Coexpression cluster:C4783

Full id: C4783_CD14_CD19_breast_Burkitt_chronic_Mast_gall

Phase1 CAGE Peaks

Hg19::chr8:96146053..96146079,+	p4@PLEKHF2
Hg19::chr8:96146086..96146125,+	p3@PLEKHF2
Hg19::chr8:96146132..96146155,+	p2@PLEKHF2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
hematopoietic stem cell	4.23e-46	172
angioblastic mesenchymal cell	4.23e-46	172
hematopoietic oligopotent progenitor cell	1.11e-43	165
hematopoietic multipotent progenitor cell	1.11e-43	165
hematopoietic cell	7.83e-40	182
leukocyte	2.88e-38	140
myeloid cell	2.35e-33	112
common myeloid progenitor	2.35e-33	112
hematopoietic lineage restricted progenitor cell	3.38e-32	124
nongranular leukocyte	6.47e-29	119
myeloid leukocyte	6.53e-26	76
granulocyte monocyte progenitor cell	3.07e-23	71
myeloid lineage restricted progenitor cell	4.04e-23	70
macrophage dendritic cell progenitor	7.54e-20	65
monopoietic cell	3.39e-19	63
monocyte	3.39e-19	63
monoblast	3.39e-19	63
promonocyte	3.39e-19	63
CD14-positive, CD16-negative classical monocyte	1.32e-15	42
classical monocyte	2.26e-15	45
lymphocyte of B lineage	8.04e-12	24
pro-B cell	8.04e-12	24
B cell	2.04e-09	14
lymphocyte	2.05e-09	53
common lymphoid progenitor	2.05e-09	53
lymphoid lineage restricted progenitor cell	5.13e-09	52
endo-epithelial cell	7.26e-07	43

Uber Anatomy

Ontology term	p-value	n
hematopoietic system	5.67e-22	102
blood island	5.67e-22	102
hemolymphoid system	4.72e-20	112
bone marrow	3.71e-17	80
bone element	5.44e-16	86
immune system	2.73e-13	115
skeletal element	2.78e-11	101
skeletal system	2.78e-11	101

Disease

Ontology term	p-value	n
hematologic cancer	9.94e-08	51
immune system cancer	9.94e-08	51
cancer	2.15e-07	235
disease of cellular proliferation	3.18e-07	239
carcinoma	4.95e-07	106
organ system cancer	5.63e-07	137

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
BHLHE40#8553	3	44.8718135469774	1.10603738662898e-05	0.000285995143902313
CCNT2#905	3	6.33620157696263	0.00393075003576489	0.0191377373075963
CHD2#1106	3	10.3440228341169	0.000903370110274688	0.00663155063941647
E2F1#1869	3	4.90738921487932	0.00846098534723939	0.0328082293265142
E2F6#1876	3	5.01715573169739	0.0079176980688633	0.0324675671841852
EGR1#1958	3	4.98817909481014	0.00805648813738344	0.0322788032600679
FOXA1#3169	3	11.0814197493855	0.00073475527569867	0.00584663666580521
GATA1#2623	3	13.5603081438004	0.000400961596378263	0.00389725715813396
GATA3#2625	3	27.236516357206	4.94721007899563e-05	0.00085529162959812
GTF2F1#2962	3	12.7396608767577	0.000483552504743859	0.00436187079313732
HMGN3#9324	3	8.17854772335059	0.00182776694216421	0.0109336245874728
HNF4G#3174	3	28.7534225264468	4.20470658818262e-05	0.000761066466833977
IRF1#3659	3	7.6371637535639	0.00224469274729724	0.012883083246413
JUND#3727	3	6.99466394187103	0.00292184504273499	0.0157767849456209
MAX#4149	3	6.45255550900712	0.00372191383426551	0.0187539421497011
MXI1#4601	3	9.9615716287593	0.00101147054125902	0.0072388797271672
MYC#4609	3	5.2222818716094	0.00702084375574015	0.029635837887226
NFKB1#4790	3	5.48806342419384	0.00604938181565543	0.0270969028755034
NRF1#4899	3	12.2102794477109	0.000549217240102001	0.00473890443977304
POU2F2#5452	3	9.10612405774252	0.00132416519268213	0.00885991982564732
SIN3A#25942	3	5.40888472681514	0.00631896197799152	0.0278540526746067
TAF7#6879	3	11.4330694049239	0.000669018198194583	0.00546170496374924
TAL1#6886	3	29.8686166774402	3.75103522793067e-05	0.000723461437063437
TCF12#6938	3	10.6344649021864	0.000831352399020207	0.00632378828851212
USF1#7391	3	6.36149927720796	0.0038840405729056	0.0191315056073993
USF2#7392	3	12.9921973850696	0.000455897939342781	0.00423381868104399

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.