MCL coexpression mm9:1022

Phase1 CAGE Peaks

	Short description
Mm9::chr10:40349793..40349859,+	p1@Ddo
Mm9::chr11:94901820..94901857,-	p7@Pdk2
Mm9::chr17:27154950..27155012,+	p2@Ggnbp1
Mm9::chr19:44620299..44620322,-	p2@Sec31b
Mm9::chr19:44620326..44620361,-	p1@Sec31b
Mm9::chr19:7131357..7131423,+	p1@Macrod1
Mm9::chr4:33276385..33276430,-	p1@Pm20d2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0015922	aspartate oxidase activity	0.0173986206403512
GO:0008445	D-aspartate oxidase activity	0.0173986206403512
GO:0003884	D-amino-acid oxidase activity	0.0173986206403512
GO:0006531	aspartate metabolic process	0.0173986206403512
GO:0044444	cytoplasmic part	0.0173986206403512
GO:0006086	acetyl-CoA biosynthetic process from pyruvate	0.0194060622428501
GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	0.0194060622428501
GO:0007320	insemination	0.0194060622428501
GO:0018106	peptidyl-histidine phosphorylation	0.0194060622428501
GO:0007620	copulation	0.0194060622428501
GO:0006085	acetyl-CoA biosynthetic process	0.0194060622428501
GO:0018202	peptidyl-histidine modification	0.0194060622428501
GO:0007625	grooming behavior	0.0194060622428501
GO:0004673	protein histidine kinase activity	0.0300167411853002
GO:0007618	mating	0.0345885816586775
GO:0009066	aspartate family amino acid metabolic process	0.0345885816586775
GO:0016775	phosphotransferase activity, nitrogenous group as acceptor	0.0345885816586775
GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	0.037323481861197
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	0.0440581817269506
GO:0006090	pyruvate metabolic process	0.0440581817269506
GO:0000003	reproduction	0.0454201494827825
GO:0019752	carboxylic acid metabolic process	0.046996765005203
GO:0006082	organic acid metabolic process	0.046996765005203

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
epithelial tube	2.02e-09	47
multi-cellular organism	3.86e-07	333
primary circulatory organ	4.85e-07	18
heart	4.85e-07	18
primitive heart tube	4.85e-07	18
primary heart field	4.85e-07	18
anterior lateral plate mesoderm	4.85e-07	18
heart tube	4.85e-07	18
heart primordium	4.85e-07	18
cardiac mesoderm	4.85e-07	18
cardiogenic plate	4.85e-07	18
heart rudiment	4.85e-07	18

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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