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(Created page with "{{CL |id=CL:0000127 |name=astrocyte |namespace=cell |def="A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neur...")
 
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|id=CL:0000127
|id=CL:0000127
|name=astrocyte
|name=astrocyte
|namespace=cell
|namespace=efo
|def="A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury." [GOC: tfm, GOC:dsd, MESH:A.08.637.200, MESH:D001253, PMID:11746784, PMID:12162730, PMID:12898703, PMID:20942978]
|def="A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury." [GOC:dsd, GOC:tfm, MESH:A.08.637.200, MESH:D001253, PMID:11746784, PMID:12162730, PMID:12898703, PMID:20942978]
|xref=BTO:0000099;;FMA:54537
|xref=BTO:0000099;;FMA:54537
|is_a=CL:0000128
|is_a=CL:0000128;;EFO:0002963
|synonym="astrocytic glia" EXACT []
|synonym="astrocytic glia" EXACT []
|comment=Astrocytes are reportedly CD68-negative, CD121a-positive, CD184-positive, CD192-positive, CRF-positive, EGFR-positive, GFAP-positive, GLUT1-positive, MBP-negative, and NGFR-positive.
|comment=Astrocytes are reportedly CD68-negative, CD121a-positive, CD184-positive, CD192-positive, CRF-positive, EGFR-positive, GFAP-positive, GLUT1-positive, MBP-negative, and NGFR-positive.
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|located_in=
|located_in=
|part_of=UBERON:0001017
|part_of=UBERON:0001017
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl-to-uberon.obo.owl;;IAO:0000412 http://purl.obolibrary.org/obo/cl.owl;;IAO:0000412 http://purl.obolibrary.org/obo/efo.obo.owl
|is_obsolete=
|preceded_by=
}}
}}

Revision as of 17:36, 15 June 2012

Name:astrocyte
Namespace:efo
Definition:"A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury." [GOC:dsd, GOC:tfm, MESH:A.08.637.200, MESH:D001253, PMID:11746784, PMID:12162730, PMID:12898703, PMID:20942978]
Xrefs:
links:

BTO:0000099

FMA:54537
Synonyms: "astrocytic glia" EXACT []
Comments:Astrocytes are reportedly CD68-negative, CD121a-positive, CD184-positive, CD192-positive, CRF-positive, EGFR-positive, GFAP-positive, GLUT1-positive, MBP-negative, and NGFR-positive.


Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:CL:0000128(oligodendrocyte),EFO:0002963()
part_of:UBERON:0001017(central nervous system)



Children


is a:CL:0002603 (astrocyte of the cerebellum),CL:0002606 (astrocyte of the spinal cord),CL:0012000 (astrocyte of the forebrain)
derives from:FF:0000105 (mouse astrocyte sample),FF:0100101 (astrocytoma cell line sample)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)


FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.

Human (Homo sapiens)

... further results Mouse (Mus musculus)

... further results


Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000127 (astrocyte), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
6.94e-140FFCP PHASE1:Hg19::chr4:169553987..169553999,+#_8a295bf52f97a6bfa5bff7ee634d5236p@chr4:169553987..169553999, +
6.94e-140FFCP PHASE2:Hg19::chr4:169553987..169553999,+#_8a295bf52f97a6bfa5bff7ee634d5236p@chr4:169553987..169553999, +
1.28e-84FFCP PHASE1:Hg19::chr9:122602283..122602290,-#_791e3644dcbe78a3d2f11a59400560a3p@chr9:122602283..122602290, -
1.28e-84FFCP PHASE2:Hg19::chr9:122602283..122602290,-#_791e3644dcbe78a3d2f11a59400560a3p@chr9:122602283..122602290, -
6.32e-78FFCP PHASE1:Hg19::chr2:48919725..48919761,+#_1b2b45c0b5b708f4036db58b1ba86afdp@chr2:48919725..48919761, +
6.32e-78FFCP PHASE2:Hg19::chr2:48919725..48919761,+#_1b2b45c0b5b708f4036db58b1ba86afdp@chr2:48919725..48919761, +
8.34e-78FFCP PHASE2:Hg19::chr2:48919688..48919703,+#_02620eedcb4c92d2428cf4f2b736046fp@chr2:48919688..48919703, +
8.34e-78FFCP PHASE1:Hg19::chr2:48919688..48919703,+#_02620eedcb4c92d2428cf4f2b736046fp@chr2:48919688..48919703, +
1.79e-75FFCP PHASE1:Hg19::chr9:127025189..127025200,+#_d7b570f1a2b31a263640619e7014fa36p1@ENST00000437461
1.79e-75FFCP PHASE1:Hg19::chr11:68808268..68808276,-#_d7b570f1a2b31a263640619e7014fa36p@chr11:68808268..68808276, -
1.79e-75FFCP PHASE2:Hg19::chr9:127025189..127025200,+#_d7b570f1a2b31a263640619e7014fa36p1@ENST00000437461
1.79e-75FFCP PHASE2:Hg19::chr11:68808268..68808276,-#_d7b570f1a2b31a263640619e7014fa36p@chr11:68808268..68808276, -
2.17e-75FFCP PHASE1:Hg19::chr13:99349888..99349893,+#_b1ab64d8daba86b2f21e5b68c657976ap@chr13:99349888..99349893, +
2.17e-75FFCP PHASE2:Hg19::chr13:99349888..99349893,+#_b1ab64d8daba86b2f21e5b68c657976ap@chr13:99349888..99349893, +
2.83e-68FFCP PHASE1:Hg19::chr22:30176932..30176938,+#_b9c6f74bd0fa89dd78022904e9bc0818p@chr22:30176932..30176938, +
2.83e-68FFCP PHASE2:Hg19::chr22:30176932..30176938,+#_b9c6f74bd0fa89dd78022904e9bc0818p@chr22:30176932..30176938, +
2.25e-65FFCP PHASE1:Mm9::chr8:96704054..96704065,-#_a8b25e7d5c017c6692bf24b9e8d2a6f9p@chr8:96704054..96704065, -
2.25e-65FFCP PHASE2:Mm9::chr8:96704054..96704065,-#_a8b25e7d5c017c6692bf24b9e8d2a6f9p@chr8:96704054..96704065, -
1.33e-60FFCP PHASE1:Mm9::chr1:72895689..72895698,-#_e63b1162d3d693ccf41d78da6e685158p@chr1:72895689..72895698, -
1.33e-60FFCP PHASE2:Mm9::chr14:70592673..70592699,-#_e63b1162d3d693ccf41d78da6e685158p@chr14:70592673..70592699, -
1.33e-60FFCP PHASE1:Mm9::chr14:70592673..70592699,-#_e63b1162d3d693ccf41d78da6e685158p@chr14:70592673..70592699, -
1.33e-60FFCP PHASE2:Mm9::chr1:72895689..72895698,-#_e63b1162d3d693ccf41d78da6e685158p@chr1:72895689..72895698, -
2.34e-60FFCP PHASE1:Mm9::chr1:72898728..72898736,+#_fc29129dfa30ad385d1c4acace1b1006p@chr1:72898728..72898736, +
2.34e-60FFCP PHASE2:Mm9::chr1:72898728..72898736,+#_fc29129dfa30ad385d1c4acace1b1006p@chr1:72898728..72898736, +
3.91e-58FFCP PHASE2:Mm9::chr9:43915826..43915844,+#_6cf8abf1a685241ff628879967341089p@chr9:43915826..43915844, +
3.91e-58FFCP PHASE2:Mm9::chr6:92777773..92777784,+#_6cf8abf1a685241ff628879967341089p4@ENSMUST00000133858
3.91e-58FFCP PHASE1:Mm9::chr6:92777773..92777784,+#_6cf8abf1a685241ff628879967341089p4@ENSMUST00000133858
3.91e-58FFCP PHASE1:Mm9::chr9:43915826..43915844,+#_6cf8abf1a685241ff628879967341089p@chr9:43915826..43915844, +
3.91e-58FFCP PHASE1:Mm9::chr7:29152679..29152684,-#_6cf8abf1a685241ff628879967341089p@chr7:29152679..29152684, -
3.91e-58FFCP PHASE2:Mm9::chr7:29152679..29152684,-#_6cf8abf1a685241ff628879967341089p@chr7:29152679..29152684, -
4.76e-57FFCP PHASE1:Hg19::chr8:32488262..32488265,+#_5d28eab50e7aed23efc1c668e22eb1f6p@chr8:32488262..32488265, +
4.76e-57FFCP PHASE2:Hg19::chr8:32488262..32488265,+#_5d28eab50e7aed23efc1c668e22eb1f6p@chr8:32488262..32488265, +
8.4e-54FFCP PHASE1:Hg19::chr6:45296191..45296203,+#_0807433a110c6ec59dc9c9bcaff11b22p13@RUNX2
8.4e-54FFCP PHASE2:Hg19::chr6:45296191..45296203,+#_0807433a110c6ec59dc9c9bcaff11b22p13@RUNX2
2.53e-52FFCP PHASE1:Mm9::chr19:17030554..17030565,+#_3bb2474698ee3693b0e0acc970c1c9c9p5@Prune2
2.53e-52FFCP PHASE2:Mm9::chr19:17030554..17030565,+#_3bb2474698ee3693b0e0acc970c1c9c9p5@Prune2
3.23e-52FFCP PHASE2:Mm9::chr14:70592626..70592638,-#_999fe89f67240e6321ae50e17291b0fep@chr14:70592626..70592638, -
3.23e-52FFCP PHASE1:Mm9::chr14:70592626..70592638,-#_999fe89f67240e6321ae50e17291b0fep@chr14:70592626..70592638, -
4.11e-52FFCP PHASE1:Mm9::chr8:28132545..28132551,+#_6f7f0fce1fbf13d5c8b76fdd4f632aaap@chr8:28132545..28132551, +
4.11e-52FFCP PHASE2:Mm9::chr1:72873192..72873206,+#_6f7f0fce1fbf13d5c8b76fdd4f632aaap@chr1:72873192..72873206, +
4.11e-52FFCP PHASE1:Mm9::chr1:72873192..72873206,+#_6f7f0fce1fbf13d5c8b76fdd4f632aaap@chr1:72873192..72873206, +
4.11e-52FFCP PHASE2:Mm9::chr8:28132545..28132551,+#_6f7f0fce1fbf13d5c8b76fdd4f632aaap@chr8:28132545..28132551, +
5.23e-52FFCP PHASE2:Mm9::chr9:37174919..37174932,+#_2f633da3da5090c946d6651ea044e75cp3@Hepacam
5.23e-52FFCP PHASE1:Mm9::chr1:72898789..72898796,+#_2f633da3da5090c946d6651ea044e75cp@chr1:72898789..72898796, +
5.23e-52FFCP PHASE2:Mm9::chr1:72898789..72898796,+#_2f633da3da5090c946d6651ea044e75cp@chr1:72898789..72898796, +
5.23e-52FFCP PHASE1:Mm9::chr9:37174919..37174932,+#_2f633da3da5090c946d6651ea044e75cp3@Hepacam
2.3e-51FFCP PHASE2:Hg19::chr7:42192092..42192108,-#_d29e9601465005cedb0a4ee5d5832adcp13@GLI3
2.3e-51FFCP PHASE1:Hg19::chr7:42192092..42192108,-#_d29e9601465005cedb0a4ee5d5832adcp13@GLI3
3.85e-51FFCP PHASE1:Hg19::chr20:35856764..35856768,+#_0b3e3697cb511aac9d238a130e09b0c3p25@RPN2
3.85e-51FFCP PHASE2:Hg19::chr20:35856764..35856768,+#_0b3e3697cb511aac9d238a130e09b0c3p25@RPN2
5.43e-51FFCP PHASE1:Hg19::chr14:33403217..33403226,+#_d00908c062cb3504ce18e7f38a9efedap@chr14:33403217..33403226, +
5.43e-51FFCP PHASE2:Hg19::chr14:33403217..33403226,+#_d00908c062cb3504ce18e7f38a9efedap@chr14:33403217..33403226, +
6.95e-51FFCP PHASE2:Hg19::chr4:169553961..169553972,+#_cb8864eee0cc2d5377aa1582c51739d2p@chr4:169553961..169553972, +
6.95e-51FFCP PHASE1:Hg19::chr4:169553961..169553972,+#_cb8864eee0cc2d5377aa1582c51739d2p@chr4:169553961..169553972, +
7.9e-51FFCP PHASE1:Hg19::chr1:98642833..98642844,+#_f4087e281ce6c2373d83cabb2af06dc5p@chr1:98642833..98642844, +
7.9e-51FFCP PHASE2:Hg19::chr1:98642833..98642844,+#_f4087e281ce6c2373d83cabb2af06dc5p@chr1:98642833..98642844, +
8.98e-51FFCP PHASE1:Hg19::chr1:98518907..98518920,+#_f28408075f91fc7bdc0e34929e7de4bbp@chr1:98518907..98518920, +
8.98e-51FFCP PHASE2:Hg19::chr1:98518907..98518920,+#_f28408075f91fc7bdc0e34929e7de4bbp@chr1:98518907..98518920, +
4.49e-48FFCP PHASE1:Mm9::chr1:72895732..72895747,-#_e19ad27cd468cc9fcbe99f1fc2c6916cp@chr1:72895732..72895747, -
4.49e-48FFCP PHASE2:Mm9::chr1:72895732..72895747,-#_e19ad27cd468cc9fcbe99f1fc2c6916cp@chr1:72895732..72895747, -
1.09e-46FFCP PHASE2:Mm9::chr8:73022520..73022524,+#_6f36edea4e98ab0158bfb4762e16999fp@chr8:73022520..73022524, +
1.09e-46FFCP PHASE1:Mm9::chr8:73022520..73022524,+#_6f36edea4e98ab0158bfb4762e16999fp@chr8:73022520..73022524, +
1.09e-46FFCP PHASE1:Mm9::chr1:72895881..72895885,-#_6f36edea4e98ab0158bfb4762e16999fp@chr1:72895881..72895885, -
1.09e-46FFCP PHASE2:Mm9::chr1:72895881..72895885,-#_6f36edea4e98ab0158bfb4762e16999fp@chr1:72895881..72895885, -
1.12e-46FFCP PHASE1:Hg19::chr4:77356957..77356973,+#_fa3802f85877db27705ceab8a1efc08bp20@SHROOM3
1.12e-46FFCP PHASE2:Hg19::chr4:77356957..77356973,+#_fa3802f85877db27705ceab8a1efc08bp20@SHROOM3
1.42e-46FFCP PHASE2:Mm9::chr19:40457627..40457636,-#_3f2f06d7e53a478eed0f5b6140acc02cp9@Sorbs1
1.42e-46FFCP PHASE1:Mm9::chr19:40457627..40457636,-#_3f2f06d7e53a478eed0f5b6140acc02cp9@Sorbs1
1.86e-46FFCP PHASE1:Mm9::chr3:88990698..88990709,+#_963b846113d836c503b763758882c049p@chr3:88990698..88990709, +
1.86e-46FFCP PHASE2:Mm9::chr3:88990698..88990709,+#_963b846113d836c503b763758882c049p@chr3:88990698..88990709, +
4.13e-46FFCP PHASE1:Mm9::chr19:8788816..8788826,-#_b4a930b8a484ef1fe85cfd5923e10935p14@Slc3a2
4.13e-46FFCP PHASE2:Mm9::chr19:8788816..8788826,-#_b4a930b8a484ef1fe85cfd5923e10935p14@Slc3a2
4.13e-46FFCP PHASE1:Mm9::chr11:7114172..7114182,-#_b4a930b8a484ef1fe85cfd5923e10935p4@Igfbp3
4.13e-46FFCP PHASE2:Mm9::chr11:7114172..7114182,-#_b4a930b8a484ef1fe85cfd5923e10935p4@Igfbp3
4.13e-46FFCP PHASE1:Mm9::chr19:8788690..8788697,-#_b4a930b8a484ef1fe85cfd5923e10935p17@Slc3a2
4.13e-46FFCP PHASE2:Mm9::chr19:8788690..8788697,-#_b4a930b8a484ef1fe85cfd5923e10935p17@Slc3a2
7.81e-46FFCP PHASE1:Mm9::chr11:7110185..7110197,-#_cfdfc6a7a5cf6c8813786eb0a4e7c671p@chr11:7110185..7110197, -
7.81e-46FFCP PHASE2:Mm9::chr11:7110185..7110197,-#_cfdfc6a7a5cf6c8813786eb0a4e7c671p@chr11:7110185..7110197, -
1.19e-45FFCP PHASE2:Mm9::chr8:11006242..11006246,-#_83fd1a22ab8abff0093ab084fbedbfa2p@chr8:11006242..11006246, -
1.19e-45FFCP PHASE1:Mm9::chr8:11006242..11006246,-#_83fd1a22ab8abff0093ab084fbedbfa2p@chr8:11006242..11006246, -
1.77e-45FFCP PHASE1:Hg19::chr5:135540733..135540788,-#_6a04854343b6b36aa2b998fd3b6daec5p@chr5:135540733..135540788, -
1.77e-45FFCP PHASE2:Hg19::chr5:135540733..135540788,-#_6a04854343b6b36aa2b998fd3b6daec5p@chr5:135540733..135540788, -
5.38e-44FFCP PHASE2:Mm9::chr12:86222392..86222395,-#_343cb6382c7ce04c0b0223adb6fb5deap@chr12:86222392..86222395, -
5.38e-44FFCP PHASE2:Mm9::chr11:45940767..45940771,+#_343cb6382c7ce04c0b0223adb6fb5deap@chr11:45940767..45940771, +
5.38e-44FFCP PHASE1:Mm9::chr1:154940591..154940634,+#_343cb6382c7ce04c0b0223adb6fb5deap@chr1:154940591..154940634, +
5.38e-44FFCP PHASE2:Mm9::chr6:84135739..84135768,+#_343cb6382c7ce04c0b0223adb6fb5deap@chr6:84135739..84135768, +
5.38e-44FFCP PHASE1:Mm9::chr6:84135739..84135768,+#_343cb6382c7ce04c0b0223adb6fb5deap@chr6:84135739..84135768, +
5.38e-44FFCP PHASE2:Mm9::chr1:154940591..154940634,+#_343cb6382c7ce04c0b0223adb6fb5deap@chr1:154940591..154940634, +
5.38e-44FFCP PHASE1:Mm9::chr11:66340488..66340520,-#_343cb6382c7ce04c0b0223adb6fb5deap@chr11:66340488..66340520, -
5.38e-44FFCP PHASE1:Mm9::chr12:86222392..86222395,-#_343cb6382c7ce04c0b0223adb6fb5deap@chr12:86222392..86222395, -
5.38e-44FFCP PHASE1:Mm9::chr11:45940767..45940771,+#_343cb6382c7ce04c0b0223adb6fb5deap@chr11:45940767..45940771, +
5.38e-44FFCP PHASE2:Mm9::chr14:70592586..70592593,-#_343cb6382c7ce04c0b0223adb6fb5deap@chr14:70592586..70592593, -
5.38e-44FFCP PHASE2:Mm9::chr11:66340488..66340520,-#_343cb6382c7ce04c0b0223adb6fb5deap@chr11:66340488..66340520, -
5.38e-44FFCP PHASE1:Mm9::chr14:70592586..70592593,-#_343cb6382c7ce04c0b0223adb6fb5deap@chr14:70592586..70592593, -
5.58e-44FFCP PHASE2:Mm9::chr1:72896186..72896195,+#_cab0a8fed99c6e1fdbd78c59983e3438p@chr1:72896186..72896195, +
5.58e-44FFCP PHASE1:Mm9::chr1:72896186..72896195,+#_cab0a8fed99c6e1fdbd78c59983e3438p@chr1:72896186..72896195, +
5.22e-43FFCP PHASE1:Hg19::chr12:41374792..41374806,+#_8ead371efe502c9edbc3f4c76f5c032ep@chr12:41374792..41374806, +
5.22e-43FFCP PHASE2:Hg19::chr12:41374792..41374806,+#_8ead371efe502c9edbc3f4c76f5c032ep@chr12:41374792..41374806, +
6.96e-43FFCP PHASE1:Hg19::chr11:60615014..60615025,+#_44c73a280fd3b67444d38630ad2261c3p8@CCDC86
6.96e-43FFCP PHASE2:Hg19::chr11:60615014..60615025,+#_44c73a280fd3b67444d38630ad2261c3p8@CCDC86

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