Coexpression cluster:C558

Full id: C558_Mesenchymal_testis_Smooth_Endothelial_Placental_Tracheal_Hair

Phase1 CAGE Peaks

Hg19::chr11:120317216..120317220,+	p@chr11:120317216..120317220 +
Hg19::chr11:500479..500483,-	p@chr11:500479..500483 -
Hg19::chr16:15128409..15128413,+	p@chr16:15128409..15128413 +
Hg19::chr16:87400976..87400979,-	p@chr16:87400976..87400979 -
Hg19::chr17:38324198..38324204,+	p7@CASC3
Hg19::chr17:79873312..79873316,-	p@chr17:79873312..79873316 -
Hg19::chr18:77096710..77096715,+	p@chr18:77096710..77096715 +
Hg19::chr19:2353015..2353053,+	p@chr19:2353015..2353053 +
Hg19::chr1:156893889..156893893,+	p@chr1:156893889..156893893 +
Hg19::chr20:44582326..44582328,-	p@chr20:44582326..44582328 -
Hg19::chr22:19376002..19376007,-	p@chr22:19376002..19376007 -
Hg19::chr22:24431967..24431972,+	p@chr22:24431967..24431972 +
Hg19::chr2:242607635..242607639,+	p7@ATG4B
Hg19::chr3:49070544..49070558,-	p8@QRICH1
Hg19::chr3:52381988..52381993,+	p@chr3:52381988..52381993 +
Hg19::chr9:131864675..131864680,-	p@chr9:131864675..131864680 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0008298	intracellular mRNA localization	0.0135990345038516
GO:0000045	autophagic vacuole formation	0.0203943486750239
GO:0016236	macroautophagy	0.0203943486750239
GO:0006914	autophagy	0.0401466589318227
GO:0033036	macromolecule localization	0.0401466589318227
GO:0006612	protein targeting to membrane	0.0407562844025515

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
smooth muscle cell	2.28e-10	42
smooth muscle myoblast	2.28e-10	42
contractile cell	3.06e-10	59
electrically responsive cell	2.17e-09	60
electrically active cell	2.17e-09	60
muscle cell	4.92e-09	54
mesodermal cell	8.75e-09	119
muscle precursor cell	2.27e-08	57
myoblast	2.27e-08	57
multi-potent skeletal muscle stem cell	2.27e-08	57
vascular associated smooth muscle cell	3.93e-07	32

Uber Anatomy

Ontology term	p-value	n
cell layer	1.89e-11	312
epithelium	3.21e-11	309
vasculature	1.45e-10	79
vascular system	1.45e-10	79
cardiovascular system	3.41e-10	110
circulatory system	6.03e-10	113
vessel	1.09e-08	69
anatomical cluster	1.33e-08	286
anatomical conduit	3.24e-08	241
organism subdivision	3.65e-08	365
muscle tissue	7.61e-08	63
musculature	7.61e-08	63
musculature of body	7.61e-08	63
splanchnic layer of lateral plate mesoderm	8.55e-08	84
artery	1.08e-07	42
arterial blood vessel	1.08e-07	42
arterial system	1.08e-07	42
skeletal muscle tissue	1.10e-07	61
striated muscle tissue	1.10e-07	61
myotome	1.10e-07	61
tube	1.11e-07	194
unilaminar epithelium	1.25e-07	138
blood vessel	1.94e-07	60
epithelial tube open at both ends	1.94e-07	60
blood vasculature	1.94e-07	60
vascular cord	1.94e-07	60
intermediate mesoderm	2.87e-07	37
trunk mesenchyme	3.21e-07	143
systemic artery	3.24e-07	33
systemic arterial system	3.24e-07	33
dermomyotome	4.04e-07	70
multilaminar epithelium	8.92e-07	82
multi-tissue structure	9.97e-07	347

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.