CL:0000815: Difference between revisions
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|located_in= | |located_in= | ||
|name=regulatory T cell | |name=regulatory T cell | ||
|namespace= | |namespace=FANTOM | ||
|obo_creation_date= | |obo_creation_date= | ||
|part_of= | |part_of= | ||
Latest revision as of 16:37, 12 September 2014
| Name: | regulatory T cell | ||
|---|---|---|---|
| Namespace: | FANTOM | ||
| Definition: | "A T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." [GO_REF:0000031, GOC:add] | ||
| Xrefs: |
| ||
| Synonyms: |
"regulatory T lymphocyte" EXACT [] "regulatory T-cell" EXACT [] "regulatory T-lymphocyte" EXACT [] "suppressor T cell" BROAD [] "suppressor T lymphocyte" BROAD [] "suppressor T-cell" BROAD [] "suppressor T-lymphocyte" BROAD [] | ||
| Comments: | This cell type may express FoxP3 and CD25 and secretes IL-10 and TGF-beta. |
Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data
Parents
| is_a: | CL:0002419(mature T cell) |
|---|
Children
| is a: | CL:0000792 (CD4-positive, CD25-positive, alpha-beta regulatory T cell),FF:11943-126A8 (CD4+CD25+ regulatory T cells, antiCD3 CD28 stimulation, 06hr, pool1 (BalbcA)),FF:11944-126A9 (CD4+CD25+ regulatory T cells, antiCD3 CD28 stimulation, 06hr, pool1 (C57BL 6J)),FF:11946-126B2 (CD4+CD25+ regulatory T cells, PMA and ionomycin stimulation, 02hr, pool1 (BalbcA)) |
|---|
Ontology Tree: Loaded from BioPortal
Ontorolgy tree(Small window open)
FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.
Human (Homo sapiens)
- 11780-124A7 (CD4+CD25+CD45RA+ naive regulatory T cells, donor1)
- 11782-124A9 (CD4+CD25+CD45RA- memory regulatory T cells, donor1)
- 11814-124E5 (CD4+CD25+ regulatory T cells, pool1 (C57BL_6J))
- 11818-124E9 (CD4+CD25+ regulatory T cells, pool2 (Balb_cAJcl))
- 11943-126A8 (CD4+CD25+ regulatory T cells, antiCD3 CD28 stimulation, 06hr, pool1 (BalbcA))
- 11944-126A9 (CD4+CD25+ regulatory T cells, antiCD3 CD28 stimulation, 06hr, pool1 (C57BL 6J))
- 11945-126B1 (CD4+CD25+ regulatory T cells, PMA and ionomycin stimulation, 02hr, pool1 (C57BL 6J))
- 11946-126B2 (CD4+CD25+ regulatory T cells, PMA and ionomycin stimulation, 02hr, pool1 (BalbcA))
Mouse (Mus musculus)
- 11780-124A7 (CD4+CD25+CD45RA+ naive regulatory T cells, donor1)
- 11782-124A9 (CD4+CD25+CD45RA- memory regulatory T cells, donor1)
- 11814-124E5 (CD4+CD25+ regulatory T cells, pool1 (C57BL_6J))
- 11818-124E9 (CD4+CD25+ regulatory T cells, pool2 (Balb_cAJcl))
- 11943-126A8 (CD4+CD25+ regulatory T cells, antiCD3 CD28 stimulation, 06hr, pool1 (BalbcA))
- 11944-126A9 (CD4+CD25+ regulatory T cells, antiCD3 CD28 stimulation, 06hr, pool1 (C57BL 6J))
- 11945-126B1 (CD4+CD25+ regulatory T cells, PMA and ionomycin stimulation, 02hr, pool1 (C57BL 6J))
- 11946-126B2 (CD4+CD25+ regulatory T cells, PMA and ionomycin stimulation, 02hr, pool1 (BalbcA))
Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000815 (regulatory T cell), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data
| P-value | FFCP | Short description |
|---|---|---|
| 4.61e-131 | FFCP PHASE2:Hg19::chr1:113160702..113160706,-#_7ab95dd728078da90f616e2dae394ac4 | p21@ST7L |
| 4.61e-131 | FFCP PHASE1:Hg19::chr1:113160702..113160706,-#_7ab95dd728078da90f616e2dae394ac4 | p21@ST7L |
| 5.68e-99 | FFCP PHASE1:Hg19::chr11:111410267..111410269,+#_f728bf5dc8a8de558b9e23cc82f780cf | p@chr11:111410267..111410269, + |
| 5.68e-99 | FFCP PHASE2:Hg19::chr11:111410267..111410269,+#_f728bf5dc8a8de558b9e23cc82f780cf | p@chr11:111410267..111410269, + |
| 1.55e-98 | FFCP PHASE1:Hg19::chr3:73015629..73015632,+#_b0723bc5add031d9fbb142c1f032198b | p@chr3:73015629..73015632, + |
| 1.55e-98 | FFCP PHASE2:Hg19::chr3:73015629..73015632,+#_b0723bc5add031d9fbb142c1f032198b | p@chr3:73015629..73015632, + |
| 3.07e-86 | FFCP PHASE2:Mm9::chr17:12884847..12884852,-#_5884893199fa68790cd27702941e5924 | p@chr17:12884847..12884852, - |
| 3.07e-86 | FFCP PHASE2:Mm9::chr4:151490501..151490511,+#_5884893199fa68790cd27702941e5924 | p5@Tnfrsf25 |
| 3.07e-86 | FFCP PHASE1:Mm9::chr12:17040514..17040521,+#_5884893199fa68790cd27702941e5924 | p@chr12:17040514..17040521, + |
| 3.07e-86 | FFCP PHASE2:Mm9::chr17:26709187..26709203,-#_5884893199fa68790cd27702941e5924 | p@chr17:26709187..26709203, - |
| 3.07e-86 | FFCP PHASE2:Mm9::chr12:111613723..111613727,+#_5884893199fa68790cd27702941e5924 | p@chr12:111613723..111613727, + |
| 3.07e-86 | FFCP PHASE1:Mm9::chr7:106142059..106142061,-#_5884893199fa68790cd27702941e5924 | p@chr7:106142059..106142061, - |
| 3.07e-86 | FFCP PHASE2:Mm9::chr1:60967956..60967966,+#_5884893199fa68790cd27702941e5924 | p@chr1:60967956..60967966, + |
| 3.07e-86 | FFCP PHASE2:Mm9::chr8:74526522..74526532,-#_5884893199fa68790cd27702941e5924 | p@chr8:74526522..74526532, - |
| 3.07e-86 | FFCP PHASE2:Mm9::chr2:78812885..78812894,+#_5884893199fa68790cd27702941e5924 | p@chr2:78812885..78812894, + |
| 3.07e-86 | FFCP PHASE1:Mm9::chr9:14708334..14708341,-#_5884893199fa68790cd27702941e5924 | p11@Folr4 |
| 3.07e-86 | FFCP PHASE1:Mm9::chr15:12160236..12160239,+#_5884893199fa68790cd27702941e5924 | p@chr15:12160236..12160239, + |
| 3.07e-86 | FFCP PHASE2:Mm9::chr7:106142059..106142061,-#_5884893199fa68790cd27702941e5924 | p@chr7:106142059..106142061, - |
| 3.07e-86 | FFCP PHASE2:Mm9::chr6:49536818..49536841,+#_5884893199fa68790cd27702941e5924 | p@chr6:49536818..49536841, + |
| 3.07e-86 | FFCP PHASE2:Mm9::chr6:106741792..106741797,+#_5884893199fa68790cd27702941e5924 | p@chr6:106741792..106741797, + |
| 3.07e-86 | FFCP PHASE1:Mm9::chrX:7154622..7154647,+#_5884893199fa68790cd27702941e5924 | p@chrX:7154622..7154647, + |
| 3.07e-86 | FFCP PHASE2:Mm9::chrX:7170204..7170205,+#_5884893199fa68790cd27702941e5924 | p@chrX:7170204..7170205, + |
| 3.07e-86 | FFCP PHASE1:Mm9::chr4:151490501..151490511,+#_5884893199fa68790cd27702941e5924 | p5@Tnfrsf25 |
| 3.07e-86 | FFCP PHASE1:Mm9::chr3:142250588..142250598,+#_5884893199fa68790cd27702941e5924 | p@chr3:142250588..142250598, + |
| 3.07e-86 | FFCP PHASE1:Mm9::chr17:35164593..35164602,-#_5884893199fa68790cd27702941e5924 | p6@Ng23 |
| 3.07e-86 | FFCP PHASE1:Mm9::chr11:118084068..118084106,-#_5884893199fa68790cd27702941e5924 | p@chr11:118084068..118084106, - |
| 3.07e-86 | FFCP PHASE1:Mm9::chr10:92842861..92842879,-#_5884893199fa68790cd27702941e5924 | p@chr10:92842861..92842879, - |
| 3.07e-86 | FFCP PHASE1:Mm9::chr1:60967956..60967966,+#_5884893199fa68790cd27702941e5924 | p@chr1:60967956..60967966, + |
| 3.07e-86 | FFCP PHASE2:Mm9::chr1:60770897..60770901,+#_5884893199fa68790cd27702941e5924 | p@chr1:60770897..60770901, + |
| 3.07e-86 | FFCP PHASE1:Mm9::chr1:162743278..162743283,-#_5884893199fa68790cd27702941e5924 | p@chr1:162743278..162743283, - |
| 3.07e-86 | FFCP PHASE2:Mm9::chr1:69729718..69729723,-#_5884893199fa68790cd27702941e5924 | p@chr1:69729718..69729723, - |
| 3.07e-86 | FFCP PHASE2:Mm9::chr4:102843557..102843585,+#_5884893199fa68790cd27702941e5924 | p@chr4:102843557..102843585, + |
| 3.07e-86 | FFCP PHASE2:Mm9::chr16:36770181..36770184,-#_5884893199fa68790cd27702941e5924 | p@chr16:36770181..36770184, - |
| 3.07e-86 | FFCP PHASE2:Mm9::chr17:26688385..26688421,+#_5884893199fa68790cd27702941e5924 | p@chr17:26688385..26688421, + |
| 3.07e-86 | FFCP PHASE1:Mm9::chr17:12884847..12884852,-#_5884893199fa68790cd27702941e5924 | p@chr17:12884847..12884852, - |
| 3.07e-86 | FFCP PHASE2:Mm9::chrX:7148320..7148329,+#_5884893199fa68790cd27702941e5924 | p@chrX:7148320..7148329, + |
| 3.07e-86 | FFCP PHASE1:Mm9::chr6:94615187..94615214,-#_5884893199fa68790cd27702941e5924 | p@chr6:94615187..94615214, - |
| 3.07e-86 | FFCP PHASE2:Mm9::chr1:69727659..69727696,-#_5884893199fa68790cd27702941e5924 | p@chr1:69727659..69727696, - |
| 3.07e-86 | FFCP PHASE2:Mm9::chr9:13699290..13699296,+#_5884893199fa68790cd27702941e5924 | p@chr9:13699290..13699296, + |
| 3.07e-86 | FFCP PHASE2:Mm9::chr1:60967565..60967590,-#_5884893199fa68790cd27702941e5924 | p@chr1:60967565..60967590, - |
| 3.07e-86 | FFCP PHASE2:Mm9::chr15:59356135..59356143,-#_5884893199fa68790cd27702941e5924 | p@chr15:59356135..59356143, - |
| 3.07e-86 | FFCP PHASE1:Mm9::chr4:102823636..102823677,+#_5884893199fa68790cd27702941e5924 | p@chr4:102823636..102823677, + |
| 3.07e-86 | FFCP PHASE1:Mm9::chr15:59357130..59357143,-#_5884893199fa68790cd27702941e5924 | p@chr15:59357130..59357143, - |
| 3.07e-86 | FFCP PHASE2:Mm9::chr16:89826368..89826391,+#_5884893199fa68790cd27702941e5924 | p@chr16:89826368..89826391, + |
| 3.07e-86 | FFCP PHASE2:Mm9::chr1:155570551..155570558,-#_5884893199fa68790cd27702941e5924 | p@chr1:155570551..155570558, - |
| 3.07e-86 | FFCP PHASE2:Mm9::chr11:4397552..4397557,-#_5884893199fa68790cd27702941e5924 | p@chr11:4397552..4397557, - |
| 3.07e-86 | FFCP PHASE1:Mm9::chr1:69728149..69728150,+#_5884893199fa68790cd27702941e5924 | p@chr1:69728149..69728150, + |
| 3.07e-86 | FFCP PHASE2:Mm9::chr8:84303823..84303825,+#_5884893199fa68790cd27702941e5924 | p@chr8:84303823..84303825, + |
| 3.07e-86 | FFCP PHASE1:Mm9::chrX:7161176..7161185,-#_5884893199fa68790cd27702941e5924 | p@chrX:7161176..7161185, - |
| 3.07e-86 | FFCP PHASE2:Mm9::chrX:7172178..7172190,-#_5884893199fa68790cd27702941e5924 | p@chrX:7172178..7172190, - |
| 3.07e-86 | FFCP PHASE1:Mm9::chr10:13779506..13779514,-#_5884893199fa68790cd27702941e5924 | p@chr10:13779506..13779514, - |
| 3.07e-86 | FFCP PHASE2:Mm9::chr10:18908457..18908466,-#_5884893199fa68790cd27702941e5924 | p@chr10:18908457..18908466, - |
| 3.07e-86 | FFCP PHASE2:Mm9::chr4:151490543..151490552,+#_5884893199fa68790cd27702941e5924 | p6@Tnfrsf25 |
| 3.07e-86 | FFCP PHASE2:Mm9::chr9:14708334..14708341,-#_5884893199fa68790cd27702941e5924 | p11@Folr4 |
| 3.07e-86 | FFCP PHASE1:Mm9::chr12:114668438..114668451,+#_5884893199fa68790cd27702941e5924 | p@chr12:114668438..114668451, + |
| 3.07e-86 | FFCP PHASE1:Mm9::chr7:132631174..132631179,+#_5884893199fa68790cd27702941e5924 | p@chr7:132631174..132631179, + |
| 3.07e-86 | FFCP PHASE1:Mm9::chr2:32306609..32306610,+#_5884893199fa68790cd27702941e5924 | p@chr2:32306609..32306610, + |
| 3.07e-86 | FFCP PHASE2:Mm9::chr1:69595515..69595518,-#_5884893199fa68790cd27702941e5924 | p@chr1:69595515..69595518, - |
| 3.07e-86 | FFCP PHASE2:Mm9::chr9:14706346..14706355,-#_5884893199fa68790cd27702941e5924 | p@chr9:14706346..14706355, - |
| 3.07e-86 | FFCP PHASE2:Mm9::chr13:105413537..105413540,+#_5884893199fa68790cd27702941e5924 | p@chr13:105413537..105413540, + |
| 3.07e-86 | FFCP PHASE1:Mm9::chr9:14706346..14706355,-#_5884893199fa68790cd27702941e5924 | p@chr9:14706346..14706355, - |
| 3.07e-86 | FFCP PHASE1:Mm9::chr1:69595515..69595518,-#_5884893199fa68790cd27702941e5924 | p@chr1:69595515..69595518, - |
| 3.07e-86 | FFCP PHASE2:Mm9::chr9:123843234..123843237,+#_5884893199fa68790cd27702941e5924 | p@chr9:123843234..123843237, + |
| 3.07e-86 | FFCP PHASE2:Mm9::chr1:69815958..69815961,+#_5884893199fa68790cd27702941e5924 | p@chr1:69815958..69815961, + |
| 3.07e-86 | FFCP PHASE1:Mm9::chr4:151490543..151490552,+#_5884893199fa68790cd27702941e5924 | p6@Tnfrsf25 |
| 3.07e-86 | FFCP PHASE2:Mm9::chr4:32512204..32512214,+#_5884893199fa68790cd27702941e5924 | p@chr4:32512204..32512214, + |
| 3.07e-86 | FFCP PHASE1:Mm9::chr17:35164610..35164618,-#_5884893199fa68790cd27702941e5924 | p5@Ng23 |
| 3.07e-86 | FFCP PHASE1:Mm9::chr1:60970179..60970192,-#_5884893199fa68790cd27702941e5924 | p@chr1:60970179..60970192, - |
| 3.07e-86 | FFCP PHASE1:Mm9::chr12:109240261..109240265,+#_5884893199fa68790cd27702941e5924 | p@chr12:109240261..109240265, + |
| 3.07e-86 | FFCP PHASE1:Mm9::chr12:15821719..15821726,+#_5884893199fa68790cd27702941e5924 | p@chr12:15821719..15821726, + |
| 3.07e-86 | FFCP PHASE2:Mm9::chr6:48670473..48670480,+#_5884893199fa68790cd27702941e5924 | p@chr6:48670473..48670480, + |
| 3.07e-86 | FFCP PHASE1:Mm9::chr1:60944156..60944166,+#_5884893199fa68790cd27702941e5924 | p@chr1:60944156..60944166, + |
| 3.07e-86 | FFCP PHASE2:Mm9::chr12:108370128..108370136,-#_5884893199fa68790cd27702941e5924 | p@chr12:108370128..108370136, - |
| 3.07e-86 | FFCP PHASE1:Mm9::chr3:101090598..101090601,+#_5884893199fa68790cd27702941e5924 | p@chr3:101090598..101090601, + |
| 3.07e-86 | FFCP PHASE1:Mm9::chr9:14812338..14812345,-#_5884893199fa68790cd27702941e5924 | p@chr9:14812338..14812345, - |
| 3.07e-86 | FFCP PHASE2:Mm9::chr8:129378573..129378577,+#_5884893199fa68790cd27702941e5924 | p@chr8:129378573..129378577, + |
| 3.07e-86 | FFCP PHASE1:Mm9::chr4:102843557..102843585,+#_5884893199fa68790cd27702941e5924 | p@chr4:102843557..102843585, + |
| 3.07e-86 | FFCP PHASE1:Mm9::chr15:59357447..59357449,+#_5884893199fa68790cd27702941e5924 | p@chr15:59357447..59357449, + |
| 3.07e-86 | FFCP PHASE2:Mm9::chr8:74526430..74526446,-#_5884893199fa68790cd27702941e5924 | p@chr8:74526430..74526446, - |
| 3.07e-86 | FFCP PHASE2:Mm9::chr10:22022863..22022865,+#_5884893199fa68790cd27702941e5924 | p@chr10:22022863..22022865, + |
| 3.07e-86 | FFCP PHASE1:Mm9::chr5:150229693..150229735,+#_5884893199fa68790cd27702941e5924 | p@chr5:150229693..150229735, + |
| 3.07e-86 | FFCP PHASE1:Mm9::chrX:7161574..7161577,+#_5884893199fa68790cd27702941e5924 | p@chrX:7161574..7161577, + |
| 3.07e-86 | FFCP PHASE1:Mm9::chr8:74526480..74526487,-#_5884893199fa68790cd27702941e5924 | p@chr8:74526480..74526487, - |
| 3.07e-86 | FFCP PHASE2:Mm9::chr1:60944205..60944230,+#_5884893199fa68790cd27702941e5924 | p@chr1:60944205..60944230, + |
| 3.07e-86 | FFCP PHASE1:Mm9::chr4:155396655..155396659,+#_5884893199fa68790cd27702941e5924 | p@chr4:155396655..155396659, + |
| 3.07e-86 | FFCP PHASE1:Mm9::chr13:113079356..113079360,-#_5884893199fa68790cd27702941e5924 | p@chr13:113079356..113079360, - |
| 3.07e-86 | FFCP PHASE2:Mm9::chrX:7161059..7161081,-#_5884893199fa68790cd27702941e5924 | p@chrX:7161059..7161081, - |
| 3.07e-86 | FFCP PHASE1:Mm9::chr17:29566022..29566044,+#_5884893199fa68790cd27702941e5924 | p@chr17:29566022..29566044, + |
| 3.07e-86 | FFCP PHASE2:Mm9::chr13:46831423..46831426,+#_5884893199fa68790cd27702941e5924 | p@chr13:46831423..46831426, + |
| 3.07e-86 | FFCP PHASE2:Mm9::chr17:12884884..12884887,-#_5884893199fa68790cd27702941e5924 | p@chr17:12884884..12884887, - |
| 3.07e-86 | FFCP PHASE1:Mm9::chr6:106741792..106741797,+#_5884893199fa68790cd27702941e5924 | p@chr6:106741792..106741797, + |
| 3.07e-86 | FFCP PHASE1:Mm9::chr1:60967565..60967590,-#_5884893199fa68790cd27702941e5924 | p@chr1:60967565..60967590, - |
| 3.07e-86 | FFCP PHASE1:Mm9::chr1:155570551..155570558,-#_5884893199fa68790cd27702941e5924 | p@chr1:155570551..155570558, - |
| 3.07e-86 | FFCP PHASE2:Mm9::chr2:139885951..139885958,-#_5884893199fa68790cd27702941e5924 | p@chr2:139885951..139885958, - |
| 3.07e-86 | FFCP PHASE1:Mm9::chrX:7147964..7147979,-#_5884893199fa68790cd27702941e5924 | p@chrX:7147964..7147979, - |
| 3.07e-86 | FFCP PHASE2:Mm9::chr1:60970179..60970192,-#_5884893199fa68790cd27702941e5924 | p@chr1:60970179..60970192, - |
| 3.07e-86 | FFCP PHASE2:Mm9::chr16:89837454..89837462,-#_5884893199fa68790cd27702941e5924 | p@chr16:89837454..89837462, - |
| 3.07e-86 | FFCP PHASE1:Mm9::chr1:60770897..60770901,+#_5884893199fa68790cd27702941e5924 | p@chr1:60770897..60770901, + |
| 3.07e-86 | FFCP PHASE2:Mm9::chr10:92842861..92842879,-#_5884893199fa68790cd27702941e5924 | p@chr10:92842861..92842879, - |
| 3.07e-86 | FFCP PHASE1:Mm9::chr10:22022863..22022865,+#_5884893199fa68790cd27702941e5924 | p@chr10:22022863..22022865, + |
