MCL coexpression mm9:1754

Phase1 CAGE Peaks

	Short description
Mm9::chr1:74283053..74283172,+	p1@Arpc2
Mm9::chr5:145875118..145875144,+	p2@Arpc1b p2@Gm5637
Mm9::chr5:145875149..145875169,+	p1@Arpc1b p1@Gm5637
Mm9::chr6:117856915..117856940,+	p10@Hnrnpf
Mm9::chr8:97856179..97856242,+	p1@AA960436

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005885	Arp2/3 protein complex	7.43800709243691e-06
GO:0015629	actin cytoskeleton	0.00317974803201679
GO:0003779	actin binding	0.00344285277496116
GO:0008092	cytoskeletal protein binding	0.00467999406256131
GO:0042995	cell projection	0.00467999406256131
GO:0044430	cytoskeletal part	0.00796575140518601
GO:0030833	regulation of actin filament polymerization	0.00923299553872398
GO:0030041	actin filament polymerization	0.0125585240120914
GO:0005856	cytoskeleton	0.0125585240120914
GO:0005925	focal adhesion	0.0125585240120914
GO:0005924	cell-substrate adherens junction	0.0125585240120914
GO:0008064	regulation of actin polymerization and/or depolymerization	0.0125585240120914
GO:0032535	regulation of cellular component size	0.0125585240120914
GO:0032956	regulation of actin cytoskeleton organization and biogenesis	0.0125585240120914
GO:0030832	regulation of actin filament length	0.0125585240120914
GO:0051493	regulation of cytoskeleton organization and biogenesis	0.0125585240120914
GO:0033043	regulation of organelle organization and biogenesis	0.0125585240120914
GO:0030055	cell-matrix junction	0.0125585240120914
GO:0051258	protein polymerization	0.0129155680297958
GO:0008154	actin polymerization and/or depolymerization	0.0129155680297958
GO:0051128	regulation of cellular component organization and biogenesis	0.0164040819038522
GO:0043232	intracellular non-membrane-bound organelle	0.0164040819038522
GO:0043228	non-membrane-bound organelle	0.0164040819038522
GO:0005912	adherens junction	0.0164040819038522
GO:0043234	protein complex	0.0171839640313105
GO:0016323	basolateral plasma membrane	0.0173720377187782
GO:0032991	macromolecular complex	0.0252617152944039
GO:0044446	intracellular organelle part	0.0321503276516958
GO:0044422	organelle part	0.0321503276516958
GO:0030036	actin cytoskeleton organization and biogenesis	0.033046321710988
GO:0030029	actin filament-based process	0.0342542506351467
GO:0051246	regulation of protein metabolic process	0.0461734766919451

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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