MCL coexpression mm9:1355

Phase1 CAGE Peaks

	Short description
Mm9::chr14:121434731..121434742,+	p7@Farp1
Mm9::chr18:37966664..37966677,+	p@chr18:37966664..37966677 +
Mm9::chr1:95532218..95532229,-	p4@Stk25
Mm9::chr4:115894226..115894237,+	p3@Pik3r3
Mm9::chr8:114267768..114267787,-	p3@Bcar1
Mm9::chr8:127187311..127187332,-	p4@2310022B05Rik

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	0.0246534816194598
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	0.0308033469676536
GO:0048008	platelet-derived growth factor receptor signaling pathway	0.0308033469676536
GO:0035014	phosphoinositide 3-kinase regulator activity	0.0308033469676536
GO:0007167	enzyme linked receptor protein signaling pathway	0.0351845416805496
GO:0005942	phosphoinositide 3-kinase complex	0.0351845416805496
GO:0016339	calcium-dependent cell-cell adhesion	0.0351845416805496
GO:0030054	cell junction	0.0473742144187332

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
neural cell	5.92e-13	43
ectodermal cell	5.97e-13	44
neurectodermal cell	5.97e-13	44
non-terminally differentiated cell	1.55e-12	49
CNS neuron (sensu Vertebrata)	4.22e-12	23
neuroblast (sensu Vertebrata)	4.22e-12	23
neuron	1.10e-11	33
neuronal stem cell	1.10e-11	33
neuroblast	1.10e-11	33
electrically signaling cell	1.10e-11	33
electrically responsive cell	4.23e-11	39
electrically active cell	4.23e-11	39

Uber Anatomy

Ontology term	p-value	n
central nervous system	5.92e-26	73
nervous system	7.83e-26	75
ectoderm-derived structure	1.42e-24	95
ectoderm	1.42e-24	95
presumptive ectoderm	1.42e-24	95
neurectoderm	5.70e-24	64
neural plate	5.70e-24	64
presumptive neural plate	5.70e-24	64
neural tube	2.53e-23	52
neural rod	2.53e-23	52
future spinal cord	2.53e-23	52
neural keel	2.53e-23	52
regional part of nervous system	6.14e-23	54
ecto-epithelium	2.15e-21	73
structure with developmental contribution from neural crest	2.33e-21	92
brain	2.81e-20	47
future brain	2.81e-20	47
regional part of brain	6.47e-20	46
gray matter	1.36e-18	34
pre-chordal neural plate	2.25e-18	49
anterior neural tube	1.06e-17	40
regional part of forebrain	3.47e-17	39
forebrain	3.47e-17	39
future forebrain	3.47e-17	39
brain grey matter	1.31e-15	29
regional part of telencephalon	1.31e-15	29
telencephalon	1.31e-15	29
cerebral cortex	2.17e-12	21
cerebral hemisphere	2.17e-12	21
pallium	2.17e-12	21
tube	8.09e-11	114
anatomical conduit	3.01e-10	122
regional part of cerebral cortex	5.06e-10	17
multi-cellular organism	7.65e-08	333

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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