MCL coexpression mm9:859

Phase1 CAGE Peaks

	Short description
Mm9::chr10:128227959..128228024,+	p1@Mmp19
Mm9::chr13:4058917..4058918,+	p@chr13:4058917..4058918 +
Mm9::chr1:182926224..182926235,-	p@chr1:182926224..182926235 -
Mm9::chr1:182932030..182932048,-	p@chr1:182932030..182932048 -
Mm9::chr1:182947620..182947679,-	p1@Ephx1
Mm9::chr1:58086799..58086818,+	p1@Aox1
Mm9::chr6:124462731..124462753,+	p1@C1rb
Mm9::chr6:124492299..124492325,-	p1@C1s

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0047042	3-alpha-hydroxysteroid dehydrogenase (B-specific) activity	0.0163146808650638
GO:0003816	complement component C1s activity	0.0163146808650638
GO:0004301	epoxide hydrolase activity	0.0163146808650638
GO:0004031	aldehyde oxidase activity	0.0163146808650638
GO:0016803	ether hydrolase activity	0.0163146808650638
GO:0016623	oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor	0.0163146808650638
GO:0004463	leukotriene-A4 hydrolase activity	0.0163146808650638
GO:0016801	hydrolase activity, acting on ether bonds	0.0285413070423536
GO:0030151	molybdenum ion binding	0.0300840475642867
GO:0006805	xenobiotic metabolic process	0.0300840475642867
GO:0019439	aromatic compound catabolic process	0.0300840475642867
GO:0051537	2 iron, 2 sulfur cluster binding	0.0300840475642867
GO:0009410	response to xenobiotic stimulus	0.0300840475642867
GO:0030574	collagen catabolic process	0.0300840475642867
GO:0044259	multicellular organismal macromolecule metabolic process	0.0300840475642867
GO:0044268	multicellular organismal protein metabolic process	0.0300840475642867
GO:0044256	protein digestion	0.0300840475642867
GO:0044254	multicellular organismal protein catabolic process	0.0300840475642867
GO:0044266	multicellular organismal macromolecule catabolic process	0.0300840475642867
GO:0044243	multicellular organismal catabolic process	0.0300840475642867
GO:0032963	collagen metabolic process	0.0300840475642867
GO:0004175	endopeptidase activity	0.0300840475642867
GO:0009636	response to toxin	0.0300840475642867
GO:0044236	multicellular organismal metabolic process	0.0300840475642867
GO:0016229	steroid dehydrogenase activity	0.031913762660244
GO:0051287	NAD binding	0.0321440404871541
GO:0009056	catabolic process	0.0393149711488276
GO:0006958	complement activation, classical pathway	0.0393149711488276
GO:0002455	humoral immune response mediated by circulating immunoglobulin	0.0428880772729188
GO:0006508	proteolysis	0.0428880772729188
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	0.0428880772729188
GO:0005615	extracellular space	0.0428880772729188
GO:0007586	digestion	0.0428880772729188
GO:0006956	complement activation	0.0428880772729188
GO:0002541	activation of plasma proteins during acute inflammatory response	0.0428880772729188
GO:0016787	hydrolase activity	0.0428880772729188
GO:0051536	iron-sulfur cluster binding	0.0428880772729188
GO:0051540	metal cluster binding	0.0428880772729188
GO:0008233	peptidase activity	0.0434545151844588
GO:0044421	extracellular region part	0.0434545151844588

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
trunk mesenchyme	1.45e-13	45
trunk	4.80e-13	90
immaterial anatomical entity	5.32e-11	79
trunk region element	1.41e-10	79
mesenchyme	1.43e-10	61
entire embryonic mesenchyme	1.43e-10	61
subdivision of trunk	2.49e-09	66
exocrine gland	8.94e-09	25
exocrine system	8.94e-09	25
epithelial tube	1.70e-08	47
liver	5.08e-08	22
epithelial sac	5.08e-08	22
digestive gland	5.08e-08	22
epithelium of foregut-midgut junction	5.08e-08	22
anatomical boundary	5.08e-08	22
hepatobiliary system	5.08e-08	22
foregut-midgut junction	5.08e-08	22
hepatic diverticulum	5.08e-08	22
liver primordium	5.08e-08	22
septum transversum	5.08e-08	22
liver bud	5.08e-08	22
abdomen element	7.24e-08	49
abdominal segment element	7.24e-08	49
abdominal segment of trunk	7.24e-08	49
abdomen	7.24e-08	49
digestive tract diverticulum	1.05e-07	23
sac	1.05e-07	23
organism subdivision	4.31e-07	150

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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