MCL coexpression mm9:977

Phase1 CAGE Peaks

	Short description
Mm9::chr18:52689249..52689272,-	p1@Lox
Mm9::chr18:52689284..52689297,-	p3@Lox
Mm9::chr18:52689310..52689327,-	p2@Lox
Mm9::chr18:52689346..52689363,-	p4@Lox
Mm9::chr18:52689457..52689483,-	p6@Lox
Mm9::chr18:61204893..61204902,+	p6@Pdgfrb
Mm9::chr2:30297583..30297598,+	p@chr2:30297583..30297598 +
Mm9::chr6:113640950..113640970,+	p@chr6:113640950..113640970 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	0.0078468093272825
GO:0007167	enzyme linked receptor protein signaling pathway	0.0104734073596937
GO:0048251	elastic fiber assembly	0.010846937592383
GO:0004720	protein-lysine 6-oxidase activity	0.0162690691681711
GO:0005021	vascular endothelial growth factor receptor activity	0.0216897149435109
GO:0030199	collagen fibril organization	0.0247841703113544
GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	0.0247841703113544
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	0.0271047146771474
GO:0050730	regulation of peptidyl-tyrosine phosphorylation	0.0306023212323308
GO:0005581	collagen	0.0306023212323308
GO:0001932	regulation of protein amino acid phosphorylation	0.0306023212323308
GO:0033238	regulation of amine metabolic process	0.0306023212323308
GO:0006521	regulation of amino acid metabolic process	0.0306023212323308
GO:0005507	copper ion binding	0.0306023212323308
GO:0018212	peptidyl-tyrosine modification	0.0306023212323308
GO:0042325	regulation of phosphorylation	0.0306023212323308
GO:0018108	peptidyl-tyrosine phosphorylation	0.0306023212323308
GO:0051174	regulation of phosphorus metabolic process	0.0306023212323308
GO:0019220	regulation of phosphate metabolic process	0.0306023212323308
GO:0030198	extracellular matrix organization and biogenesis	0.0306023212323308
GO:0004714	transmembrane receptor protein tyrosine kinase activity	0.0306023212323308
GO:0030324	lung development	0.0306023212323308
GO:0030323	respiratory tube development	0.0306023212323308
GO:0019199	transmembrane receptor protein kinase activity	0.0329294981744104
GO:0044420	extracellular matrix part	0.0387029986977406
GO:0018193	peptidyl-amino acid modification	0.0387029986977406
GO:0043062	extracellular structure organization and biogenesis	0.0396675041538477
GO:0005615	extracellular space	0.0411665423765647
GO:0044421	extracellular region part	0.04465246371108

Relative expression of the co-expression cluster over median <br>Analyst:

---

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

---

Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}