CL:0000235: Difference between revisions
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{{CL | {{CL | ||
| | |alt_id= | ||
|comment=Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid. | |comment=Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid. | ||
|created_by= | |created_by= | ||
| | |def="A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." [GO_REF:0000031, GOC:add, GOC:tfm, http://www.clt.astate.edu/wwilliam/, PMID:16213494, PMID:1919437] | ||
|derives_from= | |derives_from= | ||
|develops_from=CL:0000576 | |develops_from=CL:0000576 | ||
|disjoint_from= | |||
|has_quality= | |has_quality= | ||
|id=CL:0000235 | |||
|is_a=CL:0000234 ;;CL:0000766 | |||
|is_obsolete= | |||
|located_in= | |located_in= | ||
|name=macrophage | |||
|namespace=cell;;efo | |||
|obo_creation_date= | |||
|part_of= | |part_of= | ||
|preceded_by= | |||
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl.owl;;IAO:0000412 http://purl.obolibrary.org/obo/efo.owl | |property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl.owl;;IAO:0000412 http://purl.obolibrary.org/obo/efo.owl | ||
| | |subset= | ||
| | |synonym="histiocyte" EXACT [] | ||
|union_of= | |||
|xref=BTO:0000801;;FMA:63261;;FMA:83585 | |||
}} | }} | ||
Revision as of 10:16, 12 September 2014
| Name: | macrophage | ||
|---|---|---|---|
| Namespace: | cell;;efo | ||
| Definition: | "A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." [GO_REF:0000031, GOC:add, GOC:tfm, http://www.clt.astate.edu/wwilliam/, PMID:16213494, PMID:1919437] | ||
| Xrefs: |
| ||
| Synonyms: | "histiocyte" EXACT [] | ||
| Comments: | Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid. |
Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data
Parents
| is_a: | CL:0000234(phagocyte),CL:0000766(myeloid leukocyte) |
|---|---|
| develops_from: | CL:0000576(monocyte) |
Children
| is a: | CL:0000864 (tissue-resident macrophage) |
|---|---|
| derives from: | FF:0000086 (human macrophage sample),FF:0200001 (macrophage, TB infection sample) |
Ontology Tree: Loaded from BioPortal
Ontorolgy tree(Small window open)
FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.
Human (Homo sapiens)
- 11232-116C8 (Macrophage - monocyte derived, donor1)
- 11313-117C8 (Macrophage - monocyte derived, donor2)
- 11389-118C3 (Macrophage - monocyte derived, donor3)
- 11501-119F7
- 11641-122D3 (Mouse Microglia, donor3)
- 11662-122F6
- 11718-123C8 (Mouse Microglia, donor1)
- 11736-123E8 (Mouse Microglia, donor2)
- 12698-135D7 (Monocyte-derived macrophages response to LPS)
- 12699-135D8 (Monocyte-derived macrophages response to LPS, 00hr15min, donor1 (t2 Subject1))
... further results Mouse (Mus musculus)
- 11232-116C8 (Macrophage - monocyte derived, donor1)
- 11313-117C8 (Macrophage - monocyte derived, donor2)
- 11389-118C3 (Macrophage - monocyte derived, donor3)
- 11501-119F7
- 11641-122D3 (Mouse Microglia, donor3)
- 11662-122F6
- 11718-123C8 (Mouse Microglia, donor1)
- 11736-123E8 (Mouse Microglia, donor2)
- 12698-135D7 (Monocyte-derived macrophages response to LPS)
- 12699-135D8 (Monocyte-derived macrophages response to LPS, 00hr15min, donor1 (t2 Subject1))
Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000235 (macrophage), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data
| P-value | FFCP | Short description |
|---|---|---|
| 2.37e-195 | FFCP PHASE1:Hg19::chr20:44640347..44640359,+#_1b6c67710e2aeff5edb084b7ff71cd57 | p11@MMP9 |
| 2.37e-195 | FFCP PHASE1:Hg19::chr20:44641953..44641968,+#_1b6c67710e2aeff5edb084b7ff71cd57 | p@chr20:44641953..44641968, + |
| 2.37e-195 | FFCP PHASE1:Hg19::chr20:44639118..44639130,+#_1b6c67710e2aeff5edb084b7ff71cd57 | p@chr20:44639118..44639130, + |
| 2.37e-195 | FFCP PHASE1:Hg19::chr20:44638551..44638562,+#_1b6c67710e2aeff5edb084b7ff71cd57 | p@chr20:44638551..44638562, + |
| 2.37e-195 | FFCP PHASE2:Hg19::chr20:44640347..44640359,+#_1b6c67710e2aeff5edb084b7ff71cd57 | p11@MMP9 |
| 2.37e-195 | FFCP PHASE2:Hg19::chr20:44641953..44641968,+#_1b6c67710e2aeff5edb084b7ff71cd57 | p@chr20:44641953..44641968, + |
| 2.37e-195 | FFCP PHASE2:Hg19::chr20:44639118..44639130,+#_1b6c67710e2aeff5edb084b7ff71cd57 | p@chr20:44639118..44639130, + |
| 2.37e-195 | FFCP PHASE2:Hg19::chr20:44638551..44638562,+#_1b6c67710e2aeff5edb084b7ff71cd57 | p@chr20:44638551..44638562, + |
| 5.73e-168 | FFCP PHASE1:Hg19::chr20:44638717..44638738,-#_ef1822b7512b17d46108cdf297257c23 | p@chr20:44638717..44638738, - |
| 5.73e-168 | FFCP PHASE2:Hg19::chr20:44638694..44638710,+#_ef1822b7512b17d46108cdf297257c23 | p@chr20:44638694..44638710, + |
| 5.73e-168 | FFCP PHASE2:Hg19::chr20:44638717..44638738,-#_ef1822b7512b17d46108cdf297257c23 | p@chr20:44638717..44638738, - |
| 5.73e-168 | FFCP PHASE1:Hg19::chr20:44638633..44638646,+#_ef1822b7512b17d46108cdf297257c23 | p@chr20:44638633..44638646, + |
| 5.73e-168 | FFCP PHASE2:Hg19::chr20:44638633..44638646,+#_ef1822b7512b17d46108cdf297257c23 | p@chr20:44638633..44638646, + |
| 5.73e-168 | FFCP PHASE1:Hg19::chr20:44638694..44638710,+#_ef1822b7512b17d46108cdf297257c23 | p@chr20:44638694..44638710, + |
| 7.64e-168 | FFCP PHASE1:Hg19::chr20:44638515..44638530,+#_89572743b093fd89ba9bfb7d604d7385 | p@chr20:44638515..44638530, + |
| 7.64e-168 | FFCP PHASE2:Hg19::chr20:44638515..44638530,+#_89572743b093fd89ba9bfb7d604d7385 | p@chr20:44638515..44638530, + |
| 1.02e-167 | FFCP PHASE2:Hg19::chr20:44645128..44645150,+#_bf802cdba157b0fb27b33b4f7e28cb5c | p@chr20:44645128..44645150, + |
| 1.02e-167 | FFCP PHASE2:Hg19::chr20:44640312..44640322,+#_bf802cdba157b0fb27b33b4f7e28cb5c | p10@MMP9 |
| 1.02e-167 | FFCP PHASE1:Hg19::chr20:44642333..44642369,+#_bf802cdba157b0fb27b33b4f7e28cb5c | p@chr20:44642333..44642369, + |
| 1.02e-167 | FFCP PHASE1:Hg19::chr20:44645128..44645150,+#_bf802cdba157b0fb27b33b4f7e28cb5c | p@chr20:44645128..44645150, + |
| 1.02e-167 | FFCP PHASE2:Hg19::chr20:44642333..44642369,+#_bf802cdba157b0fb27b33b4f7e28cb5c | p@chr20:44642333..44642369, + |
| 1.02e-167 | FFCP PHASE1:Hg19::chr20:44640312..44640322,+#_bf802cdba157b0fb27b33b4f7e28cb5c | p10@MMP9 |
| 5.41e-163 | FFCP PHASE2:Hg19::chr20:44640866..44640875,-#_ad3ea0be2280eecaa4dfcd97ce8f79af | p@chr20:44640866..44640875, - |
| 5.41e-163 | FFCP PHASE1:Hg19::chr20:44638625..44638633,-#_ad3ea0be2280eecaa4dfcd97ce8f79af | p@chr20:44638625..44638633, - |
| 5.41e-163 | FFCP PHASE2:Hg19::chr20:44638625..44638633,-#_ad3ea0be2280eecaa4dfcd97ce8f79af | p@chr20:44638625..44638633, - |
| 5.41e-163 | FFCP PHASE1:Hg19::chr20:44640304..44640310,+#_ad3ea0be2280eecaa4dfcd97ce8f79af | p13@MMP9 |
| 5.41e-163 | FFCP PHASE1:Hg19::chr20:44640866..44640875,-#_ad3ea0be2280eecaa4dfcd97ce8f79af | p@chr20:44640866..44640875, - |
| 5.41e-163 | FFCP PHASE2:Hg19::chr20:44640304..44640310,+#_ad3ea0be2280eecaa4dfcd97ce8f79af | p13@MMP9 |
| 1.99e-147 | FFCP PHASE2:Hg19::chr20:44638500..44638512,+#_38f35c6691261d45b7860f0835be0f85 | p@chr20:44638500..44638512, + |
| 1.99e-147 | FFCP PHASE1:Hg19::chr20:44639634..44639645,+#_38f35c6691261d45b7860f0835be0f85 | p@chr20:44639634..44639645, + |
| 1.99e-147 | FFCP PHASE1:Hg19::chr20:44640269..44640283,+#_38f35c6691261d45b7860f0835be0f85 | p7@MMP9 |
| 1.99e-147 | FFCP PHASE2:Hg19::chr20:44639634..44639645,+#_38f35c6691261d45b7860f0835be0f85 | p@chr20:44639634..44639645, + |
| 1.99e-147 | FFCP PHASE2:Hg19::chr20:44640269..44640283,+#_38f35c6691261d45b7860f0835be0f85 | p7@MMP9 |
| 1.99e-147 | FFCP PHASE1:Hg19::chr20:44638500..44638512,+#_38f35c6691261d45b7860f0835be0f85 | p@chr20:44638500..44638512, + |
| 2.56e-147 | FFCP PHASE2:Hg19::chr20:44638566..44638579,+#_9962213947827c29fc3c494f47f527a7 | p@chr20:44638566..44638579, + |
| 2.56e-147 | FFCP PHASE2:Hg19::chr20:44638613..44638632,+#_9962213947827c29fc3c494f47f527a7 | p@chr20:44638613..44638632, + |
| 2.56e-147 | FFCP PHASE1:Hg19::chr20:44638566..44638579,+#_9962213947827c29fc3c494f47f527a7 | p@chr20:44638566..44638579, + |
| 2.56e-147 | FFCP PHASE1:Hg19::chr20:44638613..44638632,+#_9962213947827c29fc3c494f47f527a7 | p@chr20:44638613..44638632, + |
| 5.45e-147 | FFCP PHASE1:Hg19::chr20:44639771..44639782,+#_5928f006d1ec65317ca25577abb2d92f | p@chr20:44639771..44639782, + |
| 5.45e-147 | FFCP PHASE2:Hg19::chr20:44639771..44639782,+#_5928f006d1ec65317ca25577abb2d92f | p@chr20:44639771..44639782, + |
| 7.01e-147 | FFCP PHASE2:Hg19::chr20:44641138..44641146,+#_61ea002cba5ccb1f22f03072ebc78f82 | p@chr20:44641138..44641146, + |
| 7.01e-147 | FFCP PHASE1:Hg19::chr20:44641138..44641146,+#_61ea002cba5ccb1f22f03072ebc78f82 | p@chr20:44641138..44641146, + |
| 3.49e-136 | FFCP PHASE2:Hg19::chr20:44639929..44639935,+#_2de983a9177354a727868f6ad017199e | p@chr20:44639929..44639935, + |
| 3.49e-136 | FFCP PHASE1:Hg19::chr20:44639929..44639935,+#_2de983a9177354a727868f6ad017199e | p@chr20:44639929..44639935, + |
| 4.61e-136 | FFCP PHASE1:Hg19::chr9:86983573..86983587,-#_ab0c398acde8e81034657cf57d72eabd | p6@SLC28A3 |
| 4.61e-136 | FFCP PHASE2:Hg19::chr9:86983573..86983587,-#_ab0c398acde8e81034657cf57d72eabd | p6@SLC28A3 |
| 1.89e-131 | FFCP PHASE2:Hg19::chr20:44639910..44639947,-#_a9d2fa14160aaba1a9dec28f7c706882 | p@chr20:44639910..44639947, - |
| 1.89e-131 | FFCP PHASE2:Hg19::chr20:44639149..44639161,+#_a9d2fa14160aaba1a9dec28f7c706882 | p@chr20:44639149..44639161, + |
| 1.89e-131 | FFCP PHASE1:Hg19::chr20:44639910..44639947,-#_a9d2fa14160aaba1a9dec28f7c706882 | p@chr20:44639910..44639947, - |
| 1.89e-131 | FFCP PHASE1:Hg19::chr20:44639149..44639161,+#_a9d2fa14160aaba1a9dec28f7c706882 | p@chr20:44639149..44639161, + |
| 5.81e-131 | FFCP PHASE1:Hg19::chr20:44641166..44641180,+#_e61b1dab2458e8334efb89215601b20e | p@chr20:44641166..44641180, + |
| 5.81e-131 | FFCP PHASE2:Hg19::chr20:44641166..44641180,+#_e61b1dab2458e8334efb89215601b20e | p@chr20:44641166..44641180, + |
| 1.07e-130 | FFCP PHASE2:Hg19::chr5:147789958..147789969,+#_ccbd6d4b303530e41efaf16c5030b331 | p5@FBXO38 |
| 1.07e-130 | FFCP PHASE2:Hg19::chr6:164082461..164082467,-#_ccbd6d4b303530e41efaf16c5030b331 | p@chr6:164082461..164082467, - |
| 1.07e-130 | FFCP PHASE1:Hg19::chr6:164082461..164082467,-#_ccbd6d4b303530e41efaf16c5030b331 | p@chr6:164082461..164082467, - |
| 1.07e-130 | FFCP PHASE1:Hg19::chr5:147789958..147789969,+#_ccbd6d4b303530e41efaf16c5030b331 | p5@FBXO38 |
| 1.15e-118 | FFCP PHASE2:Hg19::chr20:44639584..44639604,+#_c68de898b87ba5530c1d3b49f5c47e53 | p@chr20:44639584..44639604, + |
| 1.15e-118 | FFCP PHASE1:Hg19::chr20:44638657..44638691,+#_c68de898b87ba5530c1d3b49f5c47e53 | p@chr20:44638657..44638691, + |
| 1.15e-118 | FFCP PHASE1:Hg19::chr20:44639584..44639604,+#_c68de898b87ba5530c1d3b49f5c47e53 | p@chr20:44639584..44639604, + |
| 1.15e-118 | FFCP PHASE2:Hg19::chr20:44638657..44638691,+#_c68de898b87ba5530c1d3b49f5c47e53 | p@chr20:44638657..44638691, + |
| 1.73e-118 | FFCP PHASE1:Hg19::chr20:44641061..44641077,+#_4c88df6ec7625d65a009554c1b7193b2 | p@chr20:44641061..44641077, + |
| 1.73e-118 | FFCP PHASE2:Hg19::chr20:44641061..44641077,+#_4c88df6ec7625d65a009554c1b7193b2 | p@chr20:44641061..44641077, + |
| 4.35e-117 | FFCP PHASE2:Hg19::chrX:46639989..46640013,-#_deb102209832f851df239d27d62cb1fd | p@chrX:46639989..46640013, - |
| 4.35e-117 | FFCP PHASE1:Hg19::chrX:46639989..46640013,-#_deb102209832f851df239d27d62cb1fd | p@chrX:46639989..46640013, - |
| 4.35e-117 | FFCP PHASE1:Hg19::chr14:61452664..61452679,+#_deb102209832f851df239d27d62cb1fd | p@chr14:61452664..61452679, + |
| 4.35e-117 | FFCP PHASE2:Hg19::chr14:61452664..61452679,+#_deb102209832f851df239d27d62cb1fd | p@chr14:61452664..61452679, + |
| 4.98e-117 | FFCP PHASE1:Hg19::chr20:44639896..44639903,+#_978d2f722ce0dfa64f3eb042ff33822a | p@chr20:44639896..44639903, + |
| 4.98e-117 | FFCP PHASE2:Hg19::chr20:44639896..44639903,+#_978d2f722ce0dfa64f3eb042ff33822a | p@chr20:44639896..44639903, + |
| 8.05e-117 | FFCP PHASE2:Hg19::chr6:4347006..4347027,-#_d5fafda2dbb434ecc724e134e89ebbf8 | p@chr6:4347006..4347027, - |
| 8.05e-117 | FFCP PHASE1:Hg19::chr6:4347006..4347027,-#_d5fafda2dbb434ecc724e134e89ebbf8 | p@chr6:4347006..4347027, - |
| 5.81e-108 | FFCP PHASE1:Hg19::chr20:44640829..44640856,+#_8165ebdcec529dacc0596359cb178de4 | p4@MMP9 |
| 5.81e-108 | FFCP PHASE2:Hg19::chr20:44640829..44640856,+#_8165ebdcec529dacc0596359cb178de4 | p4@MMP9 |
| 2.53e-107 | FFCP PHASE2:Hg19::chr8:24256905..24256914,+#_45fecd9dfd55e0c0ed2464e5389beeb2 | p@chr8:24256905..24256914, + |
| 2.53e-107 | FFCP PHASE1:Hg19::chr8:24256905..24256914,+#_45fecd9dfd55e0c0ed2464e5389beeb2 | p@chr8:24256905..24256914, + |
| 3.04e-107 | FFCP PHASE2:Hg19::chr7:137308..137321,+#_69c9cb29dd6614e8dc44ac923979ba13 | p@chr7:137308..137321, + |
| 3.04e-107 | FFCP PHASE1:Hg19::chr7:137308..137321,+#_69c9cb29dd6614e8dc44ac923979ba13 | p@chr7:137308..137321, + |
| 6.32e-107 | FFCP PHASE1:Hg19::chr19:45418067..45418076,+#_947633915711acf39a6e735aa87087e6 | p7@APOC1 |
| 6.32e-107 | FFCP PHASE2:Hg19::chr19:45418067..45418076,+#_947633915711acf39a6e735aa87087e6 | p7@APOC1 |
| 7.59e-107 | FFCP PHASE1:Hg19::chr6:46700055..46700067,-#_19c52bcdc4955a5dd9520cb5d180fc10 | p@chr6:46700055..46700067, - |
| 7.59e-107 | FFCP PHASE2:Hg19::chr6:46700055..46700067,-#_19c52bcdc4955a5dd9520cb5d180fc10 | p@chr6:46700055..46700067, - |
| 6.76e-105 | FFCP PHASE2:Hg19::chr17:62315972..62315978,-#_021d3f5a9c8a464bd65df08ab4fbabe1 | p@chr17:62315972..62315978, - |
| 6.76e-105 | FFCP PHASE1:Hg19::chr17:62315972..62315978,-#_021d3f5a9c8a464bd65df08ab4fbabe1 | p@chr17:62315972..62315978, - |
| 5.07e-102 | FFCP PHASE2:Hg19::chr17:29281302..29281321,+#_aeecea40033812b82c371ed766522dbb | p6@ADAP2 |
| 5.07e-102 | FFCP PHASE1:Hg19::chr17:29281302..29281321,+#_aeecea40033812b82c371ed766522dbb | p6@ADAP2 |
| 1.44e-101 | FFCP PHASE1:Hg19::chr5:150873510..150873548,+#_3a5ea8d82598857fa6ec684560490e89 | p@chr5:150873510..150873548, + |
| 1.44e-101 | FFCP PHASE2:Hg19::chr5:150873510..150873548,+#_3a5ea8d82598857fa6ec684560490e89 | p@chr5:150873510..150873548, + |
| 1.76e-99 | FFCP PHASE1:Hg19::chr20:44641085..44641097,+#_a516629f939638c41f9c12760f4ca6d9 | p@chr20:44641085..44641097, + |
| 1.76e-99 | FFCP PHASE1:Hg19::chr20:44639906..44639917,+#_a516629f939638c41f9c12760f4ca6d9 | p@chr20:44639906..44639917, + |
| 1.76e-99 | FFCP PHASE1:Hg19::chr20:44639141..44639152,-#_a516629f939638c41f9c12760f4ca6d9 | p@chr20:44639141..44639152, - |
| 1.76e-99 | FFCP PHASE2:Hg19::chr20:44641085..44641097,+#_a516629f939638c41f9c12760f4ca6d9 | p@chr20:44641085..44641097, + |
| 1.76e-99 | FFCP PHASE2:Hg19::chr20:44639906..44639917,+#_a516629f939638c41f9c12760f4ca6d9 | p@chr20:44639906..44639917, + |
| 1.76e-99 | FFCP PHASE2:Hg19::chr20:44639141..44639152,-#_a516629f939638c41f9c12760f4ca6d9 | p@chr20:44639141..44639152, - |
| 1.83e-98 | FFCP PHASE1:Hg19::chr20:44639616..44639619,+#_3bc0af37f50f6166a31b0f14829ba06d | p@chr20:44639616..44639619, + |
| 1.83e-98 | FFCP PHASE1:Hg19::chr20:44639171..44639178,+#_3bc0af37f50f6166a31b0f14829ba06d | p@chr20:44639171..44639178, + |
| 1.83e-98 | FFCP PHASE1:Hg19::chr1:156510852..156510859,-#_3bc0af37f50f6166a31b0f14829ba06d | p@chr1:156510852..156510859, - |
| 1.83e-98 | FFCP PHASE2:Hg19::chr20:44639616..44639619,+#_3bc0af37f50f6166a31b0f14829ba06d | p@chr20:44639616..44639619, + |
| 1.83e-98 | FFCP PHASE1:Hg19::chr20:44638538..44638547,-#_3bc0af37f50f6166a31b0f14829ba06d | p@chr20:44638538..44638547, - |
| 1.83e-98 | FFCP PHASE2:Hg19::chr20:44639171..44639178,+#_3bc0af37f50f6166a31b0f14829ba06d | p@chr20:44639171..44639178, + |
| 1.83e-98 | FFCP PHASE2:Hg19::chr1:156510852..156510859,-#_3bc0af37f50f6166a31b0f14829ba06d | p@chr1:156510852..156510859, - |
| 1.83e-98 | FFCP PHASE2:Hg19::chr6:4346987..4346998,-#_3bc0af37f50f6166a31b0f14829ba06d | p@chr6:4346987..4346998, - |
