Coexpression cluster:C687: Difference between revisions
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{{Coexpression_clusters | {{Coexpression_clusters|coexpression_dpi_cluster_scores_median=0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.052719241366981,0,0,0,0,0,0,0,0,0,0,0,0,0.338474986694436,0.247398438714038,0.348921599607192,0,0,0,0,0,0,0.466259681901648,0.318348987613667,0.401241286650242,1.07733275545363,1.00298731772849,1.07199174564179,0.583717414620066,0.585634734015165,0.547580213653886,0.931805355389084,0.794078744487071,0.678757870911674,0.688573618019788,0.68048452008908,0.662599896889682,0.808435694101382,0.724681420843021,0.839956313502855,0.621509908775258,0.693745223502215,0.578011585538383,0.913365660208946,0.820484664428355,0.622906437711325,0.660970510599511,0.652899676320635,0.568090564938478,0.946238476778042,1.08412347086247,0.906872717432131,0.749200082204804,0.644003011697843,0.497206804143708,0.968478646189592,1.00091584843187,0.908834313208082,0.239595582071719,0.214264287421827,0.208287458976109,0.455585515902365,0.363172820856307,0.40256207594264,0.195906702716978,0.174346166301265,0.189768841342719,0,0,0,0,0,0,0,0,0,0,0,0,0.0966330780564035,0,0,0,0,0,0,0,0,0.0229372392992549,0,0,0,0.0261721287455008,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0609149782727745,0.0308888945956299,0,0.0922914887002101,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0894731317091011,0,0,0.328327134296129,0.3337574323679,0.517568438834641,0.092892723212638,0,0.068591177124475,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.935971302512953,0.397326798542048,0.677767798171276,0,0,0,0,0,0,0,0.0183241141132955,0.040912657171121,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.948257827336227,0.890779533620877,0.784127541901342,0,0,0,0,0,0,0,0.0390526553261436,0,0.052441152940763,0,0,0,0,0,0,0,0.075288505537948,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.228544786035562,0.225942238893112,0.184668619030129,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.180471411475361,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.137781924021135,0,0,0,0,0.089121113667536,0,0,0.194383335102921,0.225485929319472,0,0.187529586342753,0.253610608288505,0,0,0,0,0,0,0,0,0,0.0833856393724342,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.237125132323052,0,0,0,0,0,0,0,0.0824118928404978,0,0,0,0.0394544993028877,0.105947296040957,0,0,0,0,0,0,0,0.0595274759281578,0,0,0,0.0192640039508918,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0321956448428329,0,0,0,0,0,0,0.092776003344243,0,0,0,0,0,0,0,0,0,0,0,0,0,0.102218458236077,0,0,0,0,0.0549201943193819,0,0,0,0,0,0,0,0,0.250280073756829,0,0,0,0,0,0,0,0,0,0,0,0.1301578714358,0,0,0,0,0.0402022792589852,0,0,0,0,0.0266602233572113,0,0,0.0840229578243582,0,0,0,0,0,0,0,0,0,0,0,0,0.0804146167727012,0,0,0,0.0665087266517939,0,0,0,0,0,0.0282390906884824,0,0,0,0,0,0,0,0,0.0277280434357867,0,0,0,0,0,0.0497989345555453,0,0.0921650105405382,0.0327649730749157,0,0,0,0.234186964128339,0,0,0,0,0,0,0,0,0,0.111633612091231,0,0,0.0539356558948951,0,0,0.200421598828937,0.0634100406668813,0.096622994855169,0.237170753798121,0,0,0,0,0,0,0,0,0,0,0.0256131114977391,0,0.0663535486603203,0.0508408017580101,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0281204388731878,0,0.051170482087302,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0270351810347199,0,0.0321604437118685,0,0,0,0.0325050538702846,0,0,0,0,0,0,0,0,0.031493427513643,0,0,0,0,0,0.0141915870499514,0,0.0407972803666135,0.0267031128419265,0,0,0,0,0,0,0,0,0,0.159420353662981,0,0,0.0142794723259456,0.0138323107379372,0,0,0.0775818196829066,0,0,0,0,0,0.0836188439410081,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0212213629697974,0,0,0,0,0,0,0,0,0.0473113998716444,0.0429233806980168,0,0,0,0,0.056477756371092,0,0,0.364696333375929,0.171165754608097,0,0,0,0,0,0,0.0838227541486238,0,0.0285677922263843,0,0,0,0,0,0,0,0,0,0,0,0,0.0612855891386548,0,0,0.0213729832432021,0,0,0.051397602931175,0.0963185729165539,0,0.0267975841371139,0.039973403565921,0,0,0.038860407494829,0.109541028439739,0,0,0,0,0,0,0,0,0,0.12889276101619,0|full_id=C687_CD14_Macrophage_Monocytederived_Dendritic_Endothelial_Pericytes_schwannoma|gostat_on_coexpression_clusters=GO:0031325!positive regulation of cellular metabolic process!1.44708864309662e-05!9826;1200;7849;3586$GO:0009893!positive regulation of metabolic process!1.44708864309662e-05!9826;1200;7849;3586$GO:0048522!positive regulation of cellular process!0.000340399707680242!9826;1200;7849;3586$GO:0048518!positive regulation of biological process!0.00039129294247486!9826;1200;7849;3586$GO:0048856!anatomical structure development!0.00346825179540455!9826;1200;7849;3586$GO:0051247!positive regulation of protein metabolic process!0.00346825179540455!1200;3586$GO:0050794!regulation of cellular process!0.00414557086227873!9826;10788;1200;7849;3586$GO:0030886!negative regulation of myeloid dendritic cell activation!0.00414557086227873!3586$GO:0045355!negative regulation of interferon-alpha biosynthetic process!0.00414557086227873!3586$GO:0005141!interleukin-10 receptor binding!0.00414557086227873!3586$GO:0032695!negative regulation of interleukin-12 production!0.00414557086227873!3586$GO:0019131!tripeptidyl-peptidase I activity!0.00414557086227873!1200$GO:0050789!regulation of biological process!0.005007604007807!9826;10788;1200;7849;3586$GO:0004996!thyroid-stimulating hormone receptor activity!0.00542547742072489!7849$GO:0043171!peptide catabolic process!0.00542547742072489!1200$GO:0045347!negative regulation of MHC class II biosynthetic process!0.00542547742072489!3586$GO:0008240!tripeptidyl-peptidase activity!0.00542547742072489!1200$GO:0030885!regulation of myeloid dendritic cell activation!0.00542547742072489!3586$GO:0065007!biological regulation!0.00542547742072489!9826;10788;1200;7849;3586$GO:0045893!positive regulation of transcription, DNA-dependent!0.00678286267540764!9826;7849$GO:0032502!developmental process!0.00678286267540764!9826;1200;7849;3586$GO:0032655!regulation of interleukin-12 production!0.00678286267540764!3586$GO:0007253!cytoplasmic sequestering of NF-kappaB!0.00731399062475549!3586$GO:0001773!myeloid dendritic cell activation!0.00731399062475549!3586$GO:0045941!positive regulation of transcription!0.00731399062475549!9826;7849$GO:0045935!positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process!0.00731399062475549!9826;7849$GO:0032501!multicellular organismal process!0.00731399062475549!9826;1200;7849;3586$GO:0042347!negative regulation of NF-kappaB import into nucleus!0.00731399062475549!3586$GO:0030010!establishment of cell polarity!0.00731399062475549!9826$GO:0045862!positive regulation of proteolysis!0.00731399062475549!1200$GO:0045348!positive regulation of MHC class II biosynthetic process!0.00731399062475549!3586$GO:0045354!regulation of interferon-alpha biosynthetic process!0.00731399062475549!3586$GO:0032607!interferon-alpha production!0.00731399062475549!3586$GO:0045349!interferon-alpha biosynthetic process!0.00731399062475549!3586$GO:0031323!regulation of cellular metabolic process!0.00785245391915232!9826;1200;7849;3586$GO:0045342!MHC class II biosynthetic process!0.00785245391915232!3586$GO:0045346!regulation of MHC class II biosynthetic process!0.00785245391915232!3586$GO:0032615!interleukin-12 production!0.00785245391915232!3586$GO:0019222!regulation of metabolic process!0.00866295884396289!9826;1200;7849;3586$GO:0005096!GTPase activator activity!0.00866295884396289!9826;10788$GO:0042130!negative regulation of T cell proliferation!0.00868084560304669!3586$GO:0045351!interferon type I biosynthetic process!0.00868084560304669!3586$GO:0032606!interferon type I production!0.00868084560304669!3586$GO:0006928!cell motility!0.00868084560304669!9826;3586$GO:0051674!localization of cell!0.00868084560304669!9826;3586$GO:0005515!protein binding!0.00868084560304669!9826;10788;1200;7849;3586$GO:0042994!cytoplasmic sequestering of transcription factor!0.00868084560304669!3586$GO:0045191!regulation of isotype switching!0.00868084560304669!3586$GO:0042092!T-helper 2 type immune response!0.00868084560304669!3586$GO:0005095!GTPase inhibitor activity!0.00868084560304669!10788$GO:0051220!cytoplasmic sequestering of protein!0.00868084560304669!3586$GO:0002237!response to molecule of bacterial origin!0.00868084560304669!3586$GO:0001818!negative regulation of cytokine production!0.00868084560304669!3586$GO:0051246!regulation of protein metabolic process!0.00868084560304669!1200;3586$GO:0002208!somatic diversification of immunoglobulins during immune response!0.00868084560304669!3586$GO:0002381!immunoglobulin production during immune response!0.00868084560304669!3586$GO:0050868!negative regulation of T cell activation!0.00868084560304669!3586$GO:0042308!negative regulation of protein import into nucleus!0.00868084560304669!3586$GO:0042992!negative regulation of transcription factor import into nucleus!0.00868084560304669!3586$GO:0050672!negative regulation of lymphocyte proliferation!0.00868084560304669!3586$GO:0002204!somatic recombination of immunoglobulin genes during immune response!0.00868084560304669!3586$GO:0045190!isotype switching!0.00868084560304669!3586$GO:0032945!negative regulation of mononuclear cell proliferation!0.00868084560304669!3586$GO:0008047!enzyme activator activity!0.00879225782841612!9826;10788$GO:0042348!NF-kappaB import into nucleus!0.00879225782841612!3586$GO:0046823!negative regulation of nucleocytoplasmic transport!0.00879225782841612!3586$GO:0042345!regulation of NF-kappaB import into nucleus!0.00879225782841612!3586$GO:0007242!intracellular signaling cascade!0.00879225782841612!9826;10788;3586$GO:0005083!small GTPase regulator activity!0.00885277140044013!9826;10788$GO:0051056!regulation of small GTPase mediated signal transduction!0.00885277140044013!9826;10788$GO:0016447!somatic recombination of immunoglobulin gene segments!0.00885277140044013!3586$GO:0045453!bone resorption!0.00885277140044013!1200$GO:0051224!negative regulation of protein transport!0.00885277140044013!3586$GO:0016444!somatic cell DNA recombination!0.00981036771088836!3586$GO:0016445!somatic diversification of immunoglobulins!0.00981036771088836!3586$GO:0002562!somatic diversification of immune receptors via germline recombination within a single locus!0.00981036771088836!3586$GO:0002200!somatic diversification of immune receptors!0.0101954741945606!3586$GO:0042036!negative regulation of cytokine biosynthetic process!0.0101954741945606!3586$GO:0030162!regulation of proteolysis!0.0106949389685248!1200$GO:0002377!immunoglobulin production!0.0110437965500934!3586$GO:0042100!B cell proliferation!0.0110437965500934!3586$GO:0007275!multicellular organismal development!0.0111081060449981!1200;7849;3586$GO:0048871!multicellular organismal homeostasis!0.0111081060449981!1200$GO:0051250!negative regulation of lymphocyte activation!0.0111081060449981!3586$GO:0001894!tissue homeostasis!0.0111081060449981!1200$GO:0042990!regulation of transcription factor import into nucleus!0.0119937293804143!3586$GO:0042991!transcription factor import into nucleus!0.0119937293804143!3586$GO:0042306!regulation of protein import into nucleus!0.0121453156237049!3586$GO:0016500!protein-hormone receptor activity!0.0121453156237049!7849$GO:0033157!regulation of intracellular protein transport!0.0121453156237049!3586$GO:0030595!leukocyte chemotaxis!0.0125571044995709!3586$GO:0032507!maintenance of cellular protein localization!0.0129598778977745!3586$GO:0051651!maintenance of cellular localization!0.0130727913479262!3586$GO:0050864!regulation of B cell activation!0.0130727913479262!3586$GO:0032386!regulation of intracellular transport!0.0130727913479262!3586$GO:0045185!maintenance of protein localization!0.0134532890036535!3586$GO:0002440!production of molecular mediator of immune response!0.0136848006735213!3586$GO:0002274!myeloid leukocyte activation!0.0136848006735213!3586$GO:0030695!GTPase regulator activity!0.0137693004310155!9826;10788$GO:0051223!regulation of protein transport!0.0137693004310155!3586$GO:0006518!peptide metabolic process!0.0137693004310155!1200$GO:0007163!establishment and/or maintenance of cell polarity!0.0138488690139391!9826$GO:0046822!regulation of nucleocytoplasmic transport!0.0138488690139391!3586$GO:0030183!B cell differentiation!0.0138488690139391!3586$GO:0051051!negative regulation of transport!0.0145229331747046!3586$GO:0050900!leukocyte migration!0.0145229331747046!3586$GO:0000910!cytokinesis!0.0156306473236618!9826$GO:0042129!regulation of T cell proliferation!0.0156306473236618!3586$GO:0004289!subtilase activity!0.0159418155417927!1200$GO:0009966!regulation of signal transduction!0.0162332840639816!9826;10788$GO:0006941!striated muscle contraction!0.0165471742413023!9826$GO:0042098!T cell proliferation!0.0172838520684026!3586$GO:0051235!maintenance of localization!0.0176941145288218!3586$GO:0017148!negative regulation of translation!0.0176941145288218!3586$GO:0001817!regulation of cytokine production!0.0176941145288218!3586$GO:0032944!regulation of mononuclear cell proliferation!0.0178147887588494!3586$GO:0050670!regulation of lymphocyte proliferation!0.0178147887588494!3586$GO:0007264!small GTPase mediated signal transduction!0.0179841717525187!9826;10788$GO:0031327!negative regulation of cellular biosynthetic process!0.0187631647938454!3586$GO:0065008!regulation of biological quality!0.0207346863543757!9826;1200$GO:0016064!immunoglobulin mediated immune response!0.0207346863543757!3586$GO:0009890!negative regulation of biosynthetic process!0.0207346863543757!3586$GO:0019724!B cell mediated immunity!0.0208612972281041!3586$GO:0032943!mononuclear cell proliferation!0.0208612972281041!3586$GO:0045727!positive regulation of translation!0.0208612972281041!3586$GO:0046651!lymphocyte proliferation!0.0208612972281041!3586$GO:0005126!hematopoietin/interferon-class (D200-domain) cytokine receptor binding!0.0228520209123766!3586$GO:0050863!regulation of T cell activation!0.0228520209123766!3586$GO:0042035!regulation of cytokine biosynthetic process!0.0228804678061735!3586$GO:0031328!positive regulation of cellular biosynthetic process!0.0228804678061735!3586$GO:0009653!anatomical structure morphogenesis!0.0229080085282027!9826;7849$GO:0042113!B cell activation!0.0229080085282027!3586$GO:0030098!lymphocyte differentiation!0.0238497075266876!3586$GO:0042089!cytokine biosynthetic process!0.024776960082457!3586$GO:0042107!cytokine metabolic process!0.0249590236052958!3586$GO:0009891!positive regulation of biosynthetic process!0.0255011896296816!3586$GO:0002449!lymphocyte mediated immunity!0.0260352708378146!3586$GO:0002250!adaptive immune response!0.0268864492015738!3586$GO:0002460!adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains!0.0268864492015738!3586$GO:0051249!regulation of lymphocyte activation!0.0268864492015738!3586$GO:0002443!leukocyte mediated immunity!0.0273950593245228!3586$GO:0050865!regulation of cell activation!0.027896342042255!3586$GO:0010468!regulation of gene expression!0.0279530799537249!9826;7849;3586$GO:0043283!biopolymer metabolic process!0.0279530799537249!9826;1200;7849;3586$GO:0004177!aminopeptidase activity!0.0279530799537249!1200$GO:0048770!pigment granule!0.0279530799537249!1200$GO:0042470!melanosome!0.0279530799537249!1200$GO:0002521!leukocyte differentiation!0.0300933626416046!3586$GO:0042742!defense response to bacterium!0.0314507346991382!3586$GO:0046849!bone remodeling!0.0314507346991382!1200$GO:0006606!protein import into nucleus!0.0314507346991382!3586$GO:0051170!nuclear import!0.0316825417547719!3586$GO:0042110!T cell activation!0.0316825417547719!3586$GO:0051248!negative regulation of protein metabolic process!0.0333921647463723!3586$GO:0048771!tissue remodeling!0.0334937664481431!1200$GO:0009617!response to bacterium!0.0335940283593114!3586$GO:0002252!immune effector process!0.0344123347683006!3586$GO:0051049!regulation of transport!0.0344123347683006!3586$GO:0001816!cytokine production!0.0351223165365737!3586$GO:0017038!protein import!0.0376627093899688!3586$GO:0048731!system development!0.0423386320615437!1200;3586$GO:0007249!I-kappaB kinase/NF-kappaB cascade!0.0423386320615437!3586$GO:0005516!calmodulin binding!0.0426793116647242!10788$GO:0042330!taxis!0.0430514455933189!3586$GO:0006935!chemotaxis!0.0430514455933189!3586$GO:0005089!Rho guanyl-nucleotide exchange factor activity!0.0451481686323264!9826$GO:0006913!nucleocytoplasmic transport!0.0454629643846659!3586$GO:0046649!lymphocyte activation!0.0454831304372573!3586$GO:0051169!nuclear transport!0.0455030236474464!3586$GO:0030097!hemopoiesis!0.0461895273061865!3586$GO:0035023!regulation of Rho protein signal transduction!0.0461895273061865!9826$GO:0001558!regulation of cell growth!0.0461895273061865!9826$GO:0003012!muscle system process!0.0461895273061865!9826$GO:0006936!muscle contraction!0.0461895273061865!9826$GO:0005099!Ras GTPase activator activity!0.0461895273061865!10788$GO:0005088!Ras guanyl-nucleotide exchange factor activity!0.0461895273061865!9826$GO:0006916!anti-apoptosis!0.0473064165394246!3586$GO:0048534!hemopoietic or lymphoid organ development!0.0478280163152249!3586$GO:0048869!cellular developmental process!0.0478280163152249!7849;3586$GO:0030154!cell differentiation!0.0478280163152249!7849;3586$GO:0045321!leukocyte activation!0.0489505828554582!3586$GO:0007626!locomotory behavior!0.0489505828554582!3586$GO:0002520!immune system development!0.0489505828554582!3586$GO:0006417!regulation of translation!0.0492137468793967!3586$GO:0008238!exopeptidase activity!0.0494652716338911!1200$GO:0007165!signal transduction!0.0494652716338911!9826;10788;3586$GO:0007266!Rho protein signal 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| ||
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}} |
Latest revision as of 11:28, 17 September 2013
Full id: C687_CD14_Macrophage_Monocytederived_Dendritic_Endothelial_Pericytes_schwannoma
Phase1 CAGE Peaks
Hg19::chr11:6640638..6640665,- | p1@TPP1 |
Hg19::chr16:81031957..81031962,- | p@chr16:81031957..81031962 - |
Hg19::chr19:54887674..54887700,- | p@chr19:54887674..54887700 - |
Hg19::chr19:55836684..55836695,- | p2@TMEM150B |
Hg19::chr19:55836697..55836717,- | p1@TMEM150B |
Hg19::chr1:156933510..156933528,- | p5@ARHGEF11 |
Hg19::chr1:206944527..206944552,- | p2@IL10 |
Hg19::chr2:113999360..113999386,- | p4@PAX8 |
Hg19::chr4:185314151..185314178,- | p@chr4:185314151..185314178 - |
Hg19::chr4:185314188..185314207,- | p@chr4:185314188..185314207 - |
Hg19::chr5:75698757..75698769,+ | p16@IQGAP2 |
Hg19::chr5:75698771..75698784,+ | p8@IQGAP2 |
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
No results for this coexpression
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0031325 | positive regulation of cellular metabolic process | 1.44708864309662e-05 |
GO:0009893 | positive regulation of metabolic process | 1.44708864309662e-05 |
GO:0048522 | positive regulation of cellular process | 0.000340399707680242 |
GO:0048518 | positive regulation of biological process | 0.00039129294247486 |
GO:0048856 | anatomical structure development | 0.00346825179540455 |
GO:0051247 | positive regulation of protein metabolic process | 0.00346825179540455 |
GO:0050794 | regulation of cellular process | 0.00414557086227873 |
GO:0030886 | negative regulation of myeloid dendritic cell activation | 0.00414557086227873 |
GO:0045355 | negative regulation of interferon-alpha biosynthetic process | 0.00414557086227873 |
GO:0005141 | interleukin-10 receptor binding | 0.00414557086227873 |
GO:0032695 | negative regulation of interleukin-12 production | 0.00414557086227873 |
GO:0019131 | tripeptidyl-peptidase I activity | 0.00414557086227873 |
GO:0050789 | regulation of biological process | 0.005007604007807 |
GO:0004996 | thyroid-stimulating hormone receptor activity | 0.00542547742072489 |
GO:0043171 | peptide catabolic process | 0.00542547742072489 |
GO:0045347 | negative regulation of MHC class II biosynthetic process | 0.00542547742072489 |
GO:0008240 | tripeptidyl-peptidase activity | 0.00542547742072489 |
GO:0030885 | regulation of myeloid dendritic cell activation | 0.00542547742072489 |
GO:0065007 | biological regulation | 0.00542547742072489 |
GO:0045893 | positive regulation of transcription, DNA-dependent | 0.00678286267540764 |
GO:0032502 | developmental process | 0.00678286267540764 |
GO:0032655 | regulation of interleukin-12 production | 0.00678286267540764 |
GO:0007253 | cytoplasmic sequestering of NF-kappaB | 0.00731399062475549 |
GO:0001773 | myeloid dendritic cell activation | 0.00731399062475549 |
GO:0045941 | positive regulation of transcription | 0.00731399062475549 |
GO:0045935 | positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.00731399062475549 |
GO:0032501 | multicellular organismal process | 0.00731399062475549 |
GO:0042347 | negative regulation of NF-kappaB import into nucleus | 0.00731399062475549 |
GO:0030010 | establishment of cell polarity | 0.00731399062475549 |
GO:0045862 | positive regulation of proteolysis | 0.00731399062475549 |
GO:0045348 | positive regulation of MHC class II biosynthetic process | 0.00731399062475549 |
GO:0045354 | regulation of interferon-alpha biosynthetic process | 0.00731399062475549 |
GO:0032607 | interferon-alpha production | 0.00731399062475549 |
GO:0045349 | interferon-alpha biosynthetic process | 0.00731399062475549 |
GO:0031323 | regulation of cellular metabolic process | 0.00785245391915232 |
GO:0045342 | MHC class II biosynthetic process | 0.00785245391915232 |
GO:0045346 | regulation of MHC class II biosynthetic process | 0.00785245391915232 |
GO:0032615 | interleukin-12 production | 0.00785245391915232 |
GO:0019222 | regulation of metabolic process | 0.00866295884396289 |
GO:0005096 | GTPase activator activity | 0.00866295884396289 |
GO:0042130 | negative regulation of T cell proliferation | 0.00868084560304669 |
GO:0045351 | interferon type I biosynthetic process | 0.00868084560304669 |
GO:0032606 | interferon type I production | 0.00868084560304669 |
GO:0006928 | cell motility | 0.00868084560304669 |
GO:0051674 | localization of cell | 0.00868084560304669 |
GO:0005515 | protein binding | 0.00868084560304669 |
GO:0042994 | cytoplasmic sequestering of transcription factor | 0.00868084560304669 |
GO:0045191 | regulation of isotype switching | 0.00868084560304669 |
GO:0042092 | T-helper 2 type immune response | 0.00868084560304669 |
GO:0005095 | GTPase inhibitor activity | 0.00868084560304669 |
GO:0051220 | cytoplasmic sequestering of protein | 0.00868084560304669 |
GO:0002237 | response to molecule of bacterial origin | 0.00868084560304669 |
GO:0001818 | negative regulation of cytokine production | 0.00868084560304669 |
GO:0051246 | regulation of protein metabolic process | 0.00868084560304669 |
GO:0002208 | somatic diversification of immunoglobulins during immune response | 0.00868084560304669 |
GO:0002381 | immunoglobulin production during immune response | 0.00868084560304669 |
GO:0050868 | negative regulation of T cell activation | 0.00868084560304669 |
GO:0042308 | negative regulation of protein import into nucleus | 0.00868084560304669 |
GO:0042992 | negative regulation of transcription factor import into nucleus | 0.00868084560304669 |
GO:0050672 | negative regulation of lymphocyte proliferation | 0.00868084560304669 |
GO:0002204 | somatic recombination of immunoglobulin genes during immune response | 0.00868084560304669 |
GO:0045190 | isotype switching | 0.00868084560304669 |
GO:0032945 | negative regulation of mononuclear cell proliferation | 0.00868084560304669 |
GO:0008047 | enzyme activator activity | 0.00879225782841612 |
GO:0042348 | NF-kappaB import into nucleus | 0.00879225782841612 |
GO:0046823 | negative regulation of nucleocytoplasmic transport | 0.00879225782841612 |
GO:0042345 | regulation of NF-kappaB import into nucleus | 0.00879225782841612 |
GO:0007242 | intracellular signaling cascade | 0.00879225782841612 |
GO:0005083 | small GTPase regulator activity | 0.00885277140044013 |
GO:0051056 | regulation of small GTPase mediated signal transduction | 0.00885277140044013 |
GO:0016447 | somatic recombination of immunoglobulin gene segments | 0.00885277140044013 |
GO:0045453 | bone resorption | 0.00885277140044013 |
GO:0051224 | negative regulation of protein transport | 0.00885277140044013 |
GO:0016444 | somatic cell DNA recombination | 0.00981036771088836 |
GO:0016445 | somatic diversification of immunoglobulins | 0.00981036771088836 |
GO:0002562 | somatic diversification of immune receptors via germline recombination within a single locus | 0.00981036771088836 |
GO:0002200 | somatic diversification of immune receptors | 0.0101954741945606 |
GO:0042036 | negative regulation of cytokine biosynthetic process | 0.0101954741945606 |
GO:0030162 | regulation of proteolysis | 0.0106949389685248 |
GO:0002377 | immunoglobulin production | 0.0110437965500934 |
GO:0042100 | B cell proliferation | 0.0110437965500934 |
GO:0007275 | multicellular organismal development | 0.0111081060449981 |
GO:0048871 | multicellular organismal homeostasis | 0.0111081060449981 |
GO:0051250 | negative regulation of lymphocyte activation | 0.0111081060449981 |
GO:0001894 | tissue homeostasis | 0.0111081060449981 |
GO:0042990 | regulation of transcription factor import into nucleus | 0.0119937293804143 |
GO:0042991 | transcription factor import into nucleus | 0.0119937293804143 |
GO:0042306 | regulation of protein import into nucleus | 0.0121453156237049 |
GO:0016500 | protein-hormone receptor activity | 0.0121453156237049 |
GO:0033157 | regulation of intracellular protein transport | 0.0121453156237049 |
GO:0030595 | leukocyte chemotaxis | 0.0125571044995709 |
GO:0032507 | maintenance of cellular protein localization | 0.0129598778977745 |
GO:0051651 | maintenance of cellular localization | 0.0130727913479262 |
GO:0050864 | regulation of B cell activation | 0.0130727913479262 |
GO:0032386 | regulation of intracellular transport | 0.0130727913479262 |
GO:0045185 | maintenance of protein localization | 0.0134532890036535 |
GO:0002440 | production of molecular mediator of immune response | 0.0136848006735213 |
GO:0002274 | myeloid leukocyte activation | 0.0136848006735213 |
GO:0030695 | GTPase regulator activity | 0.0137693004310155 |
GO:0051223 | regulation of protein transport | 0.0137693004310155 |
GO:0006518 | peptide metabolic process | 0.0137693004310155 |
GO:0007163 | establishment and/or maintenance of cell polarity | 0.0138488690139391 |
GO:0046822 | regulation of nucleocytoplasmic transport | 0.0138488690139391 |
GO:0030183 | B cell differentiation | 0.0138488690139391 |
GO:0051051 | negative regulation of transport | 0.0145229331747046 |
GO:0050900 | leukocyte migration | 0.0145229331747046 |
GO:0000910 | cytokinesis | 0.0156306473236618 |
GO:0042129 | regulation of T cell proliferation | 0.0156306473236618 |
GO:0004289 | subtilase activity | 0.0159418155417927 |
GO:0009966 | regulation of signal transduction | 0.0162332840639816 |
GO:0006941 | striated muscle contraction | 0.0165471742413023 |
GO:0042098 | T cell proliferation | 0.0172838520684026 |
GO:0051235 | maintenance of localization | 0.0176941145288218 |
GO:0017148 | negative regulation of translation | 0.0176941145288218 |
GO:0001817 | regulation of cytokine production | 0.0176941145288218 |
GO:0032944 | regulation of mononuclear cell proliferation | 0.0178147887588494 |
GO:0050670 | regulation of lymphocyte proliferation | 0.0178147887588494 |
GO:0007264 | small GTPase mediated signal transduction | 0.0179841717525187 |
GO:0031327 | negative regulation of cellular biosynthetic process | 0.0187631647938454 |
GO:0065008 | regulation of biological quality | 0.0207346863543757 |
GO:0016064 | immunoglobulin mediated immune response | 0.0207346863543757 |
GO:0009890 | negative regulation of biosynthetic process | 0.0207346863543757 |
GO:0019724 | B cell mediated immunity | 0.0208612972281041 |
GO:0032943 | mononuclear cell proliferation | 0.0208612972281041 |
GO:0045727 | positive regulation of translation | 0.0208612972281041 |
GO:0046651 | lymphocyte proliferation | 0.0208612972281041 |
GO:0005126 | hematopoietin/interferon-class (D200-domain) cytokine receptor binding | 0.0228520209123766 |
GO:0050863 | regulation of T cell activation | 0.0228520209123766 |
GO:0042035 | regulation of cytokine biosynthetic process | 0.0228804678061735 |
GO:0031328 | positive regulation of cellular biosynthetic process | 0.0228804678061735 |
GO:0009653 | anatomical structure morphogenesis | 0.0229080085282027 |
GO:0042113 | B cell activation | 0.0229080085282027 |
GO:0030098 | lymphocyte differentiation | 0.0238497075266876 |
GO:0042089 | cytokine biosynthetic process | 0.024776960082457 |
GO:0042107 | cytokine metabolic process | 0.0249590236052958 |
GO:0009891 | positive regulation of biosynthetic process | 0.0255011896296816 |
GO:0002449 | lymphocyte mediated immunity | 0.0260352708378146 |
GO:0002250 | adaptive immune response | 0.0268864492015738 |
GO:0002460 | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | 0.0268864492015738 |
GO:0051249 | regulation of lymphocyte activation | 0.0268864492015738 |
GO:0002443 | leukocyte mediated immunity | 0.0273950593245228 |
GO:0050865 | regulation of cell activation | 0.027896342042255 |
GO:0010468 | regulation of gene expression | 0.0279530799537249 |
GO:0043283 | biopolymer metabolic process | 0.0279530799537249 |
GO:0004177 | aminopeptidase activity | 0.0279530799537249 |
GO:0048770 | pigment granule | 0.0279530799537249 |
GO:0042470 | melanosome | 0.0279530799537249 |
GO:0002521 | leukocyte differentiation | 0.0300933626416046 |
GO:0042742 | defense response to bacterium | 0.0314507346991382 |
GO:0046849 | bone remodeling | 0.0314507346991382 |
GO:0006606 | protein import into nucleus | 0.0314507346991382 |
GO:0051170 | nuclear import | 0.0316825417547719 |
GO:0042110 | T cell activation | 0.0316825417547719 |
GO:0051248 | negative regulation of protein metabolic process | 0.0333921647463723 |
GO:0048771 | tissue remodeling | 0.0334937664481431 |
GO:0009617 | response to bacterium | 0.0335940283593114 |
GO:0002252 | immune effector process | 0.0344123347683006 |
GO:0051049 | regulation of transport | 0.0344123347683006 |
GO:0001816 | cytokine production | 0.0351223165365737 |
GO:0017038 | protein import | 0.0376627093899688 |
GO:0048731 | system development | 0.0423386320615437 |
GO:0007249 | I-kappaB kinase/NF-kappaB cascade | 0.0423386320615437 |
GO:0005516 | calmodulin binding | 0.0426793116647242 |
GO:0042330 | taxis | 0.0430514455933189 |
GO:0006935 | chemotaxis | 0.0430514455933189 |
GO:0005089 | Rho guanyl-nucleotide exchange factor activity | 0.0451481686323264 |
GO:0006913 | nucleocytoplasmic transport | 0.0454629643846659 |
GO:0046649 | lymphocyte activation | 0.0454831304372573 |
GO:0051169 | nuclear transport | 0.0455030236474464 |
GO:0030097 | hemopoiesis | 0.0461895273061865 |
GO:0035023 | regulation of Rho protein signal transduction | 0.0461895273061865 |
GO:0001558 | regulation of cell growth | 0.0461895273061865 |
GO:0003012 | muscle system process | 0.0461895273061865 |
GO:0006936 | muscle contraction | 0.0461895273061865 |
GO:0005099 | Ras GTPase activator activity | 0.0461895273061865 |
GO:0005088 | Ras guanyl-nucleotide exchange factor activity | 0.0461895273061865 |
GO:0006916 | anti-apoptosis | 0.0473064165394246 |
GO:0048534 | hemopoietic or lymphoid organ development | 0.0478280163152249 |
GO:0048869 | cellular developmental process | 0.0478280163152249 |
GO:0030154 | cell differentiation | 0.0478280163152249 |
GO:0045321 | leukocyte activation | 0.0489505828554582 |
GO:0007626 | locomotory behavior | 0.0489505828554582 |
GO:0002520 | immune system development | 0.0489505828554582 |
GO:0006417 | regulation of translation | 0.0492137468793967 |
GO:0008238 | exopeptidase activity | 0.0494652716338911 |
GO:0007165 | signal transduction | 0.0494652716338911 |
GO:0007266 | Rho protein signal transduction | 0.0494652716338911 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
Ontology term | p-value | n |
---|---|---|
monopoietic cell | 1.05e-73 | 59 |
monocyte | 1.05e-73 | 59 |
monoblast | 1.05e-73 | 59 |
promonocyte | 1.05e-73 | 59 |
defensive cell | 1.22e-71 | 48 |
phagocyte | 1.22e-71 | 48 |
myeloid leukocyte | 5.01e-71 | 72 |
macrophage dendritic cell progenitor | 1.15e-70 | 61 |
myeloid lineage restricted progenitor cell | 2.57e-68 | 66 |
granulocyte monocyte progenitor cell | 5.27e-67 | 67 |
classical monocyte | 4.07e-62 | 42 |
CD14-positive, CD16-negative classical monocyte | 4.07e-62 | 42 |
myeloid cell | 1.82e-43 | 108 |
common myeloid progenitor | 1.82e-43 | 108 |
leukocyte | 1.60e-40 | 136 |
nongranular leukocyte | 1.88e-39 | 115 |
hematopoietic lineage restricted progenitor cell | 4.83e-35 | 120 |
stuff accumulating cell | 1.22e-31 | 87 |
hematopoietic stem cell | 1.46e-29 | 168 |
angioblastic mesenchymal cell | 1.46e-29 | 168 |
hematopoietic oligopotent progenitor cell | 3.11e-27 | 161 |
hematopoietic multipotent progenitor cell | 3.11e-27 | 161 |
hematopoietic cell | 6.41e-27 | 177 |
intermediate monocyte | 8.73e-13 | 9 |
CD14-positive, CD16-positive monocyte | 8.73e-13 | 9 |
macrophage | 1.42e-10 | 6 |
Ontology term | p-value | n |
---|---|---|
hematopoietic system | 4.52e-62 | 98 |
blood island | 4.52e-62 | 98 |
hemolymphoid system | 8.08e-58 | 108 |
bone marrow | 9.59e-57 | 76 |
immune system | 9.86e-54 | 93 |
bone element | 3.70e-51 | 82 |
skeletal element | 7.11e-45 | 90 |
skeletal system | 7.00e-40 | 100 |
lateral plate mesoderm | 1.97e-25 | 203 |
adult organism | 4.12e-22 | 114 |
musculoskeletal system | 9.96e-19 | 167 |
mesoderm | 3.14e-13 | 315 |
mesoderm-derived structure | 3.14e-13 | 315 |
presumptive mesoderm | 3.14e-13 | 315 |
germ layer | 2.98e-09 | 560 |
germ layer / neural crest | 2.98e-09 | 560 |
embryonic tissue | 2.98e-09 | 560 |
presumptive structure | 2.98e-09 | 560 |
germ layer / neural crest derived structure | 2.98e-09 | 560 |
epiblast (generic) | 2.98e-09 | 560 |
organ | 3.64e-09 | 503 |
embryonic structure | 5.64e-09 | 564 |
developing anatomical structure | 1.04e-08 | 581 |
embryo | 5.46e-08 | 592 |
anatomical system | 6.44e-07 | 624 |
anatomical group | 7.37e-07 | 625 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
MA0003.1 | 0.00869098 |
MA0004.1 | 0.32225 |
MA0006.1 | 0.188769 |
MA0007.1 | 0.825205 |
MA0009.1 | 0.756202 |
MA0014.1 | 0.00958972 |
MA0017.1 | 0.220105 |
MA0019.1 | 1.15437 |
MA0024.1 | 0.654931 |
MA0025.1 | 0.886436 |
MA0027.1 | 2.35633 |
MA0028.1 | 0.583404 |
MA0029.1 | 0.673506 |
MA0030.1 | 0.662482 |
MA0031.1 | 0.600685 |
MA0038.1 | 0.414169 |
MA0040.1 | 0.67914 |
MA0041.1 | 0.89827 |
MA0042.1 | 0.310552 |
MA0043.1 | 0.756508 |
MA0046.1 | 0.745626 |
MA0048.1 | 0.155795 |
MA0050.1 | 2.30599 |
MA0051.1 | 0.410316 |
MA0052.1 | 0.682867 |
MA0055.1 | 0.0371476 |
MA0056.1 | 0 |
MA0057.1 | 0.617373 |
MA0058.1 | 0.676094 |
MA0059.1 | 0.673606 |
MA0060.1 | 0.103131 |
MA0061.1 | 0.28989 |
MA0063.1 | 0 |
MA0066.1 | 1.0654 |
MA0067.1 | 1.06751 |
MA0068.1 | 2.96303 |
MA0069.1 | 0.741884 |
MA0070.1 | 0.731026 |
MA0071.1 | 0.379038 |
MA0072.1 | 0.726666 |
MA0073.1 | 1.03026 |
MA0074.1 | 0.40963 |
MA0076.1 | 0.254045 |
MA0077.1 | 0.719193 |
MA0078.1 | 0.502027 |
MA0081.1 | 1.25193 |
MA0083.1 | 0.763502 |
MA0084.1 | 1.25286 |
MA0087.1 | 0.724294 |
MA0088.1 | 0.20556 |
MA0089.1 | 0 |
MA0090.1 | 0.266215 |
MA0091.1 | 0.324543 |
MA0092.1 | 0.291716 |
MA0093.1 | 0.558691 |
MA0095.1 | 0 |
MA0098.1 | 0 |
MA0100.1 | 0.426863 |
MA0101.1 | 0.19375 |
MA0103.1 | 0.535462 |
MA0105.1 | 0.0320473 |
MA0106.1 | 0.452066 |
MA0107.1 | 0.137948 |
MA0108.2 | 0.597764 |
MA0109.1 | 0 |
MA0111.1 | 0.761158 |
MA0113.1 | 1.17934 |
MA0114.1 | 0.418165 |
MA0115.1 | 0.992167 |
MA0116.1 | 0.433848 |
MA0117.1 | 0.792789 |
MA0119.1 | 0.226505 |
MA0122.1 | 0.818044 |
MA0124.1 | 0.951337 |
MA0125.1 | 0.868909 |
MA0130.1 | 0 |
MA0131.1 | 0.519055 |
MA0132.1 | 0 |
MA0133.1 | 0 |
MA0135.1 | 0.785738 |
MA0136.1 | 0.420617 |
MA0139.1 | 0.268952 |
MA0140.1 | 0.982486 |
MA0141.1 | 1.24597 |
MA0142.1 | 0.570448 |
MA0143.1 | 0.467429 |
MA0144.1 | 0.124153 |
MA0145.1 | 0.0932202 |
MA0146.1 | 0.00710499 |
MA0147.1 | 0.440281 |
MA0148.1 | 0.910784 |
MA0149.1 | 0.367947 |
MA0062.2 | 0.280813 |
MA0035.2 | 0.376007 |
MA0039.2 | 0.19592 |
MA0138.2 | 0.503176 |
MA0002.2 | 1.08633 |
MA0137.2 | 0.20663 |
MA0104.2 | 0.335786 |
MA0047.2 | 0.440861 |
MA0112.2 | 0.0192555 |
MA0065.2 | 0.23889 |
MA0150.1 | 0.723395 |
MA0151.1 | 0 |
MA0152.1 | 0.382565 |
MA0153.1 | 0.852412 |
MA0154.1 | 0.5526 |
MA0155.1 | 0.0793743 |
MA0156.1 | 0.600064 |
MA0157.1 | 0.544523 |
MA0158.1 | 0 |
MA0159.1 | 0.143477 |
MA0160.1 | 0.357736 |
MA0161.1 | 0 |
MA0162.1 | 0.138499 |
MA0163.1 | 0.00158421 |
MA0164.1 | 0.478818 |
MA0080.2 | 0.558855 |
MA0018.2 | 0.453345 |
MA0099.2 | 0.996203 |
MA0079.2 | 0.0295657 |
MA0102.2 | 1.28978 |
MA0258.1 | 0.117513 |
MA0259.1 | 0.149181 |
MA0442.1 | 0 |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)
TF | #promoters | Enrichment | p-value | q-value |
---|---|---|---|---|
SPI1#6688 | 6 | 4.10216175426136 | 0.00156889654803008 | 0.00994984130311594 |
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data
This analysis result is provided for C0 - C305 clusters.