Coexpression cluster:C1762: Difference between revisions

Revision as of 15:05, 26 November 2012

Full id: C1762_Basophils_Natural_CD8_heart_Peripheral_CD4_CD14

Phase1 CAGE Peaks

Hg19::chr16:50187556..50187567,+	p8@PAPD5
Hg19::chr5:58334901..58334921,-	p32@PDE4D
Hg19::chr5:58334931..58334942,-	p33@PDE4D
Hg19::chr5:58334948..58334962,-	p21@PDE4D
Hg19::chr5:58334967..58334976,-	p44@PDE4D

Enriched pathways on this co-expression clusterSummary: Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons. Analyst: Emmanuel Dimont link to source dataset data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. Analyst: Erik Arner link to source dataset data

GO ID	GO name	FDR corrected p-value
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	0.0226637230903166
GO:0005626	insoluble fraction	0.0317095964097316
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	0.0317095964097316
GO:0004112	cyclic-nucleotide phosphodiesterase activity	0.0317095964097316
GO:0003887	DNA-directed DNA polymerase activity	0.0317095964097316

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji links to source dataset cell_data

Cell Type
Ontology term	p-value	n
mature alpha-beta T cell	5.54e-08	18
alpha-beta T cell	5.54e-08	18
immature T cell	5.54e-08	18
mature T cell	5.54e-08	18
immature alpha-beta T cell	5.54e-08	18
T cell	9.23e-07	25
pro-T cell	9.23e-07	25
circulating cell	9.32e-07	6

Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon link to source data Novel motifs data Jaspar motifs data

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. Analyst: Erik Arner link to source dataset data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
FOS#2353	4	7.19836424711553	0.000694785845338251	0.00559638584770026
FOSL2#2355	3	10.158120362737	0.00188199070341543	0.0110915426372103
REST#5978	4	7.72002297290242	0.000528636377365057	0.00457303525351025

Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. Analyst:NA link to data source data

This analysis result is provided for C0 - C305 clusters.

@@ Line 9: / Line 9: @@
 |tf_chipseq_enrich=FOS#2353;4:7.19836424711553:0.000694785845338251:0.00559638584770026!FOSL2#2355;3:10.158120362737:0.00188199070341543:0.0110915426372103!REST#5978;4:7.72002297290242:0.000528636377365057:0.00457303525351025
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+|tfbs_overrepresentation_for_novel_motifs=0.508327,1.68128,0.500341,0.654974,0.454983,0.653236,1.73914,0.866061,0.859849,0.703495,2.55627,0.778743,0.752887,0.721271,1.14971,0.478935,2.21256,0.395009,0.287891,0.167776,0.500405,0.384437,2.63265,0.44943,1.35492,0.802434,0.25115,1.55072,2.02225,0.233785,0.598009,1.00172,0.359091,0.27659,0.417272,0.432883,3.81581,2.66282,0.388123,0.301779,0.415749,0.580638,1.33238,0.451846,0.476793,0.533483,0.734485,0.609718,0.124583,1.16046,0.817229,1.76707,0.560115,1.08035,1.2359,2.88512,0.4631,0.689906,0.659455,1.64682,1.04369,0.736968,0.86107,0.935408,2.98433,0.899893,1.32544,1.69665,0.991065,1.53343,0.566575,0.330474,2.36503,1.23387,0.269111,2.02182,0.675933,0.917983,0.987729,0.543014,0.293154,0.934302,0.755403,0.873042,1.18161,1.37242,0.166306,1.88098,0.844289,1.79645,1.41984,1.15413,1.01895,0.367039,2.9911,0.381528,0.28626,1.06255,0.849074,0.211081,0.389604,1.01316,1.05685,0.967698,0.88799,0.616433,0.951411,0.717647,3.41206,0.437618,0.512457,1.05402,0.494368,1.52665,1.37132,0.412056,0.597842,1.45429,0.897476,0.370186,1.22546,1.96265,0.650322,0.767198,1.48307,0.918767,0.72668,1.02407,1.2687,0.382577,1.15483,0.601055,1.28328,0.763715,1.43285,0.221105,1.44357,0.643339,1.38998,2.25246,1.84906,1.35224,0.728494,1.05895,2.06113,0.680988,0.87256,2.09294,2.41357,0.363423,1.60094,2.53309,1.15522,2.31232,0.736459,1.56426,0.827475,0.439798,0.54968,0.518696,1.35101,1.13636,0.98692,0.522159,0.906429,0.754576,0.35004,0.731946,0.720819
 }}

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Coexpression cluster:C1762: Difference between revisions

From FANTOM5_SSTAR

Revision as of 15:05, 26 November 2012

Phase1 CAGE Peaks

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