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{{Coexpression_clusters
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|coexpression_dpi_cluster_scores_median=0,0,

Latest revision as of 11:41, 17 September 2013


Full id: C1296_thalamus_diencephalon_NK_corpus_heart_testis_left



Phase1 CAGE Peaks

Hg19::chr10:114886533..114886542,+p48@TCF7L2
Hg19::chr10:134901694..134901706,+p@chr10:134901694..134901706
+
Hg19::chr8:27336675..27336693,-p3@CHRNA2
Hg19::chr9:112191134..112191155,-p5@PTPN3
Hg19::chr9:112191163..112191174,-p10@PTPN3
Hg19::chr9:112191244..112191257,-p4@PTPN3


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
regional part of nervous system1.76e-3353
regional part of brain1.76e-3353
regional part of forebrain7.85e-3341
forebrain7.85e-3341
anterior neural tube7.85e-3341
future forebrain7.85e-3341
neural tube1.37e-3156
neural rod1.37e-3156
future spinal cord1.37e-3156
neural keel1.37e-3156
pre-chordal neural plate4.74e-2961
brain7.18e-2968
future brain7.18e-2968
neural plate2.59e-2782
presumptive neural plate2.59e-2782
central nervous system2.88e-2781
neurectoderm6.27e-2686
adult organism2.15e-24114
nervous system2.51e-2489
telencephalon4.17e-2334
ecto-epithelium5.31e-21104
cerebral hemisphere8.55e-2032
neocortex3.06e-1920
dorsal plus ventral thalamus4.49e-192
thalamic complex4.49e-192
brain grey matter1.72e-1834
gray matter1.72e-1834
regional part of cerebral cortex1.65e-1722
structure with developmental contribution from neural crest5.60e-16132
regional part of telencephalon1.27e-1532
cerebral cortex2.07e-1525
pallium2.07e-1525
ectoderm-derived structure6.88e-15171
ectoderm6.88e-15171
presumptive ectoderm6.88e-15171
diencephalon3.08e-127
future diencephalon3.08e-127
corpus callosum1.98e-101
central nervous system cell part cluster1.98e-101
axon tract1.98e-101
intercerebral commissure1.98e-101
dorsal telencephalic commissure1.98e-101
brain white matter1.98e-101
brain commissure1.98e-101
white matter1.98e-101
nervous system commissure1.98e-101
cerebral hemisphere white matter1.98e-101
occipital pole3.71e-101
pole of cerebral hemisphere3.71e-101
paracentral gyrus4.06e-101
nucleus accumbens4.44e-101
ventral striatum4.44e-101
regional part of diencephalon5.31e-104
postcentral gyrus8.24e-101
insula9.82e-101
organ system subdivision2.27e-09223
occipital lobe7.01e-085
parietal lobe1.02e-075
tube1.60e-07192
retina9.42e-076
photoreceptor array9.42e-076
posterior segment of eyeball9.42e-076


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.756372
MA0004.11.37419
MA0006.11.01439
MA0007.10.539222
MA0009.11.03681
MA0014.10.108006
MA0017.10.432438
MA0019.10.7124
MA0024.10.929647
MA0025.11.17262
MA0027.12.65688
MA0028.10.408079
MA0029.10.949428
MA0030.10.937696
MA0031.10.871496
MA0038.10.665566
MA0040.10.955415
MA0041.10.578072
MA0042.10.544748
MA0043.11.03713
MA0046.11.02569
MA0048.10.464411
MA0050.10.545671
MA0051.10.661179
MA0052.10.959373
MA0055.10.213007
MA0056.10
MA0057.10.147053
MA0058.13.00536
MA0059.12.01959
MA0060.10.267412
MA0061.10.671725
MA0063.10
MA0066.10.66601
MA0067.11.35893
MA0068.10.199491
MA0069.11.02175
MA0070.11.01032
MA0071.10.625297
MA0072.11.00572
MA0073.10.959858
MA0074.10.660398
MA0076.10.475586
MA0077.10.997832
MA0078.10.763954
MA0081.10.457725
MA0083.11.04447
MA0084.11.5477
MA0087.11.00322
MA0088.10.0971959
MA0089.10
MA0090.10.490736
MA0091.10.561458
MA0092.10.522012
MA0093.12.7063
MA0095.10
MA0098.10
MA0100.10.679972
MA0101.10.397846
MA0103.10.381434
MA0105.10.134725
MA0106.10.70837
MA0107.10.320267
MA0108.20.868347
MA0109.10
MA0111.11.25994
MA0113.10.725375
MA0114.10.314898
MA0115.11.28169
MA0116.10.865577
MA0117.11.07516
MA0119.10.440684
MA0122.11.10154
MA0124.11.23968
MA0125.11.15445
MA0130.10
MA0131.10.782708
MA0132.10
MA0133.10
MA0135.11.06778
MA0136.10.672893
MA0139.10.641617
MA0140.10.622527
MA0141.10.455728
MA0142.10.838805
MA0143.10.725558
MA0144.10.299851
MA0145.10.107156
MA0146.10.093337
MA0147.11.57246
MA0148.10.584698
MA0149.10.612449
MA0062.20.23336
MA0035.20.621793
MA0039.20.00570825
MA0138.20.765223
MA0002.20.255126
MA0137.20.414885
MA0104.21.35181
MA0047.20.695777
MA0112.20.332548
MA0065.20.109623
MA0150.10.484557
MA0151.10
MA0152.10.629368
MA0153.11.13732
MA0154.10.413181
MA0155.10.65596
MA0156.10.417278
MA0157.10.810597
MA0158.10
MA0159.10.328286
MA0160.10.600559
MA0161.10
MA0162.10.347838
MA0163.10.0270301
MA0164.10.738243
MA0080.20.394469
MA0018.20.709805
MA0099.20.629739
MA0079.20.00575781
MA0102.21.58513
MA0258.10.788656
MA0259.10.336472
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.