MCL coexpression mm9:1873

Phase1 CAGE Peaks

	Short description
Mm9::chr10:126625832..126625862,-	p@chr10:126625832..126625862 -
Mm9::chr10:69903391..69903420,+	p3@Fam13c
Mm9::chr10:69903424..69903468,+	p1@Fam13c
Mm9::chr4:151460939..151461002,+	p1@Plekhg5

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0043542	endothelial cell migration	0.0118884566920506
GO:0005089	Rho guanyl-nucleotide exchange factor activity	0.0250506766011067
GO:0035023	regulation of Rho protein signal transduction	0.0250506766011067
GO:0005088	Ras guanyl-nucleotide exchange factor activity	0.0250506766011067
GO:0007266	Rho protein signal transduction	0.0256450994357092
GO:0046578	regulation of Ras protein signal transduction	0.0256450994357092
GO:0005085	guanyl-nucleotide exchange factor activity	0.0256450994357092
GO:0051056	regulation of small GTPase mediated signal transduction	0.0256450994357092
GO:0007265	Ras protein signal transduction	0.0256450994357092
GO:0005083	small GTPase regulator activity	0.0256450994357092
GO:0016477	cell migration	0.0357715170109023
GO:0030695	GTPase regulator activity	0.0357715170109023
GO:0051674	localization of cell	0.0357715170109023
GO:0006928	cell motility	0.0357715170109023
GO:0009966	regulation of signal transduction	0.0357715170109023
GO:0007264	small GTPase mediated signal transduction	0.0357715170109023

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
electrically responsive cell	2.68e-09	39
electrically active cell	2.68e-09	39
non-terminally differentiated cell	5.11e-08	49

Uber Anatomy

Ontology term	p-value	n
central nervous system	1.41e-18	73
nervous system	1.58e-17	75
regional part of nervous system	1.95e-16	54
neural tube	3.18e-15	52
neural rod	3.18e-15	52
future spinal cord	3.18e-15	52
neural keel	3.18e-15	52
ectoderm-derived structure	1.31e-14	95
ectoderm	1.31e-14	95
presumptive ectoderm	1.31e-14	95
brain	3.78e-14	47
future brain	3.78e-14	47
regional part of brain	1.31e-13	46
structure with developmental contribution from neural crest	6.33e-13	92
neurectoderm	1.06e-12	64
neural plate	1.06e-12	64
presumptive neural plate	1.06e-12	64
ecto-epithelium	3.36e-12	73
anterior neural tube	4.70e-12	40
regional part of forebrain	1.49e-11	39
forebrain	1.49e-11	39
future forebrain	1.49e-11	39
gray matter	4.12e-11	34
tube	2.13e-10	114
brain grey matter	3.86e-10	29
regional part of telencephalon	3.86e-10	29
telencephalon	3.86e-10	29
pre-chordal neural plate	4.10e-10	49
anatomical conduit	9.16e-10	122
multi-cellular organism	4.68e-08	333
cerebral cortex	4.78e-08	21
cerebral hemisphere	4.78e-08	21
pallium	4.78e-08	21
occipital lobe	1.45e-07	10
visual cortex	1.45e-07	10
neocortex	1.45e-07	10
regional part of cerebral cortex	3.04e-07	17

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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