Coexpression cluster:C362

Full id: C362_Small_Mallassezderived_Urothelial_Gingival_Prostate_Keratinocyte_Tracheal

Phase1 CAGE Peaks

Hg19::chr12:28124953..28124957,-	p6@PTHLH
Hg19::chr12:28126393..28126427,-	p@chr12:28126393..28126427 -
Hg19::chr14:51955483..51955495,+	p23@FRMD6
Hg19::chr14:51955502..51955515,+	p17@FRMD6
Hg19::chr14:51955524..51955550,+	p9@FRMD6
Hg19::chr14:51955690..51955699,+	p28@FRMD6
Hg19::chr14:51955719..51955733,+	p15@FRMD6
Hg19::chr14:51955760..51955769,+	p29@FRMD6
Hg19::chr14:51955771..51955826,+	p6@FRMD6
Hg19::chr14:51955831..51955864,+	p5@FRMD6
Hg19::chr14:51955873..51955899,+	p12@FRMD6
Hg19::chr14:51955905..51955921,+	p14@FRMD6
Hg19::chr14:51955948..51955957,+	p34@FRMD6
Hg19::chr18:9617195..9617198,-	p@chr18:9617195..9617198 -
Hg19::chr18:9649081..9649088,+	p@chr18:9649081..9649088 +
Hg19::chr1:183213092..183213099,+	p@chr1:183213092..183213099 +
Hg19::chr1:183213177..183213210,+	p@chr1:183213177..183213210 +
Hg19::chr1:183213228..183213235,+	p@chr1:183213228..183213235 +
Hg19::chr1:183213249..183213267,+	p@chr1:183213249..183213267 +
Hg19::chr1:183213300..183213316,+	p@chr1:183213300..183213316 +
Hg19::chr1:183213326..183213338,+	p@chr1:183213326..183213338 +
Hg19::chr1:183213340..183213356,+	p@chr1:183213340..183213356 +
Hg19::chr1:183213362..183213385,+	p@chr1:183213362..183213385 +
Hg19::chr1:183213387..183213401,+	p@chr1:183213387..183213401 +
Hg19::chr1:183213404..183213419,+	p@chr1:183213404..183213419 +
Hg19::chr1:183213421..183213517,+	p@chr1:183213421..183213517 +
Hg19::chr21:44957893..44957903,-	p@chr21:44957893..44957903 -
Hg19::chr2:186298808..186298827,+	p@chr2:186298808..186298827 +
Hg19::chr2:186298833..186298844,+	p@chr2:186298833..186298844 +
Hg19::chr3:190252374..190252383,-	p@chr3:190252374..190252383 -
Hg19::chr9:113802831..113802865,-	p@chr9:113802831..113802865 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0007595	lactation	0.038081176237861
GO:0046058	cAMP metabolic process	0.038081176237861
GO:0007189	G-protein signaling, adenylate cyclase activating pathway	0.038081176237861
GO:0009187	cyclic nucleotide metabolic process	0.038081176237861
GO:0048609	reproductive process in a multicellular organism	0.038081176237861
GO:0032504	multicellular organism reproduction	0.038081176237861
GO:0007565	female pregnancy	0.038081176237861
GO:0007188	G-protein signaling, coupled to cAMP nucleotide second messenger	0.038081176237861
GO:0019933	cAMP-mediated signaling	0.038081176237861
GO:0007187	G-protein signaling, coupled to cyclic nucleotide second messenger	0.0436693462621119
GO:0019935	cyclic-nucleotide-mediated signaling	0.0436693462621119
GO:0008544	epidermis development	0.0442043833252614
GO:0007398	ectoderm development	0.0442043833252614

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
epithelial cell	6.40e-20	254
endo-epithelial cell	8.87e-17	43
endodermal cell	3.95e-11	59
embryonic cell	1.89e-10	248
squamous epithelial cell	2.66e-09	62
respiratory epithelial cell	1.51e-08	13
epithelial cell of alimentary canal	6.05e-08	21
ecto-epithelial cell	8.21e-07	33

Uber Anatomy

Ontology term	p-value	n
endoderm-derived structure	7.16e-12	169
endoderm	7.16e-12	169
presumptive endoderm	7.16e-12	169
respiratory system	1.21e-09	72
orifice	3.12e-09	35
digestive system	2.19e-08	155
digestive tract	2.19e-08	155
primitive gut	2.19e-08	155
endo-epithelium	2.76e-07	82
reproductive structure	3.90e-07	59
reproductive system	3.90e-07	59
oral opening	4.41e-07	21
surface structure	5.62e-07	95

Disease

Ontology term	p-value	n
squamous cell carcinoma	1.79e-09	14

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
STAT3#6774	13	4.41138854719371	2.03318712616835e-06	7.42981211581164e-05

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.