MCL coexpression mm9:413

Phase1 CAGE Peaks

	Short description
Mm9::chr10:13737752..13737775,+	p@chr10:13737752..13737775 +
Mm9::chr11:3995347..3995443,-	p1@Mtfp1
Mm9::chr13:45634175..45634208,+	p5@Gmpr
Mm9::chr13:46513635..46513685,+	p2@Rbm24
Mm9::chr13:46514389..46514406,+	p@chr13:46514389..46514406 +
Mm9::chr13:46597418..46597476,+	p2@Cap2
Mm9::chr13:46597482..46597509,+	p3@Cap2
Mm9::chr13:46597510..46597556,+	p1@Cap2
Mm9::chr13:46733595..46733599,+	p@chr13:46733595..46733599 +
Mm9::chr13:94074021..94074093,+	p1@Homer1
Mm9::chr14:55594201..55594242,-	p@chr14:55594201..55594242 -
Mm9::chr17:8476281..8476306,+	p2@Brp44l p2@LOC100503245
Mm9::chr1:136852485..136852532,-	p2@Ppp1r12b
Mm9::chr2:120070893..120070982,-	p1@Pla2g4e
Mm9::chr7:19918416..19918447,+	p@chr7:19918416..19918447 +
Mm9::chrX:80205901..80205930,+	p@chrX:80205901..80205930 +
Mm9::chrX:80314745..80314748,+	p@chrX:80314745..80314748 +
Mm9::chrX:80333138..80333139,+	p@chrX:80333138..80333139 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0016657	oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor	0.030237461888318
GO:0003920	GMP reductase activity	0.030237461888318
GO:0007216	metabotropic glutamate receptor signaling pathway	0.0403055723210818

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
structure with developmental contribution from neural crest	1.99e-14	92
multi-cellular organism	1.00e-09	333
ecto-epithelium	1.29e-09	73
neurectoderm	3.14e-09	64
neural plate	3.14e-09	64
presumptive neural plate	3.14e-09	64
pre-chordal neural plate	1.73e-08	49
anatomical conduit	1.95e-08	122
regional part of nervous system	4.37e-08	54
occipital lobe	5.60e-08	10
visual cortex	5.60e-08	10
neocortex	5.60e-08	10
tube	6.84e-08	114
neural tube	7.09e-08	52
neural rod	7.09e-08	52
future spinal cord	7.09e-08	52
neural keel	7.09e-08	52
brain	7.27e-08	47
future brain	7.27e-08	47
ectoderm-derived structure	1.44e-07	95
ectoderm	1.44e-07	95
presumptive ectoderm	1.44e-07	95
brain grey matter	1.51e-07	29
regional part of telencephalon	1.51e-07	29
telencephalon	1.51e-07	29
gray matter	1.70e-07	34
regional part of brain	1.98e-07	46
primary circulatory organ	4.25e-07	18
heart	4.25e-07	18
primitive heart tube	4.25e-07	18
primary heart field	4.25e-07	18
anterior lateral plate mesoderm	4.25e-07	18
heart tube	4.25e-07	18
heart primordium	4.25e-07	18
cardiac mesoderm	4.25e-07	18
cardiogenic plate	4.25e-07	18
heart rudiment	4.25e-07	18
anterior neural tube	7.99e-07	40
tissue	9.11e-07	349

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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