MCL coexpression mm9:1664

Phase1 CAGE Peaks

	Short description
Mm9::chr14:46149805..46149857,-	p4@Fermt2
Mm9::chr17:44325552..44325567,+	p2@Clic5
Mm9::chr17:44325602..44325613,+	p4@Clic5
Mm9::chr17:44325614..44325625,+	p5@Clic5
Mm9::chr17:44325638..44325651,+	p3@Clic5

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0060088	auditory receptor cell stereocilium organization and biogenesis	0.00584378823572381
GO:0002093	auditory receptor cell morphogenesis	0.00584378823572381
GO:0060122	inner ear receptor stereocilium organization and biogenesis	0.00584378823572381
GO:0032420	stereocilium	0.00584378823572381
GO:0060119	inner ear receptor cell development	0.00584378823572381
GO:0060117	auditory receptor cell development	0.00584378823572381
GO:0032421	stereocilium bundle	0.00626120168113265
GO:0005247	voltage-gated chloride channel activity	0.00730473529465476
GO:0022844	voltage-gated anion channel activity	0.00730473529465476
GO:0005902	microvillus	0.00745083000054786
GO:0042491	auditory receptor cell differentiation	0.00916412246056688
GO:0060113	inner ear receptor cell differentiation	0.00986139264778393
GO:0050885	neuromuscular process controlling balance	0.0103309827738689
GO:0042490	mechanoreceptor differentiation	0.0103309827738689
GO:0050905	neuromuscular process	0.0119532032094351
GO:0043168	anion binding	0.0119532032094351
GO:0042472	inner ear morphogenesis	0.0119532032094351
GO:0031404	chloride ion binding	0.0119532032094351
GO:0005254	chloride channel activity	0.0119532032094351
GO:0006821	chloride transport	0.0119532032094351
GO:0042471	ear morphogenesis	0.0119532032094351
GO:0005253	anion channel activity	0.0119532032094351
GO:0048839	inner ear development	0.013339081842413
GO:0043583	ear development	0.013878997059844
GO:0007605	sensory perception of sound	0.0161288555305977
GO:0050954	sensory perception of mechanical stimulus	0.0163513690057272
GO:0008509	anion transmembrane transporter activity	0.0181806745111407
GO:0015698	inorganic anion transport	0.0219142058839643
GO:0006820	anion transport	0.0236107895653035
GO:0022832	voltage-gated channel activity	0.0236107895653035
GO:0005244	voltage-gated ion channel activity	0.0236107895653035
GO:0007423	sensory organ development	0.0254752643401085
GO:0048598	embryonic morphogenesis	0.0266954871677383
GO:0022836	gated channel activity	0.0316275295730728
GO:0032990	cell part morphogenesis	0.0316275295730728
GO:0030030	cell projection organization and biogenesis	0.0316275295730728
GO:0048858	cell projection morphogenesis	0.0316275295730728
GO:0005216	ion channel activity	0.0389238037843747
GO:0022838	substrate specific channel activity	0.0389238037843747
GO:0042995	cell projection	0.0389238037843747
GO:0022803	passive transmembrane transporter activity	0.0389238037843747
GO:0015267	channel activity	0.0389238037843747
GO:0009790	embryonic development	0.0448023764738825
GO:0000902	cell morphogenesis	0.0448023764738825
GO:0032989	cellular structure morphogenesis	0.0448023764738825
GO:0009887	organ morphogenesis	0.0474490196965835

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
epithelial bud	9.14e-08	17
primary circulatory organ	1.11e-07	18
heart	1.11e-07	18
primitive heart tube	1.11e-07	18
primary heart field	1.11e-07	18
anterior lateral plate mesoderm	1.11e-07	18
heart tube	1.11e-07	18
heart primordium	1.11e-07	18
cardiac mesoderm	1.11e-07	18
cardiogenic plate	1.11e-07	18
heart rudiment	1.11e-07	18
splanchnic layer of lateral plate mesoderm	1.28e-07	33
lung	1.40e-07	14
respiratory tube	1.40e-07	14
respiration organ	1.40e-07	14
pair of lungs	1.40e-07	14
lung primordium	1.40e-07	14
lung bud	1.40e-07	14

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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