MCL coexpression mm9:907

Phase1 CAGE Peaks

	Short description
Mm9::chr11:60043268..60043282,-	p@chr11:60043268..60043282 -
Mm9::chr11:98216623..98216634,+	p@chr11:98216623..98216634 +
Mm9::chr11:98218352..98218393,+	p@chr11:98218352..98218393 +
Mm9::chr12:101444635..101444669,+	p@chr12:101444635..101444669 +
Mm9::chr14:22652104..22652140,+	p3@Vdac2
Mm9::chr3:101396429..101396470,-	p@chr3:101396429..101396470 -
Mm9::chr4:154932366..154932388,+	p@chr4:154932366..154932388 +
Mm9::chr6:17616260..17616279,+	p@chr6:17616260..17616279 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0003869	4-nitrophenylphosphatase activity	0.0121607183681279
GO:0031944	negative regulation of glucocorticoid metabolic process	0.0121607183681279
GO:0031947	negative regulation of glucocorticoid biosynthetic process	0.0121607183681279
GO:0048521	negative regulation of behavior	0.0121607183681279
GO:0045989	positive regulation of striated muscle contraction	0.0121607183681279
GO:0007621	negative regulation of female receptivity	0.0121607183681279
GO:0005890	sodium:potassium-exchanging ATPase complex	0.0121607183681279
GO:0007603	phototransduction, visible light	0.0121607183681279
GO:0050795	regulation of behavior	0.0121607183681279
GO:0060181	female receptivity	0.0121607183681279
GO:0045924	regulation of female receptivity	0.0121607183681279
GO:0031946	regulation of glucocorticoid biosynthetic process	0.0121607183681279
GO:0006942	regulation of striated muscle contraction	0.0121607183681279
GO:0060180	female mating behavior	0.0121607183681279
GO:0030641	cellular hydrogen ion homeostasis	0.0159587566872052
GO:0031943	regulation of glucocorticoid metabolic process	0.0159587566872052
GO:0004865	type 1 serine/threonine specific protein phosphatase inhibitor activity	0.0170180109904335
GO:0007213	acetylcholine receptor signaling, muscarinic pathway	0.0170180109904335
GO:0006891	intra-Golgi vesicle-mediated transport	0.0170180109904335
GO:0043388	positive regulation of DNA binding	0.0170180109904335
GO:0045933	positive regulation of muscle contraction	0.0170180109904335
GO:0006704	glucocorticoid biosynthetic process	0.0170180109904335
GO:0045823	positive regulation of heart contraction	0.0170180109904335
GO:0008599	protein phosphatase type 1 regulator activity	0.0170180109904335
GO:0008308	voltage-gated ion-selective channel activity	0.0170180109904335
GO:0045822	negative regulation of heart contraction	0.0180444616373082
GO:0022892	substrate-specific transporter activity	0.0180444616373082
GO:0051099	positive regulation of binding	0.0180444616373082
GO:0019218	regulation of steroid metabolic process	0.0180444616373082
GO:0030004	cellular monovalent inorganic cation homeostasis	0.0180444616373082
GO:0015991	ATP hydrolysis coupled proton transport	0.0180444616373082
GO:0033057	reproductive behavior in a multicellular organism	0.0180444616373082
GO:0055067	monovalent inorganic cation homeostasis	0.0180444616373082
GO:0015988	energy coupled proton transport, against electrochemical gradient	0.0200129639191323
GO:0007617	mating behavior	0.021260861824116
GO:0008211	glucocorticoid metabolic process	0.021260861824116
GO:0005391	sodium:potassium-exchanging ATPase activity	0.0223767893786798
GO:0051101	regulation of DNA binding	0.0223767893786798
GO:0005795	Golgi stack	0.0239800433466738
GO:0002026	regulation of the force of heart contraction	0.0269502260834755
GO:0007618	mating	0.0269502260834755
GO:0019098	reproductive behavior	0.0283284086761825
GO:0004864	protein phosphatase inhibitor activity	0.0316137486258903
GO:0019212	phosphatase inhibitor activity	0.0350785630125739
GO:0019216	regulation of lipid metabolic process	0.0350785630125739
GO:0005741	mitochondrial outer membrane	0.0350785630125739
GO:0051098	regulation of binding	0.0361342198503228
GO:0030317	sperm motility	0.0366201476483536
GO:0031968	organelle outer membrane	0.0366201476483536
GO:0051705	behavioral interaction between organisms	0.0366201476483536
GO:0007602	phototransduction	0.0366201476483536
GO:0009584	detection of visible light	0.0377195160290655
GO:0050962	detection of light stimulus during sensory perception	0.0377195160290655
GO:0050908	detection of light stimulus during visual perception	0.0377195160290655
GO:0017111	nucleoside-triphosphatase activity	0.0393926317897043
GO:0009583	detection of light stimulus	0.0393926317897043
GO:0042383	sarcolemma	0.0396695758421618
GO:0016462	pyrophosphatase activity	0.0396695758421618
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.0396695758421618
GO:0016817	hydrolase activity, acting on acid anhydrides	0.0396695758421618
GO:0051241	negative regulation of multicellular organismal process	0.0396695758421618
GO:0006941	striated muscle contraction	0.0396695758421618
GO:0042493	response to drug	0.0397496267172885
GO:0007200	G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)	0.0397496267172885
GO:0019888	protein phosphatase regulator activity	0.0417358677902161
GO:0006937	regulation of muscle contraction	0.0417496164970557
GO:0005834	heterotrimeric G-protein complex	0.0417496164970557
GO:0019208	phosphatase regulator activity	0.0435752009425995
GO:0042446	hormone biosynthetic process	0.0435752009425995
GO:0008016	regulation of heart contraction	0.0435752009425995
GO:0048193	Golgi vesicle transport	0.0453357959224003
GO:0008217	regulation of blood pressure	0.0470462002640027
GO:0048015	phosphoinositide-mediated signaling	0.048363880397671
GO:0003015	heart process	0.048363880397671
GO:0050909	sensory perception of taste	0.048363880397671
GO:0009582	detection of abiotic stimulus	0.048363880397671
GO:0060047	heart contraction	0.048363880397671
GO:0019867	outer membrane	0.0499003376276443

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
anatomical system	1.23e-13	308
anatomical group	1.23e-13	308
developing anatomical structure	2.61e-12	304
adult organism	2.08e-10	51
germ layer	2.50e-10	291
germ layer / neural crest	2.50e-10	291
embryonic tissue	2.50e-10	291
presumptive structure	2.50e-10	291
germ layer / neural crest derived structure	2.50e-10	291
epiblast (generic)	2.50e-10	291
embryonic structure	2.55e-10	294
anatomical cluster	1.12e-08	244

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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