Coexpression cluster:C112: Difference between revisions
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Latest revision as of 10:34, 17 September 2013
Full id: C112_gastric_pancreas_temporal_duodenum_small_extraskeletal_adrenal
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
No results for this coexpression
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0005515 | protein binding | 0.000666432550302563 |
GO:0048869 | cellular developmental process | 0.000666432550302563 |
GO:0030154 | cell differentiation | 0.000666432550302563 |
GO:0032502 | developmental process | 0.000684302246634942 |
GO:0030111 | regulation of Wnt receptor signaling pathway | 0.0101269456508289 |
GO:0032501 | multicellular organismal process | 0.0110569204705015 |
GO:0007275 | multicellular organismal development | 0.011313664961938 |
GO:0050767 | regulation of neurogenesis | 0.011313664961938 |
GO:0030182 | neuron differentiation | 0.011313664961938 |
GO:0005102 | receptor binding | 0.011313664961938 |
GO:0009653 | anatomical structure morphogenesis | 0.011313664961938 |
GO:0016043 | cellular component organization and biogenesis | 0.011313664961938 |
GO:0050793 | regulation of developmental process | 0.011313664961938 |
GO:0048699 | generation of neurons | 0.011313664961938 |
GO:0008083 | growth factor activity | 0.011313664961938 |
GO:0009605 | response to external stimulus | 0.011313664961938 |
GO:0022008 | neurogenesis | 0.011313664961938 |
GO:0021902 | commitment of a neuronal cell to a specific type of neuron in the forebrain | 0.011313664961938 |
GO:0030177 | positive regulation of Wnt receptor signaling pathway | 0.011313664961938 |
GO:0050674 | urothelial cell proliferation | 0.011313664961938 |
GO:0050675 | regulation of urothelial cell proliferation | 0.011313664961938 |
GO:0021877 | forebrain neuron fate commitment | 0.011313664961938 |
GO:0050677 | positive regulation of urothelial cell proliferation | 0.011313664961938 |
GO:0048468 | cell development | 0.0113869173760949 |
GO:0007610 | behavior | 0.0113869173760949 |
GO:0045596 | negative regulation of cell differentiation | 0.0113869173760949 |
GO:0048856 | anatomical structure development | 0.0126056496574786 |
GO:0045165 | cell fate commitment | 0.0126056496574786 |
GO:0008283 | cell proliferation | 0.0128047057897627 |
GO:0051093 | negative regulation of developmental process | 0.0135501785815822 |
GO:0007423 | sensory organ development | 0.0135501785815822 |
GO:0021879 | forebrain neuron differentiation | 0.0135501785815822 |
GO:0021872 | generation of neurons in the forebrain | 0.0135501785815822 |
GO:0007435 | salivary gland morphogenesis | 0.0135501785815822 |
GO:0021798 | forebrain dorsal/ventral pattern formation | 0.0135501785815822 |
GO:0022612 | gland morphogenesis | 0.0135501785815822 |
GO:0050482 | arachidonic acid secretion | 0.0135501785815822 |
GO:0003002 | regionalization | 0.0135501785815822 |
GO:0009887 | organ morphogenesis | 0.0135501785815822 |
GO:0048286 | alveolus development | 0.0181443336156858 |
GO:0019834 | phospholipase A2 inhibitor activity | 0.0181443336156858 |
GO:0030297 | transmembrane receptor protein tyrosine kinase activator activity | 0.0181443336156858 |
GO:0008046 | axon guidance receptor activity | 0.0181443336156858 |
GO:0048731 | system development | 0.0193292871414374 |
GO:0007409 | axonogenesis | 0.0193292871414374 |
GO:0048667 | neuron morphogenesis during differentiation | 0.0193292871414374 |
GO:0048812 | neurite morphogenesis | 0.0193292871414374 |
GO:0046717 | acid secretion | 0.0193292871414374 |
GO:0048260 | positive regulation of receptor-mediated endocytosis | 0.0193292871414374 |
GO:0021871 | forebrain regionalization | 0.0193292871414374 |
GO:0007431 | salivary gland development | 0.0193292871414374 |
GO:0030971 | receptor tyrosine kinase binding | 0.0193292871414374 |
GO:0030949 | positive regulation of vascular endothelial growth factor receptor signaling pathway | 0.0193292871414374 |
GO:0065007 | biological regulation | 0.0193292871414374 |
GO:0007389 | pattern specification process | 0.0193292871414374 |
GO:0000904 | cellular morphogenesis during differentiation | 0.0194054358599516 |
GO:0042127 | regulation of cell proliferation | 0.0194054358599516 |
GO:0032989 | cellular structure morphogenesis | 0.0197832759713202 |
GO:0000902 | cell morphogenesis | 0.0197832759713202 |
GO:0031175 | neurite development | 0.020934182437169 |
GO:0009950 | dorsal/ventral axis specification | 0.0209615622830589 |
GO:0030947 | regulation of vascular endothelial growth factor receptor signaling pathway | 0.0209615622830589 |
GO:0007420 | brain development | 0.0211110636785166 |
GO:0042330 | taxis | 0.0215622815095724 |
GO:0006935 | chemotaxis | 0.0215622815095724 |
GO:0045595 | regulation of cell differentiation | 0.0215622815095724 |
GO:0016055 | Wnt receptor signaling pathway | 0.0215622815095724 |
GO:0048514 | blood vessel morphogenesis | 0.0216542255060573 |
GO:0009986 | cell surface | 0.0216542255060573 |
GO:0030296 | protein tyrosine kinase activator activity | 0.0216542255060573 |
GO:0042462 | eye photoreceptor cell development | 0.0216542255060573 |
GO:0015272 | ATP-activated inward rectifier potassium channel activity | 0.0216542255060573 |
GO:0048666 | neuron development | 0.021871863817229 |
GO:0048523 | negative regulation of cellular process | 0.021871863817229 |
GO:0048513 | organ development | 0.021871863817229 |
GO:0021543 | pallium development | 0.021871863817229 |
GO:0010092 | specification of organ identity | 0.021871863817229 |
GO:0001754 | eye photoreceptor cell differentiation | 0.021871863817229 |
GO:0048566 | embryonic gut development | 0.021871863817229 |
GO:0005104 | fibroblast growth factor receptor binding | 0.021871863817229 |
GO:0001759 | induction of an organ | 0.021871863817229 |
GO:0001974 | blood vessel remodeling | 0.021871863817229 |
GO:0048259 | regulation of receptor-mediated endocytosis | 0.021871863817229 |
GO:0001568 | blood vessel development | 0.021871863817229 |
GO:0001944 | vasculature development | 0.0221309968842317 |
GO:0048519 | negative regulation of biological process | 0.0223114032265178 |
GO:0005634 | nucleus | 0.0223114032265178 |
GO:0031128 | induction | 0.0223114032265178 |
GO:0035272 | exocrine system development | 0.0223114032265178 |
GO:0045168 | cell-cell signaling during cell fate commitment | 0.0223114032265178 |
GO:0042461 | photoreceptor cell development | 0.0223114032265178 |
GO:0051145 | smooth muscle cell differentiation | 0.0223114032265178 |
GO:0050930 | induction of positive chemotaxis | 0.0223114032265178 |
GO:0042221 | response to chemical stimulus | 0.0223114032265178 |
GO:0007626 | locomotory behavior | 0.0234294788141137 |
GO:0006950 | response to stress | 0.0234345336193008 |
GO:0050926 | regulation of positive chemotaxis | 0.0259560297700271 |
GO:0046530 | photoreceptor cell differentiation | 0.0259560297700271 |
GO:0050927 | positive regulation of positive chemotaxis | 0.0259560297700271 |
GO:0050918 | positive chemotaxis | 0.0259560297700271 |
GO:0032990 | cell part morphogenesis | 0.0261868381351817 |
GO:0048858 | cell projection morphogenesis | 0.0261868381351817 |
GO:0030030 | cell projection organization and biogenesis | 0.0261868381351817 |
GO:0045665 | negative regulation of neuron differentiation | 0.0261868381351817 |
GO:0048565 | gut development | 0.0261868381351817 |
GO:0021983 | pituitary gland development | 0.0261868381351817 |
GO:0050921 | positive regulation of chemotaxis | 0.0261868381351817 |
GO:0021537 | telencephalon development | 0.0261868381351817 |
GO:0048010 | vascular endothelial growth factor receptor signaling pathway | 0.0261868381351817 |
GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 0.0269822242495383 |
GO:0050920 | regulation of chemotaxis | 0.0275485218398447 |
GO:0021536 | diencephalon development | 0.0275485218398447 |
GO:0030295 | protein kinase activator activity | 0.0275485218398447 |
GO:0007601 | visual perception | 0.0289773842701976 |
GO:0050953 | sensory perception of light stimulus | 0.0289773842701976 |
GO:0050772 | positive regulation of axonogenesis | 0.0289773842701976 |
GO:0008285 | negative regulation of cell proliferation | 0.0289773842701976 |
GO:0007399 | nervous system development | 0.03021425911993 |
GO:0048663 | neuron fate commitment | 0.03021425911993 |
GO:0005625 | soluble fraction | 0.03021425911993 |
GO:0007417 | central nervous system development | 0.03021425911993 |
GO:0009790 | embryonic development | 0.03021425911993 |
GO:0008543 | fibroblast growth factor receptor signaling pathway | 0.0331680580880202 |
GO:0042383 | sarcolemma | 0.0331680580880202 |
GO:0050769 | positive regulation of neurogenesis | 0.0331680580880202 |
GO:0050679 | positive regulation of epithelial cell proliferation | 0.0361368433285746 |
GO:0009798 | axis specification | 0.0361368433285746 |
GO:0045807 | positive regulation of endocytosis | 0.0361368433285746 |
GO:0019209 | kinase activator activity | 0.0361368433285746 |
GO:0001657 | ureteric bud development | 0.0369869110297901 |
GO:0004859 | phospholipase inhibitor activity | 0.0369869110297901 |
GO:0016998 | cell wall catabolic process | 0.0369869110297901 |
GO:0055102 | lipase inhibitor activity | 0.0369869110297901 |
GO:0010382 | cell wall metabolic process | 0.0378399979117725 |
GO:0048568 | embryonic organ development | 0.0378399979117725 |
GO:0007047 | cell wall organization and biogenesis | 0.0378399979117725 |
GO:0007166 | cell surface receptor linked signal transduction | 0.0378399979117725 |
GO:0000060 | protein import into nucleus, translocation | 0.0406515262191312 |
GO:0001533 | cornified envelope | 0.0406515262191312 |
GO:0045229 | external encapsulating structure organization and biogenesis | 0.0406515262191312 |
GO:0043229 | intracellular organelle | 0.0408042810139765 |
GO:0043226 | organelle | 0.0408042810139765 |
GO:0007167 | enzyme linked receptor protein signaling pathway | 0.0410990211796084 |
GO:0001656 | metanephros development | 0.0430911822645252 |
GO:0048592 | eye morphogenesis | 0.0447898115022178 |
GO:0043624 | cellular protein complex disassembly | 0.0447898115022178 |
GO:0005242 | inward rectifier potassium channel activity | 0.0447898115022178 |
GO:0018149 | peptide cross-linking | 0.0447898115022178 |
GO:0050770 | regulation of axonogenesis | 0.0447898115022178 |
GO:0045664 | regulation of neuron differentiation | 0.0447898115022178 |
GO:0042472 | inner ear morphogenesis | 0.0458876775950725 |
GO:0043241 | protein complex disassembly | 0.0458876775950725 |
GO:0005003 | ephrin receptor activity | 0.0463540943469556 |
GO:0032984 | macromolecular complex disassembly | 0.0463540943469556 |
GO:0048754 | branching morphogenesis of a tube | 0.0463540943469556 |
GO:0009953 | dorsal/ventral pattern formation | 0.0463540943469556 |
GO:0001709 | cell fate determination | 0.0476904902705381 |
GO:0030216 | keratinocyte differentiation | 0.0487008291420214 |
GO:0050678 | regulation of epithelial cell proliferation | 0.0487008291420214 |
GO:0042471 | ear morphogenesis | 0.0496910683309607 |
GO:0050789 | regulation of biological process | 0.0496910683309607 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br>disease_data<br>
Ontology term | p-value | n |
---|---|---|
stomach | 5.22e-26 | 8 |
food storage organ | 5.22e-26 | 8 |
gastrointestinal system | 4.34e-09 | 25 |
Ontology term | p-value | n |
---|---|---|
gastrointestinal system cancer | 1.43e-15 | 14 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
MA0003.1 | 1.6408e-13 |
MA0004.1 | 0.0880421 |
MA0006.1 | 0.090674 |
MA0007.1 | 0.034381 |
MA0009.1 | 0.523217 |
MA0014.1 | 6.16736e-13 |
MA0017.1 | 0.0410081 |
MA0019.1 | 0.063436 |
MA0024.1 | 0.0122036 |
MA0025.1 | 0.0635465 |
MA0027.1 | 1.21268 |
MA0028.1 | 0.00547973 |
MA0029.1 | 1.22888 |
MA0030.1 | 0.166157 |
MA0031.1 | 0.399876 |
MA0038.1 | 0.777194 |
MA0040.1 | 0.184549 |
MA0041.1 | 0.286501 |
MA0042.1 | 0.431236 |
MA0043.1 | 0.0283808 |
MA0046.1 | 0.0262004 |
MA0048.1 | 0.115614 |
MA0050.1 | 0.12965 |
MA0051.1 | 0.0356931 |
MA0052.1 | 0.0157591 |
MA0055.1 | 4.91754 |
MA0056.1 | 0 |
MA0057.1 | 0.500865 |
MA0058.1 | 0.00764348 |
MA0059.1 | 0.00741391 |
MA0060.1 | 1.01227 |
MA0061.1 | 0.0990787 |
MA0063.1 | 0 |
MA0066.1 | 0.0133942 |
MA0067.1 | 0.141036 |
MA0068.1 | 0.303213 |
MA0069.1 | 1.14913 |
MA0070.1 | 1.10491 |
MA0071.1 | 0.10507 |
MA0072.1 | 0.242588 |
MA0073.1 | 0.00564634 |
MA0074.1 | 0.0791867 |
MA0076.1 | 0.048049 |
MA0077.1 | 0.719265 |
MA0078.1 | 0.52131 |
MA0081.1 | 0.166228 |
MA0083.1 | 0.122916 |
MA0084.1 | 0.250798 |
MA0087.1 | 0.453383 |
MA0088.1 | 1.27905e-05 |
MA0089.1 | 0 |
MA0090.1 | 0.0321478 |
MA0091.1 | 2.51395 |
MA0092.1 | 0.158307 |
MA0093.1 | 0.0184035 |
MA0095.1 | 0 |
MA0098.1 | 0 |
MA0100.1 | 0.29444 |
MA0101.1 | 0.220153 |
MA0103.1 | 0.0757244 |
MA0105.1 | 0.00281665 |
MA0106.1 | 0.363729 |
MA0107.1 | 0.22821 |
MA0108.2 | 1.57021 |
MA0109.1 | 0 |
MA0111.1 | 0.292644 |
MA0113.1 | 0.00775359 |
MA0114.1 | 0.0708963 |
MA0115.1 | 0.104885 |
MA0116.1 | 0.0107499 |
MA0117.1 | 0.144788 |
MA0119.1 | 0.00498388 |
MA0122.1 | 0.670075 |
MA0124.1 | 0.295135 |
MA0125.1 | 0.210495 |
MA0130.1 | 0 |
MA0131.1 | 0.0512401 |
MA0132.1 | 0 |
MA0133.1 | 0 |
MA0135.1 | 0.929977 |
MA0136.1 | 0.1682 |
MA0139.1 | 0.000370528 |
MA0140.1 | 1.25886 |
MA0141.1 | 0.033883 |
MA0142.1 | 3.61003 |
MA0143.1 | 1.0853 |
MA0144.1 | 0.0176986 |
MA0145.1 | 0.110002 |
MA0146.1 | 1.65122e-12 |
MA0147.1 | 0.0614267 |
MA0148.1 | 0.598257 |
MA0149.1 | 0.161596 |
MA0062.2 | 8.82784e-06 |
MA0035.2 | 0.581732 |
MA0039.2 | 0.00158182 |
MA0138.2 | 0.343018 |
MA0002.2 | 0.0336681 |
MA0137.2 | 0.198064 |
MA0104.2 | 0.0183476 |
MA0047.2 | 0.113143 |
MA0112.2 | 0.000670387 |
MA0065.2 | 0.15664 |
MA0150.1 | 0.0968546 |
MA0151.1 | 0 |
MA0152.1 | 1.04764 |
MA0153.1 | 0.0526728 |
MA0154.1 | 0.0456202 |
MA0155.1 | 0.00112655 |
MA0156.1 | 0.794686 |
MA0157.1 | 1.59076 |
MA0158.1 | 0 |
MA0159.1 | 0.342605 |
MA0160.1 | 0.015487 |
MA0161.1 | 0 |
MA0162.1 | 0.0133656 |
MA0163.1 | 9.29456e-09 |
MA0164.1 | 0.881882 |
MA0080.2 | 0.0346526 |
MA0018.2 | 0.00627871 |
MA0099.2 | 0.0558283 |
MA0079.2 | 2.73977e-10 |
MA0102.2 | 0.275729 |
MA0258.1 | 0.00334227 |
MA0259.1 | 0.161276 |
MA0442.1 | 0 |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
No analysis results for this cluster
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data