MCL coexpression mm9:979

Phase1 CAGE Peaks

	Short description
Mm9::chr19:50753132..50753192,-	p1@Sorcs1
Mm9::chr19:50753202..50753223,-	p2@Sorcs1
Mm9::chr1:168931170..168931202,+	p1@Fam78b
Mm9::chr5:112658087..112658107,-	p5@Miat
Mm9::chr7:38557752..38557793,-	p3@Zfp536
Mm9::chr9:47338426..47338445,+	p1@Cadm1
Mm9::chr9:62384812..62384823,-	p8@Coro2b
Mm9::chr9:62384843..62384868,-	p3@Coro2b

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0042271	susceptibility to natural killer cell mediated cytotoxicity	0.0459669089702543
GO:0016338	calcium-independent cell-cell adhesion	0.0459669089702543
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	0.0459669089702543
GO:0030165	PDZ domain binding	0.0459669089702543
GO:0042269	regulation of natural killer cell mediated cytotoxicity	0.0459669089702543
GO:0001912	positive regulation of leukocyte mediated cytotoxicity	0.0459669089702543
GO:0008022	protein C-terminus binding	0.0459669089702543
GO:0042267	natural killer cell mediated cytotoxicity	0.0459669089702543
GO:0001910	regulation of leukocyte mediated cytotoxicity	0.0459669089702543
GO:0031341	regulation of cell killing	0.0459669089702543
GO:0002228	natural killer cell mediated immunity	0.0459669089702543
GO:0007416	synaptogenesis	0.0494115251264313
GO:0001906	cell killing	0.0494115251264313
GO:0007157	heterophilic cell adhesion	0.0494115251264313
GO:0001909	leukocyte mediated cytotoxicity	0.0494115251264313

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
ectodermal cell	2.20e-18	44
neurectodermal cell	2.20e-18	44
neural cell	6.57e-18	43
neuron	1.51e-17	33
neuronal stem cell	1.51e-17	33
neuroblast	1.51e-17	33
electrically signaling cell	1.51e-17	33
non-terminally differentiated cell	2.93e-15	49
electrically responsive cell	2.32e-14	39
electrically active cell	2.32e-14	39
CNS neuron (sensu Vertebrata)	3.91e-11	23
neuroblast (sensu Vertebrata)	3.91e-11	23
autonomic neuron	1.90e-07	9

Uber Anatomy

Ontology term	p-value	n
ectoderm-derived structure	8.14e-38	95
ectoderm	8.14e-38	95
presumptive ectoderm	8.14e-38	95
nervous system	4.57e-35	75
central nervous system	5.75e-34	73
neurectoderm	2.28e-29	64
neural plate	2.28e-29	64
presumptive neural plate	2.28e-29	64
ecto-epithelium	6.67e-28	73
structure with developmental contribution from neural crest	9.32e-24	92
regional part of nervous system	8.45e-23	54
pre-chordal neural plate	1.03e-22	49
neural tube	8.13e-22	52
neural rod	8.13e-22	52
future spinal cord	8.13e-22	52
neural keel	8.13e-22	52
brain	2.47e-19	47
future brain	2.47e-19	47
regional part of brain	6.93e-19	46
anterior neural tube	1.16e-17	40
regional part of forebrain	4.59e-17	39
forebrain	4.59e-17	39
future forebrain	4.59e-17	39
gray matter	9.76e-16	34
brain grey matter	1.27e-13	29
regional part of telencephalon	1.27e-13	29
telencephalon	1.27e-13	29
multi-cellular organism	2.85e-10	333
cerebral cortex	1.56e-09	21
cerebral hemisphere	1.56e-09	21
pallium	1.56e-09	21
embryo	1.68e-08	320
tube	2.30e-08	114
peripheral nervous system	3.46e-08	11
anatomical conduit	4.53e-08	122
regional part of cerebral cortex	4.99e-08	17
autonomic nervous system	1.90e-07	9

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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