Coexpression cluster:C874

Full id: C874_Monocytederived_CD14_Mast_Lymphatic_Smooth_Neurons_Fibroblast

Phase1 CAGE Peaks

Hg19::chr10:64575696..64575711,-	p1@CU690136
Hg19::chr17:32583229..32583324,+	p2@CCL2
Hg19::chr17:32583293..32583323,-	p@chr17:32583293..32583323 -
Hg19::chr17:32583753..32583906,+	p@chr17:32583753..32583906 +
Hg19::chr17:32583823..32583891,-	p@chr17:32583823..32583891 -
Hg19::chr17:32584045..32584055,+	p@chr17:32584045..32584055 +
Hg19::chr17:32584062..32584073,+	p@chr17:32584062..32584073 +
Hg19::chr17:32584096..32584112,+	p@chr17:32584096..32584112 +
Hg19::chr8:15997784..15997797,-	p@chr8:15997784..15997797 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0019079	viral genome replication	0.0261202502901549
GO:0007259	JAK-STAT cascade	0.0261202502901549
GO:0019058	viral infectious cycle	0.0261202502901549
GO:0022415	viral reproductive process	0.0261202502901549
GO:0006959	humoral immune response	0.0261202502901549
GO:0008009	chemokine activity	0.0261202502901549
GO:0042379	chemokine receptor binding	0.0261202502901549
GO:0001664	G-protein-coupled receptor binding	0.0261202502901549
GO:0055074	calcium ion homeostasis	0.0261202502901549
GO:0006874	cellular calcium ion homeostasis	0.0261202502901549
GO:0007187	G-protein signaling, coupled to cyclic nucleotide second messenger	0.0261202502901549
GO:0019935	cyclic-nucleotide-mediated signaling	0.0261202502901549
GO:0006875	cellular metal ion homeostasis	0.0261202502901549
GO:0055065	metal ion homeostasis	0.0261202502901549
GO:0042330	taxis	0.0267573295655245
GO:0006935	chemotaxis	0.0267573295655245
GO:0006916	anti-apoptosis	0.027100372252262
GO:0030005	cellular di-, tri-valent inorganic cation homeostasis	0.027100372252262
GO:0007626	locomotory behavior	0.027100372252262
GO:0055066	di-, tri-valent inorganic cation homeostasis	0.027100372252262
GO:0030003	cellular cation homeostasis	0.027100372252262
GO:0055080	cation homeostasis	0.027100372252262
GO:0043066	negative regulation of apoptosis	0.027100372252262
GO:0043069	negative regulation of programmed cell death	0.027100372252262
GO:0055082	cellular chemical homeostasis	0.027100372252262
GO:0006873	cellular ion homeostasis	0.027100372252262
GO:0050801	ion homeostasis	0.0279285258091334
GO:0019932	second-messenger-mediated signaling	0.0279285258091334
GO:0006954	inflammatory response	0.0279285258091334
GO:0007610	behavior	0.0279285258091334
GO:0048878	chemical homeostasis	0.0279285258091334
GO:0022414	reproductive process	0.0279285258091334
GO:0005125	cytokine activity	0.0279285258091334
GO:0009887	organ morphogenesis	0.0310517157920902
GO:0019725	cellular homeostasis	0.0310517157920902
GO:0007243	protein kinase cascade	0.0310517157920902
GO:0009611	response to wounding	0.0339890402589095
GO:0042592	homeostatic process	0.0375541467586309
GO:0005615	extracellular space	0.0402503419105326
GO:0042981	regulation of apoptosis	0.0407236876333177
GO:0043067	regulation of programmed cell death	0.0407236876333177
GO:0006952	defense response	0.0407236876333177
GO:0042221	response to chemical stimulus	0.0407236876333177
GO:0009605	response to external stimulus	0.0422831874615696
GO:0007267	cell-cell signaling	0.0422831874615696

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
mesodermal cell	7.66e-18	119
electrically responsive cell	6.17e-15	60
electrically active cell	6.17e-15	60
muscle precursor cell	9.68e-15	57
myoblast	9.68e-15	57
multi-potent skeletal muscle stem cell	9.68e-15	57
muscle cell	1.62e-14	54
vascular associated smooth muscle cell	3.99e-14	32
CD14-positive, CD16-negative classical monocyte	2.57e-13	42
smooth muscle cell	3.52e-13	42
smooth muscle myoblast	3.52e-13	42
granulocyte monocyte progenitor cell	6.07e-12	71
contractile cell	7.35e-12	59
myeloid lineage restricted progenitor cell	1.27e-11	70
monopoietic cell	1.46e-11	63
monocyte	1.46e-11	63
monoblast	1.46e-11	63
promonocyte	1.46e-11	63
macrophage dendritic cell progenitor	2.49e-11	65
classical monocyte	4.51e-11	45
myeloid leukocyte	2.81e-10	76
multi fate stem cell	5.75e-10	430
non-terminally differentiated cell	1.31e-09	180
somatic stem cell	6.39e-09	436
cardiocyte	5.91e-08	16
stem cell	8.03e-08	444

Uber Anatomy

Ontology term	p-value	n
splanchnic layer of lateral plate mesoderm	8.95e-22	84
lateral plate mesoderm	5.86e-21	216
musculoskeletal system	9.53e-21	167
circulatory system	1.24e-19	113
cardiovascular system	4.19e-19	110
vasculature	4.53e-19	79
vascular system	4.53e-19	79
vessel	4.77e-19	69
blood vessel	1.87e-18	60
epithelial tube open at both ends	1.87e-18	60
blood vasculature	1.87e-18	60
vascular cord	1.87e-18	60
artery	2.27e-17	42
arterial blood vessel	2.27e-17	42
arterial system	2.27e-17	42
anatomical system	1.51e-14	625
anatomical group	2.65e-14	626
systemic artery	3.95e-14	33
systemic arterial system	3.95e-14	33
muscle tissue	9.42e-14	63
musculature	9.42e-14	63
musculature of body	9.42e-14	63
skeletal muscle tissue	1.08e-13	61
striated muscle tissue	1.08e-13	61
myotome	1.08e-13	61
dermomyotome	2.18e-12	70
epithelial tube	3.04e-12	118
bone marrow	2.64e-11	80
multi-cellular organism	1.70e-10	659
mesoderm	2.04e-10	448
mesoderm-derived structure	2.04e-10	448
presumptive mesoderm	2.04e-10	448
tube	3.75e-10	194
primary circulatory organ	7.48e-10	27
embryonic structure	9.45e-10	605
developing anatomical structure	9.45e-10	605
germ layer	1.18e-09	604
embryonic tissue	1.18e-09	604
presumptive structure	1.18e-09	604
epiblast (generic)	1.18e-09	604
bone element	1.64e-09	86
heart	1.67e-09	24
primitive heart tube	1.67e-09	24
primary heart field	1.67e-09	24
anterior lateral plate mesoderm	1.67e-09	24
heart tube	1.67e-09	24
heart primordium	1.67e-09	24
cardiac mesoderm	1.67e-09	24
cardiogenic plate	1.67e-09	24
heart rudiment	1.67e-09	24
embryo	2.66e-09	612
multilaminar epithelium	4.39e-09	82
anatomical conduit	5.72e-09	241
immune system	5.95e-09	115
somite	6.52e-09	83
paraxial mesoderm	6.52e-09	83
presomitic mesoderm	6.52e-09	83
presumptive segmental plate	6.52e-09	83
trunk paraxial mesoderm	6.52e-09	83
presumptive paraxial mesoderm	6.52e-09	83
hemolymphoid system	1.88e-08	112
anatomical cluster	8.95e-08	286
aorta	1.47e-07	21
aortic system	1.47e-07	21
skeletal element	2.07e-07	101
skeletal system	2.07e-07	101
unilaminar epithelium	3.54e-07	138
hematopoietic system	4.78e-07	102
blood island	4.78e-07	102

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.