MCL coexpression mm9:482

Phase1 CAGE Peaks

	Short description
Mm9::chr10:80164681..80164731,-	p2@Mob3a
Mm9::chr12:109149819..109149825,-	p@chr12:109149819..109149825 -
Mm9::chr12:109242296..109242307,-	p3@Bcl11b
Mm9::chr15:96473695..96473724,-	p9@Slc38a1
Mm9::chr15:98764953..98765017,-	p2@Gm5620 p2@Tuba1b
Mm9::chr16:91485298..91485311,+	p5@Ifnar1
Mm9::chr16:91485312..91485350,+	p2@Ifnar1
Mm9::chr17:13185451..13185464,-	p5@Wtap
Mm9::chr17:13185469..13185514,-	p3@Wtap
Mm9::chr17:74738040..74738089,+	p1@Spast
Mm9::chr19:40588323..40588370,-	p4@Sorbs1
Mm9::chr1:127332321..127332330,-	p6@Actr3
Mm9::chr1:157005814..157005831,+	p2@Stx6
Mm9::chr9:110019834..110019857,-	p3@Dhx30
Mm9::chrX:20195322..20195344,-	p@chrX:20195322..20195344 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0019961	interferon binding	0.0441693570460601
GO:0006868	glutamine transport	0.0441693570460601
GO:0015186	L-glutamine transmembrane transporter activity	0.0441693570460601
GO:0004637	phosphoribosylamine-glycine ligase activity	0.0441693570460601
GO:0004904	interferon receptor activity	0.0441693570460601
GO:0043149	stress fiber formation	0.0473139401846565
GO:0015802	basic amino acid transport	0.0473139401846565

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
CNS neuron (sensu Vertebrata)	5.27e-12	23
neuroblast (sensu Vertebrata)	5.27e-12	23
neuron	2.60e-09	33
neuronal stem cell	2.60e-09	33
neuroblast	2.60e-09	33
electrically signaling cell	2.60e-09	33

Uber Anatomy

Ontology term	p-value	n
regional part of nervous system	6.66e-18	54
neurectoderm	1.87e-17	64
neural plate	1.87e-17	64
presumptive neural plate	1.87e-17	64
neural tube	4.93e-17	52
neural rod	4.93e-17	52
future spinal cord	4.93e-17	52
neural keel	4.93e-17	52
ecto-epithelium	6.32e-17	73
central nervous system	9.31e-17	73
pre-chordal neural plate	1.57e-16	49
nervous system	4.14e-16	75
ectoderm-derived structure	5.41e-16	95
ectoderm	5.41e-16	95
presumptive ectoderm	5.41e-16	95
anterior neural tube	4.12e-15	40
gray matter	6.17e-15	34
brain	7.84e-15	47
future brain	7.84e-15	47
regional part of forebrain	1.00e-14	39
forebrain	1.00e-14	39
future forebrain	1.00e-14	39
regional part of brain	2.18e-14	46
brain grey matter	1.73e-12	29
regional part of telencephalon	1.73e-12	29
telencephalon	1.73e-12	29
cerebral cortex	1.45e-09	21
cerebral hemisphere	1.45e-09	21
pallium	1.45e-09	21
structure with developmental contribution from neural crest	5.67e-09	92
anterior region of body	1.04e-08	43
regional part of cerebral cortex	3.55e-07	17
organ part	8.28e-07	99

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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