MCL coexpression mm9:2374

Phase1 CAGE Peaks

	Short description
Mm9::chr3:32635665..32635699,-	p1@Mrpl47
Mm9::chr5:96639147..96639180,+	p1@Mrpl1
Mm9::chr6:71773750..71773787,-	p1@Mrpl35
Mm9::chr9:98502061..98502096,-	p1@Mrps22

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0003735	structural constituent of ribosome	1.44052928663171e-07
GO:0005840	ribosome	1.44052928663171e-07
GO:0000313	organellar ribosome	4.57523921296204e-07
GO:0005761	mitochondrial ribosome	4.57523921296204e-07
GO:0031980	mitochondrial lumen	7.22821904815425e-07
GO:0005759	mitochondrial matrix	7.22821904815425e-07
GO:0030529	ribonucleoprotein complex	2.29891456423958e-06
GO:0005739	mitochondrion	3.7681569081048e-05
GO:0044429	mitochondrial part	0.00010599580311128
GO:0043232	intracellular non-membrane-bound organelle	0.000175673274077125
GO:0043228	non-membrane-bound organelle	0.000175673274077125
GO:0006412	translation	0.000194354067993051
GO:0033279	ribosomal subunit	0.000245175487726604
GO:0032991	macromolecular complex	0.000447845837616268
GO:0009059	macromolecule biosynthetic process	0.000523740630934592
GO:0031974	membrane-enclosed lumen	0.000689158315214261
GO:0043233	organelle lumen	0.000689158315214261
GO:0044249	cellular biosynthetic process	0.00098304005342419
GO:0044444	cytoplasmic part	0.00194557283349915
GO:0009058	biosynthetic process	0.00216637039338063
GO:0000314	organellar small ribosomal subunit	0.00374318286250356
GO:0005763	mitochondrial small ribosomal subunit	0.00374318286250356
GO:0000315	organellar large ribosomal subunit	0.00771397156612733
GO:0005762	mitochondrial large ribosomal subunit	0.00771397156612733
GO:0015935	small ribosomal subunit	0.0116585593426487
GO:0015934	large ribosomal subunit	0.0116585593426487
GO:0044446	intracellular organelle part	0.0116585593426487
GO:0005737	cytoplasm	0.0116585593426487
GO:0044422	organelle part	0.0116585593426487
GO:0044267	cellular protein metabolic process	0.0160591084200635
GO:0044260	cellular macromolecule metabolic process	0.0160591084200635
GO:0010467	gene expression	0.0160591084200635
GO:0019538	protein metabolic process	0.0166250440803477
GO:0043231	intracellular membrane-bound organelle	0.0180028723501245
GO:0043227	membrane-bound organelle	0.0180028723501245
GO:0043229	intracellular organelle	0.0279670535780238
GO:0043226	organelle	0.0279670535780238

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
epithelial tube	4.11e-11	47
liver	5.87e-10	22
epithelial sac	5.87e-10	22
digestive gland	5.87e-10	22
epithelium of foregut-midgut junction	5.87e-10	22
anatomical boundary	5.87e-10	22
hepatobiliary system	5.87e-10	22
foregut-midgut junction	5.87e-10	22
hepatic diverticulum	5.87e-10	22
liver primordium	5.87e-10	22
septum transversum	5.87e-10	22
liver bud	5.87e-10	22
digestive tract diverticulum	2.80e-09	23
sac	2.80e-09	23
exocrine gland	1.02e-08	25
exocrine system	1.02e-08	25

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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