Personal tools

MCL coexpression mm9:3072: Difference between revisions

From FANTOM5_SSTAR

Jump to: navigation, search
No edit summary
No edit summary
Line 1: Line 1:
{{MCL_coexpression_mm9
{{MCL_coexpression_mm9
|coexpression_dpi_cluster_scores_mean=-0.0185214093451269,0.950845234796943,0.897439455341909,0.788229489130727,0.877450526021359,0.79047637311286,0.813252064694808,-0.21489858085028,-0.21489858085028,-0.21489858085028,-0.21489858085028,-0.21489858085028,-0.21489858085028,-0.21489858085028,-0.0406736488306203,-0.146188269090006,-0.0217041601535147,-0.144087310271482,-0.165021025470314,-0.0712416178686777,0.365004413514821,-0.21489858085028,-0.21489858085028,0.73683388912579,0.698416355402014,0.941943208133975,0.743746937165171,0.86426077618304,0.799392374530474,0.725250367636928,0.796170073132216,-0.21489858085028,-0.21489858085028,-0.21489858085028,0.838864349788015,0.690126048806974,0.730600971715111,-0.0725045970130697,0.0367549221765053,-0.0513873673139377,-0.21489858085028,-0.090221434822653,-0.058682320331534,-0.197732383608382,-0.21489858085028,-0.21489858085028,-0.21489858085028,-0.21489858085028,0.101706239161569,0.0204755830922067,-0.195932021354583,-0.21489858085028,-0.21489858085028,-0.21489858085028,-0.21489858085028,-0.21489858085028,-0.178424887851178,-0.154696829476764,-0.21489858085028,-0.15343027312595,-0.21489858085028,-0.139994756306606,-0.21489858085028,-0.091218560155149,-0.056936676240404,-0.21489858085028,-0.0378752175623883,0.00148029578343352,-0.187617347959127,-0.180295986740223,-0.144082823103292,-0.0558795463973093,-0.0675648979083577,-0.183177603400982,-0.18951070141227,-0.21489858085028,-0.21489858085028,-0.060003663200719,-0.109208737677195,-0.056909376633602,-0.0467097571718123,0.0228561730246424,-0.106343289336642,-0.0717399921860827,-0.0424131278114037,-0.0528779375038153,-0.0253000901159805,-0.169029607560037,-0.204331332989464,-0.133413858104053,0.412232173416073,0.541415247986551,0.795011582965892,0.717669280582394,0.552606085479093,0.69630640136858,0.393010285447906,-0.21489858085028,-0.21489858085028,-0.21489858085028,0.0679597553753683,-0.21489858085028,-0.21489858085028,-0.21489858085028,0.48768686561754,0.394701476108583,0.457358150561037,0.603344069597569,-0.0791794098779667,-0.12738712294615,-0.124484064663416,-0.0611095497593997,0.0238749949413632,-0.133587311992776,-0.0943018029742006,-0.168587291191975,0.220130610845202,-0.0746837428064433,0.00407035566357687,-0.075593698579674,-0.056459039946588,-0.0849034850196707,0.769617950810355,0.123680174930733,0.0548561922646733,0.706267908183396,-0.15821702749583,-0.0658609914484253,-0.0669366081724967,-0.0143635366981041,0.0995585342114117,-0.038275022738343,0.0129079047188373,0.0345718138143157,0.0165771883672658,0.0149832048193269,0.051421539739667,0.0339272089947504,0.0662933400943192,0.182763520844145,-0.0862842498624067,-0.160133710362928,-0.121957046825616,-0.050651287947512,-0.108281266230072,-0.0801042861996077,-0.0878285703326307,-0.0299867615954282,-0.14269340256581,-0.118552573692237,-0.0350678853661687,-0.0197621319211148,-0.0728212575520183,-0.00943231972825713,-0.043666117425358,-0.0885698378787553,-0.21489858085028,-0.0530490127521447,-0.0200598812581984,-0.097971326541359,-0.0742717121784873,-0.152374173047066,-0.158782901869381,-0.147739559487711,-0.194129806844701,-0.21489858085028,-0.152716649754912,-0.159415820370335,-0.127985633812043,-0.0742721384743767,-0.0709796261655427,-0.102772030166901,-0.107647297814947,-0.0577612554950644,0.0034470560307929,0.0639934693890597,0.85471452122822,0.674310404689846,0,0.200504880176616,0.417531218076053,0.439066604041666,0.528400118722549,0.534818293399378,0.73410559659262,0.701943615821551,0.637829322725181,0.68853070366639,0.702281429406822,0.765268654915141,0.657490234312664,0.844076425046961,0.299115724297461,0.266660078555591,0.382709064553859,0.349370955065519,0.401258136711582,0.524621008017233,0.701011093682507,0.707722974771432,0.847729172031132,0.836019116995205,0.718568320339727,0.056203624207328,0.087502408808538,0.118354885348477,0.230270135479464,0.332900957794505,0.322123209889866,0.389225900163873,0.483567380761816,0.564584593074016,0.699453930953997,0.662463878292859,0.591953086901748,0.748089085932975,0.720687786224595,0.795971891196558,0.338587816830538,-5.7968448578638e-05,0.056978579342081,0.138601716460799,0.14776547531995,0.296732446715682,0.271005976587409,0.33116998499927,0.240825865550075,0.15935432466463,0.238750739861568,0.1793792223361,0.303272927911688,0.473881364077498,-0.21489858085028,-0.21489858085028,0.513791944999892,0.419679147345008,-0.076267893878487,0.0076750235455818,-0.21489858085028,0.0395012111368377,0.073077133591203,-0.0581836300923163,-0.124929179633753,-0.0190837730413917,0.0365195672250417,-0.043621379039948,0.00737688559794837,0.0965782152206143,0.0046798370465836,0.0039456553580856,0.148379492713925,0.0495262726991073,0.0604822332143173,0.328876268444933,0.580003426358814,0.380988288398481,0.547518226933531,0.638622592787076,0.591614857025671,0.704186570136729,0.75673208807905,0.739440849369211,0.769219687563703,0.710551977576431,0.501516439524979,0.573463443539697,0.0205395746562846,-0.0658143205142293,-0.019899588780032,0.0319173464841328,0.0152106492570748,0.0210286024285343,0.046902226800324,-0.023934237192662,0.0307994843821622,-0.0982364070654993,0.406436509635592,-0.156717897026053,-0.142767819045429,-0.152127172371668,-0.183904645799394,-0.11982736032188,0.803527105543929,-0.045384023088464,-0.0176987982465498,-0.0261635235451794,0.0777590157432151,-0.108615112904927,-0.0600826828538317,-0.160356796593216,-0.21489858085028,-0.195936462111483,-0.21489858085028,0.80040241779073,0.0764965186611303,0.386884263434648,0.417426586661062,0.514166088272957,0.423804731708475,0.643285731362532,0.712011492287514,0.628032740752246,0.748072998904588,0.44633590572265,-0.21489858085028,-0.156853433699138,-0.141369370810406,-0.116577489812818,-0.149904586499979,-0.21489858085028,-0.159182383112491,-0.0404218782289273,-0.1729014531199,-0.183573197662452,-0.149040997403117,-0.096603595735912,-0.146120753884778,-0.154899198969248,-0.19721591011645,-0.136717144916085,-0.188663997507654,-0.198467312804712,-0.21489858085028,-0.188271839830532,-0.193634757857421,-0.165847916744867,-0.109432767218013,-0.189421716460049,-0.148278384833859,0.179847229680616,0.036083831998106,-0.0486511711834623,-0.0551546098954403,0.394875433278771,0.26637062056685,0.4484710573334,0.0577020228134177,0.365928991266176,0.110570941691537,0.0925935942308037,0.072912401029211,0.044092379402433,0.083406521715555,-0.043551800803314,-0.0254944848612201,-0.121931775897362,-0.0247621869976059,-0.01040579071551,-0.127391250720432,-0.0218976548197072,6.75702663862263e-05,0.0633382982698443,0.0175882156863295,0.076700847233687,0.104778963536866,0.0745924860190973,0.127509183320885,0.0590287523544456,0.190808085837453,0.132463648081371,0.152359245531737,0.103189041845475,0.145902306479352,0.117185648648716,0.151445524465037,0.0919262126441934,0.0528548140581943,0.185057324104433,0.131355083650467,0.199700209343818,0.217703949017206,0.14591725080419,0.156697850392611,0.164518448602032,0.165163746504155,0.1681537775285,0.173191651529863,0.269650402326963,0.12431979889389,0.119887697945216,0.171917973981417,0.156000732840772,0.0623315991302177,0.00275358678740515,0.201022189623006,0.203637113713115,-0.104238686859073,-0.0388241641528859,-0.0886928555584333
|coexpression_dpi_cluster_scores_mean=-0.0185214093451269,0.950845234796943,0.897439455341909,0.788229489130727,0.877450526021359,0.79047637311286,0.813252064694808,-0.21489858085028,-0.21489858085028,-0.21489858085028,-0.21489858085028,-0.21489858085028,-0.21489858085028,-0.21489858085028,-0.0406736488306203,-0.146188269090006,-0.0217041601535147,-0.144087310271482,-0.165021025470314,-0.0712416178686777,0.365004413514821,-0.21489858085028,-0.21489858085028,0.73683388912579,0.698416355402014,0.941943208133975,0.743746937165171,0.86426077618304,0.799392374530474,0.725250367636928,0.796170073132216,-0.21489858085028,-0.21489858085028,-0.21489858085028,0.838864349788015,0.690126048806974,0.730600971715111,-0.0725045970130697,0.0367549221765053,-0.0513873673139377,-0.21489858085028,-0.090221434822653,-0.058682320331534,-0.197732383608382,-0.21489858085028,-0.21489858085028,-0.21489858085028,-0.21489858085028,0.101706239161569,0.0204755830922067,-0.195932021354583,-0.21489858085028,-0.21489858085028,-0.21489858085028,-0.21489858085028,-0.21489858085028,-0.178424887851178,-0.154696829476764,-0.21489858085028,-0.15343027312595,-0.21489858085028,-0.139994756306606,-0.21489858085028,-0.091218560155149,-0.056936676240404,-0.21489858085028,-0.0378752175623883,0.00148029578343352,-0.187617347959127,-0.180295986740223,-0.144082823103292,-0.0558795463973093,-0.0675648979083577,-0.183177603400982,-0.18951070141227,-0.21489858085028,-0.21489858085028,-0.060003663200719,-0.109208737677195,-0.056909376633602,-0.0467097571718123,0.0228561730246424,-0.106343289336642,-0.0717399921860827,-0.0424131278114037,-0.0528779375038153,-0.0253000901159805,-0.169029607560037,-0.204331332989464,-0.133413858104053,0.412232173416073,0.541415247986551,0.795011582965892,0.717669280582394,0.552606085479093,0.69630640136858,0.393010285447906,-0.21489858085028,-0.21489858085028,-0.21489858085028,0.0679597553753683,-0.21489858085028,-0.21489858085028,-0.21489858085028,0.48768686561754,0.394701476108583,0.457358150561037,0.603344069597569,-0.0791794098779667,-0.12738712294615,-0.124484064663416,-0.0611095497593997,0.0238749949413632,-0.133587311992776,-0.0943018029742006,-0.168587291191975,0.220130610845202,-0.0746837428064433,0.00407035566357687,-0.075593698579674,-0.056459039946588,-0.0849034850196707,0.769617950810355,0.123680174930733,0.0548561922646733,0.706267908183396,-0.15821702749583,-0.0658609914484253,-0.0669366081724967,-0.0143635366981041,0.0995585342114117,-0.038275022738343,0.0129079047188373,0.0345718138143157,0.0165771883672658,0.0149832048193269,0.051421539739667,0.0339272089947504,0.0662933400943192,0.182763520844145,-0.0862842498624067,-0.160133710362928,-0.121957046825616,-0.050651287947512,-0.108281266230072,-0.0801042861996077,-0.0878285703326307,-0.0299867615954282,-0.14269340256581,-0.118552573692237,-0.0350678853661687,-0.0197621319211148,-0.0728212575520183,-0.00943231972825713,-0.043666117425358,-0.0885698378787553,-0.21489858085028,-0.0530490127521447,-0.0200598812581984,-0.097971326541359,-0.0742717121784873,-0.152374173047066,-0.158782901869381,-0.147739559487711,-0.194129806844701,-0.21489858085028,-0.152716649754912,-0.159415820370335,-0.127985633812043,-0.0742721384743767,-0.0709796261655427,-0.102772030166901,-0.107647297814947,-0.0577612554950644,0.0034470560307929,0.0639934693890597,0.85471452122822,0.674310404689846,0,0.200504880176616,0.417531218076053,0.439066604041666,0.528400118722549,0.534818293399378,0.73410559659262,0.701943615821551,0.637829322725181,0.68853070366639,0.702281429406822,0.765268654915141,0.657490234312664,0.844076425046961,0.299115724297461,0.266660078555591,0.382709064553859,0.349370955065519,0.401258136711582,0.524621008017233,0.701011093682507,0.707722974771432,0.847729172031132,0.836019116995205,0.718568320339727,0.056203624207328,0.087502408808538,0.118354885348477,0.230270135479464,0.332900957794505,0.322123209889866,0.389225900163873,0.483567380761816,0.564584593074016,0.699453930953997,0.662463878292859,0.591953086901748,0.748089085932975,0.720687786224595,0.795971891196558,0.338587816830538,-5.7968448578638e-05,0.056978579342081,0.138601716460799,0.14776547531995,0.296732446715682,0.271005976587409,0.33116998499927,0.240825865550075,0.15935432466463,0.238750739861568,0.1793792223361,0.303272927911688,0.473881364077498,-0.21489858085028,-0.21489858085028,0.513791944999892,0.419679147345008,-0.076267893878487,0.0076750235455818,-0.21489858085028,0.0395012111368377,0.073077133591203,-0.0581836300923163,-0.124929179633753,-0.0190837730413917,0.0365195672250417,-0.043621379039948,0.00737688559794837,0.0965782152206143,0.0046798370465836,0.0039456553580856,0.148379492713925,0.0495262726991073,0.0604822332143173,0.328876268444933,0.580003426358814,0.380988288398481,0.547518226933531,0.638622592787076,0.591614857025671,0.704186570136729,0.75673208807905,0.739440849369211,0.769219687563703,0.710551977576431,0.501516439524979,0.573463443539697,0.0205395746562846,-0.0658143205142293,-0.019899588780032,0.0319173464841328,0.0152106492570748,0.0210286024285343,0.046902226800324,-0.023934237192662,0.0307994843821622,-0.0982364070654993,0.406436509635592,-0.156717897026053,-0.142767819045429,-0.152127172371668,-0.183904645799394,-0.11982736032188,0.803527105543929,-0.045384023088464,-0.0176987982465498,-0.0261635235451794,0.0777590157432151,-0.108615112904927,-0.0600826828538317,-0.160356796593216,-0.21489858085028,-0.195936462111483,-0.21489858085028,0.80040241779073,0.0764965186611303,0.386884263434648,0.417426586661062,0.514166088272957,0.423804731708475,0.643285731362532,0.712011492287514,0.628032740752246,0.748072998904588,0.44633590572265,-0.21489858085028,-0.156853433699138,-0.141369370810406,-0.116577489812818,-0.149904586499979,-0.21489858085028,-0.159182383112491,-0.0404218782289273,-0.1729014531199,-0.183573197662452,-0.149040997403117,-0.096603595735912,-0.146120753884778,-0.154899198969248,-0.19721591011645,-0.136717144916085,-0.188663997507654,-0.198467312804712,-0.21489858085028,-0.188271839830532,-0.193634757857421,-0.165847916744867,-0.109432767218013,-0.189421716460049,-0.148278384833859,0.179847229680616,0.036083831998106,-0.0486511711834623,-0.0551546098954403,0.394875433278771,0.26637062056685,0.4484710573334,0.0577020228134177,0.365928991266176,0.110570941691537,0.0925935942308037,0.072912401029211,0.044092379402433,0.083406521715555,-0.043551800803314,-0.0254944848612201,-0.121931775897362,-0.0247621869976059,-0.01040579071551,-0.127391250720432,-0.0218976548197072,6.75702663862263e-05,0.0633382982698443,0.0175882156863295,0.076700847233687,0.104778963536866,0.0745924860190973,0.127509183320885,0.0590287523544456,0.190808085837453,0.132463648081371,0.152359245531737,0.103189041845475,0.145902306479352,0.117185648648716,0.151445524465037,0.0919262126441934,0.0528548140581943,0.185057324104433,0.131355083650467,0.199700209343818,0.217703949017206,0.14591725080419,0.156697850392611,0.164518448602032,0.165163746504155,0.1681537775285,0.173191651529863,0.269650402326963,0.12431979889389,0.119887697945216,0.171917973981417,0.156000732840772,0.0623315991302177,0.00275358678740515,0.201022189623006,0.203637113713115,-0.104238686859073,-0.0388241641528859,-0.0886928555584333
|coexpression_dpi_cluster_scores_median=0,0.882554860392758,0.778512406639719,0.693026127609894,0.740998786187662,0.686745566711713,0.877437806080097,0,0,0,0,0,0,0,0,0,0,0,0,0,0.431503006084835,0,0,0.639470639089617,0.546974533653744,0.927627759385897,0.554437305291256,0.790377333393939,0.663742842644956,0.655946874034094,0.698200551674405,0,0,0,0.831039561624559,0.698068471800597,0.70615318464993,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.47503208729554,0.434704241352084,0.760407353422202,0.767699598167391,0.469723258307596,0.616600292311791,0.354876380541933,0,0,0,0,0,0,0,0.649710240044706,0.443031154493651,0.60564401592082,0.516360509636566,0,0,0,0,0,0,0,0,0.395006418895556,0,0,0,0,0,0.819000914748279,0,0,0.660523860481908,0,0,0,0,0,0,0,0,0,0,0.0421182837367051,0.0509235292940968,0.0978549673988937,0.193672964691524,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.862009477978697,0.592060807873242,0,0.229607623464208,0.383374041217442,0.479551593368416,0.477324224695323,0.606769263812126,0.585141870708775,0.709055633656218,0.603796137909848,0.621519379393293,0.654114288682922,0.662311755447834,0.528597742754588,0.790824923612791,0.289664636423013,0.226726457359759,0.327783284444535,0.384811895800088,0.372482540320573,0.547145509037727,0.713793809117659,0.628125540574229,0.898063586576035,0.799759341591523,0.598191300042536,0,0,0,0.147898898843701,0.170952023220814,0.246468434036162,0.332596908054618,0.469177121138666,0.465669791425341,0.725343592025448,0.556903658811345,0.50300902760765,0.680216104025895,0.626253442633433,0.72770320828214,0.454468598296325,0,0,0.0680912293502604,0.091558018055706,0.436486350363339,0.387108023479836,0.295714018215793,0.354316149962456,0.159245076116426,0.35710320575762,0.259908275861658,0.308801213670539,0.459458495739173,0,0,0.472325903086332,0.467098376052009,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.141334312897105,0.0711694759496908,0,0.174615154231399,0.675695066681238,0.294713625191584,0.533846821718349,0.742451896456079,0.596928893942531,0.778830566860584,0.816356189734755,0.809762065021464,0.80260001898276,0.753570621793821,0.492533012172672,0.623250975651691,0,0,0,0,0,0,0,0,0,0,0.220522613690055,0,0,0,0,0,0.730153187024635,0,0,0,0.0737896374598673,0,0,0,0,0,0,0.682928309331839,0,0.304619189055585,0.452720130139115,0.677934313650774,0.502921993379919,0.805811607701615,0.809904863637499,0.490526981764259,0.627404196987572,0.209873913294111,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.467148552140314,0.265498106216045,0.282340675306148,0,0.398758544149858,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.073294297058821,0.0871588832444397,0,0.120876255993453,0.0792401462856011,0.245620709720879,0.194758206527804,0.163596775065572,0.0523284672130554,0.128597245627104,0.169172763866184,0.198498081255604,0.0766073954291401,0,0.158843797677303,0.167275044092636,0.232971531330564,0.234342257396434,0.157166310227119,0.138756502969784,0.126604887871452,0.135404897539632,0.18359421108913,0.225056016595504,0.193442483447008,0.0924644954689594,0.112441925220423,0.256049671194843,0.165781451382873,0,0,0.205473782456849,0.216063761676531,0,0,0
|gostat_on_MCL_coexpression=GO:0030165;PDZ domain binding;0.0132580945597984;72058!GO:0019904;protein domain specific binding;0.0216950638251246;72058!GO:0005923;tight junction;0.0216950638251246;72058!GO:0043296;apical junction complex;0.0216950638251246;72058!GO:0016327;apicolateral plasma membrane;0.0216950638251246;72058!GO:0005911;intercellular junction;0.0301320330904509;72058!GO:0009986;cell surface;0.0313373144140689;72058!GO:0016337;cell-cell adhesion;0.0313373144140689;72058!
|gostat_on_MCL_coexpression=GO:0030165;PDZ domain binding;0.0132580945597984;72058!GO:0019904;protein domain specific binding;0.0216950638251246;72058!GO:0005923;tight junction;0.0216950638251246;72058!GO:0043296;apical junction complex;0.0216950638251246;72058!GO:0016327;apicolateral plasma membrane;0.0216950638251246;72058!GO:0005911;intercellular junction;0.0301320330904509;72058!GO:0009986;cell surface;0.0313373144140689;72058!GO:0016337;cell-cell adhesion;0.0313373144140689;72058!
}}
}}

Revision as of 13:23, 11 October 2012


Phase1 CAGE Peaks

 Short description
Mm9::chr16:96583335..96583347,+p3@Igsf5
Mm9::chr5:64203686..64203777,+p1@0610040J01Rik
Mm9::chr7:117792331..117792347,-p@chr7:117792331..117792347
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0030165PDZ domain binding0.0132580945597984
GO:0019904protein domain specific binding0.0216950638251246
GO:0005923tight junction0.0216950638251246
GO:0043296apical junction complex0.0216950638251246
GO:0016327apicolateral plasma membrane0.0216950638251246
GO:0005911intercellular junction0.0301320330904509
GO:0009986cell surface0.0313373144140689
GO:0016337cell-cell adhesion0.0313373144140689



Relative expression of the co-expression cluster over median <br>Analyst:





Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen

Uber Anatomy
Ontology termp-valuen

Disease
Ontology termp-valuen


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs




JASPAR motifs


Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}