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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=0.063459689189229

Latest revision as of 12:16, 17 September 2013


Full id: C2958_migratory_Reticulocytes_Dendritic_CD14_vagina_thyroid_splenic



Phase1 CAGE Peaks

Hg19::chrX:154563855..154563876,-p2@CLIC2
Hg19::chrX:154563879..154563884,-p4@CLIC2
Hg19::chrX:154563889..154563966,-p1@CLIC2
Hg19::chrX:154563975..154563992,-p3@CLIC2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
myeloid lineage restricted progenitor cell2.39e-2766
granulocyte monocyte progenitor cell5.93e-2667
myeloid cell1.05e-24108
common myeloid progenitor1.05e-24108
macrophage dendritic cell progenitor2.47e-2461
monopoietic cell2.29e-2359
monocyte2.29e-2359
monoblast2.29e-2359
promonocyte2.29e-2359
defensive cell3.27e-2348
phagocyte3.27e-2348
myeloid leukocyte2.22e-2272
classical monocyte1.63e-2042
CD14-positive, CD16-negative classical monocyte1.63e-2042
hematopoietic stem cell6.02e-14168
angioblastic mesenchymal cell6.02e-14168
hematopoietic oligopotent progenitor cell4.81e-13161
hematopoietic multipotent progenitor cell4.81e-13161
hematopoietic lineage restricted progenitor cell2.05e-12120
hematopoietic cell3.59e-12177
leukocyte4.72e-12136
nongranular leukocyte2.58e-09115
stuff accumulating cell9.17e-0987
dendritic cell1.18e-0710
conventional dendritic cell2.50e-078
Uber Anatomy
Ontology termp-valuen
hemolymphoid system1.03e-31108
adult organism2.85e-31114
hematopoietic system1.36e-3098
blood island1.36e-3098
immune system7.57e-2893
bone marrow1.56e-2576
bone element3.17e-2282
skeletal element4.18e-1890
skeletal system1.18e-15100
lateral plate mesoderm1.62e-15203
mesoderm3.63e-12315
mesoderm-derived structure3.63e-12315
presumptive mesoderm3.63e-12315
tissue6.78e-09773
musculoskeletal system3.67e-07167


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0214529
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.0695829
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.125954
MA0056.10
MA0057.10.248209
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.00636811
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.182167
MA0089.10
MA0090.10.640115
MA0091.18.47171
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.12.29123
MA0103.10.521546
MA0105.10.232357
MA0106.10.869173
MA0107.11.1497
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.11.09982
MA0145.10.195821
MA0146.10.061409
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.20.483275
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.551048
MA0065.20.199162
MA0150.13.7809
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.229241
MA0155.10.180766
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.0928415
MA0163.10.539587
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.23.08317
MA0079.20.000248021
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
EP300#203346.77394172622320.0004748459821442640.00435785936108654
GATA1#2623413.56030814380042.95627390049268e-050.000615776405850727
HEY1#2346244.040111043105710.00375304636917980.018674753906845
IRF1#365947.63716375356390.0002938853996185490.00308225519690316
JUN#3725412.51282919233634.07770316866756e-050.000745703451641518
JUNB#3726430.61063265982111.13787152942193e-064.66580937029043e-05
JUND#372746.994663941871030.000417684217818580.00392889507563313
MAFK#7975427.10073313782991.85228494563408e-066.8623904731138e-05
MYC#460945.22228187160940.001344309395272740.00890400361066016
NFE2#4778477.2042606516292.80776035215453e-081.92036465893036e-06
SRF#6722413.79717826216782.75840773062708e-050.000586373590431429
STAT1#6772420.70658749719925.43610708103893e-060.000165763967134781
STAT2#6773465.26377118644075.50053512607993e-083.46902408232284e-06
STAT3#6774410.51946499715428.16377768286615e-050.00123621397335198
TAF1#687243.343046285745290.008005664898701650.0323594564732372
TAL1#6886429.86861667744021.25525650806991e-065.04998977065921e-05
TBP#690843.706770687096390.005296377814784350.0245255122194849



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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