
MA0062.2 | 0.931615 |
MA0035.2 | 0.778873 |
MA0039.2 | 2.01147 |
MA0138.2 | 0.928035 |
MA0002.2 | 0.379056 |
MA0137.2 | 0.558189 |
MA0104.2 | 1.01696 |
MA0047.2 | 0.856092 |
MA0112.2 | 0.551048 |
MA0065.2 | 1.09513 |
MA0150.1 | 0.633493 |
MA0151.1 | 0 |
MA0152.1 | 0.78681 |
MA0153.1 | 1.30799 |
MA0154.1 | 0.229241 |
MA0155.1 | 0.533581 |
MA0156.1 | 0.560797 |
MA0157.1 | 0.97481 |
MA0158.1 | 0 |
MA0159.1 | 0.462502 |
MA0160.1 | 0.756582 |
MA0161.1 | 0 |
MA0162.1 | 2.80246 |
MA0163.1 | 0.539587 |
MA0164.1 | 0.90014 |
MA0080.2 | 0.535868 |
MA0018.2 | 0.870662 |
MA0099.2 | 0.7872 |
MA0079.2 | 3.97967 |
MA0102.2 | 1.75932 |
MA0258.1 | 0.418966 |
MA0259.1 | 2.06681 |
MA0442.1 | 0 |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)
TF | #promoters | Enrichment | p-value | q-value |
---|---|---|---|---|
CCNT2#905 | 4 | 6.33620157696263 | 0.000620310058721564 | 0.00511080484559967 |
NFKB1#4790 | 4 | 5.48806342419384 | 0.00110219956630198 | 0.00766293572793318 |
PAX5#5079 | 4 | 6.66956553117783 | 0.000505277416948326 | 0.0044292989884729 |
SIN3A#25942 | 4 | 5.40888472681514 | 0.00116817238488516 | 0.0079392695845006 |
TAF1#6872 | 4 | 3.34304628574529 | 0.00800566489870165 | 0.0321072015804117 |
ZBTB7A#51341 | 3 | 5.51393198090692 | 0.00903835282108109 | 0.0342174404712686 |
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data
This analysis result is provided for C0 - C305 clusters.