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{{Coexpression_clusters
{
|full_id=C2288_mesothelioma_colon_small_Intestinal_Prostate_CD14_Macrophage
 

Latest revision as of 12:02, 17 September 2013


Full id: C2288_mesothelioma_colon_small_Intestinal_Prostate_CD14_Macrophage



Phase1 CAGE Peaks

Hg19::chr14:23284561..23284595,-p2@SLC7A7
Hg19::chr14:23284599..23284616,-p4@SLC7A7
Hg19::chr14:23284630..23284650,-p1@SLC7A7
Hg19::chr14:23284675..23284684,-p11@SLC7A7


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
monopoietic cell5.69e-3859
monocyte5.69e-3859
monoblast5.69e-3859
promonocyte5.69e-3859
macrophage dendritic cell progenitor1.23e-3561
defensive cell2.72e-3448
phagocyte2.72e-3448
myeloid leukocyte2.02e-3372
myeloid lineage restricted progenitor cell1.78e-3066
granulocyte monocyte progenitor cell1.51e-2967
classical monocyte2.16e-2942
CD14-positive, CD16-negative classical monocyte2.16e-2942
nongranular leukocyte8.52e-19115
leukocyte1.57e-16136
myeloid cell5.76e-15108
common myeloid progenitor5.76e-15108
stuff accumulating cell1.66e-1487
hematopoietic lineage restricted progenitor cell3.79e-14120
hematopoietic stem cell2.15e-09168
angioblastic mesenchymal cell2.15e-09168
hematopoietic cell6.46e-09177
hematopoietic oligopotent progenitor cell2.21e-08161
hematopoietic multipotent progenitor cell2.21e-08161
intermediate monocyte5.56e-089
CD14-positive, CD16-positive monocyte5.56e-089
Uber Anatomy
Ontology termp-valuen
hematopoietic system3.05e-2798
blood island3.05e-2798
hemolymphoid system5.37e-24108
bone marrow9.76e-2476
lateral plate mesoderm3.68e-23203
immune system5.92e-2093
bone element7.88e-2082
mesoderm1.89e-19315
mesoderm-derived structure1.89e-19315
presumptive mesoderm1.89e-19315
skeletal element1.37e-1590
musculoskeletal system3.28e-12167
skeletal system7.44e-12100
embryo2.55e-08592
germ layer2.85e-08560
germ layer / neural crest2.85e-08560
embryonic tissue2.85e-08560
presumptive structure2.85e-08560
germ layer / neural crest derived structure2.85e-08560
epiblast (generic)2.85e-08560
developing anatomical structure3.18e-08581
adult organism9.05e-08114
embryonic structure1.01e-07564
organ3.19e-07503
tissue7.36e-07773


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0938548
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.0695829
MA0017.13.53539
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.125954
MA0056.10
MA0057.11.98521
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.00636811
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.536981
MA0089.10
MA0090.10.640115
MA0091.12.85665
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.10.232357
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.11.98562
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.11.09982
MA0145.10.195821
MA0146.10.061409
MA0147.10.46175
MA0148.10.739888
MA0149.13.0262
MA0062.20.353589
MA0035.21.83323
MA0039.20.10559
MA0138.20.928035
MA0002.21.75253
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.551048
MA0065.20.577908
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.229241
MA0155.10.180766
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.11.1691
MA0160.10.756582
MA0161.10
MA0162.10.0928415
MA0163.10.0725493
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.20.122011
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BCLAF1#9774210.82632380506090.01202203816432580.0436492141089526
CEBPB#105147.971147625824820.0002476385788090830.0026770650587146
HNF4A#3172423.13229036295373.48990320893214e-060.000115378917770707
HNF4G#3174428.75342252644681.46167379934821e-065.65810785508258e-05
MAFK#7975427.10073313782991.85228494563408e-066.84539233676851e-05



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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