Coexpression cluster:C101: Difference between revisions
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Latest revision as of 10:31, 17 September 2013
Full id: C101_small_cerebellum_maxillary_colon_parietal_epididymis_merkel
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
No results for this coexpression
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0016481 | negative regulation of transcription | 0.00569544948163178 |
GO:0045934 | negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.00569544948163178 |
GO:0031324 | negative regulation of cellular metabolic process | 0.00755964970404332 |
GO:0009892 | negative regulation of metabolic process | 0.00952977996252333 |
GO:0016564 | transcription repressor activity | 0.0151647357180119 |
GO:0007275 | multicellular organismal development | 0.0151647357180119 |
GO:0048523 | negative regulation of cellular process | 0.0157689292058636 |
GO:0006355 | regulation of transcription, DNA-dependent | 0.0157689292058636 |
GO:0004363 | glutathione synthase activity | 0.0157689292058636 |
GO:0048519 | negative regulation of biological process | 0.0157689292058636 |
GO:0006351 | transcription, DNA-dependent | 0.0157689292058636 |
GO:0032774 | RNA biosynthetic process | 0.0157689292058636 |
GO:0045449 | regulation of transcription | 0.021642745754459 |
GO:0019219 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.0223548243104183 |
GO:0006350 | transcription | 0.0241386646810479 |
GO:0010468 | regulation of gene expression | 0.0241386646810479 |
GO:0042742 | defense response to bacterium | 0.0254107438310059 |
GO:0031323 | regulation of cellular metabolic process | 0.0254107438310059 |
GO:0003700 | transcription factor activity | 0.0261464457060413 |
GO:0009617 | response to bacterium | 0.0261464457060413 |
GO:0003714 | transcription corepressor activity | 0.0261464457060413 |
GO:0006357 | regulation of transcription from RNA polymerase II promoter | 0.0261464457060413 |
GO:0008134 | transcription factor binding | 0.0261464457060413 |
GO:0019222 | regulation of metabolic process | 0.0261464457060413 |
GO:0016070 | RNA metabolic process | 0.0261464457060413 |
GO:0005497 | androgen binding | 0.0263168210860954 |
GO:0048731 | system development | 0.0263168210860954 |
GO:0044451 | nucleoplasm part | 0.0263168210860954 |
GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | 0.0271229937447896 |
GO:0032502 | developmental process | 0.0281826313299467 |
GO:0008504 | monoamine transmembrane transporter activity | 0.0281826313299467 |
GO:0005515 | protein binding | 0.0295470862423253 |
GO:0015844 | monoamine transport | 0.0310627333598091 |
GO:0065007 | biological regulation | 0.0310627333598091 |
GO:0005654 | nucleoplasm | 0.0310627333598091 |
GO:0050794 | regulation of cellular process | 0.0350130822848958 |
GO:0045843 | negative regulation of striated muscle development | 0.0367532869569296 |
GO:0006750 | glutathione biosynthetic process | 0.0367532869569296 |
GO:0006952 | defense response | 0.0386664540593856 |
GO:0042221 | response to chemical stimulus | 0.0386664540593856 |
GO:0017053 | transcriptional repressor complex | 0.0425549775703636 |
GO:0032501 | multicellular organismal process | 0.0425615836320144 |
GO:0048856 | anatomical structure development | 0.0427035378600283 |
GO:0006366 | transcription from RNA polymerase II promoter | 0.0427035378600283 |
GO:0045892 | negative regulation of transcription, DNA-dependent | 0.0427035378600283 |
GO:0051707 | response to other organism | 0.0427035378600283 |
GO:0050789 | regulation of biological process | 0.0427035378600283 |
GO:0005667 | transcription factor complex | 0.0427035378600283 |
GO:0050832 | defense response to fungus | 0.0427035378600283 |
GO:0016202 | regulation of striated muscle development | 0.0451811701326321 |
GO:0045893 | positive regulation of transcription, DNA-dependent | 0.0451811701326321 |
GO:0031981 | nuclear lumen | 0.0451811701326321 |
GO:0050821 | protein stabilization | 0.0451811701326321 |
GO:0016566 | specific transcriptional repressor activity | 0.0451811701326321 |
GO:0007417 | central nervous system development | 0.0472137525682012 |
GO:0007399 | nervous system development | 0.0472205833852633 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br><br>disease_data<br>
Ontology term | p-value | n |
---|---|---|
gastrointestinal system cancer | 1.43e-15 | 14 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
MA0003.1 | 7.69492e-11 |
MA0004.1 | 0.159109 |
MA0006.1 | 0.0276228 |
MA0007.1 | 0.00758216 |
MA0009.1 | 0.230395 |
MA0014.1 | 0.000257282 |
MA0017.1 | 0.407385 |
MA0019.1 | 0.280616 |
MA0024.1 | 0.00834808 |
MA0025.1 | 0.0508445 |
MA0027.1 | 1.17088 |
MA0028.1 | 5.20988e-05 |
MA0029.1 | 0.283019 |
MA0030.1 | 1.00467 |
MA0031.1 | 0.509526 |
MA0038.1 | 1.58106 |
MA0040.1 | 0.49966 |
MA0041.1 | 0.418658 |
MA0042.1 | 0.0800612 |
MA0043.1 | 0.230781 |
MA0046.1 | 1.00819 |
MA0048.1 | 0.00214898 |
MA0050.1 | 0.0439313 |
MA0051.1 | 0.0516032 |
MA0052.1 | 2.81862 |
MA0055.1 | 1.34265 |
MA0056.1 | 0 |
MA0057.1 | 0.169929 |
MA0058.1 | 0.101998 |
MA0059.1 | 0.680448 |
MA0060.1 | 0.100572 |
MA0061.1 | 0.120245 |
MA0063.1 | 0 |
MA0066.1 | 0.108255 |
MA0067.1 | 0.120593 |
MA0068.1 | 0.195194 |
MA0069.1 | 0.409295 |
MA0070.1 | 0.199806 |
MA0071.1 | 1.02283 |
MA0072.1 | 0.935637 |
MA0073.1 | 0.157071 |
MA0074.1 | 0.178554 |
MA0076.1 | 0.000105735 |
MA0077.1 | 1.26265 |
MA0078.1 | 0.146979 |
MA0081.1 | 0.100104 |
MA0083.1 | 0.0222755 |
MA0084.1 | 1.85487 |
MA0087.1 | 1.69669 |
MA0088.1 | 0.00218164 |
MA0089.1 | 0 |
MA0090.1 | 0.0620445 |
MA0091.1 | 1.03551 |
MA0092.1 | 0.768585 |
MA0093.1 | 0.123166 |
MA0095.1 | 0 |
MA0098.1 | 0 |
MA0100.1 | 0.88216 |
MA0101.1 | 0.0869499 |
MA0103.1 | 1.38985 |
MA0105.1 | 0.00256899 |
MA0106.1 | 0.0875563 |
MA0107.1 | 0.126741 |
MA0108.2 | 1.7051 |
MA0109.1 | 0 |
MA0111.1 | 0.515491 |
MA0113.1 | 0.0481672 |
MA0114.1 | 0.278683 |
MA0115.1 | 1.52825 |
MA0116.1 | 0.000264579 |
MA0117.1 | 0.115848 |
MA0119.1 | 2.20539 |
MA0122.1 | 0.133843 |
MA0124.1 | 0.537011 |
MA0125.1 | 1.07668 |
MA0130.1 | 0 |
MA0131.1 | 0.0858033 |
MA0132.1 | 0 |
MA0133.1 | 0 |
MA0135.1 | 1.16789 |
MA0136.1 | 0.0254218 |
MA0139.1 | 0.0821274 |
MA0140.1 | 0.439295 |
MA0141.1 | 1.64345 |
MA0142.1 | 0.257899 |
MA0143.1 | 0.190264 |
MA0144.1 | 0.0342575 |
MA0145.1 | 0.0354926 |
MA0146.1 | 5.51049e-05 |
MA0147.1 | 0.14738 |
MA0148.1 | 1.20881 |
MA0149.1 | 3.44287 |
MA0062.2 | 1.06191e-08 |
MA0035.2 | 1.0004 |
MA0039.2 | 4.59423e-06 |
MA0138.2 | 0.411 |
MA0002.2 | 0.0206252 |
MA0137.2 | 0.428733 |
MA0104.2 | 0.135412 |
MA0047.2 | 0.96816 |
MA0112.2 | 0.0724126 |
MA0065.2 | 0.117626 |
MA0150.1 | 0.006191 |
MA0151.1 | 0 |
MA0152.1 | 0.324961 |
MA0153.1 | 0.367106 |
MA0154.1 | 0.144725 |
MA0155.1 | 0.131308 |
MA0156.1 | 7.36716e-05 |
MA0157.1 | 0.356399 |
MA0158.1 | 0 |
MA0159.1 | 0.203928 |
MA0160.1 | 0.506519 |
MA0161.1 | 0 |
MA0162.1 | 6.87494e-05 |
MA0163.1 | 0.0021058 |
MA0164.1 | 1.51769 |
MA0080.2 | 0.00138785 |
MA0018.2 | 0.0403392 |
MA0099.2 | 0.0717401 |
MA0079.2 | 1.1942e-06 |
MA0102.2 | 0.247412 |
MA0258.1 | 0.170987 |
MA0259.1 | 0.495412 |
MA0442.1 | 0 |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
No analysis results for this cluster
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data