MCL coexpression mm9:1554

Phase1 CAGE Peaks

	Short description
Mm9::chr11:118254634..118254659,-	p@chr11:118254634..118254659 -
Mm9::chr11:118255297..118255335,-	p@chr11:118255297..118255335 -
Mm9::chr15:100450395..100450438,+	p@chr15:100450395..100450438 +
Mm9::chr19:3903656..3903673,-	p3@Tcirg1
Mm9::chr7:109388139..109388167,-	p@chr7:109388139..109388167 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004720	protein-lysine 6-oxidase activity	0.0341580732269863
GO:0017111	nucleoside-triphosphatase activity	0.0341580732269863
GO:0016462	pyrophosphatase activity	0.0341580732269863
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.0341580732269863
GO:0016817	hydrolase activity, acting on acid anhydrides	0.0341580732269863
GO:0016601	Rac protein signal transduction	0.0341580732269863
GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	0.0341580732269863
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	0.0373522031162517
GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism	0.0388335179934275
GO:0005044	scavenger receptor activity	0.0388335179934275

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
endoderm-derived structure	2.96e-11	118
endoderm	2.96e-11	118
presumptive endoderm	2.96e-11	118
digestive system	1.35e-10	116
digestive tract	1.35e-10	116
primitive gut	1.35e-10	116
subdivision of digestive tract	3.92e-10	114
trunk	2.52e-08	90
anatomical system	7.10e-08	308
anatomical group	7.10e-08	308
trunk mesenchyme	1.31e-07	45
mesenchyme	8.52e-07	61
entire embryonic mesenchyme	8.52e-07	61
trunk region element	9.41e-07	79
abdomen element	9.62e-07	49
abdominal segment element	9.62e-07	49
abdominal segment of trunk	9.62e-07	49
abdomen	9.62e-07	49

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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