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Coexpression cluster:C3227: Difference between revisions

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{{Coexpression_clusters
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|full_id=C3227_Neutrophils_Whole_Reticulocytes_blood_Eosinophils_CD4_CD19
|id=C3227
}}

Latest revision as of 12:21, 17 September 2013


Full id: C3227_Neutrophils_Whole_Reticulocytes_blood_Eosinophils_CD4_CD19



Phase1 CAGE Peaks

Hg19::chr12:106696583..106696651,+p1@TCP11L2
Hg19::chr15:43477580..43477656,+p1@CCNDBP1
Hg19::chr16:15736897..15736928,-p2@KIAA0430


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0005777peroxisome0.0440896712647909
GO:0042579microbody0.0440896712647909



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
leukocyte4.45e-19136
hematopoietic lineage restricted progenitor cell1.28e-16120
nongranular leukocyte1.33e-15115
hematopoietic stem cell1.32e-13168
angioblastic mesenchymal cell1.32e-13168
hematopoietic oligopotent progenitor cell6.66e-13161
hematopoietic multipotent progenitor cell6.66e-13161
hematopoietic cell9.44e-12177
myeloid leukocyte1.09e-1172
mature alpha-beta T cell4.06e-1018
alpha-beta T cell4.06e-1018
immature T cell4.06e-1018
mature T cell4.06e-1018
immature alpha-beta T cell4.06e-1018
classical monocyte1.06e-0942
CD14-positive, CD16-negative classical monocyte1.06e-0942
myeloid lineage restricted progenitor cell3.62e-0966
defensive cell1.13e-0848
phagocyte1.13e-0848
nucleate cell1.40e-0855
lymphoid lineage restricted progenitor cell4.43e-0852
granulocyte monocyte progenitor cell9.07e-0867
macrophage dendritic cell progenitor1.03e-0761
monopoietic cell1.19e-0759
monocyte1.19e-0759
monoblast1.19e-0759
promonocyte1.19e-0759
lymphocyte1.21e-0753
common lymphoid progenitor1.21e-0753
CD8-positive, alpha-beta T cell9.24e-0711
Uber Anatomy
Ontology termp-valuen
adult organism7.18e-25114
hematopoietic system6.13e-1298
blood island6.13e-1298
hemolymphoid system6.65e-12108
immune system1.38e-0793
blood3.59e-0715
haemolymphatic fluid3.59e-0715
organism substance3.59e-0715


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.0927
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.12.44638
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.557638
MA0056.10
MA0057.10.886807
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.11.15625
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.11.04561
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.11.79391
MA0074.10.935474
MA0076.11.74184
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.715722
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.846801
MA0106.10.986396
MA0107.11.36919
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.11.3784
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.11.12079
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.273764
MA0146.13.00132
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.21.9924
MA0035.20.894194
MA0039.23.37171
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.21.2307
MA0047.20.973066
MA0112.21.34467
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.12.30945
MA0155.10.256269
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.11.38935
MA0160.10.871361
MA0161.10
MA0162.12.05956
MA0163.11.84145
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.25.16052
MA0102.21.88331
MA0258.11.29138
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BCL3#602223.03140186915890.002464674760842910.0138488280705693
ELF1#199734.258097958807540.01295179875054610.0460374688485564
IRF1#365937.63716375356390.002244692747297240.0127700983677403
NFKB1#479035.488063424193840.006049381815655430.0268744475496719
SIN3A#2594235.408884726815140.006318961977991520.027566669591456
SPI1#668838.204323508522730.001810593189410520.0108838806324879



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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