Coexpression cluster:C2203

Full id: C2203_non_Neutrophils_Eosinophils_lymphoma_CD19_Whole_Burkitt

Phase1 CAGE Peaks

Hg19::chr12:25205628..25205657,+	p2@LRMP
Hg19::chr12:25205666..25205690,+	p4@LRMP
Hg19::chr13:28712383..28712394,+	p9@PAN3
Hg19::chr9:130540962..130540988,-	p4@SH2D3C

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0006906	vesicle fusion	0.0195980326925824
GO:0007516	hemocyte development	0.0195980326925824
GO:0042386	hemocyte differentiation	0.0195980326925824
GO:0006903	vesicle targeting	0.0195980326925824
GO:0051650	establishment of vesicle localization	0.0195980326925824
GO:0051648	vesicle localization	0.0195980326925824
GO:0000184	mRNA catabolic process, nonsense-mediated decay	0.0281630495993967
GO:0051656	establishment of organelle localization	0.0281630495993967
GO:0006402	mRNA catabolic process	0.0315588082218239
GO:0051640	organelle localization	0.0323167659584715
GO:0006944	membrane fusion	0.032936074582253
GO:0006401	RNA catabolic process	0.0368945357790832
GO:0005070	SH3/SH2 adaptor activity	0.0368945357790832
GO:0060090	molecular adaptor activity	0.0415771974545133
GO:0007254	JNK cascade	0.0415771974545133
GO:0031098	stress-activated protein kinase signaling pathway	0.0415771974545133

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

---

Cell Type

Ontology term	p-value	n
hematopoietic stem cell	1.08e-74	172
angioblastic mesenchymal cell	1.08e-74	172
hematopoietic oligopotent progenitor cell	3.58e-70	165
hematopoietic multipotent progenitor cell	3.58e-70	165
hematopoietic cell	3.37e-68	182
leukocyte	5.28e-61	140
hematopoietic lineage restricted progenitor cell	2.24e-50	124
nongranular leukocyte	8.53e-49	119
myeloid cell	7.71e-46	112
common myeloid progenitor	7.71e-46	112
myeloid leukocyte	3.37e-33	76
granulocyte monocyte progenitor cell	3.30e-29	71
myeloid lineage restricted progenitor cell	2.65e-28	70
macrophage dendritic cell progenitor	2.21e-26	65
monopoietic cell	1.50e-25	63
monocyte	1.50e-25	63
monoblast	1.50e-25	63
promonocyte	1.50e-25	63
CD14-positive, CD16-negative classical monocyte	1.14e-24	42
classical monocyte	3.04e-22	45
lymphocyte	2.69e-20	53
common lymphoid progenitor	2.69e-20	53
lymphoid lineage restricted progenitor cell	1.11e-19	52
lymphocyte of B lineage	3.54e-16	24
pro-B cell	3.54e-16	24
B cell	1.46e-10	14
mesenchymal cell	5.13e-10	358
connective tissue cell	6.56e-09	365
intermediate monocyte	3.16e-07	9
CD14-positive, CD16-positive monocyte	3.16e-07	9
granulocyte	7.88e-07	8

Uber Anatomy

Ontology term	p-value	n
hematopoietic system	4.57e-34	102
blood island	4.57e-34	102
hemolymphoid system	7.06e-32	112
bone marrow	5.19e-25	80
adult organism	1.41e-23	115
bone element	6.48e-23	86
immune system	7.34e-20	115
skeletal element	2.71e-15	101
skeletal system	2.71e-15	101
connective tissue	4.26e-08	375
neural tube	4.93e-08	57
neural rod	4.93e-08	57
future spinal cord	4.93e-08	57
neural keel	4.93e-08	57
anterior neural tube	1.73e-07	42
regional part of forebrain	1.77e-07	41
forebrain	1.77e-07	41
future forebrain	1.77e-07	41
blood	2.28e-07	15
haemolymphatic fluid	2.28e-07	15
organism substance	2.28e-07	15

Disease

Ontology term	p-value	n
hematologic cancer	8.23e-16	51
immune system cancer	8.23e-16	51
leukemia	4.41e-13	39
myeloid leukemia	5.28e-11	31

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

---

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

---

This analysis result is provided for C0 - C305 clusters.