MCL coexpression mm9:1749

Phase1 CAGE Peaks

	Short description
Mm9::chr1:186706870..186706910,-	p1@C130074G19Rik
Mm9::chr5:117566094..117566106,-	p5@Suds3
Mm9::chr6:72340615..72340633,-	p2@Vamp8
Mm9::chr7:134614869..134614882,+	p6@Prr14
Mm9::chr9:77602333..77602348,+	p1@Gclc

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0016580	Sin3 complex	0.00793838039950046
GO:0051882	mitochondrial depolarization	0.00793838039950046
GO:0051900	regulation of mitochondrial depolarization	0.00793838039950046
GO:0017109	glutamate-cysteine ligase complex	0.00793838039950046
GO:0004357	glutamate-cysteine ligase activity	0.00793838039950046
GO:0031400	negative regulation of protein modification process	0.00793838039950046
GO:0031397	negative regulation of protein ubiquitination	0.00793838039950046
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	0.00793838039950046
GO:0045732	positive regulation of protein catabolic process	0.00793838039950046
GO:0046685	response to arsenic	0.00793838039950046
GO:0019852	L-ascorbic acid metabolic process	0.00793838039950046
GO:0051881	regulation of mitochondrial membrane potential	0.00793838039950046
GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	0.00793838039950046
GO:0042826	histone deacetylase binding	0.00917248567671488
GO:0009896	positive regulation of catabolic process	0.00917248567671488
GO:0031396	regulation of protein ubiquitination	0.0107481232450235
GO:0031399	regulation of protein modification process	0.0114637225623367
GO:0006750	glutathione biosynthetic process	0.0114637225623367
GO:0042176	regulation of protein catabolic process	0.0199024952786521
GO:0010035	response to inorganic substance	0.0203103648031622
GO:0043161	proteasomal ubiquitin-dependent protein catabolic process	0.0203103648031622
GO:0009894	regulation of catabolic process	0.0203103648031622
GO:0009410	response to xenobiotic stimulus	0.0209199939838632
GO:0051899	membrane depolarization	0.0243383954177021
GO:0006749	glutathione metabolic process	0.026109373956511
GO:0000118	histone deacetylase complex	0.0290619734447417
GO:0005769	early endosome	0.0292552720323949
GO:0044272	sulfur compound biosynthetic process	0.0355521467343833
GO:0016567	protein ubiquitination	0.0445874032465923
GO:0006767	water-soluble vitamin metabolic process	0.0445874032465923
GO:0042391	regulation of membrane potential	0.0464568016525159
GO:0032446	protein modification by small protein conjugation	0.0482077793142717

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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