MCL coexpression mm9:467

Phase1 CAGE Peaks

	Short description
Mm9::chr13:105078012..105078042,+	p4@Adamts6
Mm9::chr13:105412781..105412798,+	p@chr13:105412781..105412798 +
Mm9::chr19:10800783..10800787,-	p@chr19:10800783..10800787 -
Mm9::chr2:153104456..153104461,+	p@chr2:153104456..153104461 +
Mm9::chr4:155387944..155387958,+	p1@Tnfrsf4
Mm9::chr4:155387967..155387981,+	p2@Tnfrsf4
Mm9::chr4:155388007..155388018,+	p3@Tnfrsf4
Mm9::chr4:155400315..155400334,-	p@chr4:155400315..155400334 -
Mm9::chr4:155400413..155400480,+	p1@Tnfrsf18
Mm9::chr6:129189762..129189789,-	p@chr6:129189762..129189789 -
Mm9::chr6:129189813..129189824,-	p@chr6:129189813..129189824 -
Mm9::chr6:129189844..129189851,-	p@chr6:129189844..129189851 -
Mm9::chr8:84290231..84290238,+	p@chr8:84290231..84290238 +
Mm9::chr9:107200546..107200558,-	p@chr9:107200546..107200558 -
Mm9::chr9:107200687..107200702,+	p@chr9:107200687..107200702 +
Mm9::chr9:14708434..14708444,-	p8@Folr4

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0009897	external side of plasma membrane	0.00912791783016858
GO:0009986	cell surface	0.00912791783016858
GO:0050710	negative regulation of cytokine secretion	0.00912791783016858
GO:0050709	negative regulation of protein secretion	0.00912791783016858
GO:0043120	tumor necrosis factor binding	0.00912791783016858
GO:0008517	folic acid transporter activity	0.00912791783016858
GO:0005031	tumor necrosis factor receptor activity	0.00912791783016858
GO:0050707	regulation of cytokine secretion	0.00912791783016858
GO:0005035	death receptor activity	0.00912791783016858
GO:0050663	cytokine secretion	0.00985734105678631
GO:0051183	vitamin transporter activity	0.0104538964262594
GO:0051184	cofactor transporter activity	0.010950800927537
GO:0005542	folic acid binding	0.0126334626276267
GO:0051048	negative regulation of secretion	0.0140749730015192
GO:0050708	regulation of protein secretion	0.0153235624722565
GO:0006915	apoptosis	0.0261885469613398
GO:0012501	programmed cell death	0.0261885469613398
GO:0009306	protein secretion	0.0261885469613398
GO:0008219	cell death	0.0261885469613398
GO:0016265	death	0.0261885469613398
GO:0051046	regulation of secretion	0.0405275446485512
GO:0004872	receptor activity	0.0422874158580565
GO:0019955	cytokine binding	0.0458356463213889
GO:0060089	molecular transducer activity	0.0458356463213889
GO:0004871	signal transducer activity	0.0458356463213889

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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