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Coexpression cluster:C3341: Difference between revisions

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|full_id=C3341_extraskeletal_CD14_adrenal_gastric_Basophils_Mesothelial_Mast
|full_id=C3341_extraskeletal_CD14_adrenal_gastric_Basophils_Mesothelial_Mast
|id=C3341
|id=C3341
|ontology_enrichment_celltype=CL:0002057!8.21e-27!42;CL:0000860!2.88e-22!45;CL:0000766!1.93e-20!76;CL:0000839!1.20e-15!70;CL:0000557!1.73e-15!71;CL:0002194!3.02e-15!63;CL:0000576!3.02e-15!63;CL:0000040!3.02e-15!63;CL:0000559!3.02e-15!63;CL:0002009!2.92e-14!65;CL:0002371!8.55e-10!591;CL:0000763!2.97e-08!112;CL:0000049!2.97e-08!112;CL:0000359!1.39e-07!32;CL:0000723!1.55e-07!436;CL:0000034!1.91e-07!444;CL:0000048!2.02e-07!430;CL:0000144!3.04e-07!625;CL:0000192!4.52e-07!42;CL:0000514!4.52e-07!42;CL:0002393!7.01e-07!9;CL:0002397!7.01e-07!9
|ontology_enrichment_celltype=CL:0000473!7.76e-27!48;CL:0000234!7.76e-27!48;CL:0000860!9.30e-27!42;CL:0002057!9.30e-27!42;CL:0000766!4.00e-25!72;CL:0000557!4.41e-20!67;CL:0002194!7.16e-20!59;CL:0000576!7.16e-20!59;CL:0000040!7.16e-20!59;CL:0000559!7.16e-20!59;CL:0000839!1.37e-19!66;CL:0000325!2.03e-19!87;CL:0002009!1.02e-18!61;CL:0000763!1.21e-10!108;CL:0000049!1.21e-10!108;CL:0002371!1.44e-09!588;CL:0000359!8.12e-08!32;CL:0000048!1.05e-07!427;CL:0000723!1.09e-07!433;CL:0000034!1.39e-07!441
|ontology_enrichment_disease=
|ontology_enrichment_disease=DOID:2394!9.89e-07!14
|ontology_enrichment_uberon=UBERON:0003081!4.01e-16!216;UBERON:0002204!1.63e-15!167;UBERON:0002193!5.36e-14!112;UBERON:0002371!1.03e-13!80;UBERON:0002390!2.63e-13!102;UBERON:0003061!2.63e-13!102;UBERON:0002405!4.58e-13!115;UBERON:0004765!1.66e-12!101;UBERON:0001434!1.66e-12!101;UBERON:0004535!2.30e-12!110;UBERON:0001474!2.61e-12!86;UBERON:0000926!8.66e-12!448;UBERON:0004120!8.66e-12!448;UBERON:0006603!8.66e-12!448;UBERON:0000467!1.02e-11!625;UBERON:0000480!1.62e-11!626;UBERON:0001009!2.37e-11!113;UBERON:0001637!1.08e-10!42;UBERON:0003509!1.08e-10!42;UBERON:0004572!1.08e-10!42;UBERON:0002049!1.22e-10!79;UBERON:0007798!1.22e-10!79;UBERON:0000055!1.82e-10!69;UBERON:0000923!2.84e-10!604;UBERON:0005291!2.84e-10!604;UBERON:0006598!2.84e-10!604;UBERON:0002532!2.84e-10!604;UBERON:0001981!3.17e-10!60;UBERON:0007500!3.17e-10!60;UBERON:0004537!3.17e-10!60;UBERON:0006965!3.17e-10!60;UBERON:0002050!4.62e-10!605;UBERON:0005423!4.62e-10!605;UBERON:0000922!8.77e-10!612;UBERON:0004573!6.19e-09!33;UBERON:0004571!6.19e-09!33;UBERON:0004872!2.04e-08!84;UBERON:0000468!2.12e-08!659;UBERON:0003914!7.58e-08!118
|ontology_enrichment_uberon=UBERON:0003081!2.36e-19!203;UBERON:0002371!9.10e-18!76;UBERON:0002204!4.57e-17!167;UBERON:0002193!4.99e-17!108;UBERON:0004765!1.09e-16!90;UBERON:0002390!1.13e-16!98;UBERON:0003061!1.13e-16!98;UBERON:0001474!4.26e-16!82;UBERON:0002405!5.29e-16!93;UBERON:0001434!5.01e-15!100;UBERON:0000926!2.70e-14!315;UBERON:0004120!2.70e-14!315;UBERON:0006603!2.70e-14!315;UBERON:0004535!8.62e-12!109;UBERON:0002050!1.42e-11!564;UBERON:0000467!3.86e-11!624;UBERON:0000923!4.71e-11!560;UBERON:0010316!4.71e-11!560;UBERON:0005291!4.71e-11!560;UBERON:0006598!4.71e-11!560;UBERON:0010317!4.71e-11!560;UBERON:0002532!4.71e-11!560;UBERON:0000480!5.33e-11!625;UBERON:0001009!1.41e-10!112;UBERON:0000922!2.75e-10!592;UBERON:0001637!3.34e-10!42;UBERON:0003509!3.34e-10!42;UBERON:0004572!3.34e-10!42;UBERON:0005423!3.55e-10!581;UBERON:0002049!3.68e-10!78;UBERON:0007798!3.68e-10!78;UBERON:0000055!6.20e-10!68;UBERON:0007500!9.72e-10!59;UBERON:0001981!9.72e-10!59;UBERON:0004537!9.72e-10!59;UBERON:0006965!9.72e-10!59;UBERON:0004573!2.01e-08!33;UBERON:0004571!2.01e-08!33;UBERON:0004872!5.95e-08!83;UBERON:0000468!6.79e-08!656;UBERON:0003914!4.37e-07!117
|tf_chipseq_enrich=ELK4#2005;2:10.823787772312:0.0109128471951648:0.0401793290635202!FOXA2#3170;2:16.4203091684435:0.00481068235210548:0.022579787612761!NR3C1#2908;2:9.98201555411536:0.0127847436554717:0.0460232263419899!RAD21#5885;3:10.3550338954563:0.000900491207356542:0.00662578562809003!REST#5978;3:9.65002871612802:0.00111263624711459:0.00766002748928152!SMARCC1#6599;2:29.1089062130876:0.00154920081422414:0.00984226436138175!SREBF1#6720;2:31.3372329603255:0.0013381626513618:0.00887342026321113!TRIM28#10155;2:12.3936833635083:0.00836834412943847:0.032894783113193
|tf_chipseq_enrich=ELK4#2005;2:10.823787772312:0.0109128471951648:0.0401793290635202!FOXA2#3170;2:16.4203091684435:0.00481068235210548:0.022579787612761!NR3C1#2908;2:9.98201555411536:0.0127847436554717:0.0460232263419899!RAD21#5885;3:10.3550338954563:0.000900491207356542:0.00662578562809003!REST#5978;3:9.65002871612802:0.00111263624711459:0.00766002748928152!SMARCC1#6599;2:29.1089062130876:0.00154920081422414:0.00984226436138175!SREBF1#6720;2:31.3372329603255:0.0013381626513618:0.00887342026321113!TRIM28#10155;2:12.3936833635083:0.00836834412943847:0.032894783113193
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}}
}}

Revision as of 15:01, 19 October 2012


Full id: C3341_extraskeletal_CD14_adrenal_gastric_Basophils_Mesothelial_Mast



Phase1 CAGE Peaks

Hg19::chr12:89745775..89745786,-p4@DUSP6
Hg19::chr12:89746024..89746048,-p3@DUSP6
Hg19::chr12:89746173..89746188,-p2@DUSP6


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
lateral plate mesoderm2.36e-19203
bone marrow9.10e-1876
musculoskeletal system4.57e-17167
hemolymphoid system4.99e-17108
skeletal element1.09e-1690
hematopoietic system1.13e-1698
blood island1.13e-1698
bone element4.26e-1682
immune system5.29e-1693
skeletal system5.01e-15100
mesoderm2.70e-14315
mesoderm-derived structure2.70e-14315
presumptive mesoderm2.70e-14315
cardiovascular system8.62e-12109
embryonic structure1.42e-11564
anatomical system3.86e-11624
germ layer4.71e-11560
germ layer / neural crest4.71e-11560
embryonic tissue4.71e-11560
presumptive structure4.71e-11560
germ layer / neural crest derived structure4.71e-11560
epiblast (generic)4.71e-11560
anatomical group5.33e-11625
circulatory system1.41e-10112
embryo2.75e-10592
artery3.34e-1042
arterial blood vessel3.34e-1042
arterial system3.34e-1042
developing anatomical structure3.55e-10581
vasculature3.68e-1078
vascular system3.68e-1078
vessel6.20e-1068
epithelial tube open at both ends9.72e-1059
blood vessel9.72e-1059
blood vasculature9.72e-1059
vascular cord9.72e-1059
systemic artery2.01e-0833
systemic arterial system2.01e-0833
splanchnic layer of lateral plate mesoderm5.95e-0883
multi-cellular organism6.79e-08656
epithelial tube4.37e-07117
Disease
Ontology termp-valuen
ovarian cancer9.89e-0714


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
ELK4#2005210.8237877723120.01091284719516480.0401793290635202
FOXA2#3170216.42030916844350.004810682352105480.022579787612761
NR3C1#290829.982015554115360.01278474365547170.0460232263419899
RAD21#5885310.35503389545630.0009004912073565420.00662578562809003
REST#597839.650028716128020.001112636247114590.00766002748928152
SMARCC1#6599229.10890621308760.001549200814224140.00984226436138175
SREBF1#6720231.33723296032550.00133816265136180.00887342026321113
TRIM28#10155212.39368336350830.008368344129438470.032894783113193



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.