Novel motif:139

name:	motif139_CGTTCGAATT

Association to promoter expression in human samples<b>Summary:</b>Significance of the correlation with CAGE expression, human <br><b>Analyst:</b> Michiel de Hoon<br><br>link to source dataset <br>data

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Association to promoter expression in mouse samples <b>Summary:</b>Significance of the correlation with CAGE expression, mouse <br><b>Analyst:</b> Michiel de Hoon<br><br>link to source dataset <br>data

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GREAT analysis results for human <b>Summary:</b>Genomic Enrichment of Annotations Tool (GREAT, Nat Biotechnol. 2010 May;28(5):495-501) is used to identify, both in human and in mouse, the gene ontology terms of biological processes enriched given the predicted TFBSs, and evaluated the overlap in the top-500 gene ontology terms between human and mouse. For each novel motif, the P value for the overlap was then evaluated by calculating its relative rank with respect to this background distribution.<br>Analyst: Michiel de Hoon<br><br>link to source dataset <br>data

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GO ID	GO Term	p-value
GO:0048670	regulation of collateral sprouting	2.159285e-14
GO:0048671	negative regulation of collateral sprouting	4.539451e-14
GO:0070145	mitochondrial asparaginyl-tRNA aminoacylation	5.589721e-11
GO:0048672	positive regulation of collateral sprouting	4.492443e-10
GO:2000119	negative regulation of sodium-dependent phosphate transport	5.274307e-10
GO:0010994	free ubiquitin chain polymerization	1.543379e-9
GO:0048685	negative regulation of collateral sprouting of intact axon in response to injury	9.801539e-9
GO:0010966	regulation of phosphate transport	1.045599e-8
GO:0009597	detection of virus	1.087108e-8
GO:0072009	nephron epithelium development	1.661643e-8
GO:0032463	negative regulation of protein homooligomerization	2.280360e-8
GO:0018192	enzyme active site formation via L-cysteine persulfide	2.792470e-8
GO:0032543	mitochondrial translation	3.325629e-8
GO:0008406	gonad development	3.832658e-8
GO:0048643	positive regulation of skeletal muscle tissue development	3.843414e-8
GO:0090090	negative regulation of canonical Wnt receptor signaling pathway	3.860439e-8
GO:0048683	regulation of collateral sprouting of intact axon in response to injury	4.303617e-8
GO:0072001	renal system development	4.380123e-8
GO:0042696	menarche	4.387002e-8
GO:0050909	sensory perception of taste	5.646621e-8
GO:0022601	menstrual cycle phase	6.775735e-8
GO:0060236	regulation of mitotic spindle organization	7.433500e-8
GO:0000088	mitotic prophase	8.463566e-8
GO:0051817	modification of morphology or physiology of other organism involved in symbiotic interaction	9.232142e-8
GO:0051293	establishment of spindle localization	1.092071e-7
GO:0007100	mitotic centrosome separation	1.542755e-7
GO:0045137	development of primary sexual characteristics	1.809058e-7
GO:0061326	renal tubule development	1.852587e-7
GO:0000132	establishment of mitotic spindle orientation	2.024440e-7
GO:0061333	renal tubule morphogenesis	2.139557e-7
GO:2001013	epithelial cell proliferation involve in renal tubule morphogenesis	2.306043e-7
GO:0071498	cellular response to fluid shear stress	2.306043e-7
GO:0045884	regulation of survival gene product expression	2.662460e-7
GO:0007548	sex differentiation	2.894523e-7
GO:0035987	endodermal cell differentiation	2.920384e-7
GO:0060561	apoptosis involved in morphogenesis	3.469170e-7
GO:2000121	regulation of removal of superoxide radicals	3.754333e-7
GO:0072073	kidney epithelium development	3.846273e-7
GO:0040001	establishment of mitotic spindle localization	4.044725e-7
GO:0072160	nephron tubule epithelial cell differentiation	4.508680e-7
GO:0003127	detection of nodal flow	4.530226e-7
GO:0043393	regulation of protein binding	4.957496e-7
GO:0042100	B cell proliferation	5.006343e-7
GO:0021759	globus pallidus development	5.523510e-7
GO:0006284	base-excision repair	6.052660e-7
GO:0048640	negative regulation of developmental growth	6.403226e-7
GO:0071895	odontoblast differentiation	6.609525e-7
GO:0042113	B cell activation	6.764312e-7
GO:0048853	forebrain morphogenesis	6.871527e-7
GO:2000171	negative regulation of dendrite development	7.608989e-7
GO:0043921	modulation by host of viral transcription	7.694370e-7
GO:0033603	positive regulation of dopamine secretion	8.398013e-7
GO:0033566	gamma-tubulin complex localization	1.014628e-6
GO:0006499	N-terminal protein myristoylation	1.032727e-6
GO:0070127	tRNA aminoacylation for mitochondrial protein translation	1.054938e-6
GO:0033205	cell cycle cytokinesis	1.167804e-6
GO:2000822	regulation of behavioral fear response	1.209740e-6
GO:2000727	positive regulation of cardiac muscle cell differentiation	1.452867e-6
GO:2000987	positive regulation of behavioral fear response	1.452867e-6
GO:0035984	cellular response to trichostatin A	1.452867e-6
GO:0003185	sinoatrial valve morphogenesis	1.452867e-6
GO:0003138	primary heart field specification	1.452867e-6
GO:0030223	neutrophil differentiation	1.452867e-6
GO:0001822	kidney development	1.842393e-6
GO:0045606	positive regulation of epidermal cell differentiation	1.859314e-6
GO:0071236	cellular response to antibiotic	1.972807e-6
GO:0048069	eye pigmentation	2.081103e-6
GO:0009726	detection of endogenous stimulus	2.097607e-6
GO:0072080	nephron tubule development	2.118882e-6
GO:0051303	establishment of chromosome localization	2.409349e-6
GO:0035404	histone-serine phosphorylation	2.470103e-6
GO:0052312	modulation of transcription in other organism involved in symbiotic interaction	2.495835e-6
GO:0045063	T-helper 1 cell differentiation	3.339804e-6
GO:0001837	epithelial to mesenchymal transition	3.619931e-6
GO:0034346	positive regulation of type III interferon production	3.641432e-6
GO:0032225	regulation of synaptic transmission, dopaminergic	3.699710e-6
GO:0045844	positive regulation of striated muscle tissue development	3.768492e-6
GO:0072006	nephron development	3.800482e-6
GO:0010977	negative regulation of neuron projection development	3.907255e-6
GO:0072272	proximal/distal pattern formation involved in metanephric nephron development	4.203348e-6
GO:0030518	steroid hormone receptor signaling pathway	4.206862e-6
GO:0048341	paraxial mesoderm formation	4.314044e-6
GO:0032714	negative regulation of interleukin-5 production	4.706784e-6
GO:0071896	protein localization to adherens junction	4.892288e-6
GO:0060485	mesenchyme development	5.036696e-6
GO:0006421	asparaginyl-tRNA aminoacylation	5.050067e-6
GO:0021943	formation of radial glial scaffolds	5.183040e-6
GO:0071899	negative regulation of estrogen receptor binding	6.223427e-6
GO:0006972	hyperosmotic response	6.394302e-6
GO:0046898	response to cycloheximide	6.538522e-6
GO:0051488	activation of anaphase-promoting complex activity	6.538522e-6
GO:0032462	regulation of protein homooligomerization	6.637399e-6
GO:0061153	trachea gland development	7.096385e-6
GO:0030521	androgen receptor signaling pathway	7.138319e-6
GO:0021771	lateral geniculate nucleus development	7.280278e-6
GO:0043496	regulation of protein homodimerization activity	7.622315e-6
GO:0044403	symbiosis, encompassing mutualism through parasitism	8.409937e-6
GO:0010719	negative regulation of epithelial to mesenchymal transition	8.982380e-6
GO:0001655	urogenital system development	9.785132e-6
GO:0031507	heterochromatin formation	1.012978e-5
GO:2000111	positive regulation of macrophage apoptosis	1.058675e-5
GO:0032696	negative regulation of interleukin-13 production	1.067180e-5
GO:0032647	regulation of interferon-alpha production	1.227896e-5
GO:0046697	decidualization	1.275077e-5
GO:0030890	positive regulation of B cell proliferation	1.289135e-5
GO:2000725	regulation of cardiac muscle cell differentiation	1.410365e-5
GO:0010458	exit from mitosis	1.425355e-5
GO:0042538	hyperosmotic salinity response	1.425355e-5
GO:0044068	modulation by symbiont of host cellular process	1.446452e-5
GO:0008584	male gonad development	1.657383e-5
GO:0030501	positive regulation of bone mineralization	1.859654e-5
GO:0048608	reproductive structure development	1.861037e-5
GO:0030178	negative regulation of Wnt receptor signaling pathway	1.892329e-5
GO:0030308	negative regulation of cell growth	1.924616e-5
GO:0071864	positive regulation of cell proliferation in bone marrow	2.034034e-5
GO:0071866	negative regulation of apoptosis in bone marrow	2.034034e-5
GO:0030010	establishment of cell polarity	2.179995e-5
GO:0032226	positive regulation of synaptic transmission, dopaminergic	2.206091e-5
GO:0048762	mesenchymal cell differentiation	2.257831e-5
GO:0002092	positive regulation of receptor internalization	2.297479e-5
GO:0085029	extracellular matrix assembly	2.422231e-5
GO:2000109	regulation of macrophage apoptosis	2.426742e-5
GO:0007598	blood coagulation, extrinsic pathway	2.426742e-5
GO:0060009	Sertoli cell development	2.478386e-5
GO:0033605	positive regulation of catecholamine secretion	2.478386e-5
GO:0021784	postganglionic parasympathetic nervous system development	2.610516e-5
GO:0021932	hindbrain radial glia guided cell migration	2.646530e-5
GO:0030279	negative regulation of ossification	2.662884e-5
GO:2001033	negative regulation of double-strand break repair via nonhomologous end joining	2.881164e-5
GO:2001038	regulation of cellular response to drug	2.881164e-5
GO:2000685	positive regulation of cellular response to X-ray	2.881164e-5
GO:0035978	histone H2A-S139 phosphorylation	2.881164e-5
GO:0031052	chromosome breakage	2.881164e-5
GO:0003131	mesodermal-endodermal cell signaling	2.881164e-5
GO:0060025	regulation of synaptic activity	2.883292e-5
GO:0010771	negative regulation of cell morphogenesis involved in differentiation	2.973358e-5
GO:0010694	positive regulation of alkaline phosphatase activity	3.001696e-5
GO:0060008	Sertoli cell differentiation	3.013390e-5
GO:0034227	tRNA thio-modification	3.074032e-5
GO:0002098	tRNA wobble uridine modification	3.074032e-5
GO:2000108	positive regulation of leukocyte apoptosis	3.115279e-5
GO:0045354	regulation of interferon-alpha biosynthetic process	3.138105e-5
GO:0000236	mitotic prometaphase	3.234770e-5
GO:0048854	brain morphogenesis	3.334716e-5
GO:0051301	cell division	3.399006e-5
GO:0021670	lateral ventricle development	3.642739e-5
GO:0070169	positive regulation of biomineral tissue development	3.832300e-5
GO:0006498	N-terminal protein lipidation	3.892052e-5
GO:0045778	positive regulation of ossification	3.957424e-5
GO:0021536	diencephalon development	3.974950e-5
GO:0021798	forebrain dorsal/ventral pattern formation	4.361281e-5
GO:0050912	detection of chemical stimulus involved in sensory perception of taste	4.631149e-5
GO:0071894	histone H2B conserved C-terminal lysine ubiquitination	4.886226e-5
GO:0000087	M phase of mitotic cell cycle	4.967791e-5
GO:0046651	lymphocyte proliferation	5.231715e-5
GO:0051640	organelle localization	5.304177e-5
GO:0021879	forebrain neuron differentiation	5.351792e-5
GO:0010717	regulation of epithelial to mesenchymal transition	6.240902e-5
GO:0003139	secondary heart field specification	6.767621e-5
GO:0003211	cardiac ventricle formation	6.959628e-5
GO:0030220	platelet formation	7.006263e-5
GO:0021591	ventricular system development	7.132024e-5
GO:0030517	negative regulation of axon extension	7.164011e-5
GO:2001016	positive regulation of skeletal muscle cell differentiation	7.496335e-5
GO:0034123	positive regulation of toll-like receptor signaling pathway	7.719718e-5
GO:0030968	endoplasmic reticulum unfolded protein response	8.034835e-5
GO:0051580	regulation of neurotransmitter uptake	8.204911e-5
GO:0007164	establishment of tissue polarity	8.463812e-5
GO:0072102	glomerulus morphogenesis	8.642414e-5
GO:0048285	organelle fission	8.713084e-5
GO:0007098	centrosome cycle	8.827486e-5
GO:0035690	cellular response to drug	8.827486e-5
GO:0071374	cellular response to parathyroid hormone stimulus	9.339309e-5
GO:0033577	protein glycosylation in endoplasmic reticulum	9.439138e-5
GO:0030704	vitelline membrane formation	9.439138e-5
GO:0045356	positive regulation of interferon-alpha biosynthetic process	9.689611e-5
GO:0035412	regulation of catenin import into nucleus	1.011296e-4
GO:0008634	negative regulation of survival gene product expression	1.015772e-4
GO:0060828	regulation of canonical Wnt receptor signaling pathway	1.056813e-4
GO:0090224	regulation of spindle organization	1.061532e-4
GO:0030851	granulocyte differentiation	1.088882e-4
GO:0051851	modification by host of symbiont morphology or physiology	1.146835e-4
GO:0052572	response to host immune response	1.155586e-4
GO:0007442	hindgut morphogenesis	1.182039e-4
GO:0001738	morphogenesis of a polarized epithelium	1.229567e-4
GO:0090073	positive regulation of protein homodimerization activity	1.238782e-4
GO:0048286	lung alveolus development	1.268244e-4
GO:0009615	response to virus	1.298759e-4
GO:0001736	establishment of planar polarity	1.326809e-4
GO:0051299	centrosome separation	1.338821e-4
GO:0035803	egg coat formation	1.339984e-4
GO:0006626	protein targeting to mitochondrion	1.341135e-4
GO:0044003	modification by symbiont of host morphology or physiology	1.377720e-4
GO:0045738	negative regulation of DNA repair	1.384785e-4
GO:0051702	interaction with symbiont	1.394311e-4
GO:0007050	cell cycle arrest	1.415136e-4
GO:0000281	cytokinesis after mitosis	1.427627e-4
GO:0014031	mesenchymal cell development	1.440504e-4
GO:0055005	ventricular cardiac myofibril development	1.468771e-4
GO:2001014	regulation of skeletal muscle cell differentiation	1.493339e-4
GO:0002293	alpha-beta T cell differentiation involved in immune response	1.496408e-4
GO:0090005	negative regulation of establishment of protein localization in plasma membrane	1.515508e-4
GO:0072268	pattern specification involved in metanephros development	1.560771e-4
GO:0021892	cerebral cortex GABAergic interneuron differentiation	1.658015e-4
GO:0048340	paraxial mesoderm morphogenesis	1.663792e-4
GO:0007067	mitosis	1.729102e-4
GO:0035262	gonad morphogenesis	1.753757e-4
GO:0035988	chondrocyte proliferation	1.786346e-4
GO:0034629	cellular protein complex localization	1.786346e-4
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	1.806635e-4
GO:0010692	regulation of alkaline phosphatase activity	1.835113e-4
GO:0030888	regulation of B cell proliferation	1.885135e-4
GO:0033523	histone H2B ubiquitination	1.890741e-4
GO:0048484	enteric nervous system development	1.899835e-4
GO:0045869	negative regulation of retroviral genome replication	1.940006e-4
GO:0009566	fertilization	2.019142e-4
GO:0007492	endoderm development	2.089321e-4
GO:0051098	regulation of binding	2.116316e-4
GO:0032459	regulation of protein oligomerization	2.152093e-4
GO:0043331	response to dsRNA	2.156237e-4
GO:0046546	development of primary male sexual characteristics	2.205551e-4
GO:2000648	positive regulation of stem cell proliferation	2.280401e-4
GO:0071360	cellular response to exogenous dsRNA	2.280401e-4
GO:0070646	protein modification by small protein removal	2.325389e-4
GO:0007005	mitochondrion organization	2.328682e-4
GO:0046543	development of secondary female sexual characteristics	2.460415e-4
GO:0052033	pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity	2.468332e-4
GO:0043990	histone H2A-S1 phosphorylation	2.471022e-4
GO:0032943	mononuclear cell proliferation	2.476889e-4
GO:0051656	establishment of organelle localization	2.509038e-4
GO:0010350	cellular response to magnesium starvation	2.535088e-4
GO:0045627	positive regulation of T-helper 1 cell differentiation	2.545165e-4
GO:0034261	negative regulation of Ras GTPase activity	2.545165e-4
GO:0031508	centromeric heterochromatin formation	2.570691e-4
GO:0048681	negative regulation of axon regeneration	2.610996e-4
GO:0070681	glutaminyl-tRNAGln biosynthesis via transamidation	2.673670e-4
GO:0072070	loop of Henle development	2.707053e-4
GO:0071107	response to parathyroid hormone stimulus	2.707053e-4
GO:0060430	lung saccule development	2.877536e-4
GO:0010623	developmental programmed cell death	2.933035e-4
GO:0061337	cardiac conduction	3.056972e-4
GO:0035269	protein O-linked mannosylation	3.073827e-4
GO:0031128	developmental induction	3.116107e-4
GO:0035850	epithelial cell differentiation involved in kidney development	3.158876e-4
GO:0032897	negative regulation of viral transcription	3.182802e-4
GO:0021861	forebrain radial glial cell differentiation	3.182802e-4
GO:0090322	regulation of superoxide metabolic process	3.290530e-4
GO:0043473	pigmentation	3.571837e-4
GO:0021678	third ventricle development	3.573083e-4
GO:0003059	positive regulation of the force of heart contraction by epinephrine	3.648127e-4
GO:0001893	maternal placenta development	3.663745e-4
GO:0022602	ovulation cycle process	3.719528e-4
GO:0030500	regulation of bone mineralization	3.818436e-4
GO:0021895	cerebral cortex neuron differentiation	3.865591e-4
GO:0007512	adult heart development	3.882563e-4
GO:0002282	microglial cell activation involved in immune response	3.885249e-4
GO:2000677	regulation of transcription regulatory region DNA binding	3.951024e-4
GO:0045625	regulation of T-helper 1 cell differentiation	4.071055e-4
GO:0007521	muscle cell fate determination	4.101787e-4
GO:0010770	positive regulation of cell morphogenesis involved in differentiation	4.143739e-4
GO:0090402	oncogene-induced senescence	4.176226e-4
GO:0051298	centrosome duplication	4.196335e-4
GO:0006886	intracellular protein transport	4.221046e-4
GO:0002366	leukocyte activation involved in immune response	4.276627e-4
GO:0006883	cellular sodium ion homeostasis	4.343095e-4
GO:0090101	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	4.421091e-4
GO:0040038	polar body extrusion after meiotic divisions	4.569923e-4
GO:0072088	nephron epithelium morphogenesis	4.618895e-4
GO:0051584	regulation of dopamine uptake	4.812050e-4
GO:0045136	development of secondary sexual characteristics	4.902836e-4
GO:0070727	cellular macromolecule localization	4.922933e-4
GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste	5.006211e-4
GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway	5.035710e-4
GO:0048486	parasympathetic nervous system development	5.168244e-4
GO:0070661	leukocyte proliferation	5.620221e-4
GO:0001714	endodermal cell fate specification	5.655783e-4
GO:0002285	lymphocyte activation involved in immune response	5.657317e-4
GO:0046782	regulation of viral transcription	5.659851e-4
GO:0035967	cellular response to topologically incorrect protein	5.698716e-4
GO:2000820	negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation	5.862249e-4
GO:0071674	mononuclear cell migration	5.862249e-4
GO:0048633	positive regulation of skeletal muscle tissue growth	5.862249e-4
GO:0002825	regulation of T-helper 1 type immune response	5.889745e-4
GO:0045604	regulation of epidermal cell differentiation	5.926780e-4
GO:0042159	lipoprotein catabolic process	5.927062e-4
GO:0046660	female sex differentiation	6.446745e-4
GO:0072086	specification of loop of Henle identity	6.456543e-4
GO:0042093	T-helper cell differentiation	7.100681e-4
GO:0019054	modulation by virus of host cellular process	7.481217e-4
GO:0031109	microtubule polymerization or depolymerization	7.775583e-4
GO:0034613	cellular protein localization	7.877242e-4
GO:0015074	DNA integration	7.977456e-4
GO:0002016	regulation of blood volume by renin-angiotensin	8.035241e-4
GO:0032913	negative regulation of transforming growth factor beta3 production	8.044799e-4
GO:0032600	chemokine receptor transport out of membrane raft	8.044799e-4
GO:0032597	B cell receptor transport into membrane raft	8.044799e-4
GO:0060710	chorio-allantoic fusion	8.131512e-4
GO:0072028	nephron morphogenesis	8.596039e-4
GO:0002286	T cell activation involved in immune response	8.794485e-4
GO:0035413	positive regulation of catenin import into nucleus	8.822339e-4
GO:0001711	endodermal cell fate commitment	9.176730e-4
GO:0043271	negative regulation of ion transport	9.308837e-4
GO:0033153	T cell receptor V(D)J recombination	9.366722e-4
GO:0070167	regulation of biomineral tissue development	9.388489e-4
GO:0007368	determination of left/right symmetry	9.395278e-4
GO:0032713	negative regulation of interleukin-4 production	9.604785e-4
GO:0060084	synaptic transmission involved in micturition	9.767842e-4
GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin	9.849792e-4
GO:0072655	establishment of protein localization in mitochondrion	9.947423e-4
GO:0060033	anatomical structure regression	1.001829e-3
GO:0034421	post-translational protein acetylation	1.021654e-3
GO:0060562	epithelial tube morphogenesis	1.041425e-3
GO:0006471	protein ADP-ribosylation	1.047056e-3
GO:0000045	autophagic vacuole assembly	1.047056e-3
GO:0045168	cell-cell signaling involved in cell fate commitment	1.078750e-3
GO:0021592	fourth ventricle development	1.087980e-3
GO:0035458	cellular response to interferon-beta	1.115956e-3
GO:0001997	positive regulation of the force of heart contraction by epinephrine-norepinephrine	1.115956e-3
GO:0055062	phosphate ion homeostasis	1.118187e-3
GO:0006986	response to unfolded protein	1.118763e-3
GO:0034141	positive regulation of toll-like receptor 3 signaling pathway	1.124695e-3
GO:0048251	elastic fiber assembly	1.124769e-3
GO:0071922	regulation of cohesin localization to chromatin	1.160368e-3
GO:0006270	DNA-dependent DNA replication initiation	1.172786e-3
GO:0050913	sensory perception of bitter taste	1.179276e-3
GO:0071407	cellular response to organic cyclic compound	1.186733e-3
GO:0010092	specification of organ identity	1.191550e-3
GO:0055015	ventricular cardiac muscle cell development	1.199487e-3
GO:0014059	regulation of dopamine secretion	1.203583e-3
GO:0042698	ovulation cycle	1.217687e-3
GO:0046661	male sex differentiation	1.230604e-3
GO:0072108	positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	1.243060e-3
GO:0060154	cellular process regulating host cell cycle in response to virus	1.256532e-3
GO:0051954	positive regulation of amine transport	1.269913e-3
GO:0072283	metanephric renal vesicle morphogenesis	1.274439e-3
GO:0035966	response to topologically incorrect protein	1.295090e-3
GO:0050803	regulation of synapse structure and activity	1.300833e-3
GO:0051026	chiasma assembly	1.312534e-3
GO:0048339	paraxial mesoderm development	1.330515e-3
GO:2000774	positive regulation of cellular senescence	1.331408e-3
GO:0035986	senescence-associated heterochromatin focus formation	1.331408e-3
GO:2000036	regulation of stem cell maintenance	1.334386e-3
GO:0021535	cell migration in hindbrain	1.352564e-3
GO:0070585	protein localization in mitochondrion	1.357622e-3
GO:0043392	negative regulation of DNA binding	1.357622e-3
GO:0070889	platelet alpha granule organization	1.384919e-3
GO:0060914	heart formation	1.395406e-3
GO:0007187	G-protein signaling, coupled to cyclic nucleotide second messenger	1.403767e-3
GO:0090084	negative regulation of inclusion body assembly	1.421188e-3
GO:0072210	metanephric nephron development	1.435400e-3
GO:0007188	G-protein signaling, coupled to cAMP nucleotide second messenger	1.445549e-3
GO:0090308	regulation of methylation-dependent chromatin silencing	1.446962e-3
GO:0007063	regulation of sister chromatid cohesion	1.451464e-3
GO:0010769	regulation of cell morphogenesis involved in differentiation	1.463407e-3
GO:0090007	regulation of mitotic anaphase	1.467714e-3
GO:0042270	protection from natural killer cell mediated cytotoxicity	1.467714e-3
GO:0030111	regulation of Wnt receptor signaling pathway	1.471284e-3
GO:0019348	dolichol metabolic process	1.478924e-3
GO:0030854	positive regulation of granulocyte differentiation	1.504874e-3
GO:0021987	cerebral cortex development	1.528783e-3
GO:0016579	protein deubiquitination	1.553960e-3
GO:0043922	negative regulation by host of viral transcription	1.553963e-3
GO:0003006	developmental process involved in reproduction	1.571859e-3
GO:0046545	development of primary female sexual characteristics	1.572857e-3
GO:0043923	positive regulation by host of viral transcription	1.626302e-3
GO:0003339	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	1.626302e-3
GO:0061350	planar cell polarity pathway involved in cardiac muscle tissue morphogenesis	1.650453e-3
GO:0061354	planar cell polarity pathway involved in pericardium morphogenesis	1.650453e-3
GO:0061349	planar cell polarity pathway involved in cardiac right atrium morphogenesis	1.650453e-3
GO:0061348	planar cell polarity pathway involved in ventricular septum morphogenesis	1.650453e-3
GO:0060210	metestrus	1.650453e-3
GO:0061347	planar cell polarity pathway involved in outflow tract morphogenesis	1.650453e-3
GO:0035694	mitochondrial protein catabolic process	1.660320e-3
GO:0060486	Clara cell differentiation	1.687375e-3
GO:0046649	lymphocyte activation	1.694165e-3
GO:0007223	Wnt receptor signaling pathway, calcium modulating pathway	1.721607e-3
GO:0046329	negative regulation of JNK cascade	1.730289e-3
GO:0045652	regulation of megakaryocyte differentiation	1.748177e-3
GO:0021872	forebrain generation of neurons	1.753557e-3
GO:0045359	positive regulation of interferon-beta biosynthetic process	1.763903e-3
GO:0060021	palate development	1.825309e-3
GO:0010991	negative regulation of SMAD protein complex assembly	1.857514e-3
GO:0002086	diaphragm contraction	1.857514e-3
GO:0070571	negative regulation of neuron projection regeneration	1.859984e-3
GO:0050847	progesterone receptor signaling pathway	1.861204e-3
GO:0001706	endoderm formation	1.909257e-3
GO:0060764	cell-cell signaling involved in mammary gland development	1.925488e-3
GO:0001941	postsynaptic membrane organization	1.943689e-3
GO:0021983	pituitary gland development	1.974141e-3
GO:0072077	renal vesicle morphogenesis	2.030093e-3
GO:0002924	negative regulation of humoral immune response mediated by circulating immunoglobulin	2.194424e-3
GO:0009855	determination of bilateral symmetry	2.196146e-3
GO:0009313	oligosaccharide catabolic process	2.212318e-3
GO:0001947	heart looping	2.232613e-3
GO:0052066	entry of symbiont into host cell by promotion of host phagocytosis	2.238877e-3
GO:0035635	entry of bacterium into host cell	2.238877e-3
GO:0007339	binding of sperm to zona pellucida	2.252201e-3
GO:0032413	negative regulation of ion transmembrane transporter activity	2.257445e-3
GO:0016055	Wnt receptor signaling pathway	2.260694e-3
GO:0045357	regulation of interferon-beta biosynthetic process	2.302069e-3
GO:0072240	metanephric DCT cell differentiation	2.302484e-3
GO:0072227	metanephric macula densa development	2.302484e-3
GO:0061005	cell differentiation involved in kidney development	2.329991e-3
GO:0048566	embryonic digestive tract development	2.396505e-3
GO:0010641	positive regulation of platelet-derived growth factor receptor signaling pathway	2.428001e-3
GO:0060019	radial glial cell differentiation	2.447888e-3
GO:2000679	positive regulation of transcription regulatory region DNA binding	2.459616e-3
GO:2000779	regulation of double-strand break repair	2.512571e-3
GO:0034694	response to prostaglandin stimulus	2.581401e-3
GO:0071312	cellular response to alkaloid	2.586672e-3
GO:0031576	G2/M transition checkpoint	2.596967e-3
GO:0003409	optic cup structural organization	2.630755e-3
GO:0021623	oculomotor nerve formation	2.630755e-3
GO:0003404	optic vesicle morphogenesis	2.630755e-3
GO:0010172	embryonic body morphogenesis	2.633752e-3
GO:0021794	thalamus development	2.682810e-3
GO:0060067	cervix development	2.685954e-3
GO:0016119	carotene metabolic process	2.729961e-3
GO:0043330	response to exogenous dsRNA	2.730888e-3
GO:0009595	detection of biotic stimulus	2.817744e-3
GO:2000683	regulation of cellular response to X-ray	2.820227e-3
GO:0046796	viral genome transport in host cell	2.820254e-3
GO:0032571	response to vitamin K	2.820254e-3
GO:0002072	optic cup morphogenesis involved in camera-type eye development	2.821340e-3
GO:0048641	regulation of skeletal muscle tissue development	2.891566e-3
GO:0045885	positive regulation of survival gene product expression	2.912512e-3
GO:0051701	interaction with host	2.914392e-3
GO:0006002	fructose 6-phosphate metabolic process	2.947817e-3
GO:0044314	protein K27-linked ubiquitination	2.962899e-3
GO:0045926	negative regulation of growth	3.023672e-3
GO:0009799	specification of symmetry	3.031341e-3
GO:0072092	ureteric bud invasion	3.057767e-3
GO:0072378	blood coagulation, fibrin clot formation	3.068802e-3
GO:0072081	specification of nephron tubule identity	3.074010e-3
GO:0006720	isoprenoid metabolic process	3.090658e-3
GO:0060676	ureteric bud formation	3.093225e-3
GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure	3.108456e-3
GO:0090310	negative regulation of methylation-dependent chromatin silencing	3.108456e-3
GO:0072091	regulation of stem cell proliferation	3.111709e-3
GO:0045786	negative regulation of cell cycle	3.116206e-3
GO:0060438	trachea development	3.131119e-3
GO:0070303	negative regulation of stress-activated protein kinase signaling cascade	3.131119e-3
GO:0043966	histone H3 acetylation	3.169379e-3
GO:0072087	renal vesicle development	3.213830e-3
GO:0010821	regulation of mitochondrion organization	3.213830e-3
GO:0007095	mitotic cell cycle G2/M transition DNA damage checkpoint	3.266079e-3
GO:0043586	tongue development	3.309332e-3
GO:0048511	rhythmic process	3.332818e-3
GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity	3.374523e-3
GO:0051983	regulation of chromosome segregation	3.401787e-3
GO:0048524	positive regulation of viral reproduction	3.411639e-3
GO:0048850	hypophysis morphogenesis	3.467664e-3
GO:0055078	sodium ion homeostasis	3.472747e-3
GO:0030011	maintenance of cell polarity	3.522590e-3
GO:0034260	negative regulation of GTPase activity	3.610996e-3
GO:0003156	regulation of organ formation	3.631540e-3
GO:0031572	G2/M transition DNA damage checkpoint	3.651393e-3
GO:0030187	melatonin biosynthetic process	3.832223e-3
GO:0050916	sensory perception of sweet taste	3.840270e-3
GO:0043570	maintenance of DNA repeat elements	3.860911e-3
GO:0016236	macroautophagy	3.926762e-3
GO:0032091	negative regulation of protein binding	3.939842e-3
GO:0044257	cellular protein catabolic process	3.964699e-3
GO:0003081	regulation of systemic arterial blood pressure by renin-angiotensin	3.983404e-3
GO:0071281	cellular response to iron ion	4.124611e-3
GO:0072093	metanephric renal vesicle formation	4.159256e-3
GO:0016202	regulation of striated muscle tissue development	4.161898e-3
GO:0003337	mesenchymal to epithelial transition involved in metanephros morphogenesis	4.299957e-3
GO:0051145	smooth muscle cell differentiation	4.314943e-3
GO:0051725	protein de-ADP-ribosylation	4.325357e-3
GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	4.325357e-3
GO:0019933	cAMP-mediated signaling	4.336012e-3
GO:0032092	positive regulation of protein binding	4.341114e-3
GO:0006605	protein targeting	4.387072e-3
GO:0051100	negative regulation of binding	4.454669e-3
GO:0048598	embryonic morphogenesis	4.463181e-3
GO:0045080	positive regulation of chemokine biosynthetic process	4.464473e-3
GO:0043653	mitochondrial fragmentation involved in apoptosis	4.475540e-3
GO:0031639	plasminogen activation	4.475540e-3
GO:0042249	establishment of planar polarity of embryonic epithelium	4.475540e-3
GO:0010509	polyamine homeostasis	4.484551e-3
GO:0035036	sperm-egg recognition	4.522482e-3
GO:0002090	regulation of receptor internalization	4.535550e-3
GO:0071248	cellular response to metal ion	4.552019e-3
GO:2000378	negative regulation of reactive oxygen species metabolic process	4.640340e-3
GO:0051704	multi-organism process	4.649097e-3
GO:0072107	positive regulation of ureteric bud formation	4.675097e-3
GO:0034145	positive regulation of toll-like receptor 4 signaling pathway	4.675097e-3
GO:0048806	genitalia development	4.706368e-3
GO:0031333	negative regulation of protein complex assembly	4.739336e-3
GO:0019935	cyclic-nucleotide-mediated signaling	4.836976e-3
GO:0043988	histone H3-S28 phosphorylation	4.859519e-3
GO:0043987	histone H3-S10 phosphorylation	4.859519e-3
GO:0045008	depyrimidination	4.874887e-3
GO:0009267	cellular response to starvation	4.878293e-3
GO:0042454	ribonucleoside catabolic process	4.901248e-3
GO:0003344	pericardium morphogenesis	4.950392e-3
GO:0009972	cytidine deamination	4.950392e-3
GO:0060340	positive regulation of type I interferon-mediated signaling pathway	4.978202e-3
GO:0032388	positive regulation of intracellular transport	5.000656e-3

GREAT analysis results for mouseGenomic Enrichment of Annotations Tool (GREAT, Nat Biotechnol. 2010 May;28(5):495-501) is used to identify, both in human and in mouse, the gene ontology terms of biological processes enriched given the predicted TFBSs, and evaluated the overlap in the top-500 gene ontology terms between human and mouse. For each novel motif, the P value for the overlap was then evaluated by calculating its relative rank with respect to this background distribution.<br>Analyst: Michiel de Hoon <br><br>link to source dataset <br>data

---

GO ID	GO Term	p-value
GO:0006540	glutamate decarboxylation to succinate	3.848447e-12
GO:0030261	chromosome condensation	4.800651e-12
GO:0034105	positive regulation of tissue remodeling	1.202500e-10
GO:0071103	DNA conformation change	7.422166e-10
GO:0030308	negative regulation of cell growth	1.548190e-9
GO:0046666	retinal cell programmed cell death	1.731066e-9
GO:2000171	negative regulation of dendrite development	2.063813e-9
GO:0006538	glutamate catabolic process	2.192179e-9
GO:0045780	positive regulation of bone resorption	3.444154e-9
GO:0048706	embryonic skeletal system development	3.718236e-9
GO:0048672	positive regulation of collateral sprouting	3.843830e-9
GO:0006930	substrate-dependent cell migration, cell extension	7.288430e-9
GO:0006323	DNA packaging	9.967864e-9
GO:0060325	face morphogenesis	1.142143e-8
GO:0045926	negative regulation of growth	1.399875e-8
GO:0006259	DNA metabolic process	1.465682e-8
GO:0060323	head morphogenesis	1.789915e-8
GO:0016078	tRNA catabolic process	2.986342e-8
GO:0001682	tRNA 5'-leader removal	2.986342e-8
GO:0034103	regulation of tissue remodeling	3.641088e-8
GO:0032185	septin cytoskeleton organization	4.666825e-8
GO:0090304	nucleic acid metabolic process	5.291259e-8
GO:0048671	negative regulation of collateral sprouting	6.286225e-8
GO:0006536	glutamate metabolic process	6.724960e-8
GO:0010171	body morphogenesis	8.197776e-8
GO:0010983	positive regulation of high-density lipoprotein particle clearance	1.026152e-7
GO:0006139	nucleobase-containing compound metabolic process	1.667558e-7
GO:0042136	neurotransmitter biosynthetic process	3.027431e-7
GO:0001957	intramembranous ossification	3.598111e-7
GO:0060324	face development	4.351322e-7
GO:0046850	regulation of bone remodeling	4.524433e-7
GO:0021987	cerebral cortex development	4.923520e-7
GO:0045124	regulation of bone resorption	5.774352e-7
GO:0070625	zymogen granule exocytosis	5.934499e-7
GO:0015876	acetyl-CoA transport	5.934499e-7
GO:0010986	positive regulation of lipoprotein particle clearance	5.934499e-7
GO:0060236	regulation of mitotic spindle organization	6.062050e-7
GO:0072272	proximal/distal pattern formation involved in metanephric nephron development	7.360044e-7
GO:0032446	protein modification by small protein conjugation	7.896387e-7
GO:0060346	bone trabecula formation	1.151620e-6
GO:0034505	tooth mineralization	1.197168e-6
GO:0051301	cell division	1.330464e-6
GO:0030502	negative regulation of bone mineralization	1.493617e-6
GO:0048670	regulation of collateral sprouting	1.754512e-6
GO:0070168	negative regulation of biomineral tissue development	1.801934e-6
GO:0033566	gamma-tubulin complex localization	2.097460e-6
GO:0071894	histone H2B conserved C-terminal lysine ubiquitination	2.097460e-6
GO:0007097	nuclear migration	2.108521e-6
GO:0001503	ossification	2.388007e-6
GO:0060322	head development	2.419426e-6
GO:0006953	acute-phase response	2.881550e-6
GO:0000281	cytokinesis after mitosis	3.229949e-6
GO:0006105	succinate metabolic process	3.261708e-6
GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	3.303558e-6
GO:0060554	induction of necroptosis of activated-T cells	3.530225e-6
GO:0023035	CD40 signaling pathway	3.530225e-6
GO:0048484	enteric nervous system development	3.802788e-6
GO:0051135	positive regulation of NK T cell activation	4.052016e-6
GO:0010718	positive regulation of epithelial to mesenchymal transition	4.231030e-6
GO:0060678	dichotomous subdivision of terminal units involved in ureteric bud branching	4.538673e-6
GO:0010467	gene expression	4.556632e-6
GO:0042474	middle ear morphogenesis	5.206518e-6
GO:0030573	bile acid catabolic process	5.632299e-6
GO:0034641	cellular nitrogen compound metabolic process	6.812829e-6
GO:0016070	RNA metabolic process	7.253704e-6
GO:0060427	lung connective tissue development	8.131274e-6
GO:0060658	nipple morphogenesis	1.063963e-5
GO:0090224	regulation of spindle organization	1.077025e-5
GO:0035524	proline transmembrane transport	1.257501e-5
GO:0031214	biomineral tissue development	1.354096e-5
GO:0055015	ventricular cardiac muscle cell development	1.439672e-5
GO:0070086	ubiquitin-dependent endocytosis	1.509163e-5
GO:0032964	collagen biosynthetic process	1.527051e-5
GO:0007080	mitotic metaphase plate congression	1.582167e-5
GO:0006281	DNA repair	1.672500e-5
GO:0043588	skin development	1.767351e-5
GO:0060351	cartilage development involved in endochondral bone morphogenesis	1.834597e-5
GO:0006807	nitrogen compound metabolic process	1.861169e-5
GO:0070208	protein heterotrimerization	1.936878e-5
GO:0015825	L-serine transport	2.211613e-5
GO:0072086	specification of loop of Henle identity	2.254922e-5
GO:0032846	positive regulation of homeostatic process	2.296504e-5
GO:0030900	forebrain development	2.336695e-5
GO:0043589	skin morphogenesis	2.569081e-5
GO:0010770	positive regulation of cell morphogenesis involved in differentiation	2.615643e-5
GO:0046967	cytosol to ER transport	2.669017e-5
GO:0019060	intracellular transport of viral proteins in host cell	2.669017e-5
GO:0097039	protein linear polyubiquitination	2.762407e-5
GO:0016476	regulation of embryonic cell shape	3.418254e-5
GO:0046627	negative regulation of insulin receptor signaling pathway	3.472338e-5
GO:0035411	catenin import into nucleus	3.581234e-5
GO:0045165	cell fate commitment	3.898907e-5
GO:0051310	metaphase plate congression	3.934155e-5
GO:0070647	protein modification by small protein conjugation or removal	4.101040e-5
GO:0009443	pyridoxal 5'-phosphate salvage	4.152931e-5
GO:0045769	negative regulation of asymmetric cell division	4.152931e-5
GO:0007569	cell aging	4.878734e-5
GO:0034504	protein localization to nucleus	5.271006e-5
GO:0048880	sensory system development	5.314370e-5
GO:0006302	double-strand break repair	5.490097e-5
GO:0071300	cellular response to retinoic acid	5.637204e-5
GO:0007605	sensory perception of sound	5.790436e-5
GO:0051182	coenzyme transport	6.164156e-5
GO:0048937	lateral line nerve glial cell development	6.164156e-5
GO:0050935	iridophore differentiation	6.164156e-5
GO:0071299	cellular response to vitamin A	6.710139e-5
GO:0060574	intestinal epithelial cell maturation	6.748351e-5
GO:0010717	regulation of epithelial to mesenchymal transition	7.069344e-5
GO:0072268	pattern specification involved in metanephros development	7.394086e-5
GO:0032329	serine transport	7.394086e-5
GO:0021536	diencephalon development	7.532802e-5
GO:0072081	specification of nephron tubule identity	7.902763e-5
GO:0051303	establishment of chromosome localization	7.987920e-5
GO:0009065	glutamine family amino acid catabolic process	8.420040e-5
GO:0006974	response to DNA damage stimulus	8.439451e-5
GO:0021678	third ventricle development	9.320311e-5
GO:0015824	proline transport	9.865803e-5
GO:0046587	positive regulation of calcium-dependent cell-cell adhesion	9.946015e-5
GO:0042119	neutrophil activation	1.070827e-4
GO:0002446	neutrophil mediated immunity	1.125921e-4
GO:0051452	intracellular pH reduction	1.199990e-4
GO:0021592	fourth ventricle development	1.209174e-4
GO:0002904	positive regulation of B cell apoptosis	1.221580e-4
GO:0019543	propionate catabolic process	1.226365e-4
GO:0046621	negative regulation of organ growth	1.247821e-4
GO:0010812	negative regulation of cell-substrate adhesion	1.372929e-4
GO:0060216	definitive hemopoiesis	1.388335e-4
GO:0001777	T cell homeostatic proliferation	1.411614e-4
GO:0060764	cell-cell signaling involved in mammary gland development	1.411614e-4
GO:0000466	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	1.440043e-4
GO:0021983	pituitary gland development	1.491110e-4
GO:2000286	receptor internalization involved in canonical Wnt receptor signaling pathway	1.521093e-4
GO:0006925	inflammatory cell apoptosis	1.521093e-4
GO:0019827	stem cell maintenance	1.525978e-4
GO:0072329	monocarboxylic acid catabolic process	1.531728e-4
GO:0034629	cellular protein complex localization	1.549705e-4
GO:0044265	cellular macromolecule catabolic process	1.596462e-4
GO:0070230	positive regulation of lymphocyte apoptosis	1.608077e-4
GO:0044260	cellular macromolecule metabolic process	1.624613e-4
GO:0030644	cellular chloride ion homeostasis	1.659196e-4
GO:0032252	secretory granule localization	1.759509e-4
GO:0006401	RNA catabolic process	1.777398e-4
GO:0016071	mRNA metabolic process	1.800089e-4
GO:0046755	non-lytic virus budding	1.941851e-4
GO:0016925	protein sumoylation	1.943584e-4
GO:0060717	chorion development	2.008866e-4
GO:0000416	positive regulation of histone H3-K36 methylation	2.008866e-4
GO:0043009	chordate embryonic development	2.052037e-4
GO:0007379	segment specification	2.074457e-4
GO:0016567	protein ubiquitination	2.130076e-4
GO:0030279	negative regulation of ossification	2.195361e-4
GO:0045116	protein neddylation	2.247956e-4
GO:0019541	propionate metabolic process	2.269815e-4
GO:0072070	loop of Henle development	2.358667e-4
GO:0034645	cellular macromolecule biosynthetic process	2.395850e-4
GO:0045851	pH reduction	2.523767e-4
GO:0010623	developmental programmed cell death	2.553696e-4
GO:0034661	ncRNA catabolic process	2.670198e-4
GO:0007567	parturition	2.748537e-4
GO:0030320	cellular monovalent inorganic anion homeostasis	2.922899e-4
GO:0048625	myoblast cell fate commitment	2.969231e-4
GO:0006351	transcription, DNA-dependent	2.979709e-4
GO:0048147	negative regulation of fibroblast proliferation	3.096897e-4
GO:0044259	multicellular organismal macromolecule metabolic process	3.143640e-4
GO:0071780	mitotic cell cycle G2/M transition checkpoint	3.175793e-4
GO:0048864	stem cell development	3.188901e-4
GO:0021537	telencephalon development	3.208885e-4
GO:0050954	sensory perception of mechanical stimulus	3.230134e-4
GO:0032774	RNA biosynthetic process	3.258521e-4
GO:0051252	regulation of RNA metabolic process	3.263760e-4
GO:0051571	positive regulation of histone H3-K4 methylation	3.270023e-4
GO:0060480	lung goblet cell differentiation	3.408905e-4
GO:0034589	hydroxyproline transport	3.408905e-4
GO:0015826	threonine transport	3.408905e-4
GO:0010826	negative regulation of centrosome duplication	3.457914e-4
GO:0009786	regulation of asymmetric cell division	3.457914e-4
GO:0009792	embryo development ending in birth or egg hatching	3.529294e-4
GO:0042476	odontogenesis	3.590260e-4
GO:0046620	regulation of organ growth	3.725967e-4
GO:0016180	snRNA processing	3.800477e-4
GO:0001778	plasma membrane repair	3.800477e-4
GO:0006265	DNA topological change	3.836779e-4
GO:0048388	endosomal lumen acidification	3.880064e-4
GO:0001501	skeletal system development	3.948245e-4
GO:0032963	collagen metabolic process	3.979979e-4
GO:0046395	carboxylic acid catabolic process	4.109485e-4
GO:0070206	protein trimerization	4.212123e-4
GO:0030264	nuclear fragmentation involved in apoptotic nuclear change	4.380364e-4
GO:0002642	positive regulation of immunoglobulin biosynthetic process	4.380364e-4
GO:0030902	hindbrain development	4.497829e-4
GO:0008635	activation of caspase activity by cytochrome c	4.595077e-4
GO:0060343	trabecula formation	4.716638e-4
GO:0035871	protein K11-linked deubiquitination	4.813888e-4
GO:0051216	cartilage development	4.837967e-4
GO:0003167	atrioventricular bundle cell differentiation	4.904843e-4
GO:0060931	sinoatrial node cell development	4.904843e-4
GO:0006303	double-strand break repair via nonhomologous end joining	5.067175e-4
GO:0009057	macromolecule catabolic process	5.150294e-4
GO:0030262	apoptotic nuclear change	5.203595e-4
GO:0009059	macromolecule biosynthetic process	5.244177e-4
GO:0003409	optic cup structural organization	5.353342e-4
GO:0021623	oculomotor nerve formation	5.353342e-4
GO:0003404	optic vesicle morphogenesis	5.353342e-4
GO:0045345	positive regulation of MHC class I biosynthetic process	5.534143e-4
GO:0072091	regulation of stem cell proliferation	5.615935e-4
GO:0007095	mitotic cell cycle G2/M transition DNA damage checkpoint	5.730795e-4
GO:0031572	G2/M transition DNA damage checkpoint	5.905409e-4
GO:0021543	pallium development	5.939812e-4
GO:0050766	positive regulation of phagocytosis	5.964793e-4
GO:0021675	nerve development	6.108820e-4
GO:0033119	negative regulation of RNA splicing	6.198278e-4
GO:0071281	cellular response to iron ion	6.230550e-4
GO:0031503	protein complex localization	6.498112e-4
GO:0055013	cardiac muscle cell development	6.630664e-4
GO:0048846	axon extension involved in axon guidance	6.701427e-4
GO:0034501	protein localization to kinetochore	6.924772e-4
GO:0051568	histone H3-K4 methylation	7.115644e-4
GO:0061004	pattern specification involved in kidney development	7.225509e-4
GO:0016073	snRNA metabolic process	7.225509e-4
GO:0045629	negative regulation of T-helper 2 cell differentiation	7.330262e-4
GO:0045184	establishment of protein localization	7.672861e-4
GO:0090403	oxidative stress-induced premature senescence	7.724066e-4
GO:0048705	skeletal system morphogenesis	7.732145e-4
GO:0051640	organelle localization	7.949013e-4
GO:0051661	maintenance of centrosome location	8.029719e-4
GO:0044314	protein K27-linked ubiquitination	8.029719e-4
GO:0000059	protein import into nucleus, docking	8.029719e-4
GO:0033044	regulation of chromosome organization	8.339385e-4
GO:0015811	L-cystine transport	8.461203e-4
GO:0033205	cell cycle cytokinesis	9.000732e-4
GO:0006289	nucleotide-excision repair	9.085427e-4
GO:0030282	bone mineralization	9.239364e-4
GO:0070172	positive regulation of tooth mineralization	9.512260e-4
GO:0010977	negative regulation of neuron projection development	9.534645e-4
GO:0060921	sinoatrial node cell differentiation	9.534695e-4
GO:0002526	acute inflammatory response	9.567625e-4
GO:0048562	embryonic organ morphogenesis	9.927308e-4
GO:0032376	positive regulation of cholesterol transport	1.019857e-3
GO:0002352	B cell negative selection	1.027108e-3
GO:0006108	malate metabolic process	1.032657e-3
GO:0030514	negative regulation of BMP signaling pathway	1.043709e-3
GO:0006921	cellular component disassembly involved in apoptosis	1.046233e-3
GO:0070584	mitochondrion morphogenesis	1.055406e-3
GO:0007067	mitosis	1.067575e-3
GO:0050847	progesterone receptor signaling pathway	1.084412e-3
GO:0006355	regulation of transcription, DNA-dependent	1.105285e-3
GO:0034644	cellular response to UV	1.122905e-3
GO:0007420	brain development	1.165022e-3
GO:0060932	His-Purkinje system cell differentiation	1.165495e-3
GO:0060926	pacemaker cell development	1.165495e-3
GO:0090101	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	1.217415e-3
GO:0000301	retrograde transport, vesicle recycling within Golgi	1.223433e-3
GO:0051258	protein polymerization	1.230053e-3
GO:0048566	embryonic digestive tract development	1.230053e-3
GO:0003050	regulation of systemic arterial blood pressure by atrial natriuretic peptide	1.233634e-3
GO:0048863	stem cell differentiation	1.240326e-3
GO:0048557	embryonic digestive tract morphogenesis	1.253756e-3
GO:0055006	cardiac cell development	1.265839e-3
GO:0008104	protein localization	1.275778e-3
GO:0007062	sister chromatid cohesion	1.275856e-3
GO:0051181	cofactor transport	1.298142e-3
GO:0071295	cellular response to vitamin	1.319740e-3
GO:0051656	establishment of organelle localization	1.370825e-3
GO:0046884	follicle-stimulating hormone secretion	1.411833e-3
GO:0006699	bile acid biosynthetic process	1.411833e-3
GO:0032275	luteinizing hormone secretion	1.411833e-3
GO:2000659	regulation of interleukin-1-mediated signaling pathway	1.423055e-3
GO:0006696	ergosterol biosynthetic process	1.423055e-3
GO:0044282	small molecule catabolic process	1.442011e-3
GO:2000378	negative regulation of reactive oxygen species metabolic process	1.444539e-3
GO:0000087	M phase of mitotic cell cycle	1.446812e-3
GO:0002069	columnar/cuboidal epithelial cell maturation	1.467528e-3
GO:0031576	G2/M transition checkpoint	1.469698e-3
GO:0035295	tube development	1.482534e-3
GO:0010982	regulation of high-density lipoprotein particle clearance	1.569264e-3
GO:0006002	fructose 6-phosphate metabolic process	1.569264e-3
GO:0051453	regulation of intracellular pH	1.600217e-3
GO:0021545	cranial nerve development	1.604092e-3
GO:0044236	multicellular organismal metabolic process	1.608409e-3
GO:0051276	chromosome organization	1.656631e-3
GO:0046626	regulation of insulin receptor signaling pathway	1.754008e-3
GO:0021670	lateral ventricle development	1.780422e-3
GO:0000726	non-recombinational repair	1.780422e-3
GO:0048730	epidermis morphogenesis	1.788782e-3
GO:0000279	M phase	1.821615e-3
GO:2000648	positive regulation of stem cell proliferation	1.827185e-3
GO:0003163	sinoatrial node development	1.853319e-3
GO:0035282	segmentation	1.906115e-3
GO:0061383	trabecula morphogenesis	1.922716e-3
GO:0070271	protein complex biogenesis	1.931518e-3
GO:0007601	visual perception	1.932058e-3
GO:0043648	dicarboxylic acid metabolic process	1.935574e-3
GO:0030500	regulation of bone mineralization	1.945329e-3
GO:0060555	induction of necroptosis by extracellular signals	1.970063e-3
GO:0090184	positive regulation of kidney development	1.971968e-3
GO:0060920	pacemaker cell differentiation	2.021480e-3
GO:0002358	B cell homeostatic proliferation	2.024690e-3
GO:0010944	negative regulation of transcription by competitive promoter binding	2.056695e-3
GO:0006084	acetyl-CoA metabolic process	2.144573e-3
GO:0045627	positive regulation of T-helper 1 cell differentiation	2.200909e-3
GO:0042273	ribosomal large subunit biogenesis	2.200909e-3
GO:0050953	sensory perception of light stimulus	2.231299e-3
GO:0000819	sister chromatid segregation	2.261006e-3
GO:0090343	positive regulation of cell aging	2.263254e-3
GO:0045343	regulation of MHC class I biosynthetic process	2.351546e-3
GO:0051259	protein oligomerization	2.360652e-3
GO:0050764	regulation of phagocytosis	2.362270e-3
GO:0048619	embryonic hindgut morphogenesis	2.364440e-3
GO:0021557	oculomotor nerve development	2.392078e-3
GO:0000956	nuclear-transcribed mRNA catabolic process	2.413447e-3
GO:0048704	embryonic skeletal system morphogenesis	2.416015e-3
GO:0021915	neural tube development	2.428838e-3
GO:0006907	pinocytosis	2.440858e-3
GO:0045168	cell-cell signaling involved in cell fate commitment	2.444054e-3
GO:2000108	positive regulation of leukocyte apoptosis	2.465440e-3
GO:0010172	embryonic body morphogenesis	2.515909e-3
GO:0000209	protein polyubiquitination	2.531042e-3
GO:0030854	positive regulation of granulocyte differentiation	2.539585e-3
GO:0040023	establishment of nucleus localization	2.556203e-3
GO:0031641	regulation of myelination	2.556203e-3
GO:0010845	positive regulation of reciprocal meiotic recombination	2.559973e-3
GO:0009449	gamma-aminobutyric acid biosynthetic process	2.559973e-3
GO:0007023	post-chaperonin tubulin folding pathway	2.559973e-3
GO:0008611	ether lipid biosynthetic process	2.559973e-3
GO:0070167	regulation of biomineral tissue development	2.589100e-3
GO:0071822	protein complex subunit organization	2.611163e-3
GO:0060235	lens induction in camera-type eye	2.665915e-3
GO:0048050	post-embryonic eye morphogenesis	2.704599e-3
GO:0048597	post-embryonic camera-type eye morphogenesis	2.712938e-3
GO:0031128	developmental induction	2.738808e-3
GO:0048640	negative regulation of developmental growth	2.739238e-3
GO:0015993	molecular hydrogen transport	2.804580e-3
GO:0031591	wybutosine biosynthetic process	2.804580e-3
GO:0002223	stimulatory C-type lectin receptor signaling pathway	2.804580e-3
GO:0048854	brain morphogenesis	2.828047e-3
GO:0006402	mRNA catabolic process	2.836520e-3
GO:0009109	coenzyme catabolic process	2.838519e-3
GO:0002066	columnar/cuboidal epithelial cell development	2.892649e-3
GO:0006929	substrate-dependent cell migration	2.896732e-3
GO:0006107	oxaloacetate metabolic process	2.929913e-3
GO:0071711	basement membrane organization	2.988358e-3
GO:0042520	positive regulation of tyrosine phosphorylation of Stat4 protein	2.988358e-3
GO:2000112	regulation of cellular macromolecule biosynthetic process	2.993113e-3
GO:0060562	epithelial tube morphogenesis	3.008971e-3
GO:0048663	neuron fate commitment	3.032535e-3
GO:0006379	mRNA cleavage	3.040792e-3
GO:0007063	regulation of sister chromatid cohesion	3.087165e-3
GO:0006606	protein import into nucleus	3.150777e-3
GO:2000587	negative regulation of platelet-derived growth factor receptor-beta signaling pathway	3.205187e-3
GO:0030510	regulation of BMP signaling pathway	3.217776e-3
GO:0010159	specification of organ position	3.283711e-3
GO:0010556	regulation of macromolecule biosynthetic process	3.331228e-3
GO:0000070	mitotic sister chromatid segregation	3.369021e-3
GO:0002070	epithelial cell maturation	3.395881e-3
GO:0051291	protein heterooligomerization	3.401430e-3
GO:0035115	embryonic forelimb morphogenesis	3.413039e-3
GO:0048598	embryonic morphogenesis	3.450577e-3
GO:0031670	cellular response to nutrient	3.463564e-3
GO:0001844	protein insertion into mitochondrial membrane involved in induction of apoptosis	3.546207e-3
GO:0072348	sulfur compound transport	3.619297e-3
GO:0035234	germ cell programmed cell death	3.619297e-3
GO:0007548	sex differentiation	3.730693e-3
GO:0045623	negative regulation of T-helper cell differentiation	3.730981e-3
GO:0071482	cellular response to light stimulus	3.826789e-3
GO:0048285	organelle fission	3.833150e-3
GO:0034502	protein localization to chromosome	3.865943e-3
GO:0030538	embryonic genitalia morphogenesis	3.865943e-3
GO:0010659	cardiac muscle cell apoptosis	3.941437e-3
GO:0007019	microtubule depolymerization	3.941437e-3
GO:0007059	chromosome segregation	3.967618e-3
GO:0001783	B cell apoptosis	3.967878e-3
GO:0021603	cranial nerve formation	3.968157e-3
GO:0010940	positive regulation of necrotic cell death	3.968157e-3
GO:0045685	regulation of glial cell differentiation	4.035620e-3
GO:0006310	DNA recombination	4.064249e-3
GO:0034393	positive regulation of smooth muscle cell apoptosis	4.099360e-3
GO:0000460	maturation of 5.8S rRNA	4.099360e-3
GO:0044237	cellular metabolic process	4.124050e-3
GO:0006461	protein complex assembly	4.295731e-3
GO:0002309	T cell proliferation involved in immune response	4.340394e-3
GO:0001843	neural tube closure	4.349906e-3
GO:0032119	sequestering of zinc ion	4.537896e-3
GO:0030641	regulation of cellular pH	4.568938e-3
GO:0007049	cell cycle	4.670748e-3
GO:0030326	embryonic limb morphogenesis	4.690252e-3
GO:0009650	UV protection	4.720482e-3
GO:0007042	lysosomal lumen acidification	4.736837e-3
GO:0035519	protein K29-linked ubiquitination	4.772332e-3
GO:0032226	positive regulation of synaptic transmission, dopaminergic	4.772332e-3
GO:0015959	diadenosine polyphosphate metabolic process	4.772332e-3
GO:0051170	nuclear import	4.806762e-3
GO:0000060	protein import into nucleus, translocation	4.868107e-3
GO:0003334	keratinocyte development	4.875598e-3
GO:0070534	protein K63-linked ubiquitination	4.902630e-3
GO:0044249	cellular biosynthetic process	5.021745e-3
GO:0021549	cerebellum development	5.078563e-3
GO:0001958	endochondral ossification	5.093349e-3
GO:0010613	positive regulation of cardiac muscle hypertrophy	5.125535e-3
GO:0009887	organ morphogenesis	5.132063e-3
GO:0015031	protein transport	5.136900e-3
GO:0031223	auditory behavior	5.158311e-3
GO:0031100	organ regeneration	5.224905e-3
GO:0050768	negative regulation of neurogenesis	5.299287e-3
GO:0032456	endocytic recycling	5.318770e-3
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	5.334719e-3
GO:0021591	ventricular system development	5.626127e-3
GO:2000515	negative regulation of CD4-positive, alpha-beta T cell activation	5.626127e-3
GO:0006397	mRNA processing	5.692690e-3
GO:0051014	actin filament severing	5.700751e-3
GO:0015808	L-alanine transport	5.700751e-3
GO:0018343	protein farnesylation	5.701109e-3
GO:0006601	creatine biosynthetic process	5.701109e-3
GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin	5.701109e-3
GO:0035136	forelimb morphogenesis	5.721323e-3
GO:0050771	negative regulation of axonogenesis	5.751256e-3
GO:0060923	cardiac muscle cell fate commitment	5.778129e-3
GO:0006635	fatty acid beta-oxidation	5.842608e-3
GO:0030168	platelet activation	5.848142e-3
GO:0060606	tube closure	5.892966e-3
GO:0001656	metanephros development	6.009611e-3
GO:0007283	spermatogenesis	6.036085e-3
GO:2000052	positive regulation of non-canonical Wnt receptor signaling pathway	6.079617e-3
GO:0000733	DNA strand renaturation	6.079617e-3
GO:0046856	phosphatidylinositol dephosphorylation	6.166255e-3
GO:0010766	negative regulation of sodium ion transport	6.280440e-3
GO:0009889	regulation of biosynthetic process	6.312156e-3
GO:0006808	regulation of nitrogen utilization	6.350152e-3
GO:0051204	protein insertion into mitochondrial membrane	6.350152e-3
GO:0044238	primary metabolic process	6.366845e-3
GO:0006891	intra-Golgi vesicle-mediated transport	6.388484e-3
GO:0042133	neurotransmitter metabolic process	6.401361e-3
GO:0031623	receptor internalization	6.442218e-3
GO:0014020	primary neural tube formation	6.577660e-3
GO:0070265	necrotic cell death	6.581058e-3
GO:0007076	mitotic chromosome condensation	6.628064e-3
GO:0042823	pyridoxal phosphate biosynthetic process	6.730648e-3
GO:0021837	motogenic signaling involved in postnatal olfactory bulb interneuron migration	6.730648e-3
GO:0010994	free ubiquitin chain polymerization	6.730648e-3
GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	6.768958e-3
GO:0014813	satellite cell commitment	6.808889e-3
GO:0030199	collagen fibril organization	6.811813e-3
GO:0007442	hindgut morphogenesis	6.827366e-3
GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	6.933104e-3
GO:0009058	biosynthetic process	7.191441e-3
GO:0045625	regulation of T-helper 1 cell differentiation	7.444278e-3
GO:0022037	metencephalon development	7.516375e-3
GO:0007214	gamma-aminobutyric acid signaling pathway	7.534706e-3
GO:0021506	anterior neuropore closure	7.669465e-3
GO:0051187	cofactor catabolic process	7.699098e-3
GO:0060435	bronchiole development	7.792033e-3
GO:0010468	regulation of gene expression	7.813838e-3
GO:0033128	negative regulation of histone phosphorylation	7.863489e-3
GO:0001838	embryonic epithelial tube formation	7.887649e-3
GO:0046356	acetyl-CoA catabolic process	7.891156e-3
GO:0010952	positive regulation of peptidase activity	7.997458e-3
GO:0060284	regulation of cell development	8.024739e-3
GO:0021872	forebrain generation of neurons	8.067196e-3
GO:0065003	macromolecular complex assembly	8.085135e-3
GO:0040008	regulation of growth	8.088019e-3
GO:0006707	cholesterol catabolic process	8.162774e-3
GO:0055012	ventricular cardiac muscle cell differentiation	8.179879e-3
GO:0060596	mammary placode formation	8.196048e-3
GO:0042058	regulation of epidermal growth factor receptor signaling pathway	8.282424e-3
GO:0010661	positive regulation of muscle cell apoptosis	8.395889e-3
GO:0022402	cell cycle process	8.407674e-3
GO:0060350	endochondral bone morphogenesis	8.474156e-3
GO:0060828	regulation of canonical Wnt receptor signaling pathway	8.586962e-3
GO:2000096	positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	8.587210e-3
GO:0010457	centriole-centriole cohesion	8.587210e-3
GO:0014816	satellite cell differentiation	8.587210e-3
GO:0035019	somatic stem cell maintenance	8.847439e-3
GO:0060058	positive regulation of apoptosis involved in mammary gland involution	8.877034e-3
GO:0043933	macromolecular complex subunit organization	8.941372e-3
GO:0009064	glutamine family amino acid metabolic process	9.013387e-3
GO:0035117	embryonic arm morphogenesis	9.021312e-3
GO:0051093	negative regulation of developmental process	9.066090e-3
GO:0051782	negative regulation of cell division	9.101848e-3
GO:0016331	morphogenesis of embryonic epithelium	9.105723e-3
GO:0072175	epithelial tube formation	9.113554e-3
GO:0060484	lung-associated mesenchyme development	9.341533e-3
GO:0042269	regulation of natural killer cell mediated cytotoxicity	9.348881e-3
GO:0045358	negative regulation of interferon-beta biosynthetic process	9.394128e-3
GO:0060381	positive regulation of single-stranded telomeric DNA binding	9.394128e-3
GO:0048855	adenohypophysis morphogenesis	9.394128e-3
GO:0019482	beta-alanine metabolic process	9.394128e-3
GO:0015966	diadenosine tetraphosphate biosynthetic process	9.394128e-3
GO:0072080	nephron tubule development	9.397832e-3
GO:0031062	positive regulation of histone methylation	9.431683e-3
GO:0051238	sequestering of metal ion	9.433583e-3
GO:0045953	negative regulation of natural killer cell mediated cytotoxicity	9.474534e-3
GO:0006734	NADH metabolic process	9.474534e-3
GO:0021869	forebrain ventricular zone progenitor cell division	9.474534e-3
GO:0030388	fructose 1,6-bisphosphate metabolic process	9.527378e-3
GO:0033365	protein localization to organelle	9.706114e-3
GO:0043170	macromolecule metabolic process	9.819087e-3
GO:0048713	regulation of oligodendrocyte differentiation	9.828709e-3
GO:0006898	receptor-mediated endocytosis	9.848480e-3
GO:0045628	regulation of T-helper 2 cell differentiation	9.944163e-3
GO:0010976	positive regulation of neuron projection development	1.004546e-2
GO:0051290	protein heterotetramerization	1.016874e-2