Coexpression cluster:C380

Full id: C380_heart_left_throat_skeletal_mesothelioma_aorta_Mesothelial

Phase1 CAGE Peaks

Hg19::chr10:112462771..112462775,+	p@chr10:112462771..112462775 +
Hg19::chr11:47367243..47367257,-	p@chr11:47367243..47367257 -
Hg19::chr12:32974355..32974372,-	p3@PKP2
Hg19::chr12:32974714..32974725,-	p13@PKP2
Hg19::chr12:32974731..32974751,-	p6@PKP2
Hg19::chr12:32974753..32974763,-	p11@PKP2
Hg19::chr12:32974832..32974843,-	p9@PKP2
Hg19::chr12:3373147..3373149,-	p@chr12:3373147..3373149 -
Hg19::chr12:6041994..6041999,-	p@chr12:6041994..6041999 -
Hg19::chr19:55661803..55661807,-	p@chr19:55661803..55661807 -
Hg19::chr1:163112885..163112906,-	p6@RGS5
Hg19::chr1:201328177..201328208,-	p@chr1:201328177..201328208 -
Hg19::chr1:202550266..202550277,+	p@chr1:202550266..202550277 +
Hg19::chr1:237214095..237214115,+	p@chr1:237214095..237214115 +
Hg19::chr1:237226595..237226612,+	p@chr1:237226595..237226612 +
Hg19::chr22:44535927..44535938,+	p@chr22:44535927..44535938 +
Hg19::chr2:106039100..106039104,-	p@chr2:106039100..106039104 -
Hg19::chr2:60666949..60666962,-	p@chr2:60666949..60666962 -
Hg19::chr2:69810025..69810036,-	p@chr2:69810025..69810036 -
Hg19::chr3:188604373..188604384,+	p8@uc003fru.1
Hg19::chr4:190155067..190155109,+	p@chr4:190155067..190155109 +
Hg19::chr4:53417758..53417768,-	p@chr4:53417758..53417768 -
Hg19::chr5:123739302..123739319,-	p@chr5:123739302..123739319 -
Hg19::chr5:142269334..142269337,-	p@chr5:142269334..142269337 -
Hg19::chr5:79506498..79506503,+	p@chr5:79506498..79506503 +
Hg19::chr6:128969727..128969733,+	p@chr6:128969727..128969733 +
Hg19::chr7:113558943..113558969,-	p2@PPP1R3A
Hg19::chr9:14031288..14031299,-	p@chr9:14031288..14031299 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004865	type 1 serine/threonine specific protein phosphatase inhibitor activity	0.0286925029942332
GO:0030057	desmosome	0.0286925029942332
GO:0004864	protein phosphatase inhibitor activity	0.0343924996183941
GO:0019212	phosphatase inhibitor activity	0.0343924996183941
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway	0.0343924996183941
GO:0014704	intercalated disc	0.0343924996183941
GO:0005977	glycogen metabolic process	0.0343924996183941
GO:0006073	glucan metabolic process	0.0343924996183941
GO:0006112	energy reserve metabolic process	0.0350221767648703
GO:0019888	protein phosphatase regulator activity	0.0375536847932551
GO:0019208	phosphatase regulator activity	0.0375536847932551
GO:0044264	cellular polysaccharide metabolic process	0.0375536847932551
GO:0005976	polysaccharide metabolic process	0.0375536847932551
GO:0043296	apical junction complex	0.0375536847932551
GO:0009968	negative regulation of signal transduction	0.0375536847932551
GO:0016327	apicolateral plasma membrane	0.0375536847932551
GO:0015980	energy derivation by oxidation of organic compounds	0.0393701076521977

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br>disease_data<br>

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Uber Anatomy

Ontology term	p-value	n
primary circulatory organ	3.82e-51	27
valve	8.37e-39	3
cardiac mesenchyme	8.37e-39	3
cardial valve	8.37e-39	3
tunica intima	8.37e-39	3
heart layer	8.37e-39	3
endocardium	8.37e-39	3
endocardial cushion	8.37e-39	3
presumptive endocardium	8.37e-39	3
pulmonary valve	7.48e-30	1
semi-lunar valve	7.48e-30	1
mitral valve	1.33e-29	1
left cardiac atrium	2.37e-29	1
compound organ	1.45e-20	68
heart	1.92e-19	24
primitive heart tube	1.92e-19	24
primary heart field	1.92e-19	24
anterior lateral plate mesoderm	1.92e-19	24
heart tube	1.92e-19	24
heart primordium	1.92e-19	24
cardiac mesoderm	1.92e-19	24
cardiogenic plate	1.92e-19	24
heart rudiment	1.92e-19	24
blood vessel layer	2.67e-17	7
atrioventricular valve	1.54e-15	2
cardiac atrium	2.05e-15	2
future cardiac atrium	2.05e-15	2
circulatory system	1.36e-12	112
neural crest-derived structure	2.00e-12	10
neural crest	2.00e-12	10
neural fold	2.00e-12	10
cardiac chamber	9.90e-11	3
adult organism	3.71e-09	114

Disease

Ontology term	p-value	n
heart disease	1.13e-56	2
vascular disease	4.20e-29	1
ischemia	4.20e-29	1
extrinsic cardiomyopathy	4.20e-29	1
myocardial ischemia	4.20e-29	1
myocardial infarction	4.20e-29	1
cardiovascular system disease	5.61e-29	4

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.