MCL coexpression mm9:935

Phase1 CAGE Peaks

	Short description
Mm9::chr12:38606893..38606928,+	p4@Dgkb
Mm9::chr14:31951511..31951534,+	p@chr14:31951511..31951534 +
Mm9::chr14:31951544..31951561,+	p@chr14:31951544..31951561 +
Mm9::chr4:126421474..126421488,-	p@chr4:126421474..126421488 -
Mm9::chr4:126429321..126429353,-	p@chr4:126429321..126429353 -
Mm9::chr4:126429355..126429362,-	p@chr4:126429355..126429362 -
Mm9::chr4:128799308..128799339,-	p3@Hpca
Mm9::chr7:68749528..68749541,-	p1@uc009hez.1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0007205	protein kinase C activation	0.0337567961805886
GO:0004143	diacylglycerol kinase activity	0.0337567961805886
GO:0045453	bone resorption	0.0337567961805886
GO:0001894	tissue homeostasis	0.0337567961805886
GO:0048871	multicellular organismal homeostasis	0.0337567961805886
GO:0007200	G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)	0.0337567961805886
GO:0032147	activation of protein kinase activity	0.0337567961805886
GO:0048015	phosphoinositide-mediated signaling	0.039350554041878
GO:0019992	diacylglycerol binding	0.039350554041878

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
CNS neuron (sensu Vertebrata)	1.76e-13	23
neuroblast (sensu Vertebrata)	1.76e-13	23
neuron	1.86e-07	33
neuronal stem cell	1.86e-07	33
neuroblast	1.86e-07	33
electrically signaling cell	1.86e-07	33

Uber Anatomy

Ontology term	p-value	n
regional part of nervous system	3.08e-29	54
neural tube	5.17e-27	52
neural rod	5.17e-27	52
future spinal cord	5.17e-27	52
neural keel	5.17e-27	52
neurectoderm	1.56e-25	64
neural plate	1.56e-25	64
presumptive neural plate	1.56e-25	64
central nervous system	2.05e-25	73
nervous system	2.95e-25	75
brain	6.25e-23	47
future brain	6.25e-23	47
regional part of brain	5.36e-22	46
ectoderm-derived structure	2.78e-21	95
ectoderm	2.78e-21	95
presumptive ectoderm	2.78e-21	95
ecto-epithelium	2.48e-20	73
gray matter	3.17e-20	34
pre-chordal neural plate	3.55e-19	49
anterior neural tube	1.42e-18	40
regional part of forebrain	1.55e-17	39
forebrain	1.55e-17	39
future forebrain	1.55e-17	39
brain grey matter	1.83e-16	29
regional part of telencephalon	1.83e-16	29
telencephalon	1.83e-16	29
structure with developmental contribution from neural crest	1.50e-13	92
cerebral cortex	1.67e-11	21
cerebral hemisphere	1.67e-11	21
pallium	1.67e-11	21
occipital lobe	8.37e-11	10
visual cortex	8.37e-11	10
neocortex	8.37e-11	10
regional part of cerebral cortex	2.44e-10	17
posterior neural tube	4.69e-09	12
chordal neural plate	4.69e-09	12
tube	4.77e-08	114

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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