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{{Coexpression_clusters
{
|full_id=C2148_Eosinophils_CD4_CD19_Neutrophils_CD14_Basophils_CD14CD16

Latest revision as of 11:59, 17 September 2013


Full id: C2148_Eosinophils_CD4_CD19_Neutrophils_CD14_Basophils_CD14CD16



Phase1 CAGE Peaks

Hg19::chr11:62607111..62607161,+p@chr11:62607111..62607161
+
Hg19::chr13:98086167..98086226,-p1@AY726569
Hg19::chr18:19180794..19180824,+p@chr18:19180794..19180824
+
Hg19::chr4:78741549..78741569,+p@chr4:78741549..78741569
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
leukocyte1.21e-39136
hematopoietic cell3.98e-34177
hematopoietic stem cell4.25e-34168
angioblastic mesenchymal cell4.25e-34168
hematopoietic lineage restricted progenitor cell1.80e-31120
nongranular leukocyte1.29e-30115
hematopoietic oligopotent progenitor cell1.36e-30161
hematopoietic multipotent progenitor cell1.36e-30161
myeloid leukocyte8.66e-1872
nucleate cell4.20e-1755
classical monocyte4.87e-1742
CD14-positive, CD16-negative classical monocyte4.87e-1742
lymphoid lineage restricted progenitor cell1.22e-1652
lymphocyte1.32e-1653
common lymphoid progenitor1.32e-1653
myeloid cell2.17e-14108
common myeloid progenitor2.17e-14108
granulocyte monocyte progenitor cell4.81e-1467
myeloid lineage restricted progenitor cell6.03e-1466
macrophage dendritic cell progenitor1.12e-1361
defensive cell1.19e-1348
phagocyte1.19e-1348
monopoietic cell9.12e-1359
monocyte9.12e-1359
monoblast9.12e-1359
promonocyte9.12e-1359
mature alpha-beta T cell1.08e-1018
alpha-beta T cell1.08e-1018
immature T cell1.08e-1018
mature T cell1.08e-1018
immature alpha-beta T cell1.08e-1018
T cell2.10e-0825
pro-T cell2.10e-0825
B cell4.64e-0814
lymphocyte of B lineage6.03e-0824
pro-B cell6.03e-0824
CD8-positive, alpha-beta T cell2.59e-0711
intermediate monocyte5.94e-079
CD14-positive, CD16-positive monocyte5.94e-079
Uber Anatomy
Ontology termp-valuen
hematopoietic system1.96e-1998
blood island1.96e-1998
hemolymphoid system4.20e-18108
immune system2.02e-1393
bone marrow1.12e-1276
bone element9.06e-1282
skeletal element3.75e-0990
adult organism4.21e-09114
neural tube1.76e-0756
neural rod1.76e-0756
future spinal cord1.76e-0756
neural keel1.76e-0756
regional part of nervous system2.53e-0753
regional part of brain2.53e-0753
skeletal system6.40e-07100


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.45381
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.11.34758
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.11.35734
MA0029.11.11704
MA0030.12.49947
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.11.28887
MA0056.10
MA0057.10.248209
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.214613
MA0074.10.819248
MA0076.11.51122
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.536981
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.10.232357
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.10.195821
MA0146.10.481
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.931615
MA0035.20.778873
MA0039.22.01147
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.187982
MA0065.20.199162
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.649108
MA0155.10.180766
MA0156.11.37856
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.12.15942
MA0163.10.539587
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.22.72671
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90546.336201576962630.0006203100587215640.00511322511624479
FOXA1#316938.311064812039090.002740138182109850.015032688532929
GTF2B#2959215.97191496716210.005636585723537220.0254652150530131
HEY1#2346244.040111043105710.00375304636917980.0185571636090697
IRF1#365935.727872815172930.008097114790333330.0319851193913394
REST#597837.237521537096020.004104697304192610.0195686530219825
SIN3A#2594245.408884726815140.001168172384885160.00794443938953056
TAF1#687243.343046285745290.008005664898701650.032128175390236



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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